Home Immunology & Inflammation CXCR antagonist Navarixin (SCH-527123) For research use only.

Navarixin (SCH-527123)

Synonyms: MK-7123, PS-291822

Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.

Navarixin (SCH-527123) Chemical Structure

Navarixin (SCH-527123) Chemical Structure

CAS: 473727-83-2

Selleck's Navarixin (SCH-527123) has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.68%
99.68

Navarixin (SCH-527123) Related Products

Signaling Pathway

CXCR Signaling Pathways

CXCR Signaling Pathway

Choose Selective CXCR Inhibitors

Biological Activity

Description Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
Targets
CXCR2 [1]
(Cell-free assay)		 CXCR1 [1]
(Cell-free assay)
2.6 nM 36 nM
In vitro
In vitro

Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
In Vivo
In vivo

SCH52712, a novel, orally active CXCR1/2 receptor antagonist, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.
Animal Research Animal Models Male BALB/c mice
Dosages 3 mg/kg
Administration o.g.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01068145 Terminated
Chronic Obstructive Pulmonary Disease
Merck Sharp & Dohme LLC
 February 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 397.42 Formula

C21H23N3O5
CAS No. 473727-83-2 SDF --
Smiles CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 79 mg/mL ( (198.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 79 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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