Home Stem Cells & Wnt Fascin inhibitor NP-G2-044 For research use only.

NP-G2-044

NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.

NP-G2-044 Chemical Structure

NP-G2-044 Chemical Structure

CAS: 1807454-59-6

Selleck's NP-G2-044 has been cited by 1 publication

Purity & Quality Control

Batch: S296201 DMSO] 80 mg/mL] false] Ethanol] 80 mg/mL] false] Water] Insoluble] false Purity: 99.57%
99.57

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Biological Activity

Description NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.
Targets
fascin [1]
(Cell-free assay)
0.2 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03199586 Completed
Breast Cancer|Pancreas Cancer|Prostate Cancer|Lung Cancer|Colon Cancer|Esophagus Cancer|Liver Cancer|Ovary Cancer|Advanced or Metastatic Treatment-refractory Solid Tumor Malignancies
Novita Pharmaceuticals Inc.|Translational Drug Development
 December 21 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 399.37 Formula

C21H16F3N3O2
CAS No. 1807454-59-6 SDF --
Smiles CC1=C(C=CO1)C(=O)NC2=N[N](CC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C24
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 80 mg/mL ( (200.31 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 80 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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