NP-G2-044

Catalog No.S2962

For research use only.

NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.

NP-G2-044 Chemical Structure

CAS No. 1807454-59-6

Purity & Quality Control

Choose Selective Fascin Inhibitors

Biological Activity

Description NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.
Targets
fascin [1]
(Cell-free assay)
0.2 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 80 mg/mL
(200.31 mM)
Water Insoluble
Ethanol ''''80 mg/mL

Chemical Information

Molecular Weight 399.37
Formula

C21H16F3N3O2

CAS No. 1807454-59-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199586 Completed Drug: NP-G2-044 Breast Cancer|Pancreas Cancer|Prostate Cancer|Lung Cancer|Colon Cancer|Esophagus Cancer|Liver Cancer|Ovary Cancer|Advanced or Metastatic Treatment-refractory Solid Tumor Malignancies Novita Pharmaceuticals Inc.|Translational Drug Development December 21 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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