Netarsudil (AR-13324) 2HCl
Molecular Weight(MW): 526.45
Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
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|Description||Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.|
Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. In addition, netarsudil has been shown to increase outflow facility in non-human primate eyes and to decrease episcleral venous pressure in rabbit eyes.
|In vitro||Water||54 mg/mL (102.57 mM)|
|DMSO||20 mg/mL (37.99 mM)|
|Ethanol||2 mg/mL (3.79 mM)|
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