Benazepril HCl

Catalog No.S1284 Synonyms: CGS 14824A HCl

Benazepril HCl Chemical Structure

Molecular Weight(MW): 460.95

Benazepril HCl is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 270 In stock
USD 470 In stock
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Biological Activity

Description Benazepril HCl is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.
Targets
ACE [1]
In vivo Benazepril hydrochloride (3 or 10 mg/kg/d, p.o. for 14 days) dose-dependently inhibits the increase in the blood pressure caused by continuous norepinephrine (NE) infusion in spontaneously hypertensive rats (SHR) and suppresses in seizures induced by a monoamine oxidase inhibitor, tranylcypromine in NE infused SHR. [1] Benazepril hydrochloride (30 mg/kg p.o.) decreases the triglyceride and total cholesterol levels in normotensive rats. Benazepril hydrochloride (3 mg/kg s.c.) causes a significant decrease in aortic atherosclerosis without reducing hypercholesterolemia in cholesterol-fed rabbits. Benazepril hydrochloride (100 mg/kg p.o.) shows no effect on the urine volume and urinary excretion of electrolytes but decreases PSP excretion in normotensive rats. Benazepril hydrochloride (10 mg/kg p.o.) inhibits the increase in the excretion of urinary protein in DOCA/salt spontaneously hypertensive rats. [3] Benazepril Hydrochloride administration corrects systemic hypertension and significantly reduces angiotensin II and aldosterone in cats with experimentally induced or spontaneously occurring chronic renal failure. Benazepril hydrochloride administration reduces serum creatinine and urinary protein concentration in cat with experimentally induced or spontaneously occurring chronic renal failure. [4] Benazepril hydrochloride significantly decreases blood pressure, angiotensin II and aldosterone and, increases upon discontinuation of administration to the pre-administration levels in a canine remnant kidney model of chronic renal failure. [5]

Protocol

Solubility (25°C)

In vitro DMSO 92 mg/mL (199.58 mM)
Ethanol 92 mg/mL (199.58 mM)
Water 19 mg/mL (41.21 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 460.95
Formula

C24H28N2O5.HCl

CAS No. 86541-74-4
Storage powder
in solvent
Synonyms CGS 14824A HCl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID