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Catalog No.S1366

1 publication

BMS-707035 Chemical Structure

CAS No. 729607-74-3

BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.

Selleck's BMS-707035 has been cited by 1 publication

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Biological Activity

Description BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
HIV-I integrase [1]
15 nM
In vitro

BMS-707035 is a pyrimidine carboxamide similar to Raltegravir, the first integrase inhibitor licensed for clinical use. BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM. [1] However, several IN mutations, including V75I, Q148R, V151I, and G163R are found to confer resistance to HIV IN inhibitors. The binding of BMS-707035 and target DNA to IN are mutually exclusive events, as revealed by the fact that the inhibition of strand transfer catalysis by BMS-707035 is overcome by increasing amount of target DNA. The binding affinity of BMS-707035 to IN is also affected by the four terminal bases at the 5' end of the pre-processed U5 long terminal repeat (LTR). Gln148 of IN is crucial for the binding of BMS-707035 to IN. [1] The 3' terminus of the viral LTR, on the other hand, retards the rate of BMS-707035 association with IN, by regulating the kinetics of binding and dissociation. [2]


Solubility (25°C)

In vitro DMSO 38 mg/mL (92.58 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 410.42


CAS No. 729607-74-3
Storage powder
in solvent
Synonyms N/A
Smiles CN1C(=O)C(=C(N=C1N2CCCCS2(=O)=O)C(=O)NCC3=CC=C(C=C3)F)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00397566 Withdrawn Drug: HIV Integrase Inhibitor (BMS-707035) HIV Infections Bristol-Myers Squibb February 2007 Phase 2

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Integrase Signaling Pathway Map

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