Noradrenaline bitartrate monohydrate

For research use only.

Catalog No.S2615 Synonyms: Levophed

Noradrenaline bitartrate monohydrate Chemical Structure

CAS No. 108341-18-0

Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.

Purity & Quality Control

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
Targets
alpha-adrenergic receptor [1]
In vitro

Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations’ and would, through an enhancement of ‘bottom-up’ information processing at the expense of irrelevant ‘top-down’ expectations, favor behavioral adjustment. [1] Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. [2] Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects. [3]

Protocol

Solubility (25°C)

In vitro DMSO 64 mg/mL (189.75 mM)
Water 64 mg/mL (189.75 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 337.28
Formula

C8H11NO3.C4H6O6.H2O

CAS No. 108341-18-0
Storage powder
in solvent
Synonyms Levophed
Smiles C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04963920 Not yet recruiting Device: Cytosorb® 300 ml Septic Shock CytoSorbents Europe GmbH September 2021 Not Applicable
NCT04807413 Not yet recruiting Drug: Nitric Oxide|Other: standard of care treatment Hypoxia Rabin Medical Center April 2021 Phase 3
NCT04687540 Recruiting Drug: Tocilizumab|Drug: Saline 0.9% Obesity|Healthy Rigshospitalet Denmark April 9 2021 Not Applicable
NCT04751773 Recruiting Behavioral: Exercise training Colorectal Liver Metastasis Rigshospitalet Denmark March 12 2021 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Adrenergic Receptor Signaling Pathway Map

Related Adrenergic Receptor Products

Tags: buy Noradrenaline bitartrate monohydrate | Noradrenaline bitartrate monohydrate ic50 | Noradrenaline bitartrate monohydrate price | Noradrenaline bitartrate monohydrate cost | Noradrenaline bitartrate monohydrate solubility dmso | Noradrenaline bitartrate monohydrate purchase | Noradrenaline bitartrate monohydrate manufacturer | Noradrenaline bitartrate monohydrate research buy | Noradrenaline bitartrate monohydrate order | Noradrenaline bitartrate monohydrate mouse | Noradrenaline bitartrate monohydrate chemical structure | Noradrenaline bitartrate monohydrate mw | Noradrenaline bitartrate monohydrate molecular weight | Noradrenaline bitartrate monohydrate datasheet | Noradrenaline bitartrate monohydrate supplier | Noradrenaline bitartrate monohydrate in vitro | Noradrenaline bitartrate monohydrate cell line | Noradrenaline bitartrate monohydrate concentration | Noradrenaline bitartrate monohydrate nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID