Home Ubiquitin E1 Activating inhibitor NEDD8 inhibitor M22 For research use only.

NEDD8 inhibitor M22

Synonyms: NAE-IN-M22

NEDD8 inhibitor M22 (NAE-IN-M22) is a novel selective NEDD8 activating enzyme (NAE) inhibitor with GI50 of 5.5 μM in A549 cells.

NEDD8 inhibitor M22 Chemical Structure

NEDD8 inhibitor M22 Chemical Structure

CAS: 864420-54-2

Purity & Quality Control

Batch: S340001 DMSO] 73 mg/mL] false] Ethanol] 73 mg/mL] false] Water] 4 mg/mL] false Purity: 99.9%
99.9

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Biological Activity

Description NEDD8 inhibitor M22 (NAE-IN-M22) is a novel selective NEDD8 activating enzyme (NAE) inhibitor with GI50 of 5.5 μM in A549 cells.
Targets
NAE [1]
(in A549 cells)
5.5 μM(GI50)

Chemical Information & Solubility

Molecular Weight 363.32 Formula

C20H24Cl2N2
CAS No. 864420-54-2 SDF --
Smiles ClC1=CC(=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C=C1)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 73 mg/mL ( (200.92 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 73 mg/mL

Water : 4 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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