Home Cytoskeletal Signaling Microtubule Associated inhibitor Nab-Paclitaxel For research use only.

Nab-Paclitaxel

Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.

Nab-Paclitaxel Chemical Structure

Nab-Paclitaxel Chemical Structure

CAS:

Selleck's Nab-Paclitaxel has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.18%
99.18

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Biological Activity

Description Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
In vitro
In vitro

Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.[3]
Cell Research Cell lines Human pancreatic ductal adenocarcinoma cell lines
Concentrations 100 nM
Incubation Time 24 h
Method

Cells are seeded in 96-well plates at a density of 1,000–5,000 cells per well in 100 μL medium. Nab-Paclitaxel and gemcitabine are added and incubated at 37°C for 24 hours. Proliferation Is measured by the alamarBlue assay.
In Vivo
In vivo

In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.[4]

Chemical Information & Solubility

Molecular Weight 853.91（Only for Paclitaxel） Formula

C47H51NO14
CAS No. SDF --
Storage (From the date of receipt) Store at room temperature, 3 years Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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