Nicardipine HCl

Catalog No.S4181 Synonyms: RS-69216

Nicardipine HCl Chemical Structure

Molecular Weight(MW): 515.99

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.

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Biological Activity

Description Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
Targets
Calcium channel [1]
In vivo Nicardipine (100 mg/kg) produces a significant transient decrease in retinal blood flow in cats. Nicardipine (100 mg/kg) produces a significant increase in ONH blood flow despite a significant decrease of the mean arterial blood pressure in cats, which suggests that nicardipine could have a beneficial effect on ONH tissue. [1] Nicardipine significantly reduces systolic pressure in the spontaneously hypertensive rats (SHR). Nicardipine significantly reduces the thickness of the tunica media, the media: lumen ratio and increases the luminal area, primarily at the level of small pial arteries and of intracerebral arteries in the spontaneously hypertensive rats (SHR). Nicardipine increases the number of neurones in the frontal cortex and in the occipital cortex of SHR and counters hyperplasia and hypertrophy of GFAP-immunoreactive astrocytes. Nicardipine increases the number of neurones in the CA1 field of the hippocampus and decreases the number and the size of astrocytes of the white matter and grey matter, respectively. [2] Nicardipine (40 mg/kg twice daily for 8 weeks) reduces plaque area by 49.2% in cholesterol-fed rabbits. Nicardipine (40 mg/kg) reduces cholesterol accumulation in the aortic arch by 74.5% in cholesterol-fed rabbits. [3] Nicardipine (5 mg/kg) combined with Nimodipine (80 mg/kg) and Flunarizine(80 mg/kg) results in a significant enhancement of the protective potency of either ethosuximide (50 mg/kg) or valproate (100 mg/kg) against clonic seizures in mice. [4]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (193.8 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 515.99
Formula

C26H29N3O6.HCl

CAS No. 54527-84-3
Storage powder
in solvent
Synonyms RS-69216

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID