Navitoclax (ABT-263)

For research use only.

Catalog No.S1001

245 publications

Navitoclax (ABT-263) Chemical Structure

CAS No. 923564-51-6

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

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Selleck's Navitoclax (ABT-263) has been cited by 245 publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
Targets
Bcl-xL [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-w [1]
(Cell-free assay)
<=0.5 nM(Ki) <=1 nM(Ki) <=1 nM(Ki)
In vitro

ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. [1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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RS4:11 MmfVRZBweHSxc3nzJIF{e2G7 NHj2W4Y3KGh? MXnFR|UxKD1iMD6wNVQh|ryP M{LyW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEixOVY4Lz5{NEi4NVU3PzxxYU6=
FDC-P1 MmXqRmNNNTJiaX7obYJqfGmxbjDhd5NigQ>? NV7l[45ZOjRiaB?= MorhTWM2OCB;IECuNFE2KM7:TR?= NUjXe5R4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PFE2PjdpPkK0PFgyPTZ5PD;hQi=>
NCI-H1963 Ml3KR5l1d3SxeHnjbZR6KGG|c3H5 M{\KU|Qh\GG7cx?= MkjhTWM2OCB;IECuNFI3PiEQvF2= MlzHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NEiyPVgoRjJ|NES4Nlk5RC:jPh?=
NCI-H187 MX\DfZRwfG:6aXPpeJkh[XO|YYm= MkPaOEBl[Xm| Ml7YTWM2OCB;IECuNFM5PCEQvF2= M1;lVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NES4Nlk5Lz5{M{S0PFI6QDxxYU6=
NCI-H1417 M1yzcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MofjOEBl[Xm| NU\FU5hFUUN3MDC9JFAvODV2MjFOwG0> NIXSfYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0PFI6QCd-MkO0OFgzQTh:L3G+
FDC-P1 M{fZS2JEVC26TDDpcohq[mm2aX;uJIF{e2G7 M1LxcFI1KGh? MUjJR|UxKD1iMD6wOkDPxE1? NFLyXVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4NVU3Pyd-MkS4PFE2Pjd:L3G+
NCI-H146 NVGzd4I6S3m2b4TvfIlkcXS7IHHzd4F6 M1y4WFQ5KGh? MWLFR|UxKD1iMD6wPFY4KM7:TR?= MnjlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6NEG4PFIoRjF6OESxPFgzRC:jPh?=
RS4:11 NYjVWJp{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MW\FR|UxKD1iMD6xNVIh|ryP NUnZbIpZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlYzPDdpPkK4PVI3OjR5PD;hQi=>
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RS4-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEK1PFch|ryP M17zN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
HL-60 NHTSbHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHxW4V5UUN3ME2wMlAzQTB6IN88US=> M{\mbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
KY821 NX7rb3Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvCNmxKSzVyPUCuNFI6PzVizszN MlHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
ECC10 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHES4JKSzVyPUCuNFM4QTJizszN MlzqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
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KG-1 NUn2XZRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr5bo16UUN3ME2wMlA1PDh4IN88US=> NXT3NWZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
TGW M2LHe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDUVGdIUUN3ME2wMlA1PjN|IN88US=> MlHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
ATN-1 NWTVS5JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD6R3FqUUN3ME2wMlA1PzN|IN88US=> NF7kTGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
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EW-18 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDkTWM2OD1yLkC2PFQyKM7:TR?= NWP6OHdlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
NB17 NHi0[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXN[I1KSzVyPUCuNFcyOjRizszN MlznQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NIDISIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfBNGlKSzVyPUCuNFczOTNizszN NWrSW3VSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
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KARPAS-45 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfZTWM2OD1yLkC3PFE2KM7:TR?= MoC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
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NCI-H209 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEi3NFQh|ryP NVLBfVh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
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KARPAS-299 NH[5PXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUmyb3BGUUN3ME2zMlY4OzZzIN88US=> M2XVXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
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NOS-1 M4jnbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG2TWM2OD1|Lke5PFM1KM7:TR?= NEfvcFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
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NCI-H82 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi0fZZGUUN3ME2zMlk2QTN4IN88US=> M{jNcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
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SW1990 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTRwMEW5NFgh|ryP M3\l[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
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RPMI-7951 M33Kemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnyTWM2OD12LkKyOFE{KM7:TR?= NWPYWnc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
Calu-6 NVLYVVNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTQTWM2OD12LkK3PFgyKM7:TR?= NHHpTpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
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SW954 NEPPc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M330NWlEPTB;ND6yPVY3KM7:TR?= NYDST5N[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
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LAN-6 NILrbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLGeGNYUUN3ME20MlQ2OTh7IN88US=> M2PCNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
FTC-133 Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqzbVJKSzVyPUSuOVM6PSEQvF2= NHnSRpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
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SW620 NVKzbGJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnKUJNkUUN3ME20MlU4ODV5IN88US=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
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MDA-MB-157 MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTRwOEi3OkDPxE1? NFrEZWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
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NCI-H2029 NFHIWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrNTVZKSzVyPUSuPVQyQDVizszN M2PzRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
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RPMI-2650 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTVwM{[xOkDPxE1? M{nYV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
IA-LM M3m0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjubJo5UUN3ME21MlM6QDdzIN88US=> M4PZfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
KP-4 M13FVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[zTWpKSzVyPUWuOFY{OzRizszN M3LSOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
G-402 NIC4d2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LUU2lEPTB;NT61NVg3PSEQvF2= NUnCcZdzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
OS-RC-2 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjPbY9KSzVyPUWuOVI3ODRizszN Mor2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NCI-H1155 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm5XIxXUUN3ME21MlU1QTV3IN88US=> NXHxNIpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
OE19 Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTVwNki2NlQh|ryP MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
U-2-OS M2L4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrQb3NJUUN3ME21Mlg6ODF|IN88US=> NW\oPW9tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
SCC-15 NHLMOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInKe2RKSzVyPUWuPVM3PjJizszN M2HjelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H630 NYTlOHd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;yTnVKSzVyPUWuPVk1ODRizszN MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
PFSK-1 NXTT[Yl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPMTYhrUUN3ME22MlA2OjV7IN88US=> MlPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NCI-H1770 NYLU[oZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTZwMkC4O|Qh|ryP MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
SK-MEL-3 M{XnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q5c2lEPTB;Nj60NlkyPSEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
LB1047-RCC Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWyTYxKSzVyPU[uOFc3OjVizszN M4HIblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H446 M{C5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfuTWM2OD14Lk[yPVI2KM7:TR?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
SW780 NInoclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTZwN{CxPFUh|ryP NWToXJVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
NEC8 NVzYVXFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\aSmJkUUN3ME22Mlc3PjNizszN M{fxV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NOMO-1 NFXnRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHiVWs6UUN3ME22Mlc5OTFzIN88US=> M4HNO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
COLO-668 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTZwOESzPFch|ryP M4TrclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MC116 M3P6dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXVSHVKSzVyPU[uPVM5QTdizszN MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
HCC1937 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTZwOUmyOVEh|ryP NWnuVnNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
NCI-N87 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTiTWM2OD15LkG5Nlk{KM7:TR?= NVfFXnFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
COLO-320-HSR M4XHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fJRWlEPTB;Nz6yNlc{QCEQvF2= M3LjZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
HCC1806 Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXwTWM2OD15LkK2NFQ1KM7:TR?= M3LQ[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
OVCAR-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETO[WZKSzVyPUeuN|MxOzhizszN NFT5Nok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
NUGC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyyTWM2OD15LkO5Olk1KM7:TR?= NVS5[oMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
SW1783 NITXR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP2[5ZKSzVyPUeuOFMyPzVizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
GCT NHqz[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\YVGlEPTB;Nz61OlkxPiEQvF2= M1XYfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H2126 M3T3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\4cmlEPTB;Nz63N|YzPSEQvF2= M2fMTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MEL-HO NIiwNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWflWG9ZUUN3ME23Mlc4ODV2IN88US=> MoLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
CAPAN-1 NHzxN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTdwN{ezOVch|ryP NVXmcWM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
SW756 NFXlW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjBTWM2OD15Lke4N|M{KM7:TR?= NXv0OpZ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
SKG-IIIa MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf5WGc1UUN3ME23MlgyQDl{IN88US=> NIe5PFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
HCE-T NXPpR4xNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\lTWM2OD15Lki3O|g{KM7:TR?= M2X1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
Ca-Ski NVzLR3FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jJdmlEPTB;Nz65PVM5OyEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
COLO-684 NHvtSZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnCbphxUUN3ME24MlAyQDF6IN88US=> Mn7OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
KYSE-70 NYPPV4FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz1TWM2OD16LkC3O|I6KM7:TR?= NFjodIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
TI-73 Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H4NWlEPTB;OD6yOVg2OSEQvF2= MojXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
BT-20 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXyzOVRjUUN3ME24MlI3ODV{IN88US=> M3rWPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MHH-ES-1 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3vVHA6UUN3ME24MlUyQDN2IN88US=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
TE-12 NIXFSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzhWoxFUUN3ME24MlU6QTNzIN88US=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
YH-13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWriWXBsUUN3ME24MlYyODB6IN88US=> NXnJbmdORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
SF126 NUL1SYl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3sdYdxUUN3ME24Mlg{QDZ3IN88US=> Mk\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
J82 NF24NYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PhR2lEPTB;OD65NFA{QCEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
RCC10RGB Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDuTWM2OD16Lkm5OVYyKM7:TR?= NYfYUoFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
SK-UT-1 NX3pVoJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH3OpZKSzVyPUmuNFQ6PDVizszN Mkn5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
LB2241-RCC NF76d2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7ze2t2UUN3ME25MlE6OTN5IN88US=> Mly1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
LB996-RCC M2DJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfFb|dKSzVyPUmuNVk5QSEQvF2= M3XsWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
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BALL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTR5Lk[xOlgh|ryP NHTRZ|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
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SK-N-FI MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTR6LkCzOVgh|ryP M17SO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
KALS-1 NF2yRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELBWmJKSzVyPUS4MlEzQDlizszN NET5VZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
HO-1-N-1 NFjx[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nVcWlEPTB;NEiuO|Q1PSEQvF2= M36wWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H2452 M17tPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PhRmlEPTB;NEmuNVE2OiEQvF2= Mk\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
OC-314 NHTBV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTR7Lk[4N|Qh|ryP NVfhe|BFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc; 

PubMed: 26811457     


(A) Western blot analysis of expressions of STAT3/p-STAT3 and STAT6/p-STAT6 as well as antiapoptotic members (Bcl-2, Bcl-xL, and Mcl-1) after 48 h of treatments in HDLM-2 cells. (B) Western blot analysis of expressions of proapoptotic proteins (Bim, Puma, Bik, Bax, and p-Bad) as well as caspase cascade molecules (PARP and c-Myc) after 48 h of treatments. β-Actin was used as an input control.

caspase3 / cleaved caspase 3; 

PubMed: 24481442     


(b) (i) N/TERT, (ii) SINCE and (iii) SINEG2 cells were either untreated (0 μM/DMSO) or treated with increasing doses of Navitoclax (ABT-263; 0.025–30 μM) and were incubated for 24 h. Next, cells were collected and whole-cell lysates were prepared and immunoblotted against anti-full-length Caspase 3 (∼35 kDa) antibody, whereas β-actin (∼42 kDa) was used as a protein-loading control. Apoptosis was assessed through detecting the cleaved bands of Caspase-3 (∼19, 17 kDa). 

26811457 24481442
Growth inhibition assay
Cell viability; 

PubMed: 25685063     


(C) Hcc827, (D) H292, and (E) H1993 cells were treated with increasing concentrations of albendazole or mebendazole in the presence of navitoclax (0, 1, 2, and 4 μM). Viability was determined after 1 day.

25685063
In vivo When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. [2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. [2]

Protocol

Kinase Assay:

[1]

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Affinity determination:

Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.
Cell Research:

[1]

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  • Cell lines: SCLC cell lines
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    Human tumor cell lines SCLC cell lines are maintained at 37℃ containing 5% CO2. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 4) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: C.B.-17 scid-bg or C.B.-17 scid mice
  • Dosages: 100 mg/kg/d
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (102.6 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+corn oil
For best results, use promptly after mixing.
7mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 974.61
Formula

C47H55ClF3N5O6S3

CAS No. 923564-51-6
Storage powder
in solvent
Synonyms N/A
Smiles CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04480086 Active not recruiting Drug: Mivebresib|Drug: Navitoclax|Drug: Ruxolitinib Myelofibrosis (MF) AbbVie March 17 2021 Phase 1
NCT04454658 Recruiting Drug: ABBV-744|Drug: Navitoclax|Drug: Ruxolitinib Myelofibrosis (MF) AbbVie August 19 2020 Phase 1
NCT04041050 Recruiting Drug: Navitoclax|Drug: Ruxolitinib|Drug: Celecoxib Myeloproliferative Neoplasm AbbVie November 8 2019 Phase 1
NCT03181126 Completed Drug: Navitoclax|Drug: Chemotherapy|Drug: Venetoclax Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1
NCT02520778 Active not recruiting Drug: Navitoclax|Drug: Osimertinib Advanced Lung Non-Squamous Non-Small Cell Carcinoma|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Non-Small Cell Cancer AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7 National Cancer Institute (NCI) March 31 2016 Phase 1
NCT02591095 Completed Drug: ABT-263 Platinum-resistant or Refractory Ovarian Cancer Centre Francois Baclesse|ARCAGY/ GINECO GROUP|French Cancer Research Hospital Program January 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

  • Answer:

    S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

  • Question 2:

    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

  • Answer:

    According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID