Netarsudil (AR-13324) 2HCl
Molecular Weight(MW): 526.45
Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
Purity & Quality Control
Choose Selective ROCK Inhibitors
|Description||Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.|
|In vivo||Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. In addition, netarsudil has been shown to increase outflow facility in non-human primate eyes and to decrease episcleral venous pressure in rabbit eyes.|
|In vitro||Water||54 mg/mL (102.57 mM)|
|DMSO||20 mg/mL (37.99 mM)|
|Ethanol||2 mg/mL (3.79 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03248037||Recruiting||Fuchs'' Endothelial Dystrophy|Bullous Keratopathy||Cornea Research Foundation of America||September 5 2017||Phase 3|
|NCT03284853||Recruiting||Open Angle Glaucoma|Ocular Hypertension||Aerie Pharmaceuticals||September 5 2017||Phase 3|
|NCT02874846||Completed||Ocular Hypertension|Open Angle Glaucoma||Aerie Pharmaceuticals||July 2016||Phase 2|
|NCT02674854||Completed||Open-angle Glaucoma|Ocular Hypertension||Aerie Pharmaceuticals||February 2016||Phase 3|
|NCT02558374||Completed||Open-angle Glaucoma|Ocular Hypertension||Aerie Pharmaceuticals||September 2015||Phase 3|
|NCT02406287||Completed||Healthy Subjects||Aerie Pharmaceuticals||April 2015||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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