Name: Nifurtimox
Brand: Selleck Chemicals
SKU: S6459
Availability: InStock
Rating: 5 (1 reviews)

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Quality Control

Batch: S645901 DMSO]57 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.66%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.66

Related Targets	Integrase Bacterial Antibiotics Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Anti-infection Inhibitors	Berberine chloride Clorsulon Sodium Tauroursodeoxycholate (TUDC) Cystamine dihydrochloride Chlorquinaldol p-Coumaric Acid Ascomycin (FK520) LL37 (Human cathelicidin) Cinchonidine Berberine chloride hydrate

Solubility

In vitro
Batch:

DMSO : 57 mg/mL (198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	287.29	Formula	C₁₀H₁₃N₃O₅S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	23256-30-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	BAY-2502			Smiles	CC1CS(=O)(=O)CCN1N=CC2=CC=C(O2)[N+](=O)[O-]

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03334838	Completed	Chagas'' Disease	Bayer	June 10 2019	Phase 1
NCT03350295	Completed	Chagas Disease	Bayer	June 14 2018	Phase 1
NCT02625974	Completed	Chagas Disease	Bayer	January 27 2016	Phase 3
NCT02606864	Completed	Chagas Disease	Bayer	December 2015	Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Nifurtimox Anti-infection chemical

Chemical Structure

Molecular Weight: 287.29