Catalog No.S1742 Synonyms: NSC 641530
Molecular Weight(MW): 266.3
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
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Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
Sci Transl Med, 2014, 6(262): 262ra157 . Nevirapine purchased from Selleck.
Purity & Quality Control
Choose Selective Reverse Transcriptase Inhibitors
|Description||Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.|
Nevirapine (NVP) itself is an inhibitor of only CYP3A4 at concentrations that are well above those of therapeutic relevance (Ki = 270 mM).  Nevirapine is a non-nucleoside RT inhibitor with a well-characterized inhibitory activity on RT enzymes of retroviral origin. Nevirapine is also an effective inhibitor of the endogenous RT in murine and human cell lines. Nevirapine exposure rescues the differentiation block present in acute myeloid leukemia (AML) cell lines and primary blasts from two AML patients, as indicated by morphological, functional and immunophenotypic assays.  Nevirapine, a dipyridodiazepinone, is a highly specific inhibitor of HIV-1 reverse transcriptase (RT) which exhibits an IC50 = 84 nM in enzyme assays and IC50 = 40nM against HIV-1 replication in cell culture.  Nevirapine alters the cleavage specificity of the RNase H, resulting Nevirapine-induced stimulation of RNase H activity beyond the increase expected from the change in cleavage specificity. 
|In vivo||4-CANVP is a major metabolite in all the male animals and the female mouse, dog, and monkey. 3-OHNVP is a major fecal metabolite in all animals except for the male rat. 4-CANVP is a major metabolite along with 12-OHNVP glucuronide in the bile of rats. |
-  Erickson DA, et al. Drug Metab Dispos, 1999, 27(12), 1488-1495.
-  Mangiacasale R, et al. Oncogene, 2003, 22(18), 2750-2761.
-  Grob PM, et al. AIDS Res Hum Retroviruses, 1992, 8(2), 145-152.
|In vitro||DMSO||53 mg/mL (199.02 mM)|
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02738502||Recruiting||Drug: darunavir monotherapy||Maternal-fetal Infection Transmission||French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Institut National de la Santé Et de la Recherche Médicale France||June 2016||Phase 2|
|NCT02447159||Completed||Behavioral: Conditional Cash Transfers||HIV|HIV Infections|Pregnancy|Infant Newborn Diseases||University of California San Francisco|University of California Berkeley|New Incentives|Bill and Melinda Gates Foundation||August 2015||Not Applicable|
|NCT02429791||Active not recruiting||Drug: DTG 50 mg|Drug: RPV 25 mg|Drug: CAR||HIV Infections||ViiV Healthcare|Janssen Pharmaceuticals|GlaxoSmithKline||April 14 2015||Phase 3|
|NCT02422797||Active not recruiting||Drug: DTG 50 mg|Drug: RPV 25 mg|Drug: CAR||HIV Infections||ViiV Healthcare|Janssen Pharmaceuticals|GlaxoSmithKline||April 21 2015||Phase 3|
|NCT03023033||Completed||Behavioral: mHealth messaging|Behavioral: Transport Payments||HIV|AIDS||Elizabeth Glaser Pediatric AIDS Foundation|Population Council|Ministry of Health Tanzania||October 2014||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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