Nelfinavir Mesylate

Catalog No.S4282 Synonyms: Viracept, AG1343

Molecular Weight(MW): 663.89

Nelfinavir Mesylate is a potent HIV protease inhibitor with K_i of 2 nM.

Cited by 3 publications

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Biological Activity

Description

Nelfinavir Mesylate is a potent HIV protease inhibitor with K_i of 2 nM.

Targets

HIV protease ^[1]
(Cell-free assay)

2 nM(Ki)

In vivo

In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. Initial investigation of the compound in fed rats indicated an oral bioavailability of 43%. In contrast, the oral bioavailability was significantly reduced in fasted rats to 29%. Nelfinavir demonstrated significant oral bioavailabilability across a range of species including dogs (47%), marmosets (17%), and cynomolgus monkeys (26%). It has a long plasma half-life after oral dosing that is likely due to a combination of slow dissolution and absorption. nelfinavir is well absorbed in humans particularly when administered with food and possesses minimal and easily managed side effects^[1].

Protocol

Animal Research: ^[1]	+ Expand Animal Models: Sprague-Dawley rats Formulation: 5% dextrose Dosages: 12.5 to 25 mg/kg (i.v); 25 to 50 mg/kg (oral) Administration: i.v and oral administration (Only for Reference)

References

[1] Kaldor SW, et al.J Med Chem, 1997,40(24):3979-85.

Solubility (25°C)

In vitro	DMSO	100 mg/mL (150.62 mM)
	Ethanol	100 mg/mL (150.62 mM)
	Water	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Nelfinavir Mesylate SDF

Molecular Weight	663.89
Formula	C₃₃H₄₉N₃O₇S₂
CAS No.	159989-65-8
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	Viracept, AG1343

Bio Calculators

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The Serial Dilution Calculator Equation

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Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03829020	Not yet recruiting	Recurrent Plasma Cell Myeloma\|Refractory Plasma Cell Myeloma	Mayo Clinic\|National Cancer Institute (NCI)	March 1 2019	Phase 1
NCT03829020	Not yet recruiting	Recurrent Plasma Cell Myeloma\|Refractory Plasma Cell Myeloma	Mayo Clinic\|National Cancer Institute (NCI)	March 1 2019	Phase 1
NCT03050060	Recruiting	Metastatic Renal Cell Cancer\|Recurrent Melanoma\|Recurrent Non-Small Cell Lung Carcinoma\|Recurrent Renal Cell Carcinoma\|Stage IV Cutaneous Melanoma AJCC v6 and v7\|Stage IV Non-Small Cell Lung Cancer AJCC v7\|Stage IV Renal Cell Cancer AJCC v7	University of Washington\|National Cancer Institute (NCI)	June 9 2017	Phase 2
NCT03050060	Recruiting	Metastatic Renal Cell Cancer\|Recurrent Melanoma\|Recurrent Non-Small Cell Lung Carcinoma\|Recurrent Renal Cell Carcinoma\|Stage IV Cutaneous Melanoma AJCC v6 and v7\|Stage IV Non-Small Cell Lung Cancer AJCC v7\|Stage IV Renal Cell Cancer AJCC v7	University of Washington\|National Cancer Institute (NCI)	June 9 2017	Phase 2
NCT03077451	Recruiting	Recurrent Kaposi Sarcoma\|Skin Kaposi Sarcoma	AIDS Malignancy Consortium\|National Cancer Institute (NCI)\|The EMMES Corporation\|University of Arkansas\|University of California Los Angeles\|AIDS and Cancer Specimen Resource	March 13 2017	Phase 2
NCT03077451	Recruiting	Recurrent Kaposi Sarcoma\|Skin Kaposi Sarcoma	AIDS Malignancy Consortium\|National Cancer Institute (NCI)\|The EMMES Corporation\|University of Arkansas\|University of California Los Angeles\|AIDS and Cancer Specimen Resource	March 13 2017	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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HIV Protease Signaling Pathway Map

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Nelfinavir Mesylate

Cited by 3 publications

Purity & Quality Control

Choose Selective HIV Protease Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Nelfinavir Mesylate SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

HIV Protease Signaling Pathway Map

Related HIV Protease Products0

Choose Your Country or Region

By Signaling Pathways

By product type

Nelfinavir Mesylate

Cited by 3 publications

Purity & Quality Control

Choose Selective HIV Protease Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Nelfinavir Mesylate SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

HIV Protease Signaling Pathway Map

Related HIV Protease Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)