Nangibotide TFA

Catalog No.P1257 Purity: 99.90%

Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

Amino-acid Sequence

CAS No.

Purity & Quality Control

Batch: P125701 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.90%

99.90

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( ； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

References
https://pubmed.ncbi.nlm.nih.gov/29885068/ https://pubmed.ncbi.nlm.nih.gov/32468087/

References

https://pubmed.ncbi.nlm.nih.gov/29885068/
https://pubmed.ncbi.nlm.nih.gov/32468087/

Product Information

Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)