Netarsudil (AR-13324) 2HCl

Catalog No.S8226

For research use only.

Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.

Netarsudil (AR-13324) 2HCl Chemical Structure

CAS No. 1253952-02-1

Purity & Quality Control

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Biological Activity

Description Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
Targets
norepinephrine transporter (NET) [3] ROCK [1]
2 nM(Ki)
Assay
Methods Test Index PMID
Western blot ATM / p-ATM / ATR / p-ATR / CHK1 / p-CHK1 / p-CHK2 / BRCA1 / FANCD2 / γ-H2AX 23405159
Growth inhibition assay Cell viability 30925767
In vivo

Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. In addition, netarsudil has been shown to increase outflow facility in non-human primate eyes and to decrease episcleral venous pressure in rabbit eyes[2].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 526.45
Formula

C28H27N3O3.2HCl

CAS No. 1253952-02-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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