Home Endocrinology & Hormones Androgen Receptor antagonist Nilutamide

research use only

Nilutamide Androgen Receptor antagonist

Cat.No.S4836

Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.
Nilutamide Androgen Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 317.22

Jump to

Quality Control

Batch: S483601 DMSO]63 mg/mL]false]Ethanol]63 mg/mL]false]Water]Insoluble]false Purity: 99.19%
99.19

Solubility

In vitro
Batch:

DMSO : 63 mg/mL (198.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 63 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 317.22 Formula

C12H10F3N3O4

 Storage (From the date of receipt)
CAS No. 63612-50-0 -- Storage of Stock Solutions

Synonyms RU23908 SMILES CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
Androgen Receptor
In vivo
Nilutamide has a long half-life which permits once-daily administration. The tolerance of nilutamide is generally acceptable.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-09-11)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03678025 RECRUITING
Castration Levels of Testosterone; Metastatic Prostatic Adenocarcinoma; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8
SWOG Cancer Research Network
 2018-09-24 PHASE3
NCT01786265 ACTIVE_NOT_RECRUITING
Prostate Adenocarcinoma; Recurrent Prostate Carcinoma
M.D. Anderson Cancer Center
 2013-02-05 PHASE2
NCT04787744 RECRUITING
Prostate Cancer; Oligometastasis; Oligorecurrence; Recurrent Prostate Cancer; Metastatic Prostate Cancer; De Novo Prostate Cancer
VA Office of Research and Development
 2021-07-01 PHASE2; PHASE3
NCT03070886 COMPLETED
Stage I Prostate Adenocarcinoma AJCC v7; Stage II Prostate Adenocarcinoma AJCC v7; Stage III Prostate Adenocarcinoma AJCC v7
NRG Oncology
 2017-04-05 PHASE2; PHASE3
NCT00918385 TERMINATED
Prostate Cancer
Duke University
 2009-05 PHASE2
NCT00002633 COMPLETED
Prostate Cancer
NCIC Clinical Trials Group
 1995-02-08 PHASE3

Read more about Clinical Trials

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map