Netupitant

Catalog No.S4654 Synonyms: CID6451149, CID 6451149, CID-6451149

Netupitant Chemical Structure

Molecular Weight(MW): 578.59

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.

Size Price Stock Quantity  
USD 97 In stock
USD 297 In stock
USD 697 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Substance P Inhibitors

Biological Activity

Description Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.
Targets
Neurokinin-1 receptor [1]
In vitro

In CHO NK1 cells, Netupitant concentration-dependently antagonizes the stimulatory effects of substance P (SP) showing insurmountable antagonism (pKB 8.87). In cells expressing NK2 or NK3 receptors, Netupitant is inactive[1].

In vivo Netupitant behaves as a brain penetrant, orally active, potent and selective NK1 antagonist. In mice the intrathecal injection of SP elicited the typical scratching, biting and licking response that is dose-dependently inhibited by Netupitant given intraperitoneally in the 1-10 mg/kg dose range. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK1 agonist is dose-dependently counteracted by Netupitant given intraperitoneally (ID50 1.5 mg/kg) or orally (ID50 0.5 mg/kg). In time course experiments in gerbils Netupitant displayed long lasting effects[1].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: NG108-15 cells
  • Concentrations: 1, 3, 10, 30 nM
  • Incubation Time: 1 h
  • Method:

    cells are preincubated for 1 h at 37℃ with either growth media alone(control) or media containing antagonists. Antagonist concentrations are at least 30-fold the Kd value to ensure receptor saturation. After preincubation, antagonists are removed and cells are rinsed with growth media alone for an additional hour to allow for dissociation of antagonists still bound to receptor.Cell media are then replaced with isosmotic HEPES buffer (pH 7.4, 20 mM) containing NaCl (130 mM), KCl (2 mM), MgCl2 (1 mM) CaCl2 (2 mM), Fluo-4 acetoxymethyl (AM) ester (2 mM), pluronic acid (0.04%) and SP at various concentrations in the 3 nM to 1 mM range. The final incubation lasted for 1 h at 37 ℃. Pluronic acid is added as a nonionic surfactant to sequester the AM ester molecules into micelles for cellular uptake.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Male Swiss mice
  • Formulation: Saline containing 5% DMSO and 5% Tween 80
  • Dosages: 1 and 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (172.83 mM)
DMSO 2 mg/mL (3.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 578.59
Formula

C30H32F6N4O

CAS No. 290297-26-6
Storage powder
in solvent
Synonyms CID6451149, CID 6451149, CID-6451149

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Netupitant | Netupitant supplier | purchase Netupitant | Netupitant cost | Netupitant manufacturer | order Netupitant | Netupitant distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID