Nicardipine HCl

Catalog No.S4181 Synonyms: RS-69216

For research use only.

Nicardipine HCl (RS-69216) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.

Nicardipine HCl Chemical Structure

CAS No. 54527-84-3

Selleck's Nicardipine HCl has been cited by 2 Publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Nicardipine HCl (RS-69216) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
Targets
Calcium channel [1]
In vivo Nicardipine (100 mg/kg) produces a significant transient decrease in retinal blood flow in cats. Nicardipine (100 mg/kg) produces a significant increase in ONH blood flow despite a significant decrease of the mean arterial blood pressure in cats, which suggests that nicardipine could have a beneficial effect on ONH tissue. [1] Nicardipine significantly reduces systolic pressure in the spontaneously hypertensive rats (SHR). Nicardipine significantly reduces the thickness of the tunica media, the media: lumen ratio and increases the luminal area, primarily at the level of small pial arteries and of intracerebral arteries in the spontaneously hypertensive rats (SHR). Nicardipine increases the number of neurones in the frontal cortex and in the occipital cortex of SHR and counters hyperplasia and hypertrophy of GFAP-immunoreactive astrocytes. Nicardipine increases the number of neurones in the CA1 field of the hippocampus and decreases the number and the size of astrocytes of the white matter and grey matter, respectively. [2] Nicardipine (40 mg/kg twice daily for 8 weeks) reduces plaque area by 49.2% in cholesterol-fed rabbits. Nicardipine (40 mg/kg) reduces cholesterol accumulation in the aortic arch by 74.5% in cholesterol-fed rabbits. [3] Nicardipine (5 mg/kg) combined with Nimodipine (80 mg/kg) and Flunarizine(80 mg/kg) results in a significant enhancement of the protective potency of either ethosuximide (50 mg/kg) or valproate (100 mg/kg) against clonic seizures in mice. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 515.99
Formula

C26H29N3O6.HCl

CAS No. 54527-84-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05164159 Not yet recruiting Drug: propofol group|Drug: remimazolam group Acute Cholecystitis Yonsei University December 2021 Not Applicable
NCT04137991 Unknown status Device: Nol-Index guided analgesia|Other: Standard Analgesia Nociceptive Pain|Goal-directed Therapy|Hemodynamic Instability|Nol-Index|Remifentanil|Cardiac Surgery|Vascular Surgery|General Anesthesia Erasme University Hospital October 10 2019 Not Applicable
NCT01460563 Unknown status Drug: Magnesium Sulfate|Drug: 0.9% saline Cerebral Aneurysm Seoul National University Bundang Hospital October 2011 Not Applicable
NCT00325793 Unknown status Drug: Nicardipine Hypertension OSF Healthcare System|PDL BioPharma Inc. January 2004 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Nicardipine HCl | Nicardipine HCl supplier | purchase Nicardipine HCl | Nicardipine HCl cost | Nicardipine HCl manufacturer | order Nicardipine HCl | Nicardipine HCl distributor