Neomycin sulfate

Catalog No.S2568

For research use only.

Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.

Neomycin sulfate Chemical Structure

CAS No. 28002-70-2 或1405-10-3

Selleck's Neomycin sulfate has been cited by 1 Publication

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Biological Activity

Description Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
In vitro

Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. [1] Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. [2] Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets. [3] Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 712.72
Formula

C23H46N6O13.H2SO4

CAS No. 28002-70-2 或1405-10-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00795951 Completed Biological: T.R.U.E. Test Dermatitis Contact Allerderm November 2008 Phase 4
NCT00058617 Completed Biological: Injection of EBV Specific CTLs Epstein-Barr Virus-Related Hodgkin Lymphoma|Epstein-Barr Virus-Related Non-Hodgkin Lymphoma|EBV Positive Plasma Cell Neoplasm Baylor College of Medicine|The Methodist Hospital Research Institute|Center for Cell and Gene Therapy Baylor College of Medicine January 1996 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

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Handling Instructions

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