Netarsudil (AR-13324) 2HCl
Netarsudil (AR-13324) is a ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
Netarsudil (AR-13324) 2HCl Chemical Structure
CAS No. 1253952-02-1
Purity & Quality Control
Netarsudil (AR-13324) 2HCl Related Products
| Related Targets | ROCK1 ROCK2 | Click to Expand |
|---|---|---|
| Related Products | Y-27632 2HCl Y-27632 Fasudil HCl Thiazovivin GSK429286A RKI-1447 Ripasudil hydrochloride dihydrate GSK269962A HCl Y-39983 Dihydrochloride Hydroxyfasudil HCl | Click to Expand |
| Related Compound Libraries | Kinase Inhibitor Library PI3K/Akt Inhibitor Library MAPK Inhibitor Library DNA Damage/DNA Repair compound Library Cell Cycle compound library | Click to Expand |
Signaling Pathway
Biological Activity
| Description | Netarsudil (AR-13324) is a ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension. | ||
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| Targets |
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| In Vivo | ||
| In vivo | Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. In addition, netarsudil has been shown to increase outflow facility in non-human primate eyes and to decrease episcleral venous pressure in rabbit eyes[2]. |
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| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06033703 | Not yet recruiting | Rhegmatogenous Retinal Detachment|Proliferative Vitreoretinopathy |
Massachusetts Eye and Ear Infirmary |
February 2024 | Phase 1|Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 526.45 | Formula | C28H27N3O3.2HCl |
| CAS No. | 1253952-02-1 | SDF | Download Netarsudil (AR-13324) 2HCl SDF |
| Smiles | CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl | ||
| Storage (From the date of receipt) | |||
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In vitro |
DMSO : 100 mg/mL ( (189.95 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : Insoluble Ethanol : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
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