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Nelfinavir HIV inhibitor

Name: Nelfinavir
Brand: Selleck Chemicals
SKU: S9626
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S9626

Nelfinavir (AG-1341) is a potent inhibitor of HIV protease and induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo. It also inhibits Streptolysin S (SLS) production, a key virulence factor of Streptococcus pyogenes, with IC50 of 6 µM.

Chemical Structure

Molecular Weight: 567.78

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Quality Control

Batch: S962601 DMSO]100 mg/mL]false]Ethanol]25 mg/mL]false]Water]Insoluble]false Purity: 96.88%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

96.88

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HCV Protease
Other HIV Inhibitors	Ebselen ABX464 Swertia Bimaculata Extract Zingibroside R1 Oxindole WAY-383487 Fostemsavir Tris CQ31 Ro24-7429

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (176.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.250mg/ml (2.20mM)	Taking the 1 mL working solution as an example, add 50 μL of 25 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.500mg/ml (0.88mM)	Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	567.78	Formula	C₃₂H₄₅N₃O₄S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	159989-64-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/17785575/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-12-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06971744	RECRUITING	Ovarian Cancer	Medical University of South Carolina	2025-12-18	PHASE2
NCT05036226	RECRUITING	Prostate Cancer Recurrent; Solid Tumor, Adult	Medical University of South Carolina	2022-03-03	PHASE1; PHASE2
NCT04169763	RECRUITING	Stage II Vulvar Cancer AJCC v8; Stage III Vulvar Cancer AJCC v8; Stage IIIA Vulvar Cancer AJCC v8; Stage IIIB Vulvar Cancer AJCC v8; Stage IIIC Vulvar Cancer AJCC v8; Stage IVA Vulvar Cancer AJCC v8	M.D. Anderson Cancer Center	2020-08-07	PHASE1
NCT07281781	RECRUITING	Myelofibrosis; Myelofibrosis; Anemia	University of California, Irvine	2025-09-16	PHASE1; PHASE2
NCT03256916	COMPLETED	Carcinoma Cervix,Stage III	Tata Memorial Hospital	2018-01-16	PHASE3
NCT01925378	WITHDRAWN	Cervical Dysplasia	The University of Texas Health Science Center, Houston	2018-11-07	PHASE2

Tech Support

Handling Instructions

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