Home Ubiquitin E3 Ligase inhibitor NSC232003 For research use only.

NSC232003

NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor that binds to the 5mC binding pocket of the SRA domain of UHRF1. NSC232003 modulates DNA methylation in a cellular context.

NSC232003 Chemical Structure

NSC232003 Chemical Structure

CAS: 1905453-18-0

Purity & Quality Control

Batch: E035101 Water] 5 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.89%
99.89

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Biological Activity

Description NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor that binds to the 5mC binding pocket of the SRA domain of UHRF1. NSC232003 modulates DNA methylation in a cellular context.
Targets
UHRF1 [1]
In vitro
In vitro

NSC232003 is an effective DNA methylation inhibitor, and can significantly decrease the DNMT1/UHRF1 interaction in U251 glioma cells.[2]

Chemical Information & Solubility

Molecular Weight 169.14 Formula

C6H7N3O3
CAS No. 1905453-18-0 SDF --
Smiles CC(NO)=C1C=NC(=O)NC1=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 5 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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