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β-Nicotinamide Mononucleotide

Synonyms: β-NM, NMN

Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.

β-Nicotinamide Mononucleotide Chemical Structure

β-Nicotinamide Mononucleotide Chemical Structure

CAS: 1094-61-7

Selleck's β-Nicotinamide Mononucleotide has been cited by 17 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

Products often used together with β-Nicotinamide Mononucleotide

Nicotinamide N-oxide

β-Nicotinamide Mononucleotide and Nicotinamide N-oxide are the precursors of NAD+.

Nicotinamide Riboside Chloride

β-Nicotinamide Mononucleotide and Nicotinamide Riboside Chloride do not produce any gross lesions in Sprague-Dawley rats when administered orally.

Turner J, et al. Front Pharmacol. 2021 Nov 11;12:749727.

MDL-800

β-Nicotinamide Mononucleotide and MDL-800 promote DNA repair, alleviate SARS‐CoV‐2 infection and disease severity in vitro and in vivo.

Jin R, et al. Aging Cell. 2022 Dec;21(12):e13729.

KPT 9274 (ATG-019)

β-Nicotinamide Mononucleotide provides protection against KPT-9274-induced cytotoxicity.

Neggers JE, et al. Nat Commun. 2018 Feb 5;9(1):502.

Selisistat (EX 527)

Selisistat (EX 527) reverses the protective effect of β-Nicotinamide Mononucleotide against memory dysfunction, inflammatory and oxidative injuries.

Li HR, et al. Redox Biol. 2023 Jul;63:102745.

β-Nicotinamide Mononucleotide Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL60 cells Function assay 80 mM syrosingopine-metformin-treated HL60 cells grown in medium supplemented with NMN had a partial recovery in ATP levels 30540938
MC3T3-E1 Cell viability assay 0.1, 1, 10 mM 6 h AlCl3-induced reduction of MC3T3-E1 cell viability was successfully recovered by NMN treatment. 30292833
HepG2 Cell viability assay 0.5 mM 48 h NMN was able to restore reduced NAD concentrations but not cell viability after stimulation with palmitate. 28974242
Click to View More Cell Line Experimental Data

Biological Activity

Description Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.
In vitro
In vitro

Nicotinamide mononucleotide, the NAD+ precursor, rescues the NAD+/NADH ratio and exerts anti-senescent effects by activating SIRT1.[1]
Cell Research Cell lines mouse AT2 cells strain MLE-12
Concentrations 500 μM
Incubation Time --
Method

The mouse AT2 cells strain MLE-12 are cultured in DMEM with 10% FBS at 37 ℃ in a humidified atmosphere containing 5% CO2. Cells are treated with rapamycin (10 nM), bafilomycin (5 nM), 3 MA (3 mM), SRT1720 (4 μM), Ex527 (10 μM), NMN (500 μM), Olaparib (40 μM) and mitoquinone (50 nM). β-galactosidase staining is performed based on the manufacture s instructions. Relative protein expression levels are measured by Western blot. The level of NAD+/NADH is quantified by an NAD+/NADH detection kit.
In Vivo
In vivo

NMN reduces the loss of cochlear hair cells caused by cisplatin and improves hearing in C57BL/6 mice, by supplementation of NAD+ through de novo and salvage synthesis pathways.[2]
Animal Research Animal Models C57BL/6 mice
Dosages 100 mg/kg
Administration i.g., i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06036355 Not yet recruiting
Postoperative Prevention of Tumor
Shanghai Cell Therapy Group Co.Ltd
 September 30 2023 Early Phase 1
NCT05759468 Recruiting
Type2diabetes|Diabetic Kidney Disease
Brigham and Women''s Hospital|Boston Medical Center
 April 13 2023 Phase 2
NCT05789355 Recruiting
Sickle Cell Disease
LGD|CEN Biotech|Assistance Publique Hopitaux De Marseille|Etablissement Français du Sang
 April 1 2023 Not Applicable
NCT04910061 Completed
Healthy Volunteers
Seneque SA|Dicentra Inc.|LGD
 August 5 2021 Not Applicable

Chemical Information & Solubility

Molecular Weight 334.22 Formula

C11H15N2O8P
CAS No. 1094-61-7 SDF --
Smiles C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 67 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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