Neomycin sulfate

For research use only.

Catalog No.S2568

1 publication

Neomycin sulfate Chemical Structure

Molecular Weight(MW): 712.72

Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.

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Selleck's Neomycin sulfate has been cited by 1 publication

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Biological Activity

Description Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
In vitro

Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. [1] Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. [2] Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets. [3] Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NIjCeW5EgXSxdH;4bYNqfHliYYPzZZk> NXPKOZc6PzJiaB?= M1vBdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlYh|ryP NVX5bo5QOjZ6MUmwNFE>
HCT116 M3LrSWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnfiO|IhcA>? NH;2TXVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjBzIN88US=> NEjPVJYzPjhzOUCwNS=>
MDA-MB-231 MXfDfZRwfG:6aXPpeJkh[XO|YYm= M1P2WlczKGh? M4T3dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkGzJO69VQ>? MU[yOlgyQTByMR?=
Bel7404 NFXhXlFEgXSxdH;4bYNqfHliYYPzZZk> MYK3NkBp NIXvb4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD\Wx5NEC0JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yMTFOwG0> NF\i[WczPjhzOUCwNS=>
U87MG M{fsTWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUC3NkBp NHXDRVdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDePRzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPTN6IN88US=> M1vGblI4PDR6OUK0

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Solubility (25°C)

In vitro Water 143 mg/mL (200.63 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 712.72


CAS No. 1405-10-3
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID