Home GPCR & G Protein AChR modulator NS 1738

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NS 1738 AChR modulator

Cat.No.S0518

NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), with respect to positive modulation of Xenopus laevis oocyte α7 nAChR with EC50 of 3.4 μM, as well as a comparable efficacy at the rat α7 nAChR with EC50 of 3.9 μM.
NS 1738 AChR modulator Chemical Structure

Chemical Structure

Molecular Weight: 365.13

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Quality Control

Batch: S051801 DMSO]73 mg/mL]false]Ethanol]73 mg/mL]false]Water]Insoluble]false Purity: 99.92%
99.92

Chemical Information, Storage & Stability

Molecular Weight 365.13 Formula

C14H9Cl2F3N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 501684-93-1 -- Storage of Stock Solutions

Synonyms NSC 213859 Smiles C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl

Solubility

In vitro
Batch:

DMSO : 73 mg/mL (199.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 73 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
Xenopus laevis oocyte α7 nAChR [1]
(in an electrophysiological experiments)
3.4 μM(EC50)
rat α7 nAChR [1]
(in an electrophysiological experiments)
3.9 μM(EC50)
References

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