For research use only.
CAS No. 1134-47-0
Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
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|Description||Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.|
Baclofen induces G0/G1 phase arrest which is connected with down-regulation of intracellular cAMP level, and up-regulation of p21WAF1 protein expression as well as its phosphorylation level in human hepatocellular carcinoma cell.
|In vivo||Chronic treatment with baclofen markedly diminishes hippocampal atrophy and neuronal apoptosis in hippocampal CA1 area via the regulation of autophagy in chronic cerebral hypoperfusion in rats. Baclofen might suppress cytodestructive autophagic activity through Akt-GSK-3β-p-mTOR-Beclin 1 signaling pathway under chronic cerebral hypoperfusion. During brain ischemia, baclofen could reduce CX43 and CX36 surface expression. Baclofen-induced suppression of increased CX43 and CX36 surface expressions helps neurons survive. Baclofen reduces reinstatement to cocaine self-administration in an animal model of relapse. Baclofen suppresses Bel-7402 xenograft tumor growth in vivo.|
|In vitro||3 mg/mL warmed (14.04 mM)|
|Water||0.1 mg/mL (0.46 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04603625||Recruiting||Other: postural management||Quadriplegic Cerebral Palsy||Azienda Unità Sanitaria Locale Reggio Emilia|Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta|Ospedale IRCCS G. Gaslini di Genova|IRCCS Eugenio Medea|IRCCS Don Carlo Gnocchi di Firenze|Azienda Unita'' Sanitaria Locale Di Modena|Azienda Usl di Bologna|Azienda Unità Sanitaria Locale Romagna|Azienda ULSS di Verona e Provincia|Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico||September 1 2020||Not Applicable|
|NCT04509336||Active not recruiting||Drug: Orphenadrine|Drug: Baclofen||Cirrhosis||Mansoura University||August 20 2020||Not Applicable|
|NCT04471714||Recruiting||Drug: Baclofen||Spasticity Muscle|Spinal Cord Injuries||University of Alberta||January 10 2020||Phase 2|
|NCT03682978||Recruiting||Drug: Arbaclofen|Drug: Placebo||Autism Spectrum Disorder||Celso Arango MD PhD|UMC Utrecht||September 19 2019||Phase 2|
|NCT02760992||Unknown status||Drug: IV Baclofen|Drug: Oral Baclofen||Intravenous Baclofen||Allaysis LLC|University of Minnesota||May 2017||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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