Nizatidine

Catalog No.S1890

For research use only.

Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.

Nizatidine Chemical Structure

CAS No. 76963-41-2

Selleck's Nizatidine has been cited by 3 Publications

Purity & Quality Control

Choose Selective Histamine Receptor Inhibitors

Other Histamine Receptor Products

Biological Activity

Description Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
Targets
Histamine H2 receptor [1] AChE [2]
0.9 nM 6.7 μM
In vitro

Nizatidine, a selective histamine H2-receptor antagonist, is a potent inhibitor of gastric acid secretion, with IC50 of 0.9 nM. [1] Nizatidine also reversibly inhibits acetylcholinesterase (AChE), with IC50 of 6.7 μM, and the inhibition is noncompetitive, with a Ki value of 7.4 μM. [2]

In vivo Nizatidine exhibits maximal inhibition of gastric acid in rats within the first hour of drug administration, with EC50 of 1.383 μmol/kg. [1] Nizatidine (0.3-3 mg/kg, i.v.) significantly increases the motor index of gastrointestinal (GI) motility in a dose-dependent manner. Nizatidine inhibits gastric acid secretion with ED50 and ED90 of 0.18 and 3.22 mg/kg in dogs, and 2.94 and 19.6 mg/kg in rats, respectively. [2]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Rat
  • Dosages: 0.5-10 μmol/kg
  • Administration: s.c

Solubility (25°C)

In vitro

DMSO 66 mg/mL
(199.11 mM)
Water 28 mg/mL
(84.47 mM)
Ethanol 18 mg/mL
(54.3 mM)

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 331.46
Formula

C12H21N5O2S2

CAS No. 76963-41-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC(=C[N+](=O)[O-])NCCSCC1=CSC(=N1)CN(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01409395 Completed Drug: Metformin and nizatidine|Drug: Metformin Healthy University of California San Francisco|National Institute of General Medical Sciences (NIGMS) September 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Nizatidine | Nizatidine ic50 | Nizatidine price | Nizatidine cost | Nizatidine solubility dmso | Nizatidine purchase | Nizatidine manufacturer | Nizatidine research buy | Nizatidine order | Nizatidine mouse | Nizatidine chemical structure | Nizatidine mw | Nizatidine molecular weight | Nizatidine datasheet | Nizatidine supplier | Nizatidine in vitro | Nizatidine cell line | Nizatidine concentration | Nizatidine nmr