N6022

Catalog No.S7589

For research use only.

N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.

N6022 Chemical Structure

CAS No. 1208315-24-5

Selleck's N6022 has been cited by 2 Publications

Purity & Quality Control

Related Other Products

Biological Activity

Description N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.
Targets
S-nitrosoglutathione reductase (GSNOR) [1]
(Cell-free assay)
S-nitrosoglutathione reductase (GSNOR) [1]
(Cell-free assay)
2.5 nM(Ki) 8 nM
In vitro

N6022 shows limited off-target activity and low cytotoxicity toward A549 epithelial lung cells. [2]

In vivo N6022 (30 mg/kg iv or po) reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma. [2]

Protocol (from reference)

Animal Research:[2]
  • Animal Models: Mouse model of asthm.
  • Dosages: 0.0005 to 30 mg/kg
  • Administration: i.v. or p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 414.46
Formula

C24H22N4O3

CAS No. 1208315-24-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C=CC(=C1)C(=O)N)N2C(=CC=C2C3=CC=C(C=C3)N4C=CN=C4)CCC(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01316315 Completed Drug: Active|Drug: Placebo Asthma Nivalis Therapeutics Inc. March 2011 Phase 1|Phase 2
NCT01147406 Completed Drug: N6022|Drug: Placebo Healthy Nivalis Therapeutics Inc. August 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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