Home GPCR & G Protein Adenosine Receptor agonist Namodenoson (CF-102) For research use only.

Namodenoson (CF-102)

Synonyms: 2-Cl-IB-MECA

Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.

Namodenoson (CF-102) Chemical Structure

Namodenoson (CF-102) Chemical Structure

CAS: 163042-96-4

Purity & Quality Control

Batch: Purity: 99.93%
99.93

Namodenoson (CF-102) Related Products

Choose Selective Adenosine Receptor Inhibitors

Biological Activity

Description Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
Targets
A3AR [1]
(Cell-free assay)
0.33 nM(Ki)
In vitro
In vitro

Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR).
Cell Research Cell lines LX2 cells
Concentrations 10 nM
Incubation Time 48 h
Method

Cells were treated with indicated concentrations of drug for 48 h.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05201404 Recruiting
Hepatocellular Carcinoma|Cirrhosis
Can-Fite BioPharma
 March 15 2023 Phase 3
NCT04697810 Recruiting
NASH - Nonalcoholic Steatohepatitis
Can-Fite BioPharma
 December 10 2021 Phase 2
NCT02927314 Completed
Non-alcoholic Steatohepatitis (NASH)
Can-Fite BioPharma
 November 27 2017 Phase 2
NCT02128958 Completed
Hepatocellular Carcinoma
Can-Fite BioPharma
 September 2014 Phase 2
NCT00790673 Completed
Chronic Hepatitis C
Can-Fite BioPharma
 July 2009 Phase 1|Phase 2
NCT00790218 Completed
Hepatocellular Carcinoma
Can-Fite BioPharma
 February 2009 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 544.73 Formula

C18H18ClIN6O4
CAS No. 163042-96-4 SDF --
Smiles CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (183.57 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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