N-Acetyl-5-hydroxytryptamine

For research use only.

Catalog No.S2985 Synonyms: NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin

N-Acetyl-5-hydroxytryptamine Chemical Structure

CAS No. 1210-83-9

N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin), a precursor of melatonin, is a potent and selective agonist of TrkB receptor.

Purity & Quality Control

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Biological Activity

Description

N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin), a precursor of melatonin, is a potent and selective agonist of TrkB receptor.

Targets
TrkB receptor [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 43 mg/mL (197.02 mM)
Water Insoluble
Ethanol ''''43 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 218.25
Formula

C12H14N2O2

CAS No. 1210-83-9
Storage powder
in solvent
Synonyms NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin

In vivo Formulation Calculator (Clear solution)

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04697810 Not yet recruiting Drug: Namodenoson|Drug: Placebo NASH - Nonalcoholic Steatohepatitis Can-Fite BioPharma August 15 2021 Phase 2
NCT04932512 Recruiting Drug: ION224|Other: Placebo Steatohepatitis Nonalcoholic Ionis Pharmaceuticals Inc. June 18 2021 Phase 2
NCT04925362 Not yet recruiting Other: Biological specimens|Other: Additional visit NAFLD|NASH|NASH - Nonalcoholic Steatohepatitis|Fibrosis|Cirrhosis Assistance Publique - Hôpitaux de Paris June 2021 Not Applicable
NCT04929483 Recruiting Drug: BIO89-100 NASH - Nonalcoholic Steatohepatitis 89bio Inc. June 4 2021 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Trk receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID