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Nicotinamide (NSC 13128)
Catalog No.S1899 Synonyms: Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452
For research use only.
Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
CAS No. 98-92-0
Selleck's Nicotinamide (NSC 13128) has been cited by 25 publications
Purity & Quality Control
Choose Selective Sirtuin Inhibitors
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Biological Activity
| Description | Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
Nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. [1] Nicotinamide results in a twofold increase in DNA content and a threefold increase in insulin content in the fetal cells. Nicotinamide induces differentiation and maturation of human fetal pancreatic islet cells. [2] Nicotinamide regulates sirtuins by switching between deacetylation and base exchange. Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). [3] Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization in Alzheimer's disease transgenic mice, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increases acetylated alpha-tubulin, a primary substrate of SirT2, and MAP2c in Alzheimer's disease transgenic mice, both of which are linked to increased microtubule stability. [4] Nicotinamide fosters DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation, cellular phagocytosis and vascular thrombosis. Nicotinamide both prevents and reverses neuronal and vascular cell injury. [5] |
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| In vivo | In the mouse, nicotinamide given i.p. at doses of 100-500 mg/kg showed biphasic elimination with dose-dependent changes in half-life. The initial half-life increased significantly (P <0.05) from 0.8 to 2 h and the terminal half-life increased from 3.4 to 5.6 h over the dose range studied. Clearance, however, decreased significantly from 0.3 to 0.24 L/kg/h only at the highest dose. Peak concentrations increased in a dose-dependent manner from 1,000 to 4,800 nmol/ml. The bioavailability given via the i.p. as compared with the i. v. route was close to 100%[6]. |
Protocol (from reference)
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Solubility (25°C)
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In vitro |
DMSO |
24 mg/mL
(196.52 mM) |
| Water |
24 mg/mL
(196.52 mM) |
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| Ethanol |
'24 mg/mL
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Chemical Information
| Molecular Weight | 122.12 | ||
|---|---|---|---|
| Formula | C6H6N2O |
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| CAS No. | 98-92-0 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | C1=CC(=CN=C1)C(=O)N | ||
In vivo Formulation Calculator (Clear solution)
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT04763499 | Not yet recruiting | Other: freeze dried strawberry powder | Vascular Dilation | University of California Davis | January 1 2022 | Not Applicable |
| NCT05040321 | Not yet recruiting | Drug: MIB-626|Drug: Placebo | Alzheimer''s Disease (Incl Subtypes)|Dementia | Brigham and Women''s Hospital | December 1 2021 | Phase 1|Phase 2 |
| NCT04641663 | Enrolling by invitation | Dietary Supplement: Multi-target Dietary Supplement (MTDS) | Aging|Age-related Cognitive Decline | Douglas Boreham|McMaster University|Northern Ontario School of Medicine | September 3 2021 | Not Applicable |
| NCT04844528 | Suspended | Drug: Nicotinamide|Drug: Placebo | Chronic Lymphocytic Leukemia | University of Utah | August 5 2021 | Phase 2 |
| NCT04909489 | Recruiting | Other: cross-sectional study without intervention | Traditional Chinese Medicine|Dyslipidemias|Syndrome | Dongzhimen Hospital Beijing | April 21 2021 | -- |
| NCT04342975 | Recruiting | Drug: Nicotinamide Riboside + Pterostilbene|Drug: Placebo | AKI | Mayo Clinic|Elysium Health | December 1 2020 | Phase 2 |
(data from https://clinicaltrials.gov, updated on 2022-01-17)
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