NU7441 (KU-57788)

For research use only.

Catalog No.S2638

143 publications

NU7441 (KU-57788) Chemical Structure

CAS No. 503468-95-9

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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Selleck's NU7441 (KU-57788) has been cited by 143 publications

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
mTOR [1]
(cell-free assay)
PI3K [1]
(cell-free assay)
14 nM 1.7 μM 5 μM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 M2T5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEKxOFMh|ryP NF\RdpRUSU6JRWK=
A172 NVi4dYNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMUWzNVYh|ryP M3;ye3NCVkeHUh?=
NCI-H526 NWHjXGc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPwTWM2OD1yLkK4OFA4KM7:TR?= M1;CPHNCVkeHUh?=
HDLM-2 NUTH[FJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwM{KzOFUh|ryP M2rsbHNCVkeHUh?=
HuO-3N1 M3;3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;YW2lEPTB;MD60OlY{PiEQvF2= M{LjXXNCVkeHUh?=
NCI-SNU-1 M{\DXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNkC5PVQh|ryP NGnvR4xUSU6JRWK=
SK-N-AS MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwNkKyNVYh|ryP NXnGZ3p7W0GQR1XS
LoVo MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvTSWJKSzVyPUCuPFY4PDlizszN M4PRTHNCVkeHUh?=
LAMA-84 M1nTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwOUi4N|Mh|ryP NV[2XFhCW0GQR1XS
CTB-1 NVTsOVc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf3bm1KSzVyPUGuNVE2PDZizszN NE\IdotUSU6JRWK=
KP-N-YS NVz0W2RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37JVGlEPTB;MT6xOFI{OSEQvF2= MlL5V2FPT0WU
HH MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\GR2pNUUN3ME2xMlE5ODl|IN88US=> MXzTRW5ITVJ?
CHL-1 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M12zZmlEPTB;MT6yNVM3QCEQvF2= NH7zW3lUSU6JRWK=
NB7 NXzqOG9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnxTWM2OD1zLkK0O|Q2KM7:TR?= NWS4W3JSW0GQR1XS
HL-60 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;UZnVRUUN3ME2xMlM5OTlizszN M13mN3NCVkeHUh?=
639-V MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\RcWdKSzVyPUGuOFQyOjhizszN NH7sdJNUSU6JRWK=
NCI-H1793 NHW5NZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LERmlEPTB;MT60OVg1KM7:TR?= Ml3FV2FPT0WU
NEC8 M1nER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljVTWM2OD1zLkW1N|Uh|ryP NXLKfogyW0GQR1XS
PA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmzSZNFUUN3ME2xMlU5Ojl2IN88US=> MXnTRW5ITVJ?
D-423MG NGTpUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPZUWhKSzVyPUGuOlk{PjFizszN NVrye5lFW0GQR1XS
NCI-H292 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17BdGlEPTB;MT63OFAyOyEQvF2= NV3KR2FCW0GQR1XS
SK-MEL-1 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rxcmlEPTB;MT63PVQ4QSEQvF2= MlLZV2FPT0WU
LB2241-RCC NFSwZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSwO5lKSzVyPUKuNVQyPDZizszN MWnTRW5ITVJ?
SK-MEL-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJwMU[0PUDPxE1? M3PRfXNCVkeHUh?=
MHH-PREB-1 MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnsTWM2OD1{LkG2OlA6KM7:TR?= MY\TRW5ITVJ?
BFTC-905 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvnSIJwUUN3ME2yMlE3Pjh5IN88US=> NYHMbZF[W0GQR1XS
Ramos-2G6-4C10 M1fafWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLMbm9KSzVyPUKuNVk6ODlizszN NVrsO5hYW0GQR1XS
G-361 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37xe2lEPTB;Mj6yNVY5KM7:TR?= MWjTRW5ITVJ?
MOLT-4 NWTaOFl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJwMkG4PFgh|ryP NGTyXXJUSU6JRWK=
DEL M1rBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DLOmlEPTB;Mj6zOVU3PCEQvF2= M1X0cXNCVkeHUh?=
MV-4-11 NHvjW5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHDTWM2OD1{LkO3N|kh|ryP MWTTRW5ITVJ?
SK-NEP-1 NIW1[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHESYIzUUN3ME2yMlM5Pzh|IN88US=> NXznW|VNW0GQR1XS
RS4-11 NFjKPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3ac4RKSzVyPUKuOVYxOjNizszN M3vhcXNCVkeHUh?=
HuH-7 NF;4[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDXTWM2OD1{LkW2O|AzKM7:TR?= NUT0flQzW0GQR1XS
A101D NH[2U4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrqbItKSzVyPUKuOlE{OzhizszN MXzTRW5ITVJ?
KG-1 M4XpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNke5NlQh|ryP NHX5OWhUSU6JRWK=
KALS-1 NEfzSJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLwSlVKSzVyPUKuOlk3OzNizszN NFPQb|ZUSU6JRWK=
VMRC-RCZ NWfWXolCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJwN{ezNlgh|ryP NV6xfnc{W0GQR1XS
SK-UT-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwMUWzNUDPxE1? M{[zdnNCVkeHUh?=
SW962 NVvPU3FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnKWHd6UUN3ME2zMlIxOzV{IN88US=> NYTsOY5CW0GQR1XS
DBTRG-05MG NFnIbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLpTWM2OD1|LkK4NFg2KM7:TR?= NE\5dYlUSU6JRWK=
PANC-08-13 M2LFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTNT2ZKSzVyPUOuOFEzPzhizszN NWO0[WZ4W0GQR1XS
QIMR-WIL M1XWWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXlc3pKSzVyPUOuOFE{PDFizszN NF\XVoVUSU6JRWK=
SK-MEL-30 NELwb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zQV2lEPTB;Mz60NlU6QCEQvF2= NF;nfGRUSU6JRWK=
697 NF;sTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTNwNES5PVMh|ryP MmXOV2FPT0WU
NY NFyzSJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTNwNEWwNlIh|ryP NVnRRm5PW0GQR1XS
ES7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXVTWM2OD1|LkS2O|I6KM7:TR?= NFjXVlRUSU6JRWK=
JVM-3 NFrUZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrL[3JKSzVyPUOuOFgxPzdizszN MkjJV2FPT0WU
U031 NEDPXpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHkV5g1UUN3ME2zMlU6OzZ6IN88US=> NYnXbpBjW0GQR1XS
BHT-101 NYn2XIdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNwNUm5PFUh|ryP Mn31V2FPT0WU
8305C NIG5TJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwNkG3N|Yh|ryP M2HWTHNCVkeHUh?=
MG-63 NUHwUGI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPWW4NKSzVyPUOuOlI3PzZizszN MormV2FPT0WU
NOS-1 NEWweZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX4TWM2OD1|Lk[1N|EzKM7:TR?= MnvCV2FPT0WU
YH-13 M4jlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTZN5pyUUN3ME2zMlg4OTh7IN88US=> NVu1UXVOW0GQR1XS
LXF-289 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTNwOUGwOFEh|ryP MmLtV2FPT0WU
GOTO NVfUVZFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHzdm5rUUN3ME2zMlkyPDlizszN MXnTRW5ITVJ?
EKVX MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPYeI9mUUN3ME20MlIzPTJ2IN88US=> M2XtW3NCVkeHUh?=
CAL-51 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH31Z3FKSzVyPUSuNlQ5PTRizszN M{OwSHNCVkeHUh?=
AN3-CA NXrVSWl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwMkW4NVMh|ryP MmHsV2FPT0WU
IA-LM NHji[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnJVXFKSzVyPUSuNlc6OzVizszN MkSzV2FPT0WU
KU-19-19 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PH[WlEPTB;ND6zNlkzOSEQvF2= M3LSR3NCVkeHUh?=
A704 NHTre|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTRwNEC4PFgh|ryP MlPUV2FPT0WU
RH-18 MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXX[JJKSzVyPUSuOFQ6PTNizszN NGDYSoVUSU6JRWK=
IST-MEL1 NHfxb5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\kT2lEPTB;ND61PFI3OyEQvF2= MU\TRW5ITVJ?
LU-134-A MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu4RmpKSzVyPUSuOVk3QDVizszN NXq5[llTW0GQR1XS
SF126 NULFfXdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPQTWM2OD12Lk[wO|E2KM7:TR?= NIqxdXNUSU6JRWK=
EFO-27 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGeyVlJKSzVyPUSuOlY2OjVizszN MWnTRW5ITVJ?
SN12C MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwN{G4PVgh|ryP M3nj[nNCVkeHUh?=
L-363 M{Hid2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTUTWM2OD12Lke3NVE3KM7:TR?= MUTTRW5ITVJ?
MEL-HO M4fOdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRwN{e5PFkh|ryP NYTuWJhUW0GQR1XS
TYK-nu MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlKwTWM2OD12LkiwNVI5KM7:TR?= NEf0dmhUSU6JRWK=
MDA-MB-415 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi5[FRKSzVyPUWuNFA{OTRizszN MUfTRW5ITVJ?
HCC70 NXztR2VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW0TWM2OD13LkCzPVM6KM7:TR?= MYPTRW5ITVJ?
IGROV-1 NFTTWYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfTTWM2OD13LkK1NlkzKM7:TR?= Mn\BV2FPT0WU
NCI-H1355 MkmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDxfopKSzVyPUWuNlk3KM7:TR?= M3q0VXNCVkeHUh?=
23132-87 NV3lVGplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTVwM{KwNlQh|ryP M4HKNnNCVkeHUh?=
NB69 M2DvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTVwM{K0NkDPxE1? NFv0UHBUSU6JRWK=
HSC-2 NFrkb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3[G1[UUN3ME21MlQyPzd|IN88US=> M{nyPHNCVkeHUh?=
KYSE-410 NGLWPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTVwNEe2N|Yh|ryP M3zoRXNCVkeHUh?=
GCIY NELWVXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHflcVVKSzVyPUWuOVE{PzhizszN MlnmV2FPT0WU
A427 M3HJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTVwNUO2OlEh|ryP MWPTRW5ITVJ?
ChaGo-K-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj5Zod6UUN3ME21MlU3PTl7IN88US=> NXyxNHdGW0GQR1XS
PFSK-1 M3Sz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuyTWM2OD13Lk[yNVk1KM7:TR?= NYDncYpuW0GQR1XS
MLMA NH3POWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnFTWM2OD13LkizOlA3KM7:TR?= NYHxeXBbW0GQR1XS
RVH-421 M2\vZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHuTWM2OD14LkC3N|M5KM7:TR?= MmrMV2FPT0WU
LB1047-RCC NUj4Z25JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXpXWZNUUN3ME22MlE4PTJ{IN88US=> NGrDR21USU6JRWK=
MHH-NB-11 M4jyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzYUZVKSzVyPU[uN|I4OjFizszN M2DmU3NCVkeHUh?=
J-RT3-T3-5 NHvxS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfO[WtKSzVyPU[uOlMzQTFizszN MofPV2FPT0WU
UM-UC-3 NEjBeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTBTWM2OD14Lk[0N|M1KM7:TR?= NWqyXJV1W0GQR1XS
IST-SL1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO1TWM2OD14Lk[5N|Y6KM7:TR?= NFSyTYtUSU6JRWK=
NB14 NGr0N5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK3bpdKSzVyPU[uO|k4PjFizszN M4fqVXNCVkeHUh?=
NBsusSR NEnIeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX2R2ZKSzVyPU[uPFI2ODJizszN NXTYdlVsW0GQR1XS
D-263MG M2fSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTZwOUGwOlgh|ryP MUDTRW5ITVJ?
NCI-H2347 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTZwOUOyNVMh|ryP MYDTRW5ITVJ?
ES8 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjNWZNKSzVyPU[uPVc2QDhizszN M2O2[nNCVkeHUh?=
786-0 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ETWM2OD15LkC5O|g3KM7:TR?= NFriZnpUSU6JRWK=
EPLC-272H NEnMTGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSxTWM2OD15LkG2NlQ3KM7:TR?= NH;Ib25USU6JRWK=
CAPAN-1 NFjOTXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LTUWlEPTB;Nz6yOFM2QSEQvF2= M1;obHNCVkeHUh?=
NCI-H82 NVf0PGlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTdwMk[2OVkh|ryP MYDTRW5ITVJ?
G-402 NWSxO5pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2xR|RRUUN3ME23MlMxODVzIN88US=> M1jUTXNCVkeHUh?=
SW982 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\TTWM2OD15LkOwNlA{KM7:TR?= NFLqW2hUSU6JRWK=
OVCAR-4 NHHWR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTdwM{GzNlgh|ryP NIrXbZBUSU6JRWK=
KARPAS-299 M1rKXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\2TWM2OD15LkOyOlIzKM7:TR?= NWXvVJpKW0GQR1XS
MIA-PaCa-2 M1;yNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDXTWM2OD15LkO2PFI{KM7:TR?= NXfN[4U{W0GQR1XS
AU565 M4DqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLlTWM2OD15LkW5PFM{KM7:TR?= NF3seGJUSU6JRWK=
GAMG NF;wOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[4UJNKSzVyPUeuOlQyOzFizszN NVTRb2t5W0GQR1XS
HuO9 NYS4PGhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PKZWlEPTB;Nz63NVc1OyEQvF2= M37MWnNCVkeHUh?=
ACN NWnGTpBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPqWpVKSzVyPUeuO|Q{OyEQvF2= NH3JXWZUSU6JRWK=
RO82-W-1 NWj3PHZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{GyUWlEPTB;Nz63OFU{OyEQvF2= NWC3UFZ[W0GQR1XS
NKM-1 NFv5RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXqTWM2OD15Lke0PVU2KM7:TR?= MXXTRW5ITVJ?
CAL-12T NWfSbZBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW5OZNKSzVyPUeuPVQ{PTJizszN Mn;mV2FPT0WU
FADU NELYV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPZN4FxUUN3ME24MlA{PjV2IN88US=> NWHYNWVxW0GQR1XS
NCI-H28 NX;D[nRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jNfGlEPTB;OD6xOlk3OiEQvF2= MknjV2FPT0WU
LCLC-97TM1 NGO3flVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHJTWM2OD16LkKxNVIzKM7:TR?= MWrTRW5ITVJ?
CHP-134 NV\FVllUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLITWM2OD16LkK0NVg2KM7:TR?= MmrsV2FPT0WU
HT-1080 NISzbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRThwMkWwPVMh|ryP Ml25V2FPT0WU
PC-3 NXHSPZVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjjR4hWUUN3ME24MlI4Ozl{IN88US=> MnjyV2FPT0WU
SNU-449 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;2OWlEPTB;OD6yO|k{KM7:TR?= NUjLR4RTW0GQR1XS
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HT Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\YfYNKSzVyPUiuN|Y1QSEQvF2= NFXiflNUSU6JRWK=
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HCC1937 M{nOemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCxTWM2OD17Lk[5PFY2KM7:TR?= MXvTRW5ITVJ?
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G-401 Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf1N3duUUN3ME2xNE44PjJ4IN88US=> MWPTRW5ITVJ?
CAL-72 M{DP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TmUmlEPTB;MUCuPFA6PCEQvF2= NHT4ZmlUSU6JRWK=
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LB996-RCC M3fiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;BUodxUUN3ME2xNU4xPzJ|IN88US=> NHzZV4FUSU6JRWK=
NCI-H1563 NV65TYZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHJTWM2OD1zMT6xNFEyKM7:TR?= M3Tw[HNCVkeHUh?=
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COLO-684 MnroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXWc4NWUUN3ME2xNU44OjZ5IN88US=> M{LmPXNCVkeHUh?=
HOP-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnkbpl5UUN3ME2xNU44PTB6IN88US=> MXXTRW5ITVJ?
NCI-H650 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j2Z2lEPTB;MUGuPFk3OSEQvF2= MVXTRW5ITVJ?
TE-11 NX2wd4g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfqSHJCUUN3ME2xNU46OzF3IN88US=> M3\pR3NCVkeHUh?=
COLO-679 NV;nZ2RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEflZ|JKSzVyPUGxMlk1PiEQvF2= MlPWV2FPT0WU
FTC-133 M17hPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfsbJh3UUN3ME2xNk4xODd4IN88US=> M4[yeXNCVkeHUh?=
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BALL-1 NIHydGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjrNXpKSzVyPUGyMlI3PjJizszN MWjTRW5ITVJ?
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HOP-92 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF{LkWyN|Mh|ryP NVviVYRZW0GQR1XS
M14 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjGTWM2OD1zMz6wN|M2KM7:TR?= NWWwR|d1W0GQR1XS
SKG-IIIa M4fhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXGeHlKSzVyPUGzMlA2PTRizszN NYTlbHdUW0GQR1XS
Becker NFm2R45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\KVJpDUUN3ME2xN{4xPThizszN NEj2bGpUSU6JRWK=
ES5 NGXY[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC3TWM2OD1zMz6xN|U3KM7:TR?= M4iyVXNCVkeHUh?=
NCI-H2030 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDldms3UUN3ME2xN{4zODZ{IN88US=> MVTTRW5ITVJ?
SNU-423 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rqO2lEPTB;MUOuN|gyKM7:TR?= MYrTRW5ITVJ?
CP50-MEL-B MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnYcnZKSzVyPUGzMlYzOzJizszN MkToV2FPT0WU
NCI-H1092 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO1TWM2OD1zMz63OFc2KM7:TR?= MU\TRW5ITVJ?
8-MG-BA NV;LV4cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDhTWM2OD1zMz63OVE{KM7:TR?= NW\PfI1qW0GQR1XS
CAL-27 M4X1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvDTWM2OD1zND6wO|I4KM7:TR?= NF7oRVhUSU6JRWK=
AGS MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PDXWlEPTB;MUSuNVMyQSEQvF2= MkHWV2FPT0WU
MZ2-MEL M{HadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fqVmlEPTB;MUSuNVQ5QCEQvF2= MkL6V2FPT0WU
BFTC-909 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Xzc2lEPTB;MUSuOVA2PSEQvF2= M2i3c3NCVkeHUh?=
D-566MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELzT3JKSzVyPUG0Mlc4ODZizszN MlrIV2FPT0WU
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TE-5 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXGTWM2OD1zNT6yN|M{KM7:TR?= M17XS3NCVkeHUh?=
647-V M2LQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF3LkK3NFUh|ryP M1Xwc3NCVkeHUh?=
DMS-114 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF3LkOyPVEh|ryP MX;TRW5ITVJ?
ME-180 NXqxfWc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjlWJVTUUN3ME2xOU41Pzh|IN88US=> MkPkV2FPT0WU
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NUGC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPGdJpiUUN3ME2xOU43OjR3IN88US=> MYLTRW5ITVJ?
GB-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTF3Lk[0N|ch|ryP MX7TRW5ITVJ?
LOXIMVI NFTyT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXT[4p2UUN3ME2xOU45QTF7IN88US=> MmXMV2FPT0WU
NCI-H1304 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX4bWV5UUN3ME2xOU45QTJ6IN88US=> NXfhS4NQW0GQR1XS
KURAMOCHI NUXicFVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[yToJKSzVyPUG1Mlk4OSEQvF2= NIKzdW1USU6JRWK=
SW1783 NFrIcnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTF4LkC5PVMh|ryP M4G3c3NCVkeHUh?=
EGI-1 NUW4O2pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDQVo45UUN3ME2xOk42OzZ3IN88US=> NXLZZpZUW0GQR1XS
KGN NIPETYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPDNmN1UUN3ME2xOk42PTh4IN88US=> M4jSWXNCVkeHUh?=
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HT-1376 NYna[mtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LBb2lEPTB;MU[uPFQ1PiEQvF2= MU\TRW5ITVJ?
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TI-73 M1j2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi5SWxKSzVyPUG2Mlk1ODhizszN NVzpZmpbW0GQR1XS
TK10 M2PZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfX[Hd1UUN3ME2xO{4xODd7IN88US=> MmjxV2FPT0WU
SW684 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTF5LkCxOVQh|ryP MWTTRW5ITVJ?
RPMI-8866 NXHEU3d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF5LkC2PVkh|ryP MlPUV2FPT0WU
LNCaP-Clone-FGC M2S1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHUPIxmUUN3ME2xO{42OjBzIN88US=> NYLwbnh2W0GQR1XS
NCI-H2291 M1G0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF6LkSzOFUh|ryP NGTyTlVUSU6JRWK=
T47D MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PN[GlEPTB;MUiuOFg5KM7:TR?= NH;u[pFUSU6JRWK=
A204 M{fxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF6LkW0OVIh|ryP MXvTRW5ITVJ?
HT-144 M2TRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[w[ZJsUUN3ME2xPE44PDJ5IN88US=> NEPMPXFUSU6JRWK=
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HCC1806 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C2bWlEPTB;MUmuNVU6OSEQvF2= NEnEclVUSU6JRWK=
NCI-H596 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD1zOT62N|kyKM7:TR?= MWLTRW5ITVJ?
K-562 MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPFTWM2OD1zOT64PVI3KM7:TR?= NVq0fXl5W0GQR1XS
D-336MG NWn1dXl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfxZZdYUUN3ME2xPU46OzJ{IN88US=> M3jDPXNCVkeHUh?=
SK-MEL-2 NFTweWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS2PY9KUUN3ME2yNE4yPTV7IN88US=> NVTKbHlZW0GQR1XS
HEC-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHEfHpKSzVyPUKwMlQ6PzhizszN MVHTRW5ITVJ?
EW-13 NFvxXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm3T2FKSzVyPUKwMlU1PDNizszN MmTxV2FPT0WU
Hs-578-T MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETNR2NKSzVyPUKwMlU2QDNizszN M2DiV3NCVkeHUh?=
SJSA-1 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDaU|NKSzVyPUKwMlU3QDhizszN NYLFVppQW0GQR1XS
RCC10RGB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq4TWM2OD1{MD62O|E6KM7:TR?= MWfTRW5ITVJ?
LAN-6 M3HjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHPb4NWUUN3ME2yNU4xOzl4IN88US=> MnXTV2FPT0WU
NCI-H1048 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjxUm9QUUN3ME2yNU4zOjV6IN88US=> M1jBTHNCVkeHUh?=
CW-2 NF3wcVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HoNWlEPTB;MkGuNlcxPSEQvF2= MWrTRW5ITVJ?
HCC2157 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXiTWM2OD1{MT6zOkDPxE1? NHrUXFNUSU6JRWK=
EW-22 M1zNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnQWpRWUUN3ME2yNU4{PzZizszN NVLy[opyW0GQR1XS
A253 M1;0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X3fGlEPTB;MkGuOFQ5OSEQvF2= MWLTRW5ITVJ?
BE-13 M2PEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrSWHVKSzVyPUKxMlYyOTNizszN NHHrZWJUSU6JRWK=
KINGS-1 NHP2cWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrzRZhqUUN3ME2yNU43OzF4IN88US=> MWTTRW5ITVJ?
ETK-1 MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnwTWM2OD1{MT64NVUzKM7:TR?= NIXjVYVUSU6JRWK=
NCI-H2452 NXryPVZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD0SotlUUN3ME2yNU45PjR5IN88US=> MmntV2FPT0WU
HPAF-II MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKxTWM2OD1{MT64PVI{KM7:TR?= NEHmcZNUSU6JRWK=
D-542MG MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJzLkmwOlkh|ryP NWXWUWJ1W0GQR1XS
NCI-H630 MkXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDXfJJGUUN3ME2yNk4xOjl4IN88US=> M{XE[HNCVkeHUh?=
TGBC11TKB MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrIWGJKSzVyPUKyMlA1QSEQvF2= NVTWVpJ5W0GQR1XS
BCPAP MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljYTWM2OD1{Mj62NVEh|ryP NX20W2ZVW0GQR1XS
HLE MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnuTWM2OD1{Mj62PVch|ryP NXriPGdxW0GQR1XS
NCI-H727 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1WxPWlEPTB;MkKuO|M2KM7:TR?= MnvnV2FPT0WU
RD MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrzTWM2OD1{Mj63OVE5KM7:TR?= NWXWOW9yW0GQR1XS
NCI-H522 NYH1fIhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPDTWM2OD1{Mj64OFMyKM7:TR?= MYrTRW5ITVJ?
CGTH-W-1 NHL5VnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G3[mlEPTB;MkOuNFY1OSEQvF2= NEDKVm5USU6JRWK=
SK-LU-1 M2PFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzBTWM2OD1{Mz60Olg{KM7:TR?= M3\p[HNCVkeHUh?=
BB65-RCC MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH23ZYVKSzVyPUKzMlc5PjNizszN NGLydpNUSU6JRWK=
HSC-3 NIfvfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz2XoFKSzVyPUKzMlg2OjdizszN MnXVV2FPT0WU
SK-MES-1 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJ2LkCxOlEh|ryP NEHjRZpUSU6JRWK=
DB M1LydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULvXFJLUUN3ME2yOE4yODJ6IN88US=> NVLOfmU3W0GQR1XS
HO-1-N-1 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LybmlEPTB;MkSuN|A6OyEQvF2= Mn;wV2FPT0WU
MKN1 NYS5dYNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPIN2ZsUUN3ME2yOE43QCEQvF2= MmHLV2FPT0WU
MN-60 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW4TWM2OD1{ND64OVE6KM7:TR?= Mn\BV2FPT0WU
8505C MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISwNmVKSzVyPUK1MlE5PDVizszN NHXSVFdUSU6JRWK=
COLO-320-HSR NUixR2NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrVTWM2OD1{NT6yNlA5KM7:TR?= M1LPeHNCVkeHUh?=
BB30-HNC M1XS[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfRfoZKSzVyPUK1MlI1QDNizszN Ml\DV2FPT0WU
KM12 NUHRTpJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;XeGlEPTB;MkWuOVgxPyEQvF2= M{\oRnNCVkeHUh?=
NB13 NHKyS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLx[pNKSzVyPUK1MlU5QThizszN NWm5ZXdQW0GQR1XS
HCC2998 Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7yTWM2OD1{Nj6wNlg{KM7:TR?= NEjHOW9USU6JRWK=
U-118-MG NVj0RXBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\ITm9KSzVyPUK2MlA5ODhizszN NH;mOG5USU6JRWK=
NB10 MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJ4LkKzOEDPxE1? MkHsV2FPT0WU
SK-LMS-1 M4PF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vD[GlEPTB;MkeuNFcxPCEQvF2= NIPjb5hUSU6JRWK=
SW1573 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULw[ZE{UUN3ME2yO{4yOSEQvF2= NHrwNZpUSU6JRWK=
LB373-MEL-D NFHYeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrQ[INFUUN3ME2yO{4yOjl2IN88US=> M{jkRXNCVkeHUh?=
DK-MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;UTWM2OD1{Nz6xPFE4KM7:TR?= MVjTRW5ITVJ?
RMG-I MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ5LkKwNlkh|ryP M2jIO3NCVkeHUh?=
SW1088 NHrFR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TvSWlEPTB;MkeuOVA1OiEQvF2= NYfqcXQyW0GQR1XS
SK-OV-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nWV2lEPTB;MkeuO|U6OyEQvF2= NIm2OmVUSU6JRWK=
KP-N-YN NVP6RYFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrnTWM2OD1{Nz64NFQ{KM7:TR?= NXu2Tlg2W0GQR1XS
RPMI-7951 M13pOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ6LkK0OVYh|ryP NIHmfIpUSU6JRWK=
CaR-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfJdpdKSzVyPUK4MlU2QDJizszN M3PUXXNCVkeHUh?=
MKN7 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJ6LkW5OlQh|ryP M3vpSnNCVkeHUh?=
CHP-212 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmwZWlKSzVyPUK4Mlc1ODFizszN NY\nSmptW0GQR1XS
KYSE-450 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly3TWM2OD1{OD64NFkyKM7:TR?= NFLrXFdUSU6JRWK=
RXF393 NFfIfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LTT2lEPTB;MkmuNlkxPiEQvF2= Ml2yV2FPT0WU
P30-OHK NWLTXpJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkntTWM2OD1{OT6zNFQ5KM7:TR?= Mnf4V2FPT0WU
Ca9-22 M17XXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrDNpRKSzVyPUK5MlQzQTlizszN MnHYV2FPT0WU
RT-112 NI\mTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfGTWM2OD1{OT60OlEyKM7:TR?= M2rkUXNCVkeHUh?=
ES1 NFnhUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TXSGlEPTB;MkmuPFU1PCEQvF2= M4\wV3NCVkeHUh?=
HCE-4 NYHz[G93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJ7Lki3PFYh|ryP MmnaV2FPT0WU
AM-38 NGf2RW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzQTWM2OD1|MD6wOlA3KM7:TR?= NVnIcYJTW0GQR1XS
AsPC-1 M{\CNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\OTWM2OD1|MD64NFU{KM7:TR?= NGLLWY9USU6JRWK=
TE-9 M17PO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNyLki3N|ch|ryP MoTqV2FPT0WU
HuP-T4 NXXsfml1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNyLkm2N|gh|ryP Ml3PV2FPT0WU
LB2518-MEL NHPFUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\lNVdmUUN3ME2zNU4xPzR2IN88US=> MVrTRW5ITVJ?
NCI-H1703 NIrCSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvQb4VKSzVyPUOxMlA6ODVizszN Mlv4V2FPT0WU
NCI-H2228 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXNTWM2OD1|MT60OlUyKM7:TR?= Mki1V2FPT0WU
SCC-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLmTWM2OD1|MT65NVgyKM7:TR?= MWDTRW5ITVJ?
KNS-81-FD NXPWVoFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN{LkCxNlgh|ryP MX\TRW5ITVJ?
NTERA-S-cl-D1 NWXtWJdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[4TWM2OD1|Mj6wO|M6KM7:TR?= M1PCXnNCVkeHUh?=
Daoy NHzlToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnHS4hKSzVyPUOyMlA5OzhizszN Mlu1V2FPT0WU
ES4 NU\BVVRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13DbWlEPTB;M{KuN|kzOiEQvF2= MVTTRW5ITVJ?
MHH-ES-1 NGiyNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jV[WlEPTB;M{KuOFg4OiEQvF2= MkDPV2FPT0WU
C-33-A NH\xe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT0TWM2OD1|Mj63O|I5KM7:TR?= NFPSNohUSU6JRWK=
BHY NETweoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTN{Lkm0PVUh|ryP NWm2WGpWW0GQR1XS
Detroit562 M2naRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7MTWM2OD1|Mz62OlU4KM7:TR?= MoO1V2FPT0WU
EW-1 NUS2ZXFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17KR2lEPTB;M{OuPVMzOiEQvF2= MkTpV2FPT0WU
NCI-H1395 Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzNTWM2OD1|ND6wO|k6KM7:TR?= NIjvc4FUSU6JRWK=
KM-H2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTN4LkS3OFMh|ryP MVvTRW5ITVJ?
NCI-H520 NH:1ZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTN4Lke1OFEh|ryP NWX5VlZqW0GQR1XS
D-392MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ew[2lEPTB;M{euN|M1PCEQvF2= NY\JZ4dHW0GQR1XS
NOMO-1 M322XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;JTWM2OD1|Nz64NFg6KM7:TR?= M4XLZXNCVkeHUh?=
TE-6 M1HId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDYTWM2OD1|OD6xNlQh|ryP M3u4OnNCVkeHUh?=
HT-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTN6LkS0N|Yh|ryP M1XBenNCVkeHUh?=
RPMI-8226 NVS4e45VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnyTWM2OD1|OD65OVE6KM7:TR?= M1Gze3NCVkeHUh?=
U251 NHn4d3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrUTWM2OD1|OT6wNVI1KM7:TR?= M4PVSXNCVkeHUh?=
GCT NHzvS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3NfYZKSzVyPUO5MlE5PTJizszN M4XrUXNCVkeHUh?=
A431 NXXIVoZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TTemlEPTB;M{muNVg6PCEQvF2= M37Gb3NCVkeHUh?=
TE-12 MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzrTWM2OD1|OT6yOFQ5KM7:TR?= M3P3OXNCVkeHUh?=
HMV-II M3jTSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33rNGlEPTB;M{muOVA1PyEQvF2= NVThVGdZW0GQR1XS
IST-MES1 NWqwWVRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRyLkG1NFIh|ryP M2rWbHNCVkeHUh?=
SW13 MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXHN4dKSzVyPUSwMlUyQSEQvF2= NHfifWFUSU6JRWK=
SF295 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXxXG5KSzVyPUSwMlgxPjZizszN NHfndldUSU6JRWK=
MDA-MB-157 NF\DZpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjSOIl5UUN3ME20NE46PDZ{IN88US=> M1u1XHNCVkeHUh?=
TE-1 NETPNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jTOmlEPTB;NEGuPFcyPCEQvF2= NEHvW2tUSU6JRWK=
HuCCT1 M1\OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3FNJFKSzVyPUSyMlUzQDlizszN MVnTRW5ITVJ?
KYSE-510 NFnXXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR|LkG3OVQh|ryP MkTMV2FPT0WU
NCI-H358 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn0TWM2OD12ND6wN|A1KM7:TR?= NGjqToVUSU6JRWK=
SW900 M1;WXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjGTWM2OD12ND6wO|U5KM7:TR?= MkOyV2FPT0WU
CAS-1 NHHGcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPCTWM2OD12ND6wPVkyKM7:TR?= NHniTHRUSU6JRWK=
TE-8 NF;oVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;UUmNKSzVyPUS0MlU3PThizszN NGTBW5BUSU6JRWK=
P12-ICHIKAWA MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\Qb2lEPTB;NESuOlEyOiEQvF2= Mn7hV2FPT0WU
YKG-1 NFO3bYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTBbHdKSzVyPUS0Mlc5OSEQvF2= NGrJNnJUSU6JRWK=
SNU-C2B MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTR2Lke5NFMh|ryP MkLLV2FPT0WU
LCLC-103H M1nTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXldXZKSzVyPUS0Mlg4ODNizszN MkPsV2FPT0WU
U-87-MG NYD4[FVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTR3LkGwNlIh|ryP NYrDRoVnW0GQR1XS
HAL-01 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LFNGlEPTB;NEWuNVM4QSEQvF2= MX;TRW5ITVJ?
OVCAR-8 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ubGlEPTB;NEWuN|U3PCEQvF2= MXTTRW5ITVJ?
KYSE-150 NIjJd4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XofGlEPTB;NEeuNVA2OiEQvF2= Ml25V2FPT0WU
OE33 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnXcpJzUUN3ME20O{4yPDJ7IN88US=> MXTTRW5ITVJ?
CAL-62 NEHyOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR5LkSwOlgh|ryP MlvxV2FPT0WU
TCCSUP MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTR5Lk[yOlQh|ryP MWnTRW5ITVJ?
H4 M4HKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrpTWM2OD12Nz62OlIyKM7:TR?= NIO5fXhUSU6JRWK=
CP66-MEL NW\pWI5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF6wbXpKSzVyPUS4MlA4ODRizszN M3XjUXNCVkeHUh?=
SNB75 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITmSYJKSzVyPUS4MlE5PzRizszN Ml7mV2FPT0WU
Mo-T MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnpTWM2OD12OD6yO|kh|ryP MUTTRW5ITVJ?
BT-549 NXzLRYZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR6LkO3Nlkh|ryP M4jZW3NCVkeHUh?=
IGR-1 NWjzZVRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:4T4VoUUN3ME20PE43PjR3IN88US=> MoL5V2FPT0WU
NCI-H1299 M1X6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTR6LkeyOFgh|ryP NELNcG5USU6JRWK=
ALL-PO M2jSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37Ie2lEPTB;NEmuPVI3QCEQvF2= MXnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; 

PubMed: 29344644     


SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR.

p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); 

PubMed: 25714019     


Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.

29344644 25714019
In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A
Smiles C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID