Neomycin sulfate

Catalog No.S2568

Neomycin sulfate Chemical Structure

Molecular Weight(MW): 712.72

Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.

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Biological Activity

Description Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
In vitro

Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. [1] Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. [2] Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets. [3] Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MYrDfZRwfG:6aXPpeJkh[XO|YYm= NXnzSZd3PzJiaB?= Mln1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOkDPxE1? NFvwOXYzPjhzOUCwNS=>
HCT116 M3nJNGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWTmTIZxPzJiaB?= MoL1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOSEQvF2= NF6wR3IzPjhzOUCwNS=>
MDA-MB-231 M1fOeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NV61U4FVPzJiaB?= NVzjOJFxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNVMh|ryP NWfLeZJNOjZ6MUmwNFE>
Bel7404 NY\6VZlqS3m2b4TvfIlkcXS7IHHzd4F6 M2HaT|czKGh? M{ThPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJmdDd2MESgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjBzIN88US=> Mo\PNlY5OTlyMEG=
U87MG NEDUSHZEgXSxdH;4bYNqfHliYYPzZZk> M33JU|czKGh? MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOVM5KM7:TR?= MX:yO|Q1QDl{NB?=

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Protocol

Solubility (25°C)

In vitro Water 143 mg/mL (200.63 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 712.72
Formula

C23H46N6O13.H2SO4

CAS No. 1405-10-3
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID