Home DNA Damage/DNA Repair PARP inhibitor Niraparib hydrochloride

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Niraparib hydrochloride PARP inhibitor

Cat.No.E4869

Niraparib hydrochloride (MK-4827 hydrochloride) is a potent poly(ADP-ribose)polymerase (PARP) inhibitor with IC50s of 3.8 and 2.1 nM against both the PARP-1 and PARP-2 enzymes, respectively.It inhibits the repair of radiation-induced DNA double-strand breaks, activates apoptosis, and exhibits anti-tumor activity.
Niraparib hydrochloride PARP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 356.85

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Quality Control

Batch: E486901 DMSO]64 mg/mL]false]Water]64 mg/mL]false]Ethanol]64 mg/mL]false Purity: 98.37%
98.37

Solubility

In vitro
Batch:

DMSO : 64 mg/mL (179.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 64 mg/mL

Ethanol : 64 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 356.85 Formula

C19H20N4O.ClH

 Storage (From the date of receipt)
CAS No. 1038915-64-8 Download SDF Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
PARP2
2.1 nM
PARP1
3.8 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-04)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06915025 RECRUITING
Epithelial Ovarian Cancer; Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma
Imunon
 2025-07-09 PHASE3
NCT05460000 RECRUITING
Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma; Clear Cell Carcinoma
North Eastern German Society of Gynaecological Oncology
 2024-10-11 PHASE2
NCT01042379 RECRUITING
Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma; TNBC - Triple-Negative Breast Cancer; HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer
QuantumLeap Healthcare Collaborative
 2010-03-01 PHASE2
NCT05700721 RECRUITING
Brain Metastases
M.D. Anderson Cancer Center
 2023-06-02 PHASE2
NCT05659381 RECRUITING
Stage III Ovarian Cancer; Stage IV Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IV Primary Peritoneal Cancer; Stage III Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer
GOG Foundation
 2024-03-08 PHASE3
NCT06412120 RECRUITING
Ovarian Cancer
University of Miami
 2026-07-28 PHASE4

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