Home Protein Tyrosine Kinase EGFR inhibitor BI-4020 For research use only.

BI-4020

BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells, respectively.

BI-4020 Chemical Structure

BI-4020 Chemical Structure

CAS: 2664214-60-0

Purity & Quality Control

Batch: S892101 Ethanol] 30 mg/mL] false] Water] 20 mg/mL] false] DMSO] 15 mg/mL] false Purity: 99.31%
99.31

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Biological Activity

Description BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells, respectively.
Targets
EGFRdel19 T790M C797S [1]
(anti-proliferation potency)		 EGFRdel19 T790M C797S [1]
(biomarker potency)
0.2 nM 0.6 nM

Chemical Information & Solubility

Molecular Weight 542.68 Formula

C30H38N8O2
CAS No. 2664214-60-0 SDF --
Smiles CC1CCCOC2=C(C=N[N]2C)C3=NC(=CC(=C3)C(=O)N=C4NC5=C(C=C(CN6CCN(C)CC6)C=C5)N4C1)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Ethanol : 30 mg/mL

Water : 20 mg/mL

DMSO : 15 mg/mL ( (27.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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