Noradrenaline bitartrate monohydrate

For research use only.

Catalog No.S2615 Synonyms: Levophed

Noradrenaline bitartrate monohydrate Chemical Structure

CAS No. 108341-18-0

Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.

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Biological Activity

Description Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
alpha-adrenergic receptor [1]
In vitro

Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations’ and would, through an enhancement of ‘bottom-up’ information processing at the expense of irrelevant ‘top-down’ expectations, favor behavioral adjustment. [1] Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. [2] Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects. [3]


Solubility (25°C)

In vitro DMSO 64 mg/mL (189.75 mM)
Water 64 mg/mL (189.75 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 337.28


CAS No. 108341-18-0
Storage powder
in solvent
Synonyms Levophed
Smiles C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04963920 Not yet recruiting Device: Cytosorb® 300 ml Septic Shock CytoSorbents Europe GmbH September 2021 Not Applicable
NCT04807413 Not yet recruiting Drug: Nitric Oxide|Other: standard of care treatment Hypoxia Rabin Medical Center April 2021 Phase 3
NCT04687540 Recruiting Drug: Tocilizumab|Drug: Saline 0.9% Obesity|Healthy Rigshospitalet Denmark April 9 2021 Not Applicable
NCT04751773 Recruiting Behavioral: Exercise training Colorectal Liver Metastasis Rigshospitalet Denmark March 12 2021 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID