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Catalog No.S1742 Synonyms: NSC 641530

5 publications

Nevirapine  Chemical Structure

CAS No. 129618-40-2

Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

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10mM (1mL in DMSO) GBP 57 In stock
GBP 57 In stock
GBP 221 In stock
GBP 529 In stock
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  • Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.

    Sci Transl Med, 2014, 6(262): 262ra157 . Nevirapine purchased from Selleck.

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Biological Activity

Description Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
Reverse transcriptase [1]
In vitro

Nevirapine (NVP) itself is an inhibitor of only CYP3A4 at concentrations that are well above those of therapeutic relevance (Ki = 270 mM). [1] Nevirapine is a non-nucleoside RT inhibitor with a well-characterized inhibitory activity on RT enzymes of retroviral origin. Nevirapine is also an effective inhibitor of the endogenous RT in murine and human cell lines. Nevirapine exposure rescues the differentiation block present in acute myeloid leukemia (AML) cell lines and primary blasts from two AML patients, as indicated by morphological, functional and immunophenotypic assays. [2] Nevirapine, a dipyridodiazepinone, is a highly specific inhibitor of HIV-1 reverse transcriptase (RT) which exhibits an IC50 = 84 nM in enzyme assays and IC50 = 40nM against HIV-1 replication in cell culture. [3] Nevirapine alters the cleavage specificity of the RNase H, resulting Nevirapine-induced stimulation of RNase H activity beyond the increase expected from the change in cleavage specificity. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CEM-SS cells MknjSpVv[3Srb36gZZN{[Xl? M{LG[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiUl[gbY4hS0WPLWPTJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBjgSC[VGSgZZN{[XluIFXDOVA:OS53IH7N M1SwTFE5OjJ{MEi4
human MT4 cells MnP3SpVv[3Srb36gZZN{[Xl? MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCrbX31co9l\W[rY3nlcoN6KH[rcoXzJFEhe3WkdInw[UBEKGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOgbY5lfWOnZDDjfZRweGG2aHnjbZR6NCCHQ{WwQVAvODB2OEig{txO NHS0R20yQTl|M{e5Oy=>
human Jurkat E6-1 cells NXfBfnQ5TnWwY4Tpc44h[XO|YYm= NUfxXnNOOiCmYYnz NYntVI1uSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDFcpYueHOndXTveolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iSoXyb4F1KEV4LUGgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEmFNUC9NE4xPCEQvF2= M2\YPVIyPDF2N{e2
human C1866 cells M3zwRWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnnsO|IhcA>? NHPLUnFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEOTh4NjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCHQ{WwQVAvODR7NEOg{txO NGrXcVMzOTF7NEmzPS=>
human MT2 cells MkHsSpVv[3Srb36gZZN{[Xl? MXq0JIRigXN? M4[5W2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJG1VOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJAzPCCjboTp[4VvKHC{b3T1Z5Rqd25iYX\0[ZIhPCCmYYnzJIJ6KEWOSWPBMEBGSzVyPUCuNFU{KM7:TR?= NXzKfIY4OjB3Mke5O|I>
HeLa cells NYDBbXdHTnWwY4Tpc44h[XO|YYm= MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXOSCrbjDI[WxiKGOnbHzzJIJ6KE2DR1mgZZN{[XluIFnDOVA:OC5yNUOg{txO NUnCOpo4OTh4NkW1PFM>
293T cells NGT3bG1HfW6ldHnvckBie3OjeR?= NELMSlhKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDITXYyKHKndnXyd4UhfHKjboPjdolxfGG|ZTDpckAzQTOWIHPlcIx{NCCLQ{WwQVAvODZizszN MXSxOlUzPzR6NB?=
MDCK2 cells NGixdVNHfW6ldHnvckBie3OjeR?= NWLYPHpHOTBizszN NHvWXmtKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEKg[ZhxemW|c3XkJIlvKE2GQ1uyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>? M2nlW|E4OTd{M{Gx

... Click to View More Cell Line Experimental Data

In vivo 4-CANVP is a major metabolite in all the male animals and the female mouse, dog, and monkey. 3-OHNVP is a major fecal metabolite in all animals except for the male rat. 4-CANVP is a major metabolite along with 12-OHNVP glucuronide in the bile of rats. [5]


Solubility (25°C)

In vitro DMSO 53 mg/mL (199.02 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.3


CAS No. 129618-40-2
Storage powder
in solvent
Synonyms NSC 641530
Smiles CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02738502 Active not recruiting Drug: darunavir monotherapy Maternal-fetal Infection Transmission French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Institut National de la Santé Et de la Recherche Médicale France June 6 2016 Phase 2
NCT02447159 Completed Behavioral: Conditional Cash Transfers HIV|HIV Infections|Pregnancy|Infant Newborn Diseases University of California San Francisco|University of California Berkeley|New Incentives|Bill and Melinda Gates Foundation August 2015 Not Applicable
NCT02429791 Active not recruiting Drug: DTG 50 mg|Drug: RPV 25 mg|Drug: CAR HIV Infections ViiV Healthcare|Janssen Pharmaceuticals|GlaxoSmithKline April 14 2015 Phase 3
NCT02422797 Active not recruiting Drug: DTG 50 mg|Drug: RPV 25 mg|Drug: CAR HIV Infections ViiV Healthcare|Janssen Pharmaceuticals|GlaxoSmithKline April 21 2015 Phase 3
NCT03023033 Completed Behavioral: mHealth messaging|Behavioral: Transport Payments HIV|AIDS Elizabeth Glaser Pediatric AIDS Foundation|Population Council|Ministry of Health Tanzania October 2014 Not Applicable

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID