For research use only.
Catalog No.S4181 Synonyms: RS-69216
Molecular Weight(MW): 515.99
Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
Purity & Quality Control
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|Description||Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.|
|In vivo||Nicardipine (100 mg/kg) produces a significant transient decrease in retinal blood flow in cats. Nicardipine (100 mg/kg) produces a significant increase in ONH blood flow despite a significant decrease of the mean arterial blood pressure in cats, which suggests that nicardipine could have a beneficial effect on ONH tissue.  Nicardipine significantly reduces systolic pressure in the spontaneously hypertensive rats (SHR). Nicardipine significantly reduces the thickness of the tunica media, the media: lumen ratio and increases the luminal area, primarily at the level of small pial arteries and of intracerebral arteries in the spontaneously hypertensive rats (SHR). Nicardipine increases the number of neurones in the frontal cortex and in the occipital cortex of SHR and counters hyperplasia and hypertrophy of GFAP-immunoreactive astrocytes. Nicardipine increases the number of neurones in the CA1 field of the hippocampus and decreases the number and the size of astrocytes of the white matter and grey matter, respectively.  Nicardipine (40 mg/kg twice daily for 8 weeks) reduces plaque area by 49.2% in cholesterol-fed rabbits. Nicardipine (40 mg/kg) reduces cholesterol accumulation in the aortic arch by 74.5% in cholesterol-fed rabbits.  Nicardipine (5 mg/kg) combined with Nimodipine (80 mg/kg) and Flunarizine(80 mg/kg) results in a significant enhancement of the protective potency of either ethosuximide (50 mg/kg) or valproate (100 mg/kg) against clonic seizures in mice. |
|In vitro||DMSO||100 mg/mL (193.8 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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