NSC 23766

Catalog No.S8031

NSC 23766 Chemical Structure

Molecular Weight(MW): 530.96

NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.

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In DMSO USD 140 In stock
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Cited by 22 Publications

Purity & Quality Control

Choose Selective Rho Inhibitors

Biological Activity

Description NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
Targets
Rac GTPase [1]
(Cell-free assay)
50 μM
In vitro

NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification. NSC23766 effectively inhibits Rac1 binding and activation by the Rac-specific GEF Trio or Tiam1 in a dose-dependent manner without interfering with the closely related Cdc42 or RhoA binding or activation by their respective GEFs or with Rac1 interaction with BcrGAP or effector PAK1. [1] NSC 23766 is active in regulating Rac GTPase functions on cytoskeleton and many cell functions including cell cycle, cell growth, adhesion, migration and gene transcription. NSC 23766 (50 μM) potently blocks serum or platelet-derived growth factor-induced Rac1 activation and lamellipodia formation without affecting the activity of endogenous Cdc42 or RhoA in NIH 3T3 cells. NSC 23766 reduces Trio or Tiam1 but not Vav, Lbc, Intersectin, or a constitutively active Rac1 mutant-stimulated NIH 3T3 cells growth and suppresses Trio, Tiam1, or Ras-induced cell transformation. NSC23766 dose-dependently inhibits PC-3 cells proliferation and anchorage-independent growth. 25 μM NSC23766 inhibits the PC-3 cell invasion through Matrigel by 85%. [1] 50 μM NSC 23766 inhibits thrombin-induced activation of Rac1 an d Rac2 in human platelets, as well as platelet aggregation. [2] NSC23766 prevents Aβ40 and Aβ42 production in swAPP-HEK293cells without affecting Notch and sAPPα. NSC23766 prevents γ-secretase activity in cell, but not act as a direct γ-secretase inhibitor. NSC23766 dose-dependently reduces levels of secreted and intracellular Aβ40 with IC50 of 48.94 μM. 50 μM NSC 23766 inhibits release of Aβ42 by 57.97%. [3] NSC23766 regulates endothelial nitric oxide synthase expression and endothelial function. 100 μM NSC23766 represses the eNOS promoter activity by 60% in bovine aortic ECs and by 30% to 35% in bEND.3 cells. Inhibition of Rac1 with NSC23766 destabilizes eNOS mRNA and shortens its half-life to 17 hours. NSC23766 dose-dependently attenuates ACh-induced relaxation of wild-type mice aortic rings. [4] NSC23766 inhibits cell growth and induces apoptosis. NSC23766 decreases MDA-MB-468 and MDA-MB-231 cells viability in a dose-dependent manner with IC50 of ~10 μM, which is not correlated with the status of estrogen receptor (ER), progesterone receptor (PR), Her2, and p53 mutation. NSC23766 has little effect on the survival of the MCF12A normal mammary epithelial cells. After 24 hours expose to NSC 23766, MDA-MB-231 cells showes an increase from 41% to 65% in G1 phase and a concomitant decrease in S and G2-M phases. 100 μM NSC23766 induces a six-fold increase of apoptotic MDA-MB-468. The inhibition of NSC23766 on cell cycle arrest or apoptosis in breast cancer cells is mediated by downregulation of cyclin D1, survivin, and X-linked inhibitor of protein apoptosis. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
RBMECs MYHGeY5kfGmxbjDBd5NigQ>? MV:xNFDDqM7:TdMg MWizNOKhdWmw NEnvdpRjdG:la3XzJFZDdnpvY1HNVE1u\WSrYYTl[EBi[3SrdnH0bY9vKG:oIGLhZ|EhcW5iRV3BVE1KUS22cnXheIVlKFKETVXDdy=> NV7ibXFmOjZ|NUiwN|k>
A431 M1TwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXqUolIOTByIN88US=> NUPhcVRjOjRxNEivO|IhcA>? NX;j[4JvcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUB1cW2nIHTldIVv\GWwdDDtZY5v\XJ? M4HocFI2OTB7M{K3
SW480  M4rIbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNFAh|ryP NGrJbYMzPC92OD:3NkBp MUXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> M3nmVVI2OTB7M{K3
U2-OS M{HmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXMNVAxKM7:TR?= MkXINlQwPDhxN{KgbC=> NX\YRZlkcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUB1cW2nIHTldIVv\GWwdDDtZY5v\XJ? M1i5R|I2OTB7M{K3
A431 NUXqWFE6TnWwY4Tpc44hSXO|YYm= NXLGNXZ6OTByIN88US=> M1O3WVI1KGh? MmTlSG1UVw>? NHvtfYxqdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIlvKHSqZTDHNUBxcGG|ZdMg MWqyOVExQTN{Nx?=
SW480  M2LwSGZ2dmO2aX;uJGF{e2G7 MWixNFAh|ryP MoPuNlQhcA>? MX7EUXNQ MVTpcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHnuJJRp\SCJMTDwbIF{\cLi NVLYVWQ5OjVzMEmzNlc>
U2-OS MnXKSpVv[3Srb36gRZN{[Xl? NYG4XlVTOTByIN88US=> NECzdm0zPCCq M2j6dWROW09? MXrpcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHnuJJRp\SCJMTDwbIF{\cLi MnfMNlUyODl|Mke=
NIH3T3  NImwSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTSdZV7OTByIN88US=> NFHOTWUzPMLiaB?= M{nYbohieyCwbzDzbYdvcW[rY3HueEBqdXCjY4Sgc44h[2WubDD2bYFjcWyrdIm= NYDBO3RnOjVyM{ewOlA>
Ki-67+ CLL M{L0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP2OVAhyrWP MmS4OUBl NEPWT5pl\WO{ZXHz[ZMhfGinIH71cYJmeiCxZjDLbU03PywEoFPMUEBk\Wyucx?= M4XJRlI1PTBzMkG3
U87MG MnrHR4VtdCCYaXHibYxqfHliQYPzZZk> NYrKUlJ7PTBibV2= NE\SdWcyPDRiaB?= MX\EUXNQ Mojt[ZhpcWKrdIOgd5lv\XKpaYP0bYMh[W62aYDyc4xq\mW{YYTpeoUh\W[oZXP0d{Bkd22kaX7l[EB1emWjdH3lcpQhf2m2aDDldoxwfGmwaXNCpC=> NIK4b4UzOzh|MkGyNC=>
A172MG MVPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGHMW5Q2OCCvTR?= MYKxOFQhcA>? MVLEUXNQ NIPQZVFmgGirYnn0d{B{gW6ncnfpd5Rq[yCjboTpdJJwdGmoZYLheIl3\SCnZn\lZ5R{KGOxbXLpcoVlKHS{ZXH0cYVvfCC5aYToJIVzdG:2aX7pZuKh NUPVdFdvOjN6M{KxNlA>
T98MG M3zrbmNmdGxiVnnhZoltcXS7IFHzd4F6 MVi1NEBuVQ>? M1u3V|E1PCCq NIX2eFlFVVOR MV3lfIhq[mm2czDzfY5memerc4TpZ{BidnSrcILvcIln\XKjdHn2[UBm\m[nY4TzJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIHXycI91cW6rYtMg NIH3SWUzOzh|MkGyNC=>
PC38 MYjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MnXvOVAhdU1? NVjN[mlsOTR2IHi= NInYfm1FVVOR MXzlfIhq[mm2czDzfY5memerc4TpZ{BidnSrcILvcIln\XKjdHn2[UBm\m[nY4TzJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIHXycI91cW6rYtMg NGDMZXczOzh|MkGyNC=>
PC40 MlrtR4VtdCCYaXHibYxqfHliQYPzZZk> MVO1NEBuVQ>? NF[3RmIyPDRiaB?= MVnEUXNQ NVXtb2tO\XiqaXLpeJMhe3mwZYLnbZN1cWNiYX70bZBzd2yrZnXyZZRqfmViZX\m[YN1eyClb33ibY5m\CC2cnXheI1mdnRid3n0bEBmemyxdHnubYLDqA>? NFzRfFUzOzh|MkGyNC=>
U87MG NY\yOYNjTnWwY4Tpc44hSXO|YYm= M3XFZVUxKG2P M{DCOVI1KGh? NWHRe4NzTE2VTx?= M2[yT4VvcGGwY3XzJJRp\SCjboTpcYloemG2b4L5JIVn\mWldDDv[kBmemyxdHnubYI> NEjaXIgzOzh|MkGyNC=>
A172MG M1Gy[GZ2dmO2aX;uJGF{e2G7 MUK1NEBuVQ>? M1rxRVI1KGh? NUPJTFNyTE2VTx?= MkW5[Y5p[W6lZYOgeIhmKGGwdHntbYdz[XSxcomg[YZn\WO2IH;mJIVzdG:2aX7pZi=> NFjxVYQzOzh|MkGyNC=>
T98MG MkjRSpVv[3Srb36gRZN{[Xl? NF7lTIE2OCCvTR?= NULw[nFlOjRiaB?= MkT5SG1UVw>? MkXu[Y5p[W6lZYOgeIhmKGGwdHntbYdz[XSxcomg[YZn\WO2IH;mJIVzdG:2aX7pZi=> NE\0XnczOzh|MkGyNC=>
NCI-H1703 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TjV|AuPTByIN88US=> MonCNlQhcA>? M2LUVIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz MljlNlI2PDlzNkC=
NCI-H1703 MmPSSpVv[3Srb36gRZN{[Xl? NWjZdmhjOTByIN88[{9udA>? MWeyOEBp M1fIeJNtd3e|IIDyc4dz\XO|aX;uJJRpem:3Z3igeIhmKEdzwrDwbIF{\SCxZjD0bIUh[2WubDDjfYNt\Q>? MortNlI2PDlzNkC=
NCI-H1703 M1rubGZ2dmO2aX;uJGF{e2G7 MYSwMVUxOCEQvF2= MmXBNlQhcA>? NH7seoplcW2rbnnzbIV{KGKjc3HsJG5HNc78QjDhZ5Rqfmm2eTDkc5NmKGSncHXu[IVvfGy7wrC= M4DXZlIzPTR7MU[w
SKBR3 MVvGeY5kfGmxbjDBd5NigQ>? NXf5TmxGPTBizszN MWSyOEBp MnnsbY5pcWKrdIOgVoFkOSCjY4TpeoF1cW:w MnrHNlE6PDN6MkW=
SKBR3-pMKO.1 NUXxZY5VTnWwY4Tpc44hSXO|YYm= M3W3WlUxKM7:TR?= NV;h[ZlvOjRiaB?= NVTNS4s5cW6qaXLpeJMhWmGlMTDhZ5RqfmG2aX;u NF34dHMzOTl2M{iyOS=>
MCF7 NH7XXm5EgXSxdH;4bYNqfHliQYPzZZk> M3mxblAuOTByIN88US=> NWL6fpczPDhiaB?= MY\k[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MnrMNlA2OTV7NEC=
T47D M4fqNGN6fG:2b4jpZ4l1gSCDc4PhfS=> MYSwMVExOCEQvF2= MXe0PEBp NVzyO41I\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy MmrhNlA2OTV7NEC=
MDA-MB-468 MnnlR5l1d3SxeHnjbZR6KEG|c3H5 Ml\aNE0yODBizszN NIHISVc1QCCq MU\k[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NEm1bXozODVzNUm0NC=>
MDA-MB-231 MXnDfZRwfG:6aXPpeJkhSXO|YYm= MomxNE0yODBizszN Mn\rOFghcA>? NFLvZXRl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= NX;LOFdDOjB3MUW5OFA>
MDA-MB-231 NGT3c2xHfW6ldHnvckBCe3OjeR?= M{fLVVAuOTByIN88US=> NEPT[2EzPCCq NIrLVnJ{\WynY4TpeoVtgSCrbnjpZol1eyCUYXOxJIFkfGm4YYTpc44hf2m2aH;1eEBqdnSncn\ldolv\yC5aYToJJRp\SCjY4Tpeol1gSCxZjD0bIUh[2yxc3XsfUBz\WyjdHXkJJNu[WyuIFfUVIF{\SCFZHO0Ni=> M1z4UlIxPTF3OUSw
MDA-MB-231  M{SzSmZ2dmO2aX;uJGF{e2G7 NXPyUXNXOTByIN88US=> NIG3fnU1QCCq NETycm9qdmO{ZXHz[ZMhfGinIHPlcIwhdnWvYnXyJIlvKEdzwrDwbIF{\SCjbnSg[IVkemWjc3XzJJRp\SClZXzsJI52dWKncjDpckBUKGGwZDDHNk1OKHCqYYPld:Kh NYPZVGo6OjB3MUW5OFA>
MCF7 MmDXSpVv[3Srb36gRZN{[Xl? MUKxNFAh|ryP NH3XcWo1QCCq MUPpcoNz\WG|ZYOgeIhmKGOnbHygcpVu[mW{IHnuJGcyyqCyaHHz[UBidmRiZHXjdoVie2W|IITo[UBk\WyuIH71cYJmeiCrbjDTJIFv\CCJMj3NJJBp[XOnc9Mg NFfkWoszODVzNUm0NC=>
T47D MlfpSpVv[3Srb36gRZN{[Xl? NHrldZUyODBizszN NIDSWFc1QCCq M3XqXYlv[3KnYYPld{B1cGViY3XscEBvfW2kZYKgbY4hTzIEoIDoZZNmKGGwZDDk[YNz\WG|ZYOgeIhmKGOnbHygcpVu[mW{IHnuJHMh[W6mIFeyMW0heGijc3XzxsA> M3OwfVIxPTF3OUSw
MDA-MB-468 NELYWGNCeG:ydH;zbZMhSXO|YYm= M4LkXFUxNzFyMDFOwG0> MojXNlQhcA>? Mo\qbY5lfWOnczDhdI9xfG:|aYO= M3vBWVIxPTF3OUSw
MDA-MB-468 MWXGeY5kfGmxbjDBd5NigQ>? MnTtNVAxKM7:TR?= NUe5[HhkOjRiaB?= M1[3eIlvcGmkaYTzxsBk[XOyYYPlMVMh[WO2aY\heIlwdsLi MXSyNFUyPTl2MB?=
MDA-MB-468 Mnq1SpVv[3Srb36gRZN{[Xl? MUK1NE8yODBizszN M2HpOVI1KGh? MYXpcoNz\WG|ZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJGpPUyCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? M2fWblIxPTF3OUSw
MDA-MB-231  MkfmSpVv[3Srb36gRZN{[Xl? NV;JfI1yPTBxMUCwJO69VQ>? MlrkNlQhcA>? Mor3bY5kemWjc3XzJJBpd3OyaH;yfYxifGmxbjDv[kBLVktiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? Ml\wNlA2OTV7NEC=
MDA-MB-468 MYXGeY5kfGmxbjDBd5NigQ>? NF\LZlU2OC9zMECg{txO M2PPelQ5KGh? Mon6bY5lfWOnczDhJIRwe2VvZHXw[Y5l\W62IHTlZ5Jm[XOnIHnuJJBpd3OyaH;yfYxifGmxbjDv[kBxPjVic4XieY5qfA>? M4HaNFIxPTF3OUSw
MDA-MB-231  NWD6[WROTnWwY4Tpc44hSXO|YYm= MYS1NE8yODBizszN M2LxSlQ5KGh? M3;kcolv\HWlZYOgZUBld3OnLXTldIVv\GWwdDDk[YNz\WG|ZTDpckBxcG:|cHjvdplt[XSrb36gc4YheDZ3IIP1ZpVvcXR? M2X2RVIxPTF3OUSw
IEC-6  MnP1SpVv[3Srb36gRZN{[Xl? M{fte|EzOCEEtV2= M4S5U|QwPi96IHi= NEn1VWRxemW4ZX70d{B1cGViaX7jdoVie2WmIHHjeIl3[XSrb36gc4YhTkGNIHH0JFYh[W6mIEigbC=> NFLFe4IzODR2OES2NS=>
RA-FLS (RA2)  NE\k[HVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmyOU82OCEQvF2= Mn\KNU06KGR? NI[yfYNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= MofUNVc3OjJ|MEi=
RA1 Moe2SpVv[3Srb36gRZN{[Xl? NXzzTIZUPTBizszN NXTiUo1YOjRiaB?= MVjpcohq[mm2czDNZZRzcWenbDDpcpZie2mxbh?= MoL4NVc3OjJ|MEi=
RA2 NULyOG0yTnWwY4Tpc44hSXO|YYm= NFO0S2g2OCEQvF2= NEi2Vo0zPCCq Ml3xbY5pcWKrdIOgUYF1emmpZXygbY53[XOrb36= NYjiSmR4OTd4MkKzNFg>
RA3 MVzGeY5kfGmxbjDBd5NigQ>? M4XzflUxKM7:TR?= NWHWVIVCOjRiaB?= MoC4bY5pcWKrdIOgUYF1emmpZXygbY53[XOrb36= NWG5N5VGOTd4MkKzNFg>
RA4 Mn;JSpVv[3Srb36gRZN{[Xl? MXS1NEDPxE1? M3jPOVI1KGh? NHnre3ZqdmirYnn0d{BO[XS{aXflcEBqdn[jc3nvci=> Ml[wNVc3OjJ|MEi=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pCREB / CREB; 

PubMed: 25319697     


Rac1 inhibitor NSC23766 decreases CREB phosphorylation at serine 133 (pCREB) in cortical neurons. Left, Temporal profiles of NSC23766 (100 μm) on basal pCREB levels. Right, Dose–response effects of NSC23766 (30 min) application on pCREB. 

OCT4 / SOX2 / Nanog ; 

PubMed: 31338333     


Down-regulation of Rac1-GTP treated with NSC23766 decreased expression of Nanog, Sox2, and Oct4 levels in TUFT1—MDA-MB-231 and TUFT1—HCC1937 cells (n = 3). 

active Rac1 / Rac1 ; 

PubMed: 31338333     


Western blot showed effect of Rac1 inhibitor NSC23766 on Rac1-GTP in MDA-MB-231 cells (n = 3). 

25319697 31338333
Immunofluorescence
IP3K-A / F-actin; 

PubMed: 19890013     


Rac1-specific inhibitor NSC23766 gradually blocked the IP3K-A expression-induced formation of filopodia in HeLa cells. Following transfection of GFP-IP3K-A, HeLa cells were incubated for 24 hrs in medium containing the Rac1 inhibitor. Treatment with 40 µM䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙

BART / Rac1; 

PubMed: 22745590     


S2-013 cells were pretreated with or without the Rac1 inhibitor (NSC23766) and were immunocytochemically stained using anti-BART (green) and anti-Rac1 (red) antibodies. Arrows indicate colocalized BART and Rac1 in lamellipodial-like protrusions; blue, DAP䲧疝Ỵ疞㧀疜膉痘 

19890013 22745590
In vivo NSC23766 induces mobilization of hematopoietic stem cells/progenitors. Intraperitoneal administration of NSC23766 (2.5 mg/kg) into the ‘‘poorly mobilizing ’’ C57Bl/6 mouse strain leads to a two-fold increase in circulating hematopoietic stem cells/progenitors 6 hr after injection. [2] NSC23766 alleviates lipopolysaccharide-induced acute pulmonary injury in mice. Treatment with NSC23766 at 1 or 3mg/kg not only reduces the inflammatory cells infiltration and MPO activities, but also inhibits pro-inflammatory mediators, tumor necrosis factor-α and interleukin-1β, mRNA expression. NSC23766 also reduces Evans Blue and albumin accumulation in LPS-challenged lungs. [6]

Protocol

Kinase Assay:[1]
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Rho GTPase activity assay:

Cells are grown in log phase in a 10-cm dish, and are starved in 0.5% serum medium or indicated otherwise for 24 h before lysis in a buffer containing 20 mM Tris HCl (pH 7.6), 100 mM NaCl, 10 mM MgCl2, 1% Nonidet P-40, 10% glycerol, and 1× protease inhibitor mixture. Lysates are clarified, the protein concentrations are normalized, and the GTP-bound Rac1 in the lysates is measured by an effector domain pull-down assay. For the His6-PAK1 PBD pull-down assay, cell lysates are incubated with Ni2+-agarose-immobilized His6-PAK1 PBD domain (∼1 μg each) purified from E. coli for 30 min. The Ni2+-agarose co-precipitates are washed twice in the wash buffer and analyzed by immunoblotting with anti-Rac1 monoclonal antibody.
Cell Research:[5]
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  • Cell lines: Human breast cancer cells MDA-MB-468
  • Concentrations: 0-100 μM
  • Incubation Time: 2 days
  • Method: Cells (1.5 × 104/mL) are seeded in each well of 96-well tissue culture plates with 200 μL of medium. After 24 hours of plating, the medium is replaced with 200 μL of fresh medium containing NSC23766 at the indicated concentrations. At the end of the treatment period 20 μL of MTS solution are added to each well and incubated at 37 ℃ for 2 hours. Absorbance at 490 nm is read on a 96-well plate reader.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (188.33 mM)
Water 100 mg/mL warmed (188.33 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 530.96
Formula

C24H35N7.3HCl

CAS No. 1177865-17-6
Storage powder
in solvent
Synonyms N/A

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Rho Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID