Home Proteases Trk receptor agonist N-Acetyl-5-hydroxytryptamine

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N-Acetyl-5-hydroxytryptamine Trk receptor agonist

Cat.No.S2985

N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin), a precursor of melatonin, is a potent and selective agonist of TrkB receptor.

N-Acetyl-5-hydroxytryptamine Trk receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 218.25

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Quality Control

Batch: S298501 DMSO]43 mg/mL]false]Ethanol]43 mg/mL]false]Water]Insoluble]false Purity: 99.93%
99.93

Solubility

In vitro
Batch:

DMSO : 43 mg/mL (197.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 43 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 218.25 Formula

C12H14N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1210-83-9 -- Storage of Stock Solutions

Synonyms NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin Smiles CC(=O)NCCC1=C[NH]C2=C1C=C(O)C=C2

Mechanism of Action

Targets/IC50/Ki
TrkB receptor
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06154590 Not yet recruiting
Metastatic Breast Cancer|Tumor|Muscle Neoplasms|Chronic Pain
DR. DIANE CHISESI NFS. MD. PHD.|IRB|Paradyne Networks A Foundation
 July 2024 --
NCT06322628 Not yet recruiting
Nash
Visirna Therapeutics HK Limited
 April 2024 Phase 2
NCT06318169 Recruiting
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis
89bio Inc.
 March 13 2024 Phase 3
NCT05979389 Recruiting
NAFLD|PCOS
University of California San Francisco|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 February 14 2024 Phase 1
NCT05118360 Withdrawn
Nonalcoholic Steatohepatitis (NASH)
Gannex Pharma Co. Ltd.
 December 1 2023 Phase 2
NCT06215716 Recruiting
NASH With Fibrosis|MASH With Fibrosis
Akero Therapeutics Inc
 December 1 2023 Phase 3

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