Home Cytoskeletal Signaling Microtubule Associated inhibitor Nab-Paclitaxel

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Nab-Paclitaxel Microtubule Polymer stabilizer

Cat.No.E1068

Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
Nab-Paclitaxel Microtubule Associated inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 853.91（Only for Paclitaxel）

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Quality Control

Batch: Purity: 99.18%
99.18

Solubility

In vitro
Batch:

Water : 3 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 853.91（Only for Paclitaxel） Formula

C47H51NO14

 Storage (From the date of receipt) Store at room temperature, 3 years
CAS No. -- Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

Mechanism of Action

In vitro

Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.
In vivo

In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/21969517/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04715542 Not yet recruiting
Chemotherapy Induced Peripheral Neuropathy (CIPN)
University of Bern|Insel Gruppe AG University Hospital Bern|Hospital of Thun|Tumor- und Brustzentrum ZeTuP St.Gallen|Gesundheitszentrum Fricktal AG|Kantonsspital Winterthur KSW|Kantonsspital Graubünden|Kantonsspital Aarau
 August 2024 Phase 3
NCT06199466 Recruiting
Metastatic Pancreatic Cancer
M.D. Anderson Cancer Center|280Bio Inc
 January 22 2024 Phase 1
NCT06059001 Recruiting
Metastatic Pancreatic Cancer
Peptomyc S.L.
 August 31 2023 Phase 1
NCT05982522 Not yet recruiting
Solid Tumor
InxMed (Shanghai) Co. Ltd.
 August 2023 Phase 1|Phase 2
NCT05562297 Not yet recruiting
Pancreatic Cancer Stage IB|Pancreatic Cancer Stage IIA|Pancreatic Cancer Stage IIB|Pancreatic Cancer Stage III
Shanghai Zhongshan Hospital|Fudan University
 July 1 2023 Phase 2

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