Nevirapine

Catalog No.S1742 Synonyms: NSC 641530

Nevirapine  Chemical Structure

Molecular Weight(MW): 266.3

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 70 In stock
USD 270 In stock
USD 647 In stock
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Cited by 2 Publications

1 Customer Review

  • Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.

    Sci Transl Med, 2014, 6(262): 262ra157 . Nevirapine purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
Targets
Reverse transcriptase [1]
In vitro

Nevirapine (NVP) itself is an inhibitor of only CYP3A4 at concentrations that are well above those of therapeutic relevance (Ki = 270 mM). [1] Nevirapine is a non-nucleoside RT inhibitor with a well-characterized inhibitory activity on RT enzymes of retroviral origin. Nevirapine is also an effective inhibitor of the endogenous RT in murine and human cell lines. Nevirapine exposure rescues the differentiation block present in acute myeloid leukemia (AML) cell lines and primary blasts from two AML patients, as indicated by morphological, functional and immunophenotypic assays. [2] Nevirapine, a dipyridodiazepinone, is a highly specific inhibitor of HIV-1 reverse transcriptase (RT) which exhibits an IC50 = 84 nM in enzyme assays and IC50 = 40nM against HIV-1 replication in cell culture. [3] Nevirapine alters the cleavage specificity of the RNase H, resulting Nevirapine-induced stimulation of RNase H activity beyond the increase expected from the change in cleavage specificity. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CEM-SS cells MoXlSpVv[3Srb36gZZN{[Xl? M{Ht[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiUl[gbY4hS0WPLWPTJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBjgSC[VGSgZZN{[XluIFXDOVA:OS53IH7N NHi3O4cyQDJ{MkC4PC=>
human MT4 cells NWLaVmZ1TnWwY4Tpc44h[XO|YYm= M{\uOWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhOSC|dXL0fZBmKENiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BqdmS3Y3XkJIN6fG:yYYTobYNqfHluIFXDOVA:OC5yMES4PEDPxE1? M37W[FE6QTN|N{m3
human Jurkat E6-1 cells M3H2V2Z2dmO2aX;uJIF{e2G7 M4\0N|Ih\GG7cx?= NIfUUlBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIFXuek1xe2W3ZH;2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCMdYLrZZQhTTZvMTDj[YxteyCjZoTldkAzKGSjeYOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3ME2wMlA1KM7:TR?= M1zyc|IyPDF2N{e2
human C1866 cells Mn3UR5l1d3SxeHnjbZR6KGG|c3H5 M2\ZRlczKGh? MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDNVg3PiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUCuNFQ6PDNizszN NYWyenNKOjFzOUS5N|k>
human MT2 cells M1vHUGZ2dmO2aX;uJIF{e2G7 NV7LO4lvPCCmYYnz NFyzXnlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxOjRiYX70bYdmdiCycn;keYN1cW:wIHHmeIVzKDRiZHH5d{BjgSCHTFnTRUwhTUN3ME2wMlA2OyEQvF2= M3fIOVIxPTJ5OUey
HeLa cells M4[xeGZ2dmO2aX;uJIF{e2G7 MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXOSCrbjDI[WxiKGOnbHzzJIJ6KE2DR1mgZZN{[XluIFnDOVA:OC5yNUOg{txO NIr5UVMyQDZ4NUW4Ny=>
293T cells M4n6S2Z2dmO2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKHerbHSgeJlx\SCKSW[xJJJmfmW{c3WgeJJidnOlcnnweIF{\SCrbjCyPVNVKGOnbHzzMEBKSzVyPUCuNFYh|ryP NIDsOHoyPjV{N{S4OC=>
MDCK2 cells MnHpSpVv[3Srb36gZZN{[Xl? MVexNEDPxE1? Mnu0TY5pcWKrdHnvckBw\iCqdX3hckBOWlB{IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> MYixO|E4OjNzMR?=

... Click to View More Cell Line Experimental Data

In vivo 4-CANVP is a major metabolite in all the male animals and the female mouse, dog, and monkey. 3-OHNVP is a major fecal metabolite in all animals except for the male rat. 4-CANVP is a major metabolite along with 12-OHNVP glucuronide in the bile of rats. [5]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (199.02 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.3
Formula

C15H14N4O

CAS No. 129618-40-2
Storage powder
in solvent
Synonyms NSC 641530

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02738502 Recruiting Drug: darunavir monotherapy Maternal-fetal Infection Transmission French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Institut National de la Santé Et de la Recherche Médicale France June 2016 Phase 2
NCT02447159 Completed Behavioral: Conditional Cash Transfers HIV|HIV Infections|Pregnancy|Infant Newborn Diseases University of California San Francisco|University of California Berkeley|New Incentives|Bill and Melinda Gates Foundation August 2015 Not Applicable
NCT02429791 Active not recruiting Drug: DTG 50 mg|Drug: RPV 25 mg|Drug: CAR HIV Infections ViiV Healthcare|Janssen Pharmaceuticals|GlaxoSmithKline April 14 2015 Phase 3
NCT02422797 Active not recruiting Drug: DTG 50 mg|Drug: RPV 25 mg|Drug: CAR HIV Infections ViiV Healthcare|Janssen Pharmaceuticals|GlaxoSmithKline April 21 2015 Phase 3
NCT03023033 Completed Behavioral: mHealth messaging|Behavioral: Transport Payments HIV|AIDS Elizabeth Glaser Pediatric AIDS Foundation|Population Council|Ministry of Health Tanzania October 2014 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID