Neostigmine Bromide

Catalog No.S2490

For research use only.

Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.

Neostigmine Bromide  Chemical Structure

CAS No. 114-80-7

Selleck's Neostigmine Bromide has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
Targets
AChR [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 60 mg/mL
(197.88 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 303.2
Formula

C12H19N2O2.Br

CAS No. 114-80-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04596735 Recruiting -- Extubation|Respiratory Complications Wake Forest University Health Sciences October 16 2020 --
NCT04545099 Not yet recruiting Drug: Sugammadex|Drug: Neostigmine Supraglottic Airway Device Insertion Yonsei University September 2020 Not Applicable
NCT04244266 Recruiting Other: NO INTERVENTION it is an observational study Obesity|Neostigmine|Residual Neuromuscular Blockade Poitiers University Hospital January 29 2020 --
NCT03585348 Completed Other: Neuromuscular blocking agents Neuromuscular Blockade|Residual Curarisation Postoperative|Surgery Under General Anaesthesia Beth Israel Deaconess Medical Center|Massachusetts General Hospital June 29 2018 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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