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Bay K 8644 L-type Ca2+ Channel Agonist

Name: Bay K 8644
Brand: Selleck Chemicals
SKU: S7924
Availability: InStock
Rating: 5 (7 reviews)

Cat.No.S7924

Bay K 8644 is a racemate. Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

Chemical Structure

Molecular Weight: 356.30

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Quality Control

Batch: Purity: 99.70%

99.70

Related Targets	CFTR CRM1 CD markers AChR Sodium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR
Other Calcium Channel Inhibitors	Tetrandrine Nilvadipine Flunarizine 2HCl Cilnidipine YM-58483 (BTP2) Ionomycin Imperatorin Manidipine 2HCl Astragaloside A Benidipine HCl

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.550mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 71 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	356.30	Formula	C₁₆H₁₅F₃N₂O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	71145-03-4	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

Mechanism of Action

Targets/IC₅₀/Ki	L-type calcium channel (in the isolated field-stimulated vas deferens of the mouse) 17.3nM(EC50)
In vitro	This compound increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel
In vivo	Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.
References	[1] https://pubmed.ncbi.nlm.nih.gov/2466518/ [2] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873501/ [3] https://pubmed.ncbi.nlm.nih.gov/8576273/ [4] https://pubmed.ncbi.nlm.nih.gov/34506129/ [5] https://pubmed.ncbi.nlm.nih.gov/2431917/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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