LXH254

Catalog No.S8745

LXH254 Chemical Structure

Molecular Weight(MW): 502.49

LXH254 is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.

Size Price Stock Quantity  
USD 157 In stock
USD 247 In stock
USD 690 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description LXH254 is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.
Targets
B-Raf [1]
()
C-Raf [1]
()
In vitro

LXH254 not only inhibits MAPK signaling activity in tumor models harboring BRAFV600 mutation, but also inhibits mutant N- and KRAS-driven signaling due to its ability to inhibit both RAF monomers and dimers with similar potencies. LXH254 is orally bioavailable, demonstrates a direct PK/PD relationship and causes tumor regression in multiple cell line and primary human tumor derived xenograft models at well-tolerated doses[1].

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (199.0 mM)
Ethanol 34 mg/mL (67.66 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 502.49
Formula

C25H25F3N4O4

CAS No. 1800398-38-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03333343 Recruiting EGFR-mutant Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis January 29 2018 Phase 1
NCT03333343 Recruiting EGFR-mutant Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis January 29 2018 Phase 1
NCT02974725 Recruiting Non-Small Cell Lung Cancer|Melanoma Novartis Pharmaceuticals|Novartis February 24 2017 Phase 1
NCT02974725 Recruiting Non-Small Cell Lung Cancer|Melanoma Novartis Pharmaceuticals|Novartis February 24 2017 Phase 1
NCT02607813 Recruiting NSCLC|Ovarian Cancer|Melanoma|Other Solid Tumors Novartis Pharmaceuticals|Novartis January 18 2016 Phase 1
NCT02607813 Recruiting NSCLC|Ovarian Cancer|Melanoma|Other Solid Tumors Novartis Pharmaceuticals|Novartis January 18 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Raf Signaling Pathway Map

Related Raf Products0

Tags: buy LXH254 | LXH254 supplier | purchase LXH254 | LXH254 cost | LXH254 manufacturer | order LXH254 | LXH254 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID