Catalog No.S9903

For research use only.

NRD167 is a potent and selective SIRT5 inhibitor.

NRD167 Chemical Structure

CAS No. 2166487-23-4

Purity & Quality Control

Choose Selective Sirtuin Inhibitors

Other Sirtuin Products

Biological Activity


NRD167 is a potent and selective SIRT5 inhibitor.

SIRT5 [1]
In vitro

NRD167 can selectively inhibit cell proliferation, metabolism, and colony formation of AML Cells by inhibiting SIRT5. <sup><a class="sref" href="#s_ref">[2]</a></sup>

Protocol (from reference)

Cell Research:

<sup><a class="sref" href="#s_ref">[2]</a></sup>

  • Cell lines: AML cell lines
  • Concentrations: 5 μΜ, 10 μΜ, 20 μΜ
  • Incubation Time: 72 h
  • Method:

    AML cell lines are seeded in triplicate in 96-well plates (5–9 × 10<sup>3</sup>cells/well) ± doxycycline (100 ng/mL). Viable cells are measured using CellTiter 96 AQueous One Solution MTS Reagent for Cell Proliferation Assays. For Colony-Forming Assays, AML Cell Lines are seeded in duplicate at 0.1–0.2 × 10<sup>3</sup>/dish in MethoCult H4230 ± 100 ng/mL doxycycline or in the presence and absence of graded concentrations of NRD167. Colonies are counted 7 to 10 days after planting.

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(149.96 mM)
Water Insoluble
Ethanol '''6 mg/mL

Chemical Information

Molecular Weight 666.83


CAS No. 2166487-23-4
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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