NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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Cited by 50 Publications

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEKxOFMh|ryP MkS4V2FPT0WU
A172 NFzqbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoeyTWM2OD1yLkG1N|E3KM7:TR?= Mo\FV2FPT0WU
NCI-H526 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDiTWM2OD1yLkK4OFA4KM7:TR?= NYnMbZA1W0GQR1XS
HDLM-2 M2[ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwM{KzOFUh|ryP MkjlV2FPT0WU
HuO-3N1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjaZmlKSzVyPUCuOFY3OzZizszN NHrIVFlUSU6JRWK=
NCI-SNU-1 NVjoU4V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNkC5PVQh|ryP NGjk[GRUSU6JRWK=
SK-N-AS MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfkdY5mUUN3ME2wMlYzOjF4IN88US=> NFXUb4hUSU6JRWK=
LoVo NGHrfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn5THNKSzVyPUCuPFY4PDlizszN Mm\0V2FPT0WU
LAMA-84 NHjhfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGx[YpKSzVyPUCuPVg5OzNizszN Ml;0V2FPT0WU
CTB-1 NHzoNYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;3fmtPUUN3ME2xMlEyPTR4IN88US=> NXHiS2RCW0GQR1XS
KP-N-YS NX7yS3FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LuO2lEPTB;MT6xOFI{OSEQvF2= MmnYV2FPT0WU
HH NXf2T45GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjNcFhMUUN3ME2xMlE5ODl|IN88US=> MWrTRW5ITVJ?
CHL-1 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkezTWM2OD1zLkKxN|Y5KM7:TR?= NEO5PXRUSU6JRWK=
NB7 M4LRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTCTWM2OD1zLkK0O|Q2KM7:TR?= NH3z[lJUSU6JRWK=
HL-60 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzqTWM2OD1zLkO4NVkh|ryP NV3FeJdqW0GQR1XS
639-V MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zRW2lEPTB;MT60OFEzQCEQvF2= MlrzV2FPT0WU
NCI-H1793 M3fqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fFXGlEPTB;MT60OVg1KM7:TR?= M1\1VXNCVkeHUh?=
NEC8 NY\XdZBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwNUWzOUDPxE1? NVW5R5ZzW0GQR1XS
PA-1 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f2cGlEPTB;MT61PFI6PCEQvF2= NUj5VVhwW0GQR1XS
D-423MG Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz3TWM2OD1zLk[5N|YyKM7:TR?= MWjTRW5ITVJ?
NCI-H292 M2LRbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwN{SwNVMh|ryP NX7wNpp4W0GQR1XS
SK-MEL-1 NF;1eI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjCfnU2UUN3ME2xMlc6PDd7IN88US=> M{XSRXNCVkeHUh?=
LB2241-RCC NYO0OGxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDQS25KSzVyPUKuNVQyPDZizszN NV7sNWRkW0GQR1XS
SK-MEL-3 NXT5foY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnhbmxKSzVyPUKuNVY1QSEQvF2= NYK3U2l1W0GQR1XS
MHH-PREB-1 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHz[olKSzVyPUKuNVY3ODlizszN NWPq[YZOW0GQR1XS
BFTC-905 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fae2lEPTB;Mj6xOlY5PyEQvF2= MlzYV2FPT0WU
Ramos-2G6-4C10 Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJwMUm5NFkh|ryP MX7TRW5ITVJ?
G-361 M1jGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLsVmVOUUN3ME2yMlIyPjhizszN NH[ybItUSU6JRWK=
MOLT-4 M4HkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz0UopKSzVyPUKuNlE5QDhizszN NYfHbJlVW0GQR1XS
DEL NEHvUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHFeXN2UUN3ME2yMlM2PTZ2IN88US=> M1nCbnNCVkeHUh?=
MV-4-11 M3XsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXmzc2tQUUN3ME2yMlM4OzlizszN NH\1TYZUSU6JRWK=
SK-NEP-1 M3LBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJwM{i3PFMh|ryP MVnTRW5ITVJ?
RS4-11 M2T1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDqdpRQUUN3ME2yMlU3ODJ|IN88US=> NF\rRYxUSU6JRWK=
HuH-7 M4nrd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwNU[3NFIh|ryP MWHTRW5ITVJ?
A101D M2HYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHKTWM2OD1{Lk[xN|M5KM7:TR?= MXTTRW5ITVJ?
KG-1 NFnYUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HmcGlEPTB;Mj62O|kzPCEQvF2= NFWxTGVUSU6JRWK=
KALS-1 NVKyV3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG0W|N5UUN3ME2yMlY6PjN|IN88US=> NGW0RpBUSU6JRWK=
VMRC-RCZ M{[5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[xOmwzUUN3ME2yMlc4OzJ6IN88US=> MVfTRW5ITVJ?
SK-UT-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LuR2lEPTB;Mz6xOVMyKM7:TR?= MmO0V2FPT0WU
SW962 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HXbWlEPTB;Mz6yNFM2OiEQvF2= MVrTRW5ITVJ?
DBTRG-05MG Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTNwMkiwPFUh|ryP MnjsV2FPT0WU
PANC-08-13 NYn6OGhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjFRVZKSzVyPUOuOFEzPzhizszN NIPzZZFUSU6JRWK=
QIMR-WIL NGjje|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTNwNEGzOFEh|ryP NXj2ZlZoW0GQR1XS
SK-MEL-30 NEjEOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLiVpJOUUN3ME2zMlQzPTl6IN88US=> M{K2dXNCVkeHUh?=
697 NHXvTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwNES5PVMh|ryP NHrQVphUSU6JRWK=
NY M2Dycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7Ze49KSzVyPUOuOFUxOjJizszN NIK3fHpUSU6JRWK=
ES7 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTNwNE[3Nlkh|ryP MnnBV2FPT0WU
JVM-3 M3XKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHIOXBKSzVyPUOuOFgxPzdizszN M2S3fnNCVkeHUh?=
U031 MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDhTWM2OD1|LkW5N|Y5KM7:TR?= MWPTRW5ITVJ?
BHT-101 M3zJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofwTWM2OD1|LkW5PVg2KM7:TR?= NInv[odUSU6JRWK=
8305C MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Hub2lEPTB;Mz62NVc{PiEQvF2= Mo\vV2FPT0WU
MG-63 NFPwXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTNwNkK2O|Yh|ryP NWexUlB[W0GQR1XS
NOS-1 MoWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXflb2d3UUN3ME2zMlY2OzF{IN88US=> MoXTV2FPT0WU
YH-13 NWPTd|dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XQO2lEPTB;Mz64O|E5QSEQvF2= M1;5THNCVkeHUh?=
LXF-289 NYDaR3A2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnKTWM2OD1|LkmxNFQyKM7:TR?= NH;1S5VUSU6JRWK=
GOTO M2jHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\XTWM2OD1|LkmxOFkh|ryP MkTHV2FPT0WU
EKVX NGH2bIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXiboo3UUN3ME20MlIzPTJ2IN88US=> NIC2fXRUSU6JRWK=
CAL-51 NV7WV29uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXNbnBKSzVyPUSuNlQ5PTRizszN NHXV[|VUSU6JRWK=
AN3-CA NVK1R5hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\tTWM2OD12LkK1PFE{KM7:TR?= NYXZNIN[W0GQR1XS
IA-LM NW\3XVBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[2bXdKSzVyPUSuNlc6OzVizszN MUPTRW5ITVJ?
KU-19-19 M1PkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHewRZRKSzVyPUSuN|I6OjFizszN MnvKV2FPT0WU
A704 NHToWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rTdWlEPTB;ND60NFg5QCEQvF2= NYj6ZWN6W0GQR1XS
RH-18 M2G3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;jfmlEPTB;ND60OFk2OyEQvF2= MV7TRW5ITVJ?
IST-MEL1 Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HBc2lEPTB;ND61PFI3OyEQvF2= NX\lTWFMW0GQR1XS
LU-134-A M1HvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W3V2lEPTB;ND61PVY5PSEQvF2= NVzFUpNxW0GQR1XS
SF126 NH7HVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HT[mlEPTB;ND62NFcyPSEQvF2= NGLrcplUSU6JRWK=
EFO-27 M2HvU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Nd5hFUUN3ME20MlY3PTJ3IN88US=> NHXGdmpUSU6JRWK=
SN12C MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLNWlEPTB;ND63NVg6QCEQvF2= NGj4N5ZUSU6JRWK=
L-363 M1K5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTRwN{exNVYh|ryP MmrRV2FPT0WU
MEL-HO NVLqTVV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[4enpKSzVyPUSuO|c6QDlizszN MXLTRW5ITVJ?
TYK-nu MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP5TWM2OD12LkiwNVI5KM7:TR?= MYfTRW5ITVJ?
MDA-MB-415 NX[3WWd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPNTWM2OD13LkCwN|E1KM7:TR?= MUXTRW5ITVJ?
HCC70 M1vnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLoZZZpUUN3ME21MlA{QTN7IN88US=> NI\4NXlUSU6JRWK=
IGROV-1 NW\XS|V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PV[WlEPTB;NT6yOVI6OiEQvF2= NXrrZVYzW0GQR1XS
NCI-H1355 NYDyVmlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTDS3F{UUN3ME21MlI6PiEQvF2= MmTPV2FPT0WU
23132-87 NELXdXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzyZ4ZKSzVyPUWuN|IxOjRizszN MYLTRW5ITVJ?
NB69 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G5cGlEPTB;NT6zNlQzKM7:TR?= M3fK[nNCVkeHUh?=
HSC-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XNW2lEPTB;NT60NVc4OyEQvF2= NXvNTYZzW0GQR1XS
KYSE-410 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTFT2c4UUN3ME21MlQ4PjN4IN88US=> M172WnNCVkeHUh?=
GCIY M1TqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTVwNUGzO|gh|ryP NYHpUm51W0GQR1XS
A427 NV\0dIR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\XXWlEPTB;NT61N|Y3OSEQvF2= MmqyV2FPT0WU
ChaGo-K-1 M1vFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HWc2lEPTB;NT61OlU6QSEQvF2= MXvTRW5ITVJ?
PFSK-1 M1Tabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O2e2lEPTB;NT62NlE6PCEQvF2= MoO2V2FPT0WU
MLMA NXPQUoNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS3TWM2OD13LkizOlA3KM7:TR?= NUOyeIRWW0GQR1XS
RVH-421 NYPmV2h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzvRVRKSzVyPU[uNFc{OzhizszN NWGwTItmW0GQR1XS
LB1047-RCC NX64WIZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTZwMUe1NlIh|ryP NXvNUpBIW0GQR1XS
MHH-NB-11 NH75[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPJTWM2OD14LkOyO|IyKM7:TR?= NHHweIVUSU6JRWK=
J-RT3-T3-5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnEW4lOUUN3ME22MlY{OjlzIN88US=> NHzQS3VUSU6JRWK=
UM-UC-3 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTZwNkSzN|Qh|ryP MWrTRW5ITVJ?
IST-SL1 MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfxXnNIUUN3ME22MlY6OzZ7IN88US=> MWnTRW5ITVJ?
NB14 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jQVmlEPTB;Nj63PVc3OSEQvF2= NXvBZ5BOW0GQR1XS
NBsusSR NW\hO4h{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4[I1ZUUN3ME22MlgzPTB{IN88US=> NV3GSlhyW0GQR1XS
D-263MG NGHr[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13nV2lEPTB;Nj65NVA3QCEQvF2= NFX0Wo9USU6JRWK=
NCI-H2347 NFXPe3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTZwOUOyNVMh|ryP MlT4V2FPT0WU
ES8 NWf1S4NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTZwOUe1PFgh|ryP NETU[ZNUSU6JRWK=
786-0 M2rtNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDSR4RnUUN3ME23MlA6Pzh4IN88US=> NYDrUZF5W0GQR1XS
EPLC-272H MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHlfGNKSzVyPUeuNVYzPDZizszN NGDqXJJUSU6JRWK=
CAPAN-1 Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HFUWlEPTB;Nz6yOFM2QSEQvF2= NV;6doRnW0GQR1XS
NCI-H82 NGC2S3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\PeJFKSzVyPUeuNlY3PTlizszN M2PkZ3NCVkeHUh?=
G-402 M1z0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml35TWM2OD15LkOwNFUyKM7:TR?= NVTRVYd[W0GQR1XS
SW982 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELRVYJKSzVyPUeuN|AzODNizszN MkWyV2FPT0WU
OVCAR-4 NYjOZ4V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnZSnFzUUN3ME23MlMyOzJ6IN88US=> M4TDfnNCVkeHUh?=
KARPAS-299 NGLheGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\zNWlEPTB;Nz6zNlYzOiEQvF2= Mly4V2FPT0WU
MIA-PaCa-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTdwM{[4NlMh|ryP MVrTRW5ITVJ?
AU565 NYfYTGp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q4[GlEPTB;Nz61PVg{OyEQvF2= NFz1N3VUSU6JRWK=
GAMG NGfp[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn3NoZKSzVyPUeuOlQyOzFizszN MoPhV2FPT0WU
HuO9 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XieWlEPTB;Nz63NVc1OyEQvF2= MlHLV2FPT0WU
ACN NYrWV4NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXkTWM2OD15Lke0N|Mh|ryP NUfJT4hSW0GQR1XS
RO82-W-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHToPIpKSzVyPUeuO|Q2OzNizszN NUPkeItJW0GQR1XS
NKM-1 NWX6NHExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnkW29EUUN3ME23Mlc1QTV3IN88US=> NWXsWWJ1W0GQR1XS
CAL-12T NID0VFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjIWHVrUUN3ME23Mlk1OzV{IN88US=> NYPU[pg4W0GQR1XS
FADU M4\yfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjCO3pKSzVyPUiuNFM3PTRizszN NF;ySmVUSU6JRWK=
NCI-H28 NHHpT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRThwMU[5OlIh|ryP NGmzfWlUSU6JRWK=
LCLC-97TM1 NIPqNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr6foNyUUN3ME24MlIyOTJ{IN88US=> NVrmWHp2W0GQR1XS
CHP-134 M3Pz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Gdok6UUN3ME24MlI1OTh3IN88US=> MkPEV2FPT0WU
HT-1080 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\CboNQUUN3ME24MlI2ODl|IN88US=> MYjTRW5ITVJ?
PC-3 M{DG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[zdlNlUUN3ME24MlI4Ozl{IN88US=> NVLVNWNQW0GQR1XS
SNU-449 NEn1ZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjXTWM2OD16LkK3PVMh|ryP MkDlV2FPT0WU
VA-ES-BJ MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDROWRKSzVyPUiuN|Q3QDZizszN M2PwVnNCVkeHUh?=
HT MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP6XFhKSzVyPUiuN|Y1QSEQvF2= MYHTRW5ITVJ?
HOS M1n0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DrPWlEPTB;OD6zO|U5QSEQvF2= NU\JdJA6W0GQR1XS
KNS-62 M2qxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvIOWhnUUN3ME24MlM4PzZ{IN88US=> M4O5cHNCVkeHUh?=
OAW-42 M1vPeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDSWVVKSzVyPUiuPVU6PjRizszN NFTBTodUSU6JRWK=
A549 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV73W|FlUUN3ME25MlA6PjF{IN88US=> MVvTRW5ITVJ?
CAKI-1 M2XGXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPHTWM2OD17LkG2OlEh|ryP NEHVWWlUSU6JRWK=
HCC1937 MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDWfXlmUUN3ME25MlY6QDZ3IN88US=> MlL0V2FPT0WU
GI-ME-N NI\0N2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO1TWM2OD17LkewNVM4KM7:TR?= NGHNVJZUSU6JRWK=
DU-4475 NFn0[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkeyTWM2OD17Lkm2PVM6KM7:TR?= NYCydGk2W0GQR1XS
EM-2 M2DFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfWUppKSzVyPUGwMlI1OjZizszN NXnMOJVuW0GQR1XS
NCI-H1755 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;WUFBKSzVyPUGwMlI1OjhizszN NGLIXo1USU6JRWK=
NCI-H1437 NYPWPINHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFyLkW3NlUh|ryP NYXTfmhwW0GQR1XS
VM-CUB-1 MljQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzzPGNKUUN3ME2xNE43OTZ2IN88US=> MWDTRW5ITVJ?
A2058 M3vjSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFyLk[0NFQh|ryP MW\TRW5ITVJ?
BPH-1 M{HHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjJTWM2OD1zMD63NVQ2KM7:TR?= M374fHNCVkeHUh?=
NB5 NHi3WI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXzWZFKSzVyPUGwMlc2PTlizszN MkfIV2FPT0WU
G-401 NXfKUmw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;4em9KSzVyPUGwMlc3OjZizszN M1vLZ3NCVkeHUh?=
CAL-72 M{TTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXKTWM2OD1zMD64NFk1KM7:TR?= MmHOV2FPT0WU
SK-MEL-28 NIjVeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW5[2VKSzVyPUGwMlgzODJizszN NFHXPWVUSU6JRWK=
C32 NXnwVVRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[4NGlEPTB;MUCuPFM1PyEQvF2= M1vCR3NCVkeHUh?=
NCI-H1155 NULxfGxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTFyLkizO|Yh|ryP NUjtO2g6W0GQR1XS
BB49-HNC NVjYNotET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7POmV{UUN3ME2xNE45PTh4IN88US=> M1j1RXNCVkeHUh?=
GMS-10 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi5TWM2OD1zMD64PVcyKM7:TR?= NVTSV|JbW0GQR1XS
K5 NETRbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHURmNpUUN3ME2xNE46ODdzIN88US=> NIjiZmVUSU6JRWK=
OS-RC-2 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFzLkC1OVkh|ryP MmDNV2FPT0WU
HTC-C3 NXzX[oM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFzLkC3NVQh|ryP M{nKVXNCVkeHUh?=
LB996-RCC NX;UOVBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn5TWM2OD1zMT6wO|I{KM7:TR?= MkjKV2FPT0WU
NCI-H1563 NVHKZ4FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1yxNmlEPTB;MUGuNVAyOSEQvF2= MoL0V2FPT0WU
CAL-54 NELNVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3ob|JXUUN3ME2xNU41QDFzIN88US=> M2jPXXNCVkeHUh?=
WM-115 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3ZeJNKSzVyPUGxMlY5OjRizszN NFTlfJNUSU6JRWK=
COLO-684 NGe4fnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTsVWZWUUN3ME2xNU44OjZ5IN88US=> MoP0V2FPT0WU
HOP-62 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SydWlEPTB;MUGuO|UxQCEQvF2= M1fodnNCVkeHUh?=
NCI-H650 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4SzfWlEPTB;MUGuPFk3OSEQvF2= NVfJV|hVW0GQR1XS
TE-11 NWWyW3N{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HBXWlEPTB;MUGuPVMyPSEQvF2= MnizV2FPT0WU
COLO-679 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFzLkm0OkDPxE1? M4H0SnNCVkeHUh?=
FTC-133 M1vqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3pfI9oUUN3ME2xNk4xODd4IN88US=> NFHhe3FUSU6JRWK=
D-283MED NHXkTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF{LkC1Olkh|ryP MXnTRW5ITVJ?
SK-PN-DW MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPOT5hKSzVyPUGyMlE6ODJizszN M4TadXNCVkeHUh?=
BALL-1 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3voV2lEPTB;MUKuNlY3OiEQvF2= MWDTRW5ITVJ?
GT3TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXP6flNJUUN3ME2xNk4{ODd2IN88US=> NILCclBUSU6JRWK=
HOP-92 NYjUNIRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF{LkWyN|Mh|ryP M1LaTnNCVkeHUh?=
M14 NVH3S5diT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPkTWM2OD1zMz6wN|M2KM7:TR?= M{jocHNCVkeHUh?=
SKG-IIIa MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHaTWM2OD1zMz6wOVU1KM7:TR?= M2ns[3NCVkeHUh?=
Becker MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXISWtKSzVyPUGzMlA2QCEQvF2= M2ThOnNCVkeHUh?=
ES5 M3Xsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPke|I1UUN3ME2xN{4yOzV4IN88US=> MV3TRW5ITVJ?
NCI-H2030 NH3PdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf5TWM2OD1zMz6yNFYzKM7:TR?= MUTTRW5ITVJ?
SNU-423 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrRTWM2OD1zMz6zPFEh|ryP NV3MSpN{W0GQR1XS
CP50-MEL-B M{PINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof5TWM2OD1zMz62NlMzKM7:TR?= NV;WWGh1W0GQR1XS
NCI-H1092 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXHTWM2OD1zMz63OFc2KM7:TR?= NH[1RodUSU6JRWK=
8-MG-BA NYfSUYtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf4TWM2OD1zMz63OVE{KM7:TR?= MWfTRW5ITVJ?
CAL-27 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7lPWNTUUN3ME2xOE4xPzJ5IN88US=> M3vnT3NCVkeHUh?=
AGS MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF2LkGzNVkh|ryP MYPTRW5ITVJ?
MZ2-MEL NFjqeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrIclVRUUN3ME2xOE4yPDh6IN88US=> NV3hNplYW0GQR1XS
BFTC-909 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkeoxWUUN3ME2xOE42ODV3IN88US=> NGrJfGhUSU6JRWK=
D-566MG NYmxcFdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DiWWlEPTB;MUSuO|cxPiEQvF2= M3XNO3NCVkeHUh?=
MZ7-mel NF3sbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTF3LkGwOlch|ryP MkS1V2FPT0WU
TE-5 Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHITWM2OD1zNT6yN|M{KM7:TR?= Mli3V2FPT0WU
647-V NWLaS4NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jjR2lEPTB;MUWuNlcxPSEQvF2= MknDV2FPT0WU
DMS-114 M17uPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF3LkOyPVEh|ryP MUXTRW5ITVJ?
ME-180 NEW5O3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjiTGlbUUN3ME2xOU41Pzh|IN88US=> MmHRV2FPT0WU
MS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;LZ2lEPTB;MUWuOVYzOyEQvF2= NHH4eWRUSU6JRWK=
NUGC-3 MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;3[IlKSzVyPUG1MlYzPDVizszN MVPTRW5ITVJ?
GB-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzLTWM2OD1zNT62OFM4KM7:TR?= NHvXTINUSU6JRWK=
LOXIMVI NWnBS4tiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnlW|JKSzVyPUG1Mlg6OTlizszN M2SwRnNCVkeHUh?=
NCI-H1304 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrCTIRnUUN3ME2xOU45QTJ6IN88US=> MVfTRW5ITVJ?
KURAMOCHI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljDTWM2OD1zNT65O|Eh|ryP NIfvdppUSU6JRWK=
SW1783 NETpZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzWUohKSzVyPUG2MlA6QTNizszN NWnIc5NOW0GQR1XS
EGI-1 NGLBTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DCcGlEPTB;MU[uOVM3PSEQvF2= MX7TRW5ITVJ?
KGN NIjTbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT3eoRKSzVyPUG2MlU2QDZizszN NYjTeFdbW0GQR1XS
PANC-03-27 M1PNPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG1NoJKSzVyPUG2Mlc3PjJizszN M37OcHNCVkeHUh?=
RH-1 NHfYWHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13uOGlEPTB;MU[uPFI2KM7:TR?= M4r2[HNCVkeHUh?=
HT-1376 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF4Lki0OFYh|ryP M{jUZnNCVkeHUh?=
ZR-75-30 NXvCOGhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPuXpVKSzVyPUG2Mlk{PjFizszN NYHSO3NiW0GQR1XS
TI-73 NU\PTXQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPvXFFHUUN3ME2xOk46PDB6IN88US=> MXzTRW5ITVJ?
TK10 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITDfmxKSzVyPUG3MlAxPzlizszN MnPYV2FPT0WU
SW684 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHrTWM2OD1zNz6wNVU1KM7:TR?= MYDTRW5ITVJ?
RPMI-8866 NWXySJVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DI[2lEPTB;MUeuNFY6QSEQvF2= M4Pae3NCVkeHUh?=
LNCaP-Clone-FGC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLBTGxKSzVyPUG3MlUzODFizszN NFXtU49USU6JRWK=
NCI-H2291 M2D5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G0V2lEPTB;MUiuOFM1PSEQvF2= NHLNXoNUSU6JRWK=
T47D MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnVeHVKSzVyPUG4MlQ5QCEQvF2= NXnDT4xFW0GQR1XS
A204 NGPXNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXwSJNDUUN3ME2xPE42PDV{IN88US=> NH;BT4tUSU6JRWK=
HT-144 M1TZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnleHFKSzVyPUG4Mlc1OjdizszN NFz1XVdUSU6JRWK=
MDA-MB-361 M1TCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfiWYhZUUN3ME2xPU4xPzF2IN88US=> M1m1fXNCVkeHUh?=
HCC1806 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfRW21KSzVyPUG5MlE2QTFizszN MWTTRW5ITVJ?
NCI-H596 NGT1RpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ITWM2OD1zOT62N|kyKM7:TR?= M4XSVnNCVkeHUh?=
K-562 M2rkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7pNI9OUUN3ME2xPU45QTJ4IN88US=> NVLqT2NZW0GQR1XS
D-336MG MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDOUGI4UUN3ME2xPU46OzJ{IN88US=> NGXPSolUSU6JRWK=
SK-MEL-2 M1rTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXJeGRKSzVyPUKwMlE2PTlizszN NUfLNZlIW0GQR1XS
HEC-1 NI\ZV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnuTZAxUUN3ME2yNE41QTd6IN88US=> Mlz6V2FPT0WU
EW-13 NEn6NZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\MUYJKSzVyPUKwMlU1PDNizszN NUTORlJuW0GQR1XS
Hs-578-T M{XwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJyLkW1PFMh|ryP MnmyV2FPT0WU
SJSA-1 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnifWhKSzVyPUKwMlU3QDhizszN NXzPeGExW0GQR1XS
RCC10RGB NGCwfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HGXmlEPTB;MkCuOlcyQSEQvF2= NHmxdWtUSU6JRWK=
LAN-6 NH[zemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH2TWM2OD1{MT6wN|k3KM7:TR?= NIHZZpVUSU6JRWK=
NCI-H1048 M13Ge2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\ENG1KSzVyPUKxMlIzPThizszN NGjaZnVUSU6JRWK=
CW-2 NFe4bGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJzLkK3NFUh|ryP NFe2TopUSU6JRWK=
HCC2157 NH\OVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLZTWM2OD1{MT6zOkDPxE1? MX;TRW5ITVJ?
EW-22 NEH6XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXnSYtKSzVyPUKxMlM4PiEQvF2= NFq5Wo5USU6JRWK=
A253 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOwOlJ1UUN3ME2yNU41PDhzIN88US=> MnjwV2FPT0WU
BE-13 NHfySG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJzLk[xNVMh|ryP MnniV2FPT0WU
KINGS-1 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPyRVJKSzVyPUKxMlY{OTZizszN MXLTRW5ITVJ?
ETK-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPyZpJKSzVyPUKxMlgyPTJizszN M4LvZXNCVkeHUh?=
NCI-H2452 M{TRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrzTnF{UUN3ME2yNU45PjR5IN88US=> NHO4bJJUSU6JRWK=
HPAF-II MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn64TWM2OD1{MT64PVI{KM7:TR?= NGLjV5JUSU6JRWK=
D-542MG M2n1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjCc3ZKSzVyPUKxMlkxPjlizszN NGTi[3VUSU6JRWK=
NCI-H630 M2riWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLqTWM2OD1{Mj6wNlk3KM7:TR?= MWPTRW5ITVJ?
TGBC11TKB MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y2dmlEPTB;MkKuNFQ6KM7:TR?= MVfTRW5ITVJ?
BCPAP NXHUWok4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfLUHk1UUN3ME2yNk43OTFizszN NIPIc|NUSU6JRWK=
HLE NFjSSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfETWM2OD1{Mj62PVch|ryP M4fRe3NCVkeHUh?=
NCI-H727 M3nB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEKxSYtKSzVyPUKyMlc{PSEQvF2= NXTQTo5jW0GQR1XS
RD MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ{Lke1NVgh|ryP NGXpfXZUSU6JRWK=
NCI-H522 MoWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3juc2lEPTB;MkKuPFQ{OSEQvF2= M1r3NXNCVkeHUh?=
CGTH-W-1 NHOzenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW3TWM2OD1{Mz6wOlQyKM7:TR?= MV\TRW5ITVJ?
SK-LU-1 NF3pTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnxWYpDUUN3ME2yN{41Pjh|IN88US=> NFW0NVJUSU6JRWK=
BB65-RCC Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vjO2lEPTB;MkOuO|g3OyEQvF2= MVLTRW5ITVJ?
HSC-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;CTWM2OD1{Mz64OVI4KM7:TR?= NHnhb|dUSU6JRWK=
SK-MES-1 M1fJOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;kc5k3UUN3ME2yOE4xOTZzIN88US=> MX7TRW5ITVJ?
DB NWewSIZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjzN2NKSzVyPUK0MlExOjhizszN NWXZSZFyW0GQR1XS
HO-1-N-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjtNWw6UUN3ME2yOE4{ODl|IN88US=> M3XvenNCVkeHUh?=
MKN1 NVzsN3N7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37YR2lEPTB;MkSuOlgh|ryP NWfLfIFHW0GQR1XS
MN-60 NXPB[plDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXjTWM2OD1{ND64OVE6KM7:TR?= NYXtb|RpW0GQR1XS
8505C MnrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfYNm9yUUN3ME2yOU4yQDR3IN88US=> MmHhV2FPT0WU
COLO-320-HSR MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ3LkKyNFgh|ryP Mn:xV2FPT0WU
BB30-HNC NFXB[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHETWM2OD1{NT6yOFg{KM7:TR?= MVLTRW5ITVJ?
KM12 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;0TWM2OD1{NT61PFA4KM7:TR?= MnL5V2FPT0WU
NB13 NWPKOG9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\UTWM2OD1{NT61PFk5KM7:TR?= NFr6[JpUSU6JRWK=
HCC2998 M1\DOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrBbYY{UUN3ME2yOk4xOjh|IN88US=> Mn3oV2FPT0WU
U-118-MG NFO1b4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvSTWM2OD1{Nj6wPFA5KM7:TR?= NI\HVGlUSU6JRWK=
NB10 NFGzbZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrNTWM2OD1{Nj6yN|Qh|ryP NFWyZ2dUSU6JRWK=
SK-LMS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ5LkC3NFQh|ryP NXLGNJhiW0GQR1XS
SW1573 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ5LkGxJO69VQ>? M1\DfHNCVkeHUh?=
LB373-MEL-D M3H2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NICzdJJKSzVyPUK3MlEzQTRizszN MUHTRW5ITVJ?
DK-MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSzZpZsUUN3ME2yO{4yQDF5IN88US=> M2rVeXNCVkeHUh?=
RMG-I NXXsZ|JPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJ5LkKwNlkh|ryP MlLEV2FPT0WU
SW1088 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHWxUmhKSzVyPUK3MlUxPDJizszN MnK4V2FPT0WU
SK-OV-3 Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzRfVN{UUN3ME2yO{44PTl|IN88US=> MlnuV2FPT0WU
KP-N-YN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ5LkiwOFMh|ryP MnG3V2FPT0WU
RPMI-7951 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vx[WlEPTB;MkiuNlQ2PiEQvF2= NXfOUVVLW0GQR1XS
CaR-1 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\UNoRDUUN3ME2yPE42PTh{IN88US=> NIHV[IhUSU6JRWK=
MKN7 M2\BT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PRS2lEPTB;MkiuOVk3PCEQvF2= M2rTUnNCVkeHUh?=
CHP-212 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPFTWM2OD1{OD63OFAyKM7:TR?= MlvkV2FPT0WU
KYSE-450 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjOTWM2OD1{OD64NFkyKM7:TR?= NFXEOVRUSU6JRWK=
RXF393 M3XCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDTOI4xUUN3ME2yPU4zQTB4IN88US=> MWDTRW5ITVJ?
P30-OHK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJ7LkOwOFgh|ryP MmjVV2FPT0WU
Ca9-22 NHz3Z|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fqSmlEPTB;MkmuOFI6QSEQvF2= MlLJV2FPT0WU
RT-112 NX[xWoZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rkSWlEPTB;MkmuOFYyOSEQvF2= M3TpbHNCVkeHUh?=
ES1 NEjlOZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\zeWc3UUN3ME2yPU45PTR2IN88US=> MVTTRW5ITVJ?
HCE-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz1PFNKSzVyPUK5Mlg4QDZizszN MYTTRW5ITVJ?
AM-38 M2LrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjic|RKSzVyPUOwMlA3ODZizszN NFXRUmhUSU6JRWK=
AsPC-1 NHzCfoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7VXJVKSzVyPUOwMlgxPTNizszN M130fHNCVkeHUh?=
TE-9 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTNyLki3N|ch|ryP M2LjNHNCVkeHUh?=
HuP-T4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrYVY1KSzVyPUOwMlk3OzhizszN NGW1U21USU6JRWK=
LB2518-MEL NXXE[WRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\WTWM2OD1|MT6wO|Q1KM7:TR?= M{fpbnNCVkeHUh?=
NCI-H1703 M3H2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\3TWM2OD1|MT6wPVA2KM7:TR?= NV20d4o2W0GQR1XS
NCI-H2228 NVTvRnp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHRPWxKSzVyPUOxMlQ3PTFizszN MmHpV2FPT0WU
SCC-4 M3O0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTNzLkmxPFEh|ryP MoXZV2FPT0WU
KNS-81-FD MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITRNHVKSzVyPUOyMlAyOjhizszN NVGxPZl2W0GQR1XS
NTERA-S-cl-D1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXVXYRSUUN3ME2zNk4xPzN7IN88US=> MlvmV2FPT0WU
Daoy NUS1O|RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HWe2lEPTB;M{KuNFg{QCEQvF2= NFnGTGxUSU6JRWK=
ES4 NE\oTHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\QVIdKSzVyPUOyMlM6OjJizszN MoPvV2FPT0WU
MHH-ES-1 Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInKcY1KSzVyPUOyMlQ5PzJizszN M4XEWnNCVkeHUh?=
C-33-A NUL6SZlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1niOWlEPTB;M{KuO|czQCEQvF2= M4\ye3NCVkeHUh?=
BHY MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OxeGlEPTB;M{KuPVQ6PSEQvF2= NXWyZ2pRW0GQR1XS
Detroit562 NXzyWYZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\TTWM2OD1|Mz62OlU4KM7:TR?= Mn7BV2FPT0WU
EW-1 NF7EUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTN|LkmzNlIh|ryP NFrMfJZUSU6JRWK=
NCI-H1395 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ruSWlEPTB;M{SuNFc6QSEQvF2= MUPTRW5ITVJ?
KM-H2 NVzYNmFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETrTpFKSzVyPUO2MlQ4PDNizszN MmnCV2FPT0WU
NCI-H520 M17Ye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ScmlEPTB;M{[uO|U1OSEQvF2= NV;JOXZCW0GQR1XS
D-392MG NXXQd|JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi5PHNKSzVyPUO3MlM{PDRizszN NGLIS3lUSU6JRWK=
NOMO-1 MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXa[Xg1UUN3ME2zO{45ODh7IN88US=> NXXxNIh7W0GQR1XS
TE-6 M3H0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz5RZNKSzVyPUO4MlEzPCEQvF2= NIS0WWRUSU6JRWK=
HT-3 NGDFfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjsSG43UUN3ME2zPE41PDN4IN88US=> NYXY[WdvW0GQR1XS
RPMI-8226 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrsN4QzUUN3ME2zPE46PTF7IN88US=> MoO4V2FPT0WU
U251 M{nSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPOc2FXUUN3ME2zPU4xOTJ2IN88US=> MkjhV2FPT0WU
GCT NHT1WmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN7LkG4OVIh|ryP MVzTRW5ITVJ?
A431 NWmxcXNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPsTWM2OD1|OT6xPFk1KM7:TR?= MlXyV2FPT0WU
TE-12 NX\oeHBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTN7LkK0OFgh|ryP NWfRWVB1W0GQR1XS
HMV-II M1jzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi5ZXpKSzVyPUO5MlUxPDdizszN M3m5WXNCVkeHUh?=
IST-MES1 NF\ybGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRyLkG1NFIh|ryP MYXTRW5ITVJ?
SW13 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqxXXVsUUN3ME20NE42OTlizszN MoHEV2FPT0WU
SF295 NGrvVm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDnTWM2OD12MD64NFY3KM7:TR?= NFLnfpVUSU6JRWK=
MDA-MB-157 M1:xOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXWzTmg1UUN3ME20NE46PDZ{IN88US=> MV7TRW5ITVJ?
TE-1 NH65RopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;LU2lEPTB;NEGuPFcyPCEQvF2= M1n2VXNCVkeHUh?=
HuCCT1 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrCT3pNUUN3ME20Nk42Ojh7IN88US=> NH;G[FFUSU6JRWK=
KYSE-510 MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHxPXpKSzVyPUSzMlE4PTRizszN M3ftRnNCVkeHUh?=
NCI-H358 MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rqPGlEPTB;NESuNFMxPCEQvF2= MWrTRW5ITVJ?
SW900 NVrNbnc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq0enRKSzVyPUS0MlA4PThizszN MljvV2FPT0WU
CAS-1 M1X0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nDWWlEPTB;NESuNFk6OSEQvF2= M4PBcnNCVkeHUh?=
TE-8 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTR2LkW2OVgh|ryP MoXQV2FPT0WU
P12-ICHIKAWA M1nWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrrOVNKSzVyPUS0MlYyOTJizszN MWTTRW5ITVJ?
YKG-1 NWL6fIxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf0T2Z1UUN3ME20OE44QDFizszN M3jG[XNCVkeHUh?=
SNU-C2B NEHifpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXT[pM6UUN3ME20OE44QTB|IN88US=> MWTTRW5ITVJ?
LCLC-103H MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjhTWM2OD12ND64O|A{KM7:TR?= M1jZN3NCVkeHUh?=
U-87-MG NW[0fnF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTR3LkGwNlIh|ryP NV[1WVdtW0GQR1XS
HAL-01 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLXNpF4UUN3ME20OU4yOzd7IN88US=> MV7TRW5ITVJ?
OVCAR-8 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonzTWM2OD12NT6zOVY1KM7:TR?= MV\TRW5ITVJ?
KYSE-150 NWPaW4J[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTkfWpKSzVyPUS3MlExPTJizszN MXPTRW5ITVJ?
OE33 M3;neGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXIdFdKSzVyPUS3MlE1OjlizszN MmfaV2FPT0WU
CAL-62 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPRSnIzUUN3ME20O{41ODZ6IN88US=> Mn7jV2FPT0WU
TCCSUP NV;XcpptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTR5Lk[yOlQh|ryP M2DocXNCVkeHUh?=
H4 M{nxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTR5Lk[2NlEh|ryP NEm4d|NUSU6JRWK=
CP66-MEL NWThcW5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;FTWM2OD12OD6wO|A1KM7:TR?= MUnTRW5ITVJ?
SNB75 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\PWIZGUUN3ME20PE4yQDd2IN88US=> NVTRb5VjW0GQR1XS
Mo-T M2TocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ezN2lEPTB;NEiuNlc6KM7:TR?= M1;QcHNCVkeHUh?=
BT-549 MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\oTVhKUUN3ME20PE4{PzJ7IN88US=> Ml3XV2FPT0WU
IGR-1 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TZU2lEPTB;NEiuOlY1PSEQvF2= M4\rUnNCVkeHUh?=
NCI-H1299 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPoWlhkUUN3ME20PE44OjR6IN88US=> NHKyS5FUSU6JRWK=
ALL-PO NFjD[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;5TWM2OD12OT65NlY5KM7:TR?= MWnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; 

PubMed: 29344644     


SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR.

p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); 

PubMed: 25714019     


Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.

29344644 25714019
In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID