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CAS No. 1405-10-3
Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
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Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors
|Description||Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.|
Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step.  Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA.  Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets.  Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV. 
|In vitro||Water||143 mg/mL (200.63 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00795951||Completed||Biological: T.R.U.E. Test||Dermatitis Contact||Allerderm||November 2008||Phase 4|
|NCT00058617||Completed||Biological: Injection of EBV Specific CTLs||Epstein-Barr Virus-Related Hodgkin Lymphoma|Epstein-Barr Virus-Related Non-Hodgkin Lymphoma|EBV Positive Plasma Cell Neoplasm||Baylor College of Medicine|The Methodist Hospital System|Center for Cell and Gene Therapy Baylor College of Medicine||January 1996||Phase 1|
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