Home Transmembrane Transporters Sodium Channel inhibitor 5-(N,N-Hexamethylene)-amiloride For research use only.

5-(N,N-Hexamethylene)-amiloride

Synonyms: Hexamethylene amiloride, HMA

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride; HMA) is a potent inhibitor of the Na⁺/H⁺ exchanger, lowering intracellular pH and inducing apoptosis. It also inhibits the HIV-1 Vpu virus ion channel and suppresses replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV-229E) in cultured L929 cells, with EC₅₀ values of 3.91 μM and 1.34 μM, respectively.

5-(N,N-Hexamethylene)-amiloride Chemical Structure

5-(N,N-Hexamethylene)-amiloride Chemical Structure

CAS No. 1428-95-1

Purity & Quality Control

5-(N,N-Hexamethylene)-amiloride Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride; HMA) is a potent inhibitor of the Na⁺/H⁺ exchanger, lowering intracellular pH and inducing apoptosis. It also inhibits the HIV-1 Vpu virus ion channel and suppresses replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV-229E) in cultured L929 cells, with EC₅₀ values of 3.91 μM and 1.34 μM, respectively.
  • https://pubmed.ncbi.nlm.nih.gov/10666221/
  • https://pubmed.ncbi.nlm.nih.gov/16815524/

Chemical Information & Solubility

Molecular Weight 311.77 Formula

C12H18ClN7O
CAS No. 1428-95-1 SDF Download 5-(N,N-Hexamethylene)-amiloride SDF
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