Nevirapine

Catalog No.S1742 Synonyms: NSC 641530

Nevirapine  Chemical Structure

Molecular Weight(MW): 266.3

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 70 In stock
USD 270 In stock
USD 647 In stock
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Cited by 1 Publication

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  • Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.

    Sci Transl Med, 2014, 6(262): 262ra157 . Nevirapine purchased from Selleck.

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Biological Activity

Description Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
Targets
Reverse transcriptase [1]
In vitro

Nevirapine (NVP) itself is an inhibitor of only CYP3A4 at concentrations that are well above those of therapeutic relevance (Ki = 270 mM). [1] Nevirapine is a non-nucleoside RT inhibitor with a well-characterized inhibitory activity on RT enzymes of retroviral origin. Nevirapine is also an effective inhibitor of the endogenous RT in murine and human cell lines. Nevirapine exposure rescues the differentiation block present in acute myeloid leukemia (AML) cell lines and primary blasts from two AML patients, as indicated by morphological, functional and immunophenotypic assays. [2] Nevirapine, a dipyridodiazepinone, is a highly specific inhibitor of HIV-1 reverse transcriptase (RT) which exhibits an IC50 = 84 nM in enzyme assays and IC50 = 40nM against HIV-1 replication in cell culture. [3] Nevirapine alters the cleavage specificity of the RNase H, resulting Nevirapine-induced stimulation of RNase H activity beyond the increase expected from the change in cleavage specificity. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CEM-SS cells NUC4SI9tTnWwY4Tpc44h[XO|YYm= NIrId2pCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIGLGJIlvKEOHTT3TV{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nliWGTUJIF{e2G7LDDFR|UxRTFwNTDuUS=> NULjVpBMOTh{MkKwPFg>
human MT4 cells MVnGeY5kfGmxbjDhd5NigQ>? M13VcmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhOSC|dXL0fZBmKENiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BqdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5yMES4PEDPxE1? M1\ocFE6QTN|N{m3
human Jurkat E6-1 cells NGTHSJlHfW6ldHnvckBie3OjeR?= M1TESFIh\GG7cx?= NWnkUnhbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDFcpYueHOndXTveolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iSoXyb4F1KEV4LUGgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEmFNUC9NE4xPCEQvF2= MUiyNVQyPDd5Nh?=
human C1866 cells NHzhOVNEgXSxdH;4bYNqfHliYYPzZZk> NWTrXVRQPzJiaB?= M2\1bGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGMyQDZ4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEWFNUC9NE4xPDl2MzFOwG0> MkjlNlEyQTR7M{m=
human MT2 cells Ml3TSpVv[3Srb36gZZN{[Xl? MWi0JIRigXN? MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXOSB|QjDpcoZm[3SnZDDpckBpfW2jbjDNWFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDwNlQh[W62aXflckBxem:mdXP0bY9vKGGodHXyJFQh\GG7czDifUBGVEmVQTygSWM2OD1yLkC1N{DPxE1? NVrnNlNyOjB3Mke5O|I>
HeLa cells MWPGeY5kfGmxbjDhd5NigQ>? M{XmNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJUVZzIHnuJGhmVGFiY3XscJMh[nliTVHHTUBie3OjeTygTWM2OD1yLkC1N{DPxE1? NXHE[oZWOTh4NkW1PFM>
293T cells MnfuSpVv[3Srb36gZZN{[Xl? NEW2RXNKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDITXYyKHKndnXyd4UhfHKjboPjdolxfGG|ZTDpckAzQTOWIHPlcIx{NCCLQ{WwQVAvODZizszN MkHiNVY2Ojd2OES=
MDCK2 cells M4GySWZ2dmO2aX;uJIF{e2G7 NV3lO5VLOTBizszN MWXJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDJiZYjwdoV{e2WmIHnuJG1FS0t{IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJiQ13GJIZtfW:{ZYPj[Y5k\SCjdDCxNEB2VSCkeTDDUWZFSSCjc4PhfS=> M1zrR|E4OTd{M{Gx

... Click to View More Cell Line Experimental Data

In vivo 4-CANVP is a major metabolite in all the male animals and the female mouse, dog, and monkey. 3-OHNVP is a major fecal metabolite in all animals except for the male rat. 4-CANVP is a major metabolite along with 12-OHNVP glucuronide in the bile of rats. [5]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (199.02 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.3
Formula

C15H14N4O

CAS No. 129618-40-2
Storage powder
in solvent
Synonyms NSC 641530

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03227653 Completed Efavirenz|Child Behavior|Cognitive Symptom|Medication Adherence|Drug-Related Side Effects and Adverse Reactions Radboud University|Kilimanjaro Christian Medical Centre Tanzania|Kilimanjaro Clinical Research Institute June 19 2017 --
NCT03194165 Recruiting Minor Patient Treated by One or More Antiretroviral and for Which a Blood Test Has Been Performed Assistance Publique - Hôpitaux de Paris June 16 2017 --
NCT03227653 Completed Efavirenz|Child Behavior|Cognitive Symptom|Medication Adherence|Drug-Related Side Effects and Adverse Reactions Radboud University|Kilimanjaro Christian Medical Centre Tanzania|Kilimanjaro Clinical Research Institute June 19 2017 --
NCT03194165 Recruiting Minor Patient Treated by One or More Antiretroviral and for Which a Blood Test Has Been Performed Assistance Publique - Hôpitaux de Paris June 16 2017 --
NCT03664440 Completed Efficacy of Rilpivirine-based Regimens as Switch Therapy Mahidol University December 1 2016 Not Applicable
NCT03223402 Completed HIV Infections Cantonal Hospital of St. Gallen December 23 2016 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Reverse Transcriptase Signaling Pathway Map

Related Reverse Transcriptase Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID