For research use only.

Catalog No.S2721 Synonyms: ARC029, FR34235

5 publications

Nilvadipine Chemical Structure

CAS No. 75530-68-6

Nilvadipine (ARC029, FR34235) is a potent calcium channel blocker with an IC50 of 0.03 nM.

Selleck's Nilvadipine has been cited by 5 publications

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Biological Activity

Description Nilvadipine (ARC029, FR34235) is a potent calcium channel blocker with an IC50 of 0.03 nM.
Calcium channel [1]
0.03 nM
In vitro

Nilvadipine strongly inhibits the chemotaxis of interleukin-1 (IL-1), leukotriene B4 (LTB4), platelet-derived growth factor (PDGF) with IC50 of 0.1 nM in rat aortic smooth muscle cells (SMC). [1] Nilvadipine is reported to increase renal blood flow and reduce filtration fraction in the isolated perfused hydronephrotic kidney, suggesting indirectly afferent and efferent arteriolar vasodilation. [2]

In vivo Nilvadipine preserves retinal morphology and electroretinogram responses in RCS rats during the initial stage of retinal degeneration. Nilvadipine significantly enhances rhodopsin kinase and alphaA-crystallin expression and suppression of caspase 1 and 2 expression in the retina of RCS rats. [3] Nilvadipine completely inhibits the vasoactivity elicited by Abeta in rat aortae and in human middle cerebral arteries. Nilvadipine restores cortical perfusion levels in Tg APPsw to values similar to those observed in control littermates without notably affecting the CBF of control mice. [4] Nilvadipine suppresses ischemia (20 min)-reflow (20 min)-induced paw edema of mice (ED30:0.4 mg/kg i.v. and 2 mg/kg p.o.). Nilvadipine suppresses carrageenan-induced paw edema (ED30:15 mg/kg in rats and 20 mg/kg in mice) at a potency corresponding to that of an anti-inflammatory drug, ibuprofen. Nifedipine, nicardipine and nimodipine results in a suppression of 30% only with 100 mg/kg oral dosing in rats. Nilvadipine inhibits superoxide radical (O-2production from xanthine oxidase (XOD) both with lactate dehydrogenase + NADH method and cytochrome c method (IC50:90 and 100 mg/mL, respectively). [5]


Solubility (25°C)

In vitro DMSO 77 mg/mL (199.8 mM)
Ethanol 33 mg/mL (85.63 mM)
Water Insoluble

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Chemical Information

Molecular Weight 385.37


CAS No. 75530-68-6
Storage powder
in solvent
Synonyms ARC029, FR34235
Smiles CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID