Nifedipine (BAY-a-1040)

For research use only.

Licensed by Pfizer Catalog No.S1808

11 publications

Nifedipine (BAY-a-1040) Chemical Structure

CAS No. 21829-25-4

Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

Selleck's Nifedipine (BAY-a-1040) has been cited by 11 publications

2 Customer Reviews

  • The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.

    Sci Rep, 2017, 7(1):3156. Nifedipine (BAY-a-1040) purchased from Selleck.

    INS-1 cells and MIN6 cells were treated by 40 mM KCl alone or combination with 10 μM nifedipine and Bay K 8664 for 1 h and then the SAD-A expression was detected by western blotting. * indicates a non-specific band.

    Biochem Biophys Res Commun, 2019, 509(1):76-81. Nifedipine (BAY-a-1040) purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.
calcium channel [1]
In vitro

Nifedipine causes a significant concentration-dependent increase in eNOS protein expression by cultured human coronary artery endothelial cells. [1] Nifedipine antagonizes L-type Ca+ channels found throughout the cardiovascular system, but also blocks Kv channels, which are members of the same supergene family. [2] Nifedipine dose-dependently decreases the values of [(3)H]-thymidine incorporation and total cellular protein content as well as the levels of phosphorylated extracellular signal-regulated protein kinase (ERK) 1/2, mitogen-activated protein kinase kinase (MEK) 1/2, and even the phosphorylation of Pyk2, in vascular smooth muscle cells (VSMC). Nifedipine suppresses the levels of proliferative cell nuclear antigen (PCNA) dose-dependently in both VSMC and balloon-injured thoracic aortae in VSMC. [3]

In vivo Nifedipine (3 mg/kg) slightly lowers the level of systolic and/or diastolic blood pressure or increased the heart rate in rats. [3] Nifedipine (1 μm) produces a maximal inhibition of the store-operated pathway in choroidal arteriolar smooth muscle. [4] Nifedipine (20 and 40 mg/kg) markedly prevents the HCl plus ethanol-induced gastric mucosal injury and the increase in the content of thiobarbituric acid-reactive substances in the injured mucosa in rats. Nifedipine (20 and 40 mg/kg) dose-dependently promotes the ulcer healing and inhibites the increase in the content of thiobarbituric acid-reactive substances in the ulcerated mucosa in rats. [5]


Solubility (25°C)

In vitro DMSO 69 mg/mL (199.23 mM)
Water Insoluble
Ethanol ''15 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 346.33


CAS No. 21829-25-4
Storage 2 years 4°C(in the dark) powder
1 week 4°C(in the dark) in solvent
Synonyms N/A
Smiles CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04392375 Recruiting Drug: Nifedipine 30 MG|Drug: Placebos Preeclampsia Severe Ohio State University June 9 2020 Phase 4
NCT03695107 Unknown status Drug: Nifedipine controlled released tablets Chronic Kidney Diseases The Third Xiangya Hospital of Central South University October 2 2019 --
NCT02902354 Withdrawn Other: Nifedipine for tocolysis Tocolysis With Nifedipine St. Louis University September 2016 Not Applicable
NCT03710395 Unknown status Procedure: Blood and breast milk sampling|Drug: Nifedipine Drug Transporter Natalia Valadares de Moraes|Hospital das Clínicas de Ribeirão Preto|Universidade Estadual Paulista Júlio de Mesquita Filho December 14 2015 Phase 4
NCT02413515 Completed Drug: Nifedipine (Adalat GITS BAY1040) Hypertension Bayer March 26 2015 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID