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NVL-655 (Neladalkib) ALK inhibitor

Name: NVL-655 (Neladalkib)
Brand: Selleck Chemicals
SKU: E1961
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1961

NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively.

Chemical Structure

Molecular Weight: 452.91

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Quality Control

Batch: E196101 Ethanol]91 mg/mL]false]DMSO]45 mg/mL]false]Water]Insoluble]false Purity: 99.84%

Cited in Nature Medicine for its top-tier quality

COA

HPLC

SDS

Datasheet

99.84

Related Targets EGFR VEGFR PDGFR FGFR c-Met Src MEK CSF-1R FLT3 HER2

Other ALK Inhibitors TAE684 (NVP-TAE684) GSK1838705A Repotrectinib (TPX-0005) AZD3463 AP26113-analog (ALK-IN-1) Ensartinib dihydrochloride ASP3026 HG-14-10-04 X-376 ALK inhibitor 1

Solubility

In vitro batch selection
In vitro
Batch:

Ethanol : 91 mg/mL

DMSO : 45 mg/mL (99.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

Mass value Mass unit Concentration value Concentration unit Volume value Volume unit Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection
In vivo
Batch:

Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

DMSO percentage % DMSO

Second solvent percentage %

Tween 80 percentage % Tween 80

Water (ddH₂O) percentage % ddH₂O

DMSO percentage % DMSO
+
Corn oil percentage %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 452.91 Formula
C₂₃H₂₂ClFN₆O
Storage (From the date of receipt) 3 years-20°Cpowder

CAS No. 2739866-40-9 Download SDF Storage of Stock Solutions
1 year-80°Cin solvent
1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki

ALK

ROS1

PYK2

FAK

TrkB

ALK(G1202R)

<0.73 nM

G1202R/G1269A

3 nM

G1202R/L1198F

3 nM

G1202R/L1196M

7 nM

References

[1] https://pubmed.ncbi.nlm.nih.gov/37057106/

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Signaling Pathway Map

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Related Targets	EGFR VEGFR PDGFR FGFR c-Met Src MEK CSF-1R FLT3 HER2
Other ALK Inhibitors	TAE684 (NVP-TAE684) GSK1838705A Repotrectinib (TPX-0005) AZD3463 AP26113-analog (ALK-IN-1) Ensartinib dihydrochloride ASP3026 HG-14-10-04 X-376 ALK inhibitor 1

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

Molecular Weight	452.91	Formula	C₂₃H₂₂ClFN₆O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2739866-40-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Targets/IC₅₀/Ki	ALK ROS1 PYK2 FAK TrkB ALK(G1202R) <0.73 nM G1202R/G1269A 3 nM G1202R/L1198F 3 nM G1202R/L1196M 7 nM
References	[1] https://pubmed.ncbi.nlm.nih.gov/37057106/