Navitoclax (ABT-263)

Name: Navitoclax (ABT-263)
Brand: Selleck Chemicals
SKU: S1001
Rating: 5 (259 reviews)

For research use only.

Catalog No.S1001

259 publications

CAS No. 923564-51-6

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with K_i of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

Selleck's Navitoclax (ABT-263) has been cited by 259 publications

Cancer Cell, 2021, S1535-6108(21)00338-X

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Cell, 2019, 178(2):302-315.e23

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Cell, 2019, 178(2):361-373

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Cancer Cell, 2019, 36(2):179-193

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 35(5):752-766

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Cancer Cell, 2019, 36(1):68-83

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Cell Metab, 2019, 30(1):129-142

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Cancer Discov, 2018, 8(12):1598-1613

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Nat Chem Biol, 2018, 14(2):112-117

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Cancer Cell, 2017, 32(4):490-505.e10

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Cell Stem Cell, 2017, 20(3):407-414.e4

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Nature, 2016, 538(7626):477-482

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Nat Med, 2016, 22(3):262-9

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Dev Cell, 2021, S1534-5807(21)00360-9

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Cell Rep, 2021, 34(11):108870

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Cell Rep, 2021, 36(1):109334

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Haematologica, 2021, 10.3324/haematol.2021.278743

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Oncogene, 2021, 10.1038/s41388-021-01910-6

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Cancers (Basel), 2021, 13(16)4123

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Cell Death Dis, 2021, 12(4):406

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Cell Death Dis, 2021, 12(8):741

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Cell Death Dis, 2021, 12(1):54

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Cell Death Dis, 2021, 12(1):121

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Br J Cancer, 2021, 10.1038/s41416-021-01441-7

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Mol Oncol, 2021, 10.1002/1878-0261.13060

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Clin Sci (Lond), 2021, 135(15):1873-1895

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Mol Cancer Res, 2021, 19(4):651-666

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Int J Mol Sci, 2021, 22(2)E752

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Int J Mol Sci, 2021, 22(8)3811

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Sci China Life Sci, 2021, 10.1007/s11427-021-1933-7

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Transl Oncol, 2021, 14(5):101048

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BMC Complement Med Ther, 2021, 21(1):88

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PLoS Comput Biol, 2021, 17(2):e1008630

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Nat Commun, 2021, 12(1):1134

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Nat Commun, 2021, 12(1):1281

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NPJ Breast Cancer, 2021, 7(1):60

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Nat Cell Biol, 2020, 4

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Sci Transl Med, 2020, 15;12(539) pii: eaax3799

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Cell Res, 2020, 27;1-16

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Mol Cell, 2020, 7;S1097-2765(20)30269-0

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Nat Commun, 2020, 11(1):752

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Nat Commun, 2020, 11(1):259

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Mol Syst Biol, 2020, 16(2):e8664

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Blood Cancer J, 2020, 10(6):72

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Aging Cell, 2020, 19(4):e13133

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Elife, 2020, 2;9:e54954

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Int J Cancer, 2020, 10.1002/ijc.33393

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Eur J Cancer, 2020, 126:93-103

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J Med Chem, 2020, 63(22):13733-13744

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Cancers (Basel), 2020, 12(9)E2551

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Cancers (Basel), 2020, 10;12(2) pii: E406

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Breast Cancer Res, 2020, 22(1):130

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Cell Death Dis, 2020, 11(10):854

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Cell Death Dis, 2020, 8;11(6):443

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Aging (Albany NY), 2020, 7;12(9):8221-8240

PubMed: 32379705 ( click the link to review the publication )

Cancer Sci, 2020, 111(10):3793-3801

PubMed: 32687646 ( click the link to review the publication )

Antioxidants (Basel), 2020, 9(11)E1143

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Mol Cancer Res, 2020, molcanres.0586.2020

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PLoS Negl Trop Dis, 2020, 14(3):e0008150

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Front Pharmacol, 2020, 11:615505

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Sci Rep, 2020, 14;10(1):222

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Biochem Biophys Res Commun, 2020, 4;526(3):612-617

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Laryngoscope, 2020, 10.1002

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Platelets, 2020, 10.1080/09537104.2020.1724276

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Mol Biol Rep, 2020, 47(6):4849-4856

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Biomater Sci, 2020, 8(8):2264-2273

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Cancer Lett, 2020, S0304-3835(20)30635-2

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Int J Radiat Oncol Biol Phys, 2020, S0360-3016(20)34731-3

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PLoS One, 2020, 15(7):e0234103

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Leuk Lymphoma, 2020, 1-5

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Mol Cancer Res, 2020, 18(4):537-548

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Aging (Albany NY), 2020, 12(14):14174-14188

PubMed: 32692721 ( click the link to review the publication )

J Hematol Oncol, 2020, 13(1):95

PubMed: 32677976 ( click the link to review the publication )

NPJ Breast Cancer, 2020, 6:30

PubMed: 32715085 ( click the link to review the publication )

Cancers (Basel), 2020, 12(8):E2137

PubMed: 32752193 ( click the link to review the publication )

Anat Cell Biol, 2020, 53(4):471-480

PubMed: 33361545 ( click the link to review the publication )

Cancers (Basel), 2020, 12(8):E2298

PubMed: 32824203 ( click the link to review the publication )

Int J Radiat Oncol Biol Phys, 2020, 15;106(4):867-877

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Cell Rep, 2020, 32(2):107897

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EMBO Mol Med, 2020, 12(12):e12391

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Trop Life Sci Res, 2020, 31(3):1-13

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Cell Rep, 2020, 31(13):107830

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Free Radic Biol Med, 2020, 152:227-234

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FASEB J, 2020, 10.1096/fj.201900218R

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Mol Cell, 2019, 74(1):19-31

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Nat Chem Biol, 2019, 15(3):232-240

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Sci Adv, 2019, 5(7):eaau9433

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-0713

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EMBO Mol Med, 2019, 11(10):e10769

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-0775

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-1398

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Thyroid, 2019, 29(4):540-548

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Elife, 2019, 8

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Oncogene, 2019, 38(1):47-59

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Br J Pharmacol, 2019, 10.1111/bph.14773

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J Med Chem, 2019, 62(15):6913-6924

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Pigment Cell Melanoma Res, 2019, 10.1111/pcmr.12841

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Cell Death Dis, 2019, 10(5):342

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Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.04.011

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Stem Cell Res Ther, 2019, 10(1):86

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Int J Mol Sci, 2019, 20(23)

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Sci Rep, 2019, 9(1):1897

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J Biol Chem, 2019, 294(3):875-886

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Mol Pharmacol, 2019, 96(4):419-429

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Cancer Cell Int, 2019, 19:218

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Cancer Cell Int, 2019, 19:222

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Prostate, 2019, 79(11):1347-1359

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BMC Cancer, 2019, 19(1):1251

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BMC Cancer, 2019, 20(1):1

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Cell Biosci, 2019, 9:60

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Transl Oncol, 2019, 12(4):683-692

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Photodiagnosis Photodyn Ther, 2019, 10.1016/j.pdpdt.2019.08.016

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Cancer Biomark, 2019, 24(1):51-59

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Nat Metab, 2019, 1(11):1074-1088

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Cell Oncol (Dordr), 2019, 42(3):287-301

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Immunity, 2018, 48(4):675-687

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J Allergy Clin Immunol, 2018, 142(5):1647-1650.e3

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Nat Commun, 2018, 9(1):215

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Nucleic Acids Res, 2018, 46(19):10195-10215

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Neuro Oncol, 2018, 20(2):203-214

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Oncogene, 2018, 37(22):2936-2952

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Cell Death Discov, 2018, 4:107

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Cell Death Dis, 2018, 9(10):944

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Cell Death Dis, 2018, 9(7):713

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Cell Death Dis, 2018, 92(10)

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Cell Death Dis, 2018, 9(5):445

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Cell Death Dis, 2018, 9(2):21

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Cell Death Dis, 2018, 9(9):907

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Cell Physiol Biochem, 2018, 48(3):1123-1138

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Mol Oncol, 2018, 12(3):287-304

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Stem Cell Res Ther, 2018, 9(1):108

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Antioxidants (Basel), 2018, 10.3390/antiox7110150

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Biochemical Pharmacology, 2018, 10.1016/j.bcp.2018.01.031

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Sci Rep, 2018, 8(1):16822

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Mar Drugs, 2018, 16(12)

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Biomed Pharmacother, 2018, 107:139-145

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Cell Cycle, 2018, 17(17):2175-2186

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Toxicol In Vitro, 2018, 46:229-236

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Oncotarget, 2018, 9(28):20075-20088

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Oncotarget, 2018, 9(24):16701-16717

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J Exp Med, 2018, 215(1):319-336

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Nat Cell Biol, 2017, 19(10):1226-1236

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Nat Cell Biol, 2017, 19(9):1116-1129

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J Clin Invest, 2017, 127(2):635-650

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Nat Commun, 2017, 8:16078

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Nat Commun, 2017, 8(1):1940

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Nat Commun, 2017, 8(1):1067

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Cancer Res, 2017, 77(8):2018-2028

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Cancer Res, 2017, 77(13):3513-3526

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Cancer Res, 2017, 77(9):2476-2487

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J Cell Biol, 2017, 216(11):3655-3675

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Cancer Res, 2017, 77(9):2512-2521

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Aging Cell, 2017, 16(4):693-703

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Cell Death Dis, 2017, 8(10):e3062

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Mol Cancer Ther, 2017, 16(11):2563-2571

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Mol Cancer Ther, 2017, 16(10):2178-2190

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Cell Commun Signal, 2017, 15(1):16

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Cell Discov, 2017, 3:16048

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Dis Model Mech, 2017, 10(9):1109-1115

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Acta Pharmacol Sin, 2017, 38(12):1632-1641

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Int J Oncol, 2017, 10.3892/ijo.2017.3914

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Biomed Pharmacother, 2017, 95:1574-1579

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Anticancer Drugs, 2017, 28(10):1141-1149

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Tumour Biol, 2017, 39(5):1010428317699120

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Oncotarget, 2017, 8(18):29558-29573

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Oncotarget, 2017, 8(49):86312-86324

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Oncotarget, 2017, 8(34):57047-57057

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Viruses, 2017, 9(10)

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Nat Microbiol, 2016, 1:15034

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Nat Commun, 2016, 7:11363

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Autophagy, 2016, 12(7):1083-93

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Clin Cancer Res, 2016, pii: clincanres.2827.2015

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Leukemia, 2016, 30(2):351-60

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Proc Natl Acad Sci U S A, 2016, 113(6):1624-9

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Cancer Res, 2016, 76(23):7001-7011

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Elife, 2016, 10.7554/eLife.18489

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Int J Cancer, 2016, 138(2):507-14

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Anal Chem, 2016, 88(16):8050-7

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Endocr Relat Cancer, 2016, 23(1):35-45

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Aging (Albany NY), 2016, 8(11):2915-2926

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Cancer Biol Ther, 2016, 17(1):27-35

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Cell Cycle, 2016, 15(3):394-402

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PLoS One, 2016, 11(10):e0164250

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Biochem Biophys Res Commun, 2016, 478(4):1792-7

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J Biomol Screen, 2016, 21(7):680-8

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Mol Med Rep, 2016, 13(1):403-11

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Data Brief, 2016, 6:710-4

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Oncotarget, 2016, 7(50):82013-82027

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EMBO Rep, 2015, 16(5):618-27

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Cell Death Differ, 2015, 10.1038/cdd.2015.73

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Int J Cancer, 2015, 137(12):2959-70

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Breast Cancer Res, 2015, 17:26

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Breast Cancer Res, 2015, 17(1):533

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Cell Death Dis, 2015, 6:e2034

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Mol Cancer Ther, 2015, 14(1):298-306

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Frontiers in Oncology, 2015, 4:368

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Sci Rep, 2015, 5:14739

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Ann Surg Oncol, 2015, 22(9):3079-86

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Open Biol, 2015, 5(3)

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PLoS One, 2015, 10(3):e0120913

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PLoS One, 2015, 10(1):e0116998

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Microvasc Res, 2015, 101:72-81

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Oncol Lett, 2015, 10(2):829-834

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Oncotarget, 2015,

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Oncotarget, 2015, 6(34):36456-71

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Sci Rep, 2015, 5:16406

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J Clin Invest, 2014, 124(1):117-28

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J Clin Invest, 2014, 124(11):4737-52

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Proc Natl Acad Sci USA, 2014, 111(41):14788-93

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Chem Sci, 2014, 5, 2794–2803

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Int J Cancer, 2014, 136(3):688-98

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Oncogene, 2014, 10.1038/onc.2014.21

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Cell Death Dis, 2014, 5:e1028

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Cell Death Dis, 2014, 5:e1291

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Antimicrob Agents Chemother, 2014, 10.1128/AAC.02798-13

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J Biol Chem, 2014, 289(38):26481-91

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Skelet Muscle, 2014, 4(1):4

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PLoS One, 2014, 9(10):e108371

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PLoS One, 2014, ;9(6):e99404

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Assay Drug Dev Technol, 2014, 12(9-10):514-26

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Oncotarget, 2014, 5(21):10237-50

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Blood, 2013, 121(10):1850-7

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Blood, 2013, 122(9):1587-98

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Cell Death Differ, 2013, 20(11):1475-84

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Haematologica, 2013,

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Int J Cancer, 2013, 132(4):978-87

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J Neurosci, 2013, 33(12):5195-207

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Cell Death Dis, 2013, 4:e883

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Cell Death Dis, 2013, 4:e742

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Neoplasia, 2013, 15(5):568-78

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Cell Cycle, 2013, 12(18):2960-8

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Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with K_i of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

Targets

Bcl-xL ^[1] (Cell-free assay)	Bcl-2 ^[1] (Cell-free assay)	Bcl-w ^[1] (Cell-free assay)
<=0.5 nM(Ki)	<=1 nM(Ki)	<=1 nM(Ki)

In vitro

ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. ^[1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. ^[1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. ^[2]

Cell Data

Cell Lines	Assay Type	Incubation Time	Activity Description	PMID
FL5.12	M{HyfGN6fG:2b4jpZ4l1gSCjc4PhfS=>	NX7FNVltOjRiaB?=	MnfaSWM2OCB;IECuNFA1OiEQvF2=	NVS1eGprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFE5QDJpPkG4PFQyQDh{PD;hQi=>
FL5.12	Mn23R5l1d3SxeHnjbZR6KGG\|c3H5	MWSyOEBp	NUD4XpExTUN3MDC9JFAvODB3OTFOwG0>	NWLFbGw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFE5QDJpPkG4PFQyQDh{PD;hQi=>
RS4:11	MonrRZBweHSxc3nzJIF{e2G7	NHHIUFc3KGh?	MlK5SWM2OCB;IECuNFE1KM7:TR?=	M{LtUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEixOVY4Lz5{NEi4NVU3PzxxYU6=
FDC-P1	MVrCR2wuOiCrbnjpZol1cW:wIHHzd4F6	MkPjNlQhcA>?	Ml7RTWM2OCB;IECuNFE2KM7:TR?=	NIm3c2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4NVU3Pyd-MkS4PFE2Pjd:L3G+
NCI-H1963	M1nKbGN6fG:2b4jpZ4l1gSCjc4PhfS=>	MVK0JIRigXN?	NHraSppKSzVyIE2gNE4xOjZ4IN88US=>	NYfnS4J4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OFgzQThpPkKzOFQ5Ojl6PD;hQi=>
NCI-H187	MU\DfZRwfG:6aXPpeJkh[XO\|YYm=	M4HsUVQh\GG7cx?=	MYHJR\|UxKD1iMD6wN\|g1KM7:TR?=	NHHZbm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0PFI6QCd-MkO0OFgzQTh:L3G+
NCI-H1417	MX;DfZRwfG:6aXPpeJkh[XO\|YYm=	NEDKeGY1KGSjeYO=	NWTGc\|FrUUN3MDC9JFAvODV2MjFOwG0>	MnjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NEiyPVgoRjJ\|NES4Nlk5RC:jPh?=
FDC-P1	MnLYRmNNNXiOIHnubIljcXSrb36gZZN{[Xl?	NGPMVJczPCCq	MXPJR\|UxKD1iMD6wOkDPxE1?	M{fKNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEixOVY4Lz5{NEi4NVU3PzxxYU6=
NCI-H146	MkL6R5l1d3SxeHnjbZR6KGG\|c3H5	MVG0PEBp	NFrm[HRGSzVyIE2gNE4xQDZ5IN88US=>	NF7zRpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEi0NVg5Oid-MUi4OFE5QDJ:L3G+
RS4:11	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MXjFR\|UxKD1iMD6xNVIh\|ryP	NH3aZmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyOlI1Pyd-Mki5NlYzPDd:L3G+
MOLT4	M13Ze2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NYPEOG1GTUN3MDC9JFAvOzB\|IN88US=>	MnHQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mk[yOFcoRjJ6OUK2NlQ4RC:jPh?=
EoL-1-cell	NXnmdolWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M3vve2lEPTB;MD6wNFY3QSEQvF2=	M1LtZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MV-4-11	NUKzW\|FyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NV:3U3NSUUN3ME2wMlAyPTh4IN88US=>	M1jhe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NKM-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M{jrZ2lEPTB;MD6wNVY6QSEQvF2=	M33kRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
ML-2	MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mn7lTWM2OD1yLkCxPVg{KM7:TR?=	M3fXSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
BV-173	NVnnfllkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NUHzSFd5UUN3ME2wMlAzOzF2IN88US=>	M2LCVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
RS4-11	NX\odWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MXzJR\|UxRTBwMEK1PFch\|ryP	M{PwPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
HL-60	M1nwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MlvsTWM2OD1yLkCyPVA5KM7:TR?=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
KY821	M2P3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnvuTWM2OD1yLkCyPVc2KM7:TR?=	NWm0PJJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
ECC10	MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYHVVW5NUUN3ME2wMlA{Pzl{IN88US=>	NEewdZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
NCI-H720	NWeyTVdNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MWHJR\|UxRTBwMESwNVEh\|ryP	NFrVZW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
QIMR-WIL	NX;VcWhYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M3;6XmlEPTB;MD6wOFI5PyEQvF2=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
KG-1	MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYnI[lZLUUN3ME2wMlA1PDh4IN88US=>	NIfDOHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
TGW	M33yRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NHjKeYxKSzVyPUCuNFQ3OzNizszN	MnPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
ATN-1	NXPDdIdjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NUOzeWNoUUN3ME2wMlA1PzN\|IN88US=>	NEW2T5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
RH-18	Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NFTnd4NKSzVyPUCuNFYxPDhizszN	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
EW-18	NX61[IhIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHHifnNKSzVyPUCuNFY5PDFizszN	MmfMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NB17	M3i0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVvxU5lEUUN3ME2wMlA4OTJ2IN88US=>	NILNSJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
SK-NEP-1	MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M1\uVGlEPTB;MD6wO\|IyOyEQvF2=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
P12-ICHIKAWA	M3Xpemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{\OfWlEPTB;MD6wO\|c4QCEQvF2=	NFrwToE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
KARPAS-45	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NFvs[3RKSzVyPUCuNFc5OTVizszN	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
EW-3	Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NGPHcGdKSzVyPUCuNFgxPTNizszN	NGrsbFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
NB13	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NY\OWJQ4UUN3ME2wMlA5OjB\|IN88US=>	M{PwXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H209	NWrKcpRmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MnTzTWM2OD1yLkC4O\|A1KM7:TR?=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NCI-H1092	MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYG1UmNSUUN3ME2wMlExOjd3IN88US=>	Mlu1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NH-12	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MlTzTWM2OD1yLkGwO\|Q1KM7:TR?=	NXPTS2txRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
697	MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M1rwTmlEPTB;MD6xNFg{QSEQvF2=	MnWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
KE-37	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NYHvWGU{UUN3ME2wMlEyOzdizszN	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
MOLT-4	NUjRXGFET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NEe0PZRKSzVyPUCuNVUyPjlizszN	M3XzfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
CHP-134	NGXCXppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M2XWO2lEPTB;MD6xOlMxPiEQvF2=	M1zMUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
D-283MED	NGS3UolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MUnJR\|UxRTBwMUe2PFYh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
LU-135	MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHfwOJNKSzVyPUCuNVg2PTJizszN	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
LU-134-A	M3fXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NH\tfnlKSzVyPUCuNVg3PzFizszN	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
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TI-73	MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mn2xTWM2OD16LkK1PFUyKM7:TR?=	NX;RT5o2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
BT-20	NF\h[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MVTJR\|UxRThwMk[wOVIh\|ryP	M3XLd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MHH-ES-1	NHvEUmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NV;5[Gk6UUN3ME24MlUyQDN2IN88US=>	MnuwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
TE-12	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1XCVWlEPTB;OD61PVk{OSEQvF2=	NEnNdVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
YH-13	M1vJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUjYUm1LUUN3ME24MlYyODB6IN88US=>	Mn3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
SF126	MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NVrmOWRZUUN3ME24Mlg{QDZ3IN88US=>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
J82	NXfrNmFkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NWXLR4hGUUN3ME24MlkxODN6IN88US=>	NXvwZoloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
RCC10RGB	M2nFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVvYZmFWUUN3ME24Mlk6PTZzIN88US=>	NYjxS3Z7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
SK-UT-1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MlvQTWM2OD17LkC0PVQ2KM7:TR?=	NUn5UXg2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
LB2241-RCC	NWq1OYZpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MmS2TWM2OD17LkG5NVM4KM7:TR?=	M4m4dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
LB996-RCC	NF;TRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NIXGNmlKSzVyPUmuNVk5QSEQvF2=	M2LRblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
EPLC-272H	M1O1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NV3yNphzUUN3ME25MlM4PjV5IN88US=>	NGDpcog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
CTV-1	M3HI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1TPUWlEPTB;OT61OlU{OiEQvF2=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
HSC-2	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1\hb2lEPTB;OT61O\|U2KM7:TR?=	MlnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
SK-MEL-28	MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mn61TWM2OD17Lk[xPFk{KM7:TR?=	NX36XGE2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
MMAC-SF	NXW0UZRxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NF;CVYtKSzVyPUmuOlg4PSEQvF2=	NInrVpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
CP50-MEL-B	NXjx[40{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NVrreYhMUUN3ME25Mlc2Pzh{IN88US=>	NUGxZldXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
HT-1080	Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4HXSWlEPTB;OT63O\|c{QSEQvF2=	NEPZOpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
HEC-1	NEfFeXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NX6wR21MUUN3ME2xNE4{OzV{IN88US=>	NYn1eZFoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
AGS	NFLSS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MULJR\|UxRTFyLkO3OEDPxE1?	NIrCZWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
GAMG	NXO2VolFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MV\JR\|UxRTFyLkWxOlIh\|ryP	NVLSVGJRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
SW48	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		Ml\PTWM2OD1zMD61NVg6KM7:TR?=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
U031	Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MXvJR\|UxRTFyLkW5NFgh\|ryP	NUHYOHp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
OVCAR-5	MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3vWTmlEPTB;MUCuOlQzQSEQvF2=	NXfGbIZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
SF295	MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MV3JR\|UxRTFyLk[3NFQh\|ryP	NFjLOW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
BHT-101	NGrJdItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3XUd2lEPTB;MUCuO\|E4PyEQvF2=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
VMRC-RCZ	M4GxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M4XIW2lEPTB;MUGuN\|IxOSEQvF2=	MlzZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
ACHN	M{\TeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{jocGlEPTB;MUGuOFIyOSEQvF2=	M3z5U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H526	M4TVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MmDSTWM2OD1zMT61NFQ{KM7:TR?=	NWn4TZVFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
MN-60	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MXzJR\|UxRTFzLkWzPUDPxE1?	M3q5W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H2291	NVzkU3lUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MmfmTWM2OD1zMT61OFY3KM7:TR?=	NIfOelg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
SCC-25	NFn4cmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NEixWlhKSzVyPUGxMlc2PTZizszN	M1HFdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
SK-MEL-2	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MU\JR\|UxRTFzLke2N\|ch\|ryP	MnmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
SN12C	NVq3R2U1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NFLFfIVKSzVyPUGxMlk{PTVizszN	NHmwdHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
NCI-H69	MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MWHJR\|UxRTF{LkSyN\|Qh\|ryP	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
ME-180	MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NH21UG9KSzVyPUGyMlcxPTRizszN	M{HKN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MC-IXC	M33VTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1\oW2lEPTB;MUKuO\|UyQCEQvF2=	NXHxOHh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
NCI-H2347	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NXK3SGRzUUN3ME2xNk44PjF2IN88US=>	NWLoZYI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
M059J	NYTVO3gzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MX\JR\|UxRTF{Lke3Nlch\|ryP	M2XnRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
A2058	M1;6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYLJR\|UxRTF{Lki2PFEh\|ryP	M133bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
VA-ES-BJ	M3rMcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1\veWlEPTB;MUKuPFc5PSEQvF2=	NFPxTIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
Ca9-22	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MlrkTWM2OD1zMj65OFUyKM7:TR?=	MoL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
KNS-42	NYfnc5NLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M3HvcGlEPTB;MUKuPVk5PCEQvF2=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
LoVo	Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MmDGTWM2OD1zMz6yN\|E{KM7:TR?=	NYPvSYplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
AM-38	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHL5VoJKSzVyPUGzMlI2PjZizszN	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NB5	M1XFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M3WxWmlEPTB;MUOuN\|c2OiEQvF2=	Mn\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
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PSN1	NWr0dXE1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NI\XZnBKSzVyPUSxMlE4PDlizszN	M3nO[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
D-566MG	NYXOU3dRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1\KVmlEPTB;NEGuNlA5PiEQvF2=	M4TiV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
EGI-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NIrmT5JKSzVyPUSyMlQzQCEQvF2=	NUnL[od7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
A204	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1\JR2lEPTB;NEKuOlM5QCEQvF2=	M2nuWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
Saos-2	M3PwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoDpTWM2OD12Mj64N\|Y6KM7:TR?=	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
SNU-C2B	NF;ibpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MlLyTWM2OD12Mz62PFc5KM7:TR?=	NWKxVoxlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
HLE	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NXr3VFdoUUN3ME20OE4xQDV4IN88US=>	M3K4NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
SW1463	M4nxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEfNZmJKSzVyPUS0Mlk6PzFizszN	NFS5SnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
DSH1	NVPNV4toT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NH3xeYxKSzVyPUS1MlAxOzNizszN	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
MCF7	NYPzbW5NT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoK0TWM2OD12NT61NFUyKM7:TR?=	MkPtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
K5	NUD2elFsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MX\JR\|UxRTR3Lkm0NFUh\|ryP	MnzWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NCI-H358	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NF\nd4JKSzVyPUS3MlIyPSEQvF2=	NVzCcGpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
NCI-H2030	M{m4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEXxe4FKSzVyPUS3MlI{PzRizszN	NV;Vepc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
SW948	MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NX7SPI1pUUN3ME20O{41PjRizszN	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
BALL-1	MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MYPJR\|UxRTR5Lk[xOlgh\|ryP	NHnITlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,
TE-9	M3The2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NXvaTmFLUUN3ME20O{46PThzIN88US=>	NXXh[2tFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
SK-N-FI	NYfuZ3lyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHHv[WdKSzVyPUS4MlA{PThizszN	M2XQT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
KALS-1	MkLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MYDJR\|UxRTR6LkGyPFkh\|ryP	NUPienZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR\|Nki0M{c,W0GQR1XSQE9iRg>?
HO-1-N-1	NUDGdXNVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYjJR\|UxRTR6Lke0OFUh\|ryP	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NCI-H2452	MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NUL0[2o6UUN3ME20PU4yOTV{IN88US=>	MoG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
OC-314	NILPUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NX[0O4Q{UUN3ME20PU43QDN2IN88US=>	NF7UUYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK\|5USU6JRWK8M4E,

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc; PubMed: 26811457 Proc Natl Acad Sci U S A (A) Western blot analysis of expressions of STAT3/p-STAT3 and STAT6/p-STAT6 as well as antiapoptotic members (Bcl-2, Bcl-xL, and Mcl-1) after 48 h of treatments in HDLM-2 cells. (B) Western blot analysis of expressions of proapoptotic proteins (Bim, Puma, Bik, Bax, and p-Bad) as well as caspase cascade molecules (PARP and c-Myc) after 48 h of treatments. β-Actin was used as an input control. caspase3 / cleaved caspase 3; PubMed: 24481442 Cell Death Dis (b) (i) N/TERT, (ii) SINCE and (iii) SINEG2 cells were either untreated (0 μM/DMSO) or treated with increasing doses of Navitoclax (ABT-263; 0.025–30 μM) and were incubated for 24 h. Next, cells were collected and whole-cell lysates were prepared and immunoblotted against anti-full-length Caspase 3 (∼35 kDa) antibody, whereas β-actin (∼42 kDa) was used as a protein-loading control. Apoptosis was assessed through detecting the cleaved bands of Caspase-3 (∼19, 17 kDa).	26811457 24481442
Growth inhibition assay	Cell viability; PubMed: 25685063 Cancer Cell Int (C) Hcc827, (D) H292, and (E) H1993 cells were treated with increasing concentrations of albendazole or mebendazole in the presence of navitoclax (0, 1, 2, and 4 μM). Viability was determined after 1 day.	25685063

In vivo

When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. ^[2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. ^[2]

Protocol

Kinase Assay: ^[1]	- Collapse Affinity determination: Binding affinities (K_i or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.
Cell Research: ^[1]	- Collapse Cell lines: SCLC cell lines Concentrations: 0-1 μM Incubation Time: 48 hours Method: Human tumor cell lines SCLC cell lines are maintained at 37℃ containing 5% CO₂. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 ⁴) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: C.B.-17 scid-bg or C.B.-17 scid mice Dosages: 100 mg/kg/d Administration: Administered via p.o. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	100 mg/mL (102.6 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+corn oil For best results, use promptly after mixing.	4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Navitoclax (ABT-263) SDF

Molecular Weight	974.61
Formula	C₄₇H₅₅ClF₃N₅O₆S₃
CAS No.	923564-51-6
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO+ % + % Tween 80+ % ddH₂O

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04480086	Active not recruiting	Drug: Mivebresib\|Drug: Navitoclax\|Drug: Ruxolitinib	Myelofibrosis (MF)	AbbVie	March 17 2021	Phase 1
NCT04454658	Recruiting	Drug: ABBV-744\|Drug: Navitoclax\|Drug: Ruxolitinib	Myelofibrosis (MF)	AbbVie	November 11 2020	Phase 1
NCT04041050	Recruiting	Drug: Navitoclax\|Drug: Ruxolitinib\|Drug: Celecoxib	Myeloproliferative Neoplasm	AbbVie	November 8 2019	Phase 1
NCT03181126	Completed	Drug: Navitoclax\|Drug: Chemotherapy\|Drug: Venetoclax	Acute Lymphoblastic Leukemia (ALL)\|Lymphoblastic Lymphoma	AbbVie	November 27 2017	Phase 1
NCT02520778	Active not recruiting	Drug: Navitoclax\|Drug: Osimertinib	Advanced Lung Non-Squamous Non-Small Cell Carcinoma\|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma\|Stage III Lung Non-Small Cell Cancer AJCC v7\|Stage IIIA Lung Non-Small Cell Cancer AJCC v7\|Stage IIIB Lung Non-Small Cell Cancer AJCC v7\|Stage IV Lung Non-Small Cell Cancer AJCC v7	National Cancer Institute (NCI)	March 31 2016	Phase 1
NCT02591095	Completed	Drug: ABT-263	Platinum-resistant or Refractory Ovarian Cancer	Centre Francois Baclesse\|ARCAGY/ GINECO GROUP\|French Cancer Research Hospital Program	January 2016	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?
Answer:
S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.
Question 2:
Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?
Answer:
According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

Selective Bcl-2 Inhibitor

ABT-199 (GDC-0199) : Bcl-2-selective, K_i<0.01 nM.
Bcl-2 Inhibitor in Clinical Trial

Obatoclax Mesylate (GX15-070) : Phase II for leukemia, lymphoma, myelofibrosis, and mastocytosis.
Classic Bcl-2 Inhibitor

ABT-737 : BH3-mimetic inhibitor, Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.

Related Bcl-2 Products

MI-773 (SAR405838) ^New

MI-773 (SAR405838) is an orally available MDM2 antagonist with K_i of 0.88 nM. Phase 1.
Venetoclax (ABT-199)

Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with K_i of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.

Features:Re-engineered version of ABT-263 (Navitoclax).
ABT-737

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
Obatoclax Mesylate (GX15-070)

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with K_i of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Features:Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Sabutoclax

Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
(R)-(-)-Gossypol acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

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Navitoclax (ABT-263)