research use only

Nangibotide TFA

Cat.No.P1257

Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

Amino-acid Sequence

CAS No.

Quality Control

Batch: P125701 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.90%

99.90

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

References
https://pubmed.ncbi.nlm.nih.gov/29885068/ https://pubmed.ncbi.nlm.nih.gov/32468087/

References

https://pubmed.ncbi.nlm.nih.gov/29885068/
https://pubmed.ncbi.nlm.nih.gov/32468087/

Product Information

Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)