NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

Size Price Stock Quantity  
USD 70 In stock
USD 120 In stock
USD 370 In stock
USD 970 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

6 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NIHZPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XnfmlEPTB;MD6wNlE1OyEQvF2= NXzLTHlSW0GQR1XS
A172 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW1SWlqUUN3ME2wMlE2OzF4IN88US=> MUfTRW5ITVJ?
NCI-H526 M3XjWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\kd5RKSzVyPUCuNlg1ODdizszN NGL6WoJUSU6JRWK=
HDLM-2 NV65SpZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X2ZmlEPTB;MD6zNlM1PSEQvF2= Mlj1V2FPT0WU
HuO-3N1 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7MdWxbUUN3ME2wMlQ3PjN4IN88US=> NILVU4lUSU6JRWK=
NCI-SNU-1 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3Leld4UUN3ME2wMlYxQTl2IN88US=> MoC5V2FPT0WU
SK-N-AS MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjXTWM2OD1yLk[yNlE3KM7:TR?= NGW4V5FUSU6JRWK=
LoVo Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPCTWM2OD1yLki2O|Q6KM7:TR?= MVzTRW5ITVJ?
LAMA-84 NH\jbmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPPWlJYUUN3ME2wMlk5QDN|IN88US=> MVvTRW5ITVJ?
CTB-1 M3O3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO4boRKSzVyPUGuNVE2PDZizszN NH\GNItUSU6JRWK=
KP-N-YS M1HvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDSR3R3UUN3ME2xMlE1OjNzIN88US=> NWPXdHRbW0GQR1XS
HH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHoWJhHUUN3ME2xMlE5ODl|IN88US=> MmHmV2FPT0WU
CHL-1 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTFwMkGzOlgh|ryP Ml[2V2FPT0WU
NB7 MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\L[GlEPTB;MT6yOFc1PSEQvF2= MlLKV2FPT0WU
HL-60 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nmWmlEPTB;MT6zPFE6KM7:TR?= M3[2XXNCVkeHUh?=
639-V M{XHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\0UZpuUUN3ME2xMlQ1OTJ6IN88US=> MWrTRW5ITVJ?
NCI-H1793 M4\pcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlKzTWM2OD1zLkS1PFQh|ryP M2fHcnNCVkeHUh?=
NEC8 NID0RVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoG1TWM2OD1zLkW1N|Uh|ryP M4PDNXNCVkeHUh?=
PA-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwNUiyPVQh|ryP NE\HV3JUSU6JRWK=
D-423MG NWmzO4s1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[2OGlEPTB;MT62PVM3OSEQvF2= NGfwVpRUSU6JRWK=
NCI-H292 NGLwZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjRTWM2OD1zLke0NFE{KM7:TR?= NFrCbpVUSU6JRWK=
SK-MEL-1 NYfFdnk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3WzdmlEPTB;MT63PVQ4QSEQvF2= MUPTRW5ITVJ?
LB2241-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwMUSxOFYh|ryP NWDaPZZTW0GQR1XS
SK-MEL-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrNVm9KSzVyPUKuNVY1QSEQvF2= MYnTRW5ITVJ?
MHH-PREB-1 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jofWlEPTB;Mj6xOlYxQSEQvF2= MVTTRW5ITVJ?
BFTC-905 M3;TWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvhVGJZUUN3ME2yMlE3Pjh5IN88US=> NV3Pb|ZPW0GQR1XS
Ramos-2G6-4C10 NWri[o1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvYTWM2OD1{LkG5PVA6KM7:TR?= NFL5e3VUSU6JRWK=
G-361 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwMkG2PEDPxE1? M2nz[nNCVkeHUh?=
MOLT-4 NUTNVVNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LUdGlEPTB;Mj6yNVg5QCEQvF2= MVLTRW5ITVJ?
DEL MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7De4JKSzVyPUKuN|U2PjRizszN M4fSVHNCVkeHUh?=
MV-4-11 M4r4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzWOZVXUUN3ME2yMlM4OzlizszN NWP3bJZDW0GQR1XS
SK-NEP-1 M{fGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nzZmlEPTB;Mj6zPFc5OyEQvF2= NWHZTXZRW0GQR1XS
RS4-11 NYjVUnUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPqZngzUUN3ME2yMlU3ODJ|IN88US=> NVTVVIZvW0GQR1XS
HuH-7 NVLtR4g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e0R2lEPTB;Mj61OlcxOiEQvF2= NH7SVYdUSU6JRWK=
A101D MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TKXWlEPTB;Mj62NVM{QCEQvF2= NIjET5RUSU6JRWK=
KG-1 NYPJNFRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnBTWM2OD1{Lk[3PVI1KM7:TR?= MnK5V2FPT0WU
KALS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LYSWlEPTB;Mj62PVY{OyEQvF2= MYfTRW5ITVJ?
VMRC-RCZ MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJwN{ezNlgh|ryP MmjBV2FPT0WU
SK-UT-1 NGLOcJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNwMUWzNUDPxE1? MXvTRW5ITVJ?
SW962 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rhV2lEPTB;Mz6yNFM2OiEQvF2= MmHsV2FPT0WU
DBTRG-05MG NI\NWJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjLTWM2OD1|LkK4NFg2KM7:TR?= Mmi3V2FPT0WU
PANC-08-13 M{PwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK5WZZKSzVyPUOuOFEzPzhizszN NWL0T|RrW0GQR1XS
QIMR-WIL NVjXfo1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvqTWM2OD1|LkSxN|QyKM7:TR?= MnzUV2FPT0WU
SK-MEL-30 NGjt[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TJbWlEPTB;Mz60NlU6QCEQvF2= M4TSPXNCVkeHUh?=
697 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fPPGlEPTB;Mz60OFk6OyEQvF2= NVXlR4x4W0GQR1XS
NY NVexTG5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG3[|N6UUN3ME2zMlQ2ODJ{IN88US=> MlLLV2FPT0WU
ES7 M3TMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS5dVlKSzVyPUOuOFY4OjlizszN MULTRW5ITVJ?
JVM-3 M1m3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP6SFY5UUN3ME2zMlQ5ODd5IN88US=> NW\lN|VUW0GQR1XS
U031 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLwTWM2OD1|LkW5N|Y5KM7:TR?= M4LzOXNCVkeHUh?=
BHT-101 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHETWM2OD1|LkW5PVg2KM7:TR?= M{\wPHNCVkeHUh?=
8305C MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DjZWlEPTB;Mz62NVc{PiEQvF2= NV72V5dNW0GQR1XS
MG-63 M2eyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPSTWM2OD1|Lk[yOlc3KM7:TR?= NV;ydpNRW0GQR1XS
NOS-1 NXP1V2xzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PTPGlEPTB;Mz62OVMyOiEQvF2= NFy1eFdUSU6JRWK=
YH-13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTNwOEexPFkh|ryP NF76RVdUSU6JRWK=
LXF-289 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTYTWM2OD1|LkmxNFQyKM7:TR?= M2DRS3NCVkeHUh?=
GOTO NWLPVoRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP5UWNKSzVyPUOuPVE1QSEQvF2= M{i4V3NCVkeHUh?=
EKVX NFu0O3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT3b4NKSzVyPUSuNlI2OjRizszN NV[2cW5FW0GQR1XS
CAL-51 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7FVGNJUUN3ME20MlI1QDV2IN88US=> M1TYdHNCVkeHUh?=
AN3-CA M{\Qcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTRwMkW4NVMh|ryP M{T4RXNCVkeHUh?=
IA-LM Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfmTWM2OD12LkK3PVM2KM7:TR?= NGrHbWNUSU6JRWK=
KU-19-19 M3rEXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fi[2lEPTB;ND6zNlkzOSEQvF2= M3SxWnNCVkeHUh?=
A704 NUflVG5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvRTWM2OD12LkSwPFg5KM7:TR?= Ml7ZV2FPT0WU
RH-18 NH3IWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnCTWM2OD12LkS0PVU{KM7:TR?= MmDvV2FPT0WU
IST-MEL1 NG\UPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTRwNUiyOlMh|ryP NVzIZ45nW0GQR1XS
LU-134-A MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTxNJZKSzVyPUSuOVk3QDVizszN NWXXU5R3W0GQR1XS
SF126 M2f1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O5fmlEPTB;ND62NFcyPSEQvF2= MVvTRW5ITVJ?
EFO-27 NE\RVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwNk[1NlUh|ryP NEfub4lUSU6JRWK=
SN12C M3v0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXNN4VKSzVyPUSuO|E5QThizszN MoHlV2FPT0WU
L-363 NHroVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LFNGlEPTB;ND63O|EyPiEQvF2= MlHqV2FPT0WU
MEL-HO M{L5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXYZoJVUUN3ME20Mlc4QTh7IN88US=> NU[wOJN1W0GQR1XS
TYK-nu Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHxTWM2OD12LkiwNVI5KM7:TR?= NGq5V3JUSU6JRWK=
MDA-MB-415 NXW2[nU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TzO2lEPTB;NT6wNFMyPCEQvF2= MoOwV2FPT0WU
HCC70 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpfnpzUUN3ME21MlA{QTN7IN88US=> NVi2[WlzW0GQR1XS
IGROV-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojwTWM2OD13LkK1NlkzKM7:TR?= MU\TRW5ITVJ?
NCI-H1355 NELLepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHMeplKSzVyPUWuNlk3KM7:TR?= NWC1Z3lLW0GQR1XS
23132-87 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTBTWM2OD13LkOyNFI1KM7:TR?= NYXhW4RxW0GQR1XS
NB69 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL3NnZKSzVyPUWuN|I1OiEQvF2= NEjuepFUSU6JRWK=
HSC-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLNTWM2OD13LkSxO|c{KM7:TR?= NHXmeHVUSU6JRWK=
KYSE-410 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTVwNEe2N|Yh|ryP MXPTRW5ITVJ?
GCIY NFnRSmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTQTWM2OD13LkWxN|c5KM7:TR?= NXLmVHJ[W0GQR1XS
A427 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlznTWM2OD13LkWzOlYyKM7:TR?= NWXm[nBZW0GQR1XS
ChaGo-K-1 NFjmOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33YcmlEPTB;NT61OlU6QSEQvF2= MYfTRW5ITVJ?
PFSK-1 NF7mV5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nET2lEPTB;NT62NlE6PCEQvF2= M{HoeHNCVkeHUh?=
MLMA MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHCb|JjUUN3ME21Mlg{PjB4IN88US=> MljVV2FPT0WU
RVH-421 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHGTWM2OD14LkC3N|M5KM7:TR?= Mnj3V2FPT0WU
LB1047-RCC NVO5Nmp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTZwMUe1NlIh|ryP NF:1UFZUSU6JRWK=
MHH-NB-11 M4XMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPVXnppUUN3ME22MlMzPzJzIN88US=> M1\jfHNCVkeHUh?=
J-RT3-T3-5 NXrLR3dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTNR4dyUUN3ME22MlY{OjlzIN88US=> NHrZT2VUSU6JRWK=
UM-UC-3 NFTYS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjVV4RuUUN3ME22MlY1OzN2IN88US=> NVvkTVhSW0GQR1XS
IST-SL1 NVHWcGNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLTdIdKSzVyPU[uOlk{PjlizszN Mo\pV2FPT0WU
NB14 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjuc4FKSzVyPU[uO|k4PjFizszN NIH4[5NUSU6JRWK=
NBsusSR NV2yepNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLVTWM2OD14LkiyOVAzKM7:TR?= NEW5VndUSU6JRWK=
D-263MG Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PBcGlEPTB;Nj65NVA3QCEQvF2= M{X5bnNCVkeHUh?=
NCI-H2347 NWLFRnllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOy[WVoUUN3ME22Mlk{OjF|IN88US=> MlrxV2FPT0WU
ES8 NFznXmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnycHRKSzVyPU[uPVc2QDhizszN MVnTRW5ITVJ?
786-0 M3K4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK3TWM2OD15LkC5O|g3KM7:TR?= NWP5dlZlW0GQR1XS
EPLC-272H MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml73TWM2OD15LkG2NlQ3KM7:TR?= Mo\qV2FPT0WU
CAPAN-1 NIG3TJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzGWIdKSzVyPUeuNlQ{PTlizszN MXvTRW5ITVJ?
NCI-H82 M2DxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTdwMk[2OVkh|ryP NHfR[oxUSU6JRWK=
G-402 NG\lT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULDUHBiUUN3ME23MlMxODVzIN88US=> MnOyV2FPT0WU
SW982 M4C5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Ge4pQUUN3ME23MlMxOjB|IN88US=> NVGxc5dUW0GQR1XS
OVCAR-4 NXfWT5N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrpSXBKSzVyPUeuN|E{OjhizszN MVnTRW5ITVJ?
KARPAS-299 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W2dGlEPTB;Nz6zNlYzOiEQvF2= M{K3bnNCVkeHUh?=
MIA-PaCa-2 M4\NUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHJTWM2OD15LkO2PFI{KM7:TR?= NYXWRWlSW0GQR1XS
AU565 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjpWHBQUUN3ME23MlU6QDN|IN88US=> MlrUV2FPT0WU
GAMG NIi1co1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTITWM2OD15Lk[0NVMyKM7:TR?= NIH2[IpUSU6JRWK=
HuO9 NXfSeGE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP4dYRrUUN3ME23MlcyPzR|IN88US=> MYjTRW5ITVJ?
ACN NEHtTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnFeVVKSzVyPUeuO|Q{OyEQvF2= NV3RcINSW0GQR1XS
RO82-W-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqxTWM2OD15Lke0OVM{KM7:TR?= NYDVS|FPW0GQR1XS
NKM-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOyO3ZKSzVyPUeuO|Q6PTVizszN MlTpV2FPT0WU
CAL-12T MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnaZ4hyUUN3ME23Mlk1OzV{IN88US=> NID3XHFUSU6JRWK=
FADU NGHVbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXyTWM2OD16LkCzOlU1KM7:TR?= MWrTRW5ITVJ?
NCI-H28 MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P5VGlEPTB;OD6xOlk3OiEQvF2= NETNbIZUSU6JRWK=
LCLC-97TM1 M4XMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHvXHVKSzVyPUiuNlEyOjJizszN MnzFV2FPT0WU
CHP-134 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlizTWM2OD16LkK0NVg2KM7:TR?= NWnEOXpXW0GQR1XS
HT-1080 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRThwMkWwPVMh|ryP MWHTRW5ITVJ?
PC-3 NW[z[YpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H1fGlEPTB;OD6yO|M6OiEQvF2= M1K2[XNCVkeHUh?=
SNU-449 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Cwc2lEPTB;OD6yO|k{KM7:TR?= M1;qRnNCVkeHUh?=
VA-ES-BJ M4r0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XlPGlEPTB;OD6zOFY5PiEQvF2= MWTTRW5ITVJ?
HT NFjvR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXLTWM2OD16LkO2OFkh|ryP NWrId4hoW0GQR1XS
HOS NEiyOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInV[45KSzVyPUiuN|c2QDlizszN M1jtfnNCVkeHUh?=
KNS-62 MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPKTWM2OD16LkO3O|YzKM7:TR?= NYTlTFR1W0GQR1XS
OAW-42 NYHaRmd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfOeoIxUUN3ME24Mlk2QTZ2IN88US=> M{O1OHNCVkeHUh?=
A549 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLxTWM2OD17LkC5OlEzKM7:TR?= MXXTRW5ITVJ?
CAKI-1 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTRTWM2OD17LkG2OlEh|ryP NF3EcpdUSU6JRWK=
HCC1937 M4LiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTlwNkm4OlUh|ryP MkHpV2FPT0WU
GI-ME-N NUTz[ZJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\NTWM2OD17LkewNVM4KM7:TR?= MXHTRW5ITVJ?
DU-4475 NFvofZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH36UHJKSzVyPUmuPVY6OzlizszN MnnGV2FPT0WU
EM-2 NFq1fWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;Kd2lEPTB;MUCuNlQzPiEQvF2= NHLDToVUSU6JRWK=
NCI-H1755 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFyLkK0Nlgh|ryP MnezV2FPT0WU
NCI-H1437 MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFyLkW3NlUh|ryP MYDTRW5ITVJ?
VM-CUB-1 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fub2lEPTB;MUCuOlE3PCEQvF2= Ml;UV2FPT0WU
A2058 NYrMZnhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjIc5R5UUN3ME2xNE43PDB2IN88US=> NYC1XoZxW0GQR1XS
BPH-1 NFHTe5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPpNFVuUUN3ME2xNE44OTR3IN88US=> MmfyV2FPT0WU
NB5 NHj5fm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjXfmg6UUN3ME2xNE44PTV7IN88US=> M1TCN3NCVkeHUh?=
G-401 NI\ncIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL6TWM2OD1zMD63OlI3KM7:TR?= M3rJfHNCVkeHUh?=
CAL-72 M2fXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFyLkiwPVQh|ryP NGDuPXFUSU6JRWK=
SK-MEL-28 M1f4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFyLkiyNFIh|ryP NYfZSVRFW0GQR1XS
C32 NXTh[GszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlflTWM2OD1zMD64N|Q4KM7:TR?= MV7TRW5ITVJ?
NCI-H1155 NWPZcoxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[yXWlEPTB;MUCuPFM4PiEQvF2= Mo\yV2FPT0WU
BB49-HNC NH75V3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\Tb25KSzVyPUGwMlg2QDZizszN M{Hi[XNCVkeHUh?=
GMS-10 NFHMbGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LzSWlEPTB;MUCuPFk4OSEQvF2= M{nJfXNCVkeHUh?=
K5 MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFyLkmwO|Eh|ryP M4LKZXNCVkeHUh?=
OS-RC-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS5TWM2OD1zMT6wOVU6KM7:TR?= NI[zO5pUSU6JRWK=
HTC-C3 NHvvcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnNTmZKSzVyPUGxMlA4OTRizszN NHzHWVhUSU6JRWK=
LB996-RCC MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFzLkC3NlMh|ryP Mnv1V2FPT0WU
NCI-H1563 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HBVGlEPTB;MUGuNVAyOSEQvF2= M2j4WnNCVkeHUh?=
CAL-54 MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFzLkS4NVEh|ryP MlfTV2FPT0WU
WM-115 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LKc2lEPTB;MUGuOlgzPCEQvF2= NED5W5FUSU6JRWK=
COLO-684 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFzLkeyOlch|ryP NEjRZpJUSU6JRWK=
HOP-62 M2DmdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFzLke1NFgh|ryP M2rncnNCVkeHUh?=
NCI-H650 M1rmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jwWWlEPTB;MUGuPFk3OSEQvF2= Mn7vV2FPT0WU
TE-11 M2ezcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DISWlEPTB;MUGuPVMyPSEQvF2= M1n3NnNCVkeHUh?=
COLO-679 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFzLkm0OkDPxE1? MVzTRW5ITVJ?
FTC-133 M{PUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PGTmlEPTB;MUKuNFA4PiEQvF2= MXvTRW5ITVJ?
D-283MED MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm0TWM2OD1zMj6wOVY6KM7:TR?= NH7IO3RUSU6JRWK=
SK-PN-DW M33Hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELzbYdKSzVyPUGyMlE6ODJizszN MnLqV2FPT0WU
BALL-1 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:zTWM2OD1zMj6yOlYzKM7:TR?= NImw[mRUSU6JRWK=
GT3TKB M4fCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXpfmx3UUN3ME2xNk4{ODd2IN88US=> MVXTRW5ITVJ?
HOP-92 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDCUXJ4UUN3ME2xNk42OjN|IN88US=> MnHrV2FPT0WU
M14 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXXcWZKSzVyPUGzMlA{OzVizszN M3;ldnNCVkeHUh?=
SKG-IIIa M2n2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHHTWM2OD1zMz6wOVU1KM7:TR?= M4Pp[XNCVkeHUh?=
Becker NVXYfldkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHj[mNKSzVyPUGzMlA2QCEQvF2= MYrTRW5ITVJ?
ES5 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTzOXVKSzVyPUGzMlE{PTZizszN NVPneZFmW0GQR1XS
NCI-H2030 M4f0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF|LkKwOlIh|ryP M2LLc3NCVkeHUh?=
SNU-423 MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rwNmlEPTB;MUOuN|gyKM7:TR?= NIDCW|lUSU6JRWK=
CP50-MEL-B NXrxXm5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfKdnQxUUN3ME2xN{43OjN{IN88US=> MYnTRW5ITVJ?
NCI-H1092 MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjJ[JFVUUN3ME2xN{44PDd3IN88US=> NX;GdmJpW0GQR1XS
8-MG-BA M3;xfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPQTWM2OD1zMz63OVE{KM7:TR?= M1vjNXNCVkeHUh?=
CAL-27 NUjzT5VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\zTWM2OD1zND6wO|I4KM7:TR?= MkTOV2FPT0WU
AGS M4jGfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:5U2lEPTB;MUSuNVMyQSEQvF2= NWPu[HpxW0GQR1XS
MZ2-MEL M2DCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPqT2lKSzVyPUG0MlE1QDhizszN MYPTRW5ITVJ?
BFTC-909 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[2WZRKSzVyPUG0MlUxPTVizszN MX3TRW5ITVJ?
D-566MG Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF2Lke3NFYh|ryP M1;zUXNCVkeHUh?=
MZ7-mel NXjM[oxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF3LkGwOlch|ryP MkjtV2FPT0WU
TE-5 NESwZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;VUWlEPTB;MUWuNlM{OyEQvF2= MkXGV2FPT0WU
647-V Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljMTWM2OD1zNT6yO|A2KM7:TR?= MXnTRW5ITVJ?
DMS-114 NF\EcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfXOpJKSzVyPUG1MlMzQTFizszN MU\TRW5ITVJ?
ME-180 NVn0OG1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn6VYVOUUN3ME2xOU41Pzh|IN88US=> NEnYS2tUSU6JRWK=
MS-1 NEjNVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\leGlEPTB;MUWuOVYzOyEQvF2= NYTiUnlYW0GQR1XS
NUGC-3 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ud4hFUUN3ME2xOU43OjR3IN88US=> MVvTRW5ITVJ?
GB-1 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF3Lk[0N|ch|ryP Mo\tV2FPT0WU
LOXIMVI NXnO[WhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;0O2VOUUN3ME2xOU45QTF7IN88US=> MlTwV2FPT0WU
NCI-H1304 MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF3Lki5Nlgh|ryP M{HtUHNCVkeHUh?=
KURAMOCHI NUXTfYp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HFSmlEPTB;MUWuPVcyKM7:TR?= Ml;IV2FPT0WU
SW1783 NWjaVGdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjRNmZTUUN3ME2xOk4xQTl|IN88US=> MU\TRW5ITVJ?
EGI-1 MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXOTWM2OD1zNj61N|Y2KM7:TR?= NXGwZY1LW0GQR1XS
KGN MoTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj5TWM2OD1zNj61OVg3KM7:TR?= MnPEV2FPT0WU
PANC-03-27 NGjJT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmzZ3pKSzVyPUG2Mlc3PjJizszN Ml:1V2FPT0WU
RH-1 M1Tnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTEeYxkUUN3ME2xOk45OjVizszN MnrLV2FPT0WU
HT-1376 M4DlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHa[FZiUUN3ME2xOk45PDR4IN88US=> MVTTRW5ITVJ?
ZR-75-30 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSzSYxuUUN3ME2xOk46OzZzIN88US=> NHfF[m1USU6JRWK=
TI-73 NVrNRZNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF4Lkm0NFgh|ryP M{nSZ3NCVkeHUh?=
TK10 NIrISoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XyOmlEPTB;MUeuNFA4QSEQvF2= NUDZRlg6W0GQR1XS
SW684 M1;he2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF5LkCxOVQh|ryP M2i0b3NCVkeHUh?=
RPMI-8866 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF5LkC2PVkh|ryP NXTOVIJnW0GQR1XS
LNCaP-Clone-FGC M1HiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\kfIxKSzVyPUG3MlUzODFizszN NEPscXlUSU6JRWK=
NCI-H2291 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[3TWM2OD1zOD60N|Q2KM7:TR?= NXPtTVZuW0GQR1XS
T47D M4TPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTF6LkS4PEDPxE1? NEO4VY5USU6JRWK=
A204 NIPid41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PETmlEPTB;MUiuOVQ2OiEQvF2= NFmxSnBUSU6JRWK=
HT-144 M{LhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTMeVg5UUN3ME2xPE44PDJ5IN88US=> MUTTRW5ITVJ?
MDA-MB-361 NWLmV3JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTFTWM2OD1zOT6wO|E1KM7:TR?= NIHWVnNUSU6JRWK=
HCC1806 NXXGPYFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7TPWZPUUN3ME2xPU4yPTlzIN88US=> MV;TRW5ITVJ?
NCI-H596 M2TFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fzWmlEPTB;MUmuOlM6OSEQvF2= NGTxSohUSU6JRWK=
K-562 MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknCTWM2OD1zOT64PVI3KM7:TR?= MVfTRW5ITVJ?
D-336MG NXm3bJhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vDdGlEPTB;MUmuPVMzOiEQvF2= MnrjV2FPT0WU
SK-MEL-2 M3nzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:xOVJbUUN3ME2yNE4yPTV7IN88US=> Mn7YV2FPT0WU
HEC-1 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe1OldKSzVyPUKwMlQ6PzhizszN NHTT[nFUSU6JRWK=
EW-13 NVjVWmg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz4RW03UUN3ME2yNE42PDR|IN88US=> NV7LWpJ1W0GQR1XS
Hs-578-T NVzDcmJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;BUmlEPTB;MkCuOVU5OyEQvF2= MX;TRW5ITVJ?
SJSA-1 NYDOdXNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDi[I1KSzVyPUKwMlU3QDhizszN MonVV2FPT0WU
RCC10RGB MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHPTWM2OD1{MD62O|E6KM7:TR?= MYrTRW5ITVJ?
LAN-6 NH;a[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHPTWM2OD1{MT6wN|k3KM7:TR?= MlHEV2FPT0WU
NCI-H1048 NWSySGRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPUTWM2OD1{MT6yNlU5KM7:TR?= Mn\QV2FPT0WU
CW-2 M4XON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJzLkK3NFUh|ryP M3naeHNCVkeHUh?=
HCC2157 NGDiUHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJzLkO2JO69VQ>? M4LhdHNCVkeHUh?=
EW-22 M1;BbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfJR3ZQUUN3ME2yNU4{PzZizszN MVXTRW5ITVJ?
A253 NIDHR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJzLkS0PFEh|ryP NEfaUJBUSU6JRWK=
BE-13 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJzLk[xNVMh|ryP MXnTRW5ITVJ?
KINGS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXLTWM2OD1{MT62N|E3KM7:TR?= MmW2V2FPT0WU
ETK-1 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO4OlVKSzVyPUKxMlgyPTJizszN NWK0WXM2W0GQR1XS
NCI-H2452 M3;qRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJzLki2OFch|ryP MVLTRW5ITVJ?
HPAF-II MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHkWoU4UUN3ME2yNU45QTJ|IN88US=> MXXTRW5ITVJ?
D-542MG NWfTN|d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm5TWM2OD1{MT65NFY6KM7:TR?= MULTRW5ITVJ?
NCI-H630 NInKZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJ{LkCyPVYh|ryP NVL3cmpEW0GQR1XS
TGBC11TKB NXjsbG1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojpTWM2OD1{Mj6wOFkh|ryP M{jufHNCVkeHUh?=
BCPAP M4C0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXvR2lKSzVyPUKyMlYyOSEQvF2= NIjPOYVUSU6JRWK=
HLE NY[xPVllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfTRXJKSzVyPUKyMlY6PyEQvF2= MkHRV2FPT0WU
NCI-H727 MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\h[GtvUUN3ME2yNk44OzVizszN M1rpe3NCVkeHUh?=
RD M3TiZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;5TWM2OD1{Mj63OVE5KM7:TR?= NUK0PXdrW0GQR1XS
NCI-H522 M17wNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr4b3o5UUN3ME2yNk45PDNzIN88US=> MUHTRW5ITVJ?
CGTH-W-1 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLw[nBKSzVyPUKzMlA3PDFizszN NYHqW446W0GQR1XS
SK-LU-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnZTYVKSzVyPUKzMlQ3QDNizszN MoflV2FPT0WU
BB65-RCC NXnzeWc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HQXWlEPTB;MkOuO|g3OyEQvF2= NF:y[4dUSU6JRWK=
HSC-3 M1\QbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET2WZhKSzVyPUKzMlg2OjdizszN Mn7yV2FPT0WU
SK-MES-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jHZWlEPTB;MkSuNFE3OSEQvF2= M{\CRXNCVkeHUh?=
DB NXXPUJpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIOwOHBKSzVyPUK0MlExOjhizszN NWXF[mNNW0GQR1XS
HO-1-N-1 NFy4WZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q3XWlEPTB;MkSuN|A6OyEQvF2= MlHOV2FPT0WU
MKN1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\6[nhKSzVyPUK0MlY5KM7:TR?= MkeyV2FPT0WU
MN-60 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T4cmlEPTB;MkSuPFUyQSEQvF2= M3Hn[XNCVkeHUh?=
8505C NFO5dmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS5TWM2OD1{NT6xPFQ2KM7:TR?= NVvNRXJqW0GQR1XS
COLO-320-HSR NIHZPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DuWGlEPTB;MkWuNlIxQCEQvF2= M2XGdHNCVkeHUh?=
BB30-HNC M{DsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJ3LkK0PFMh|ryP MXrTRW5ITVJ?
KM12 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LjRmlEPTB;MkWuOVgxPyEQvF2= NFnDNoZUSU6JRWK=
NB13 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Xs[2lEPTB;MkWuOVg6QCEQvF2= NH[1b2ZUSU6JRWK=
HCC2998 M1q4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXo[pNYUUN3ME2yOk4xOjh|IN88US=> M2L0NXNCVkeHUh?=
U-118-MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ4LkC4NFgh|ryP NVrTVI9kW0GQR1XS
NB10 Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjzcGJKSzVyPUK2MlI{PCEQvF2= MoLBV2FPT0WU
SK-LMS-1 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;qbnZvUUN3ME2yO{4xPzB2IN88US=> M17YXHNCVkeHUh?=
SW1573 NIfjcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPMTWM6UUN3ME2yO{4yOSEQvF2= MYDTRW5ITVJ?
LB373-MEL-D NXzt[|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfVc45KSzVyPUK3MlEzQTRizszN M2LXWHNCVkeHUh?=
DK-MG NXrN[4ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDLW2xwUUN3ME2yO{4yQDF5IN88US=> MVvTRW5ITVJ?
RMG-I MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ5LkKwNlkh|ryP M2XXW3NCVkeHUh?=
SW1088 M3LFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJ5LkWwOFIh|ryP MWPTRW5ITVJ?
SK-OV-3 NXO0Tmw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHOfYZKSzVyPUK3Mlc2QTNizszN NYDIOHRHW0GQR1XS
KP-N-YN Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fidmlEPTB;MkeuPFA1OyEQvF2= NFO1[ndUSU6JRWK=
RPMI-7951 NHrRVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPVfoJKSzVyPUK4MlI1PTZizszN MnHrV2FPT0WU
CaR-1 MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTzWVZKSzVyPUK4MlU2QDJizszN M3rNXHNCVkeHUh?=
MKN7 MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjZe4hKSzVyPUK4MlU6PjRizszN M37SW3NCVkeHUh?=
CHP-212 NIH6U5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XXW2lEPTB;MkiuO|QxOSEQvF2= M3vsR3NCVkeHUh?=
KYSE-450 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjGO5dKSzVyPUK4MlgxQTFizszN MVXTRW5ITVJ?
RXF393 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTJ[nRWUUN3ME2yPU4zQTB4IN88US=> Mnv2V2FPT0WU
P30-OHK MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PQcGlEPTB;MkmuN|A1QCEQvF2= MkfrV2FPT0WU
Ca9-22 NYHlPJdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7YVXBKSzVyPUK5MlQzQTlizszN NIjnTFRUSU6JRWK=
RT-112 NUPHNGM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLnbpJRUUN3ME2yPU41PjFzIN88US=> NULOfmt{W0GQR1XS
ES1 Mnn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T6VGlEPTB;MkmuPFU1PCEQvF2= NXPz[lU6W0GQR1XS
HCE-4 M1zURmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C3bGlEPTB;MkmuPFc5PiEQvF2= MlnKV2FPT0WU
AM-38 M2Pre2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHFTWM2OD1|MD6wOlA3KM7:TR?= NID2VolUSU6JRWK=
AsPC-1 NXjKVmtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIeydJJKSzVyPUOwMlgxPTNizszN MVXTRW5ITVJ?
TE-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfmZWJKSzVyPUOwMlg4OzdizszN NHrvTGZUSU6JRWK=
HuP-T4 NX\HPVVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\jfZN2UUN3ME2zNE46PjN6IN88US=> M16wOXNCVkeHUh?=
LB2518-MEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XlXmlEPTB;M{GuNFc1PCEQvF2= NV3nbXNSW0GQR1XS
NCI-H1703 NUjIeJpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrS[3FjUUN3ME2zNU4xQTB3IN88US=> M1rhSHNCVkeHUh?=
NCI-H2228 NVe1UVNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\teXdKSzVyPUOxMlQ3PTFizszN NEXleZRUSU6JRWK=
SCC-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vDOWlEPTB;M{GuPVE5OSEQvF2= MWLTRW5ITVJ?
KNS-81-FD M{jnWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zKcmlEPTB;M{KuNFEzQCEQvF2= NIfzcIlUSU6JRWK=
NTERA-S-cl-D1 Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHtPINGUUN3ME2zNk4xPzN7IN88US=> MVnTRW5ITVJ?
Daoy M1PpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnGTWM2OD1|Mj6wPFM5KM7:TR?= M2GxTXNCVkeHUh?=
ES4 NXrWRpFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:0ZlNqUUN3ME2zNk4{QTJ{IN88US=> NFfqdopUSU6JRWK=
MHH-ES-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2G0NmlEPTB;M{KuOFg4OiEQvF2= NE[5dHdUSU6JRWK=
C-33-A NV\KSY8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj3TWM2OD1|Mj63O|I5KM7:TR?= MoPJV2FPT0WU
BHY MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHwZ5VbUUN3ME2zNk46PDl3IN88US=> NGT4bVBUSU6JRWK=
Detroit562 M1TlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTUTWM2OD1|Mz62OlU4KM7:TR?= MVfTRW5ITVJ?
EW-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f6OGlEPTB;M{OuPVMzOiEQvF2= M{\rNHNCVkeHUh?=
NCI-H1395 M4\BPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvVTWM2OD1|ND6wO|k6KM7:TR?= MVjTRW5ITVJ?
KM-H2 NITWXpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTN4LkS3OFMh|ryP NUDQZ3VLW0GQR1XS
NCI-H520 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfaV5ZKSzVyPUO2Mlc2PDFizszN Mly4V2FPT0WU
D-392MG MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH3OI16UUN3ME2zO{4{OzR2IN88US=> MmW0V2FPT0WU
NOMO-1 MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fnR2lEPTB;M{euPFA5QSEQvF2= NYTyTYR5W0GQR1XS
TE-6 MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPFeHoyUUN3ME2zPE4yOjRizszN MlfWV2FPT0WU
HT-3 NIDQRolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DFcWlEPTB;M{iuOFQ{PiEQvF2= M{e2OXNCVkeHUh?=
RPMI-8226 NUPlR2MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XJdmlEPTB;M{iuPVUyQSEQvF2= NHTtN4lUSU6JRWK=
U251 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTN7LkCxNlQh|ryP M{fPTnNCVkeHUh?=
GCT Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN7LkG4OVIh|ryP MWTTRW5ITVJ?
A431 MkLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTN7LkG4PVQh|ryP MUTTRW5ITVJ?
TE-12 M2Toe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfXTWM2OD1|OT6yOFQ5KM7:TR?= NWjVc41zW0GQR1XS
HMV-II M4D0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\ocmlEPTB;M{muOVA1PyEQvF2= NILkZlVUSU6JRWK=
IST-MES1 Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS5No02UUN3ME20NE4yPTB{IN88US=> NIK0O|dUSU6JRWK=
SW13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;oTWM2OD12MD61NVkh|ryP MVjTRW5ITVJ?
SF295 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXzTWM2OD12MD64NFY3KM7:TR?= MU\TRW5ITVJ?
MDA-MB-157 NEOzcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3frU2lEPTB;NECuPVQ3OiEQvF2= NFPFNldUSU6JRWK=
TE-1 M4XWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXYOnBjUUN3ME20NU45PzF2IN88US=> M{nLbXNCVkeHUh?=
HuCCT1 NHfZfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIm0WIlKSzVyPUSyMlUzQDlizszN MXPTRW5ITVJ?
KYSE-510 NIfSRnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv5dJNKSzVyPUSzMlE4PTRizszN M3zJOHNCVkeHUh?=
NCI-H358 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnRWFJKSzVyPUS0MlA{ODRizszN MoH0V2FPT0WU
SW900 NEC4W4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHXZXNKSzVyPUS0MlA4PThizszN NYnsWVBQW0GQR1XS
CAS-1 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTR2LkC5PVEh|ryP MWfTRW5ITVJ?
TE-8 NF\QZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKwOHRXUUN3ME20OE42PjV6IN88US=> MlLKV2FPT0WU
P12-ICHIKAWA M163UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvWU4VKSzVyPUS0MlYyOTJizszN MVnTRW5ITVJ?
YKG-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXWU|JSUUN3ME20OE44QDFizszN NWLFTW5JW0GQR1XS
SNU-C2B MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu3eIxKSzVyPUS0Mlc6ODNizszN MXrTRW5ITVJ?
LCLC-103H NV\CWphST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\McWlEPTB;NESuPFcxOyEQvF2= MonBV2FPT0WU
U-87-MG M1u1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEizZ|ZKSzVyPUS1MlExOjJizszN NFzEUmxUSU6JRWK=
HAL-01 NGf0OI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX1dnZuUUN3ME20OU4yOzd7IN88US=> NFXW[mpUSU6JRWK=
OVCAR-8 M{O1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf0TWM2OD12NT6zOVY1KM7:TR?= M{T6N3NCVkeHUh?=
KYSE-150 M1HYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\YVmlEPTB;NEeuNVA2OiEQvF2= NFS4endUSU6JRWK=
OE33 M17SSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTYTWM2OD12Nz6xOFI6KM7:TR?= MV3TRW5ITVJ?
CAL-62 MnzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PNV2lEPTB;NEeuOFA3QCEQvF2= Mn\EV2FPT0WU
TCCSUP MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M160WGlEPTB;NEeuOlI3PCEQvF2= M37rcHNCVkeHUh?=
H4 NX;Ve4l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj2bo91UUN3ME20O{43PjJzIN88US=> MkX4V2FPT0WU
CP66-MEL MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTR6LkC3NFQh|ryP MmDuV2FPT0WU
SNB75 NFrwd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR6LkG4O|Qh|ryP MlfNV2FPT0WU
Mo-T NYe1XItDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDwTWM2OD12OD6yO|kh|ryP NYXGeWViW0GQR1XS
BT-549 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUizZm81UUN3ME20PE4{PzJ7IN88US=> M2XqZ3NCVkeHUh?=
IGR-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXQTWM2OD12OD62OlQ2KM7:TR?= NUPOOYJ7W0GQR1XS
NCI-H1299 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\kRWlEPTB;NEiuO|I1QCEQvF2= NIjGbZRUSU6JRWK=
ALL-PO MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPzXpIzUUN3ME20PU46OjZ6IN88US=> NHvhRVhUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

Related DNA-PK Products4

Tags: buy NU7441 (KU-57788) | NU7441 (KU-57788) supplier | purchase NU7441 (KU-57788) | NU7441 (KU-57788) cost | NU7441 (KU-57788) manufacturer | order NU7441 (KU-57788) | NU7441 (KU-57788) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID