NMDA (N-Methyl-D-aspartic acid)

For research use only.

Catalog No.S7072

1 publication

NMDA (N-Methyl-D-aspartic acid) Chemical Structure

Molecular Weight(MW): 147.13

NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 216 In stock
EUR 68 In stock
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Selleck's NMDA (N-Methyl-D-aspartic acid) has been cited by 1 publication

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Biological Activity

Description NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
Targets
NMDA receptor [1]
In vitro

NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca2+ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). [1]

Protocol

Solubility (25°C)

In vitro Water 30 mg/mL (203.9 mM)
DMSO 5 mg/mL (33.98 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 147.13
Formula

C5H9NO4

CAS No. 6384-92-5
Storage powder
in solvent
Synonyms N/A
Smiles CNC(CC(=O)O)C(=O)O

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03274375 Not yet recruiting Drug: IA session|Drug: Rituximab Anti-NMDAR Encephalitis Assistance Publique - Hôpitaux de Paris October 2019 Phase 2
NCT04165239 Recruiting Drug: KH176|Drug: Placebo Mitochondrial Diseases|Mitochondrial Myopathies|Mitochondrial Encephalomyopathies|MELAS Syndrome|MIDD Khondrion BV|Julius Clinical The Netherlands October 30 2019 Phase 2
NCT03084783 Not yet recruiting Drug: Dexamethasone HSV Encephalitis University Hospital Grenoble|University of Liverpool June 1 2018 Phase 3
NCT02909400 Completed Drug: KH176|Drug: placebo Mitochondrial Diseases|Mitochondrial Myopathies|Mitochondrial Encephalomyopathies|MELAS|MIDD Khondrion BV|Radboud University September 2016 Phase 2
NCT02398201 Completed Drug: Bezafibrate Mitochondrial Diseases Newcastle-upon-Tyne Hospitals NHS Trust|Newcastle University September 2015 Phase 2
NCT02302560 Withdrawn -- Sleep Architecture Charite University Berlin Germany February 2015 --

Tech Support

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID