Home Immunology & Inflammation PD-1/PD-L1 inhibitor BMS-1166

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BMS-1166 PD-1/PD-L1 inhibitor

Cat.No.S8859

BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
BMS-1166 PD-1/PD-L1 inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 641.11

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S885901 DMSO]100 mg/mL]false]Ethanol]13 mg/mL]false]Water]Insoluble]false Purity: 99.27%
99.27

Chemical Information, Storage & Stability

Molecular Weight 641.11 Formula

C36H33ClN2O7

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1818314-88-3 -- Storage of Stock Solutions

Synonyms N/A Smiles CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)OCC5=CC(=CC=C5)C#N)CN6CC(CC6C(=O)O)O)Cl

Solubility

In vitro
Batch:

DMSO : 100 mg/mL ( (155.97 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
PD-1/PD-L1 interaction [1]
1.4 nM
In vitro

BMS-1166 presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. This compound alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes[2].
References

Applications

Methods Biomarkers Images PMID
Growth inhibition assay Cell viability S8859-viability1 29069777

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