Namodenoson (CF-102)

Catalog No.S0498 Synonyms: 2-Cl-IB-MECA

For research use only.

Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.

Namodenoson (CF-102) Chemical Structure

CAS No. 163042-96-4

Purity & Quality Control

Choose Selective Adenosine Receptor Inhibitors

Biological Activity

Description Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
Targets
A3AR [1]
(Cell-free assay)
0.33 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 544.73
Formula

C18H18ClIN6O4

CAS No. 163042-96-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05201404 Not yet recruiting Drug: Namodenoson|Drug: Placebo Hepatocellular Carcinoma|Cirrhosis Can-Fite BioPharma October 2022 Phase 3
NCT04697810 Recruiting Drug: Namodenoson|Drug: Placebo NASH - Nonalcoholic Steatohepatitis Can-Fite BioPharma December 10 2021 Phase 2
NCT02927314 Completed Drug: CF102|Drug: Placebo Non-alcoholic Steatohepatitis (NASH) Can-Fite BioPharma November 27 2017 Phase 2
NCT02128958 Completed Drug: CF102|Drug: Placebo Hepatocellular Carcinoma Can-Fite BioPharma September 2014 Phase 2
NCT00790673 Completed Drug: CF 102|Drug: Placebo Chronic Hepatitis C Can-Fite BioPharma July 2009 Phase 1|Phase 2
NCT00790218 Completed Drug: CF102 Hepatocellular Carcinoma Can-Fite BioPharma February 2009 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Namodenoson (CF-102) | Namodenoson (CF-102) supplier | purchase Namodenoson (CF-102) | Namodenoson (CF-102) cost | Namodenoson (CF-102) manufacturer | order Namodenoson (CF-102) | Namodenoson (CF-102) distributor