N6022

Catalog No.S7589

N6022 Chemical Structure

Molecular Weight(MW): 414.46

N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.

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Biological Activity

Description N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.
Targets
S-nitrosoglutathione reductase (GSNOR) [1]
(Cell-free assay)
S-nitrosoglutathione reductase (GSNOR) [1]
(Cell-free assay)
2.5 nM(Ki) 8 nM
In vitro

N6022 shows limited off-target activity and low cytotoxicity toward A549 epithelial lung cells. [2]

In vivo N6022 (30 mg/kg iv or po) reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma. [2]

Protocol

Animal Research:[2]
+ Expand
  • Animal Models: Mouse model of asthm.
  • Formulation: i.v.: 5% 2-hydroxypropyl-beta cyclodextrin in PBS; p.o.: 1% carboxymethyl cellulose
  • Dosages: 0.0005 to 30 mg/kg
  • Administration: i.v. or p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 82 mg/mL (197.84 mM)
Ethanol 5 mg/mL warmed (12.06 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 414.46
Formula

C24H22N4O3

CAS No. 1208315-24-5
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID