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Norethindrone acetate

Name: Norethindrone acetate
Brand: Selleck Chemicals
SKU: S5785
Rating: 5 (1 reviews)

Synonyms: 19-Norethindrone acetate, NA

Catalog No.S5785 Purity: 99.50%

Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.

Norethindrone acetate Chemical Structure

CAS: 51-98-9

Purity & Quality Control

Batch: S578501 DMSO] 68 mg/mL] false] Ethanol] 68 mg/mL] false] Water] Insoluble] false Purity: 99.50%

99.50

Norethindrone acetate Related Products

Related Targets	Estrogen receptor Progesterone receptor ERR	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Exosome Secretion Related Compound Library Human Hormone Related Compound Library	Click to Expand

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description	Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05739136	Not yet recruiting	Pregnancy Related\|Pregnancy Complications\|Pregnancy High Risk	Myovant Sciences GmbH	January 2025	--
NCT06021860	Not yet recruiting	Edema Due to Heart Failure or Cirrhosis	CMP Development LLC	June 2024	Phase 4
NCT04640480	Not yet recruiting	Colorectal Cancer\|Breast Cancer\|Pancreas Cancer\|Ovarian Cancer\|Small-cell Lung Cancer\|Gastric Cancer\|Head and Neck Cancer	SN BioScience	June 21 2024	Phase 1
NCT06090526	Not yet recruiting	Urinary; Sepsis	Ain Shams University	May 1 2024	--

References

Chemical Information & Solubility

Molecular Weight	340.46	Formula	C₂₂H₂₈O₃
CAS No.	51-98-9	SDF	--
Smiles	CC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4C3CCC12C)C#C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (199.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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