NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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Cited by 55 Publications

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NYiwUmNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEKxOFMh|ryP NHPW[FBUSU6JRWK=
A172 NXv2bXJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rZTmlEPTB;MD6xOVMyPiEQvF2= MmO4V2FPT0WU
NCI-H526 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMki0NFch|ryP M2qzVnNCVkeHUh?=
HDLM-2 NVHNXWU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTmTWM2OD1yLkOyN|Q2KM7:TR?= NFjvTIZUSU6JRWK=
HuO-3N1 M{nad2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\6RWdKSzVyPUCuOFY3OzZizszN NWLUVFFsW0GQR1XS
NCI-SNU-1 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNkC5PVQh|ryP NH72eIZUSU6JRWK=
SK-N-AS NEXjWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNkKyNVYh|ryP NULFPVh1W0GQR1XS
LoVo NX7GNGQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HCeGlEPTB;MD64Olc1QSEQvF2= MWXTRW5ITVJ?
LAMA-84 M4rMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLoRnNKSzVyPUCuPVg5OzNizszN NG\2elFUSU6JRWK=
CTB-1 NYjsZnh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnUTWM2OD1zLkGxOVQ3KM7:TR?= MmPKV2FPT0WU
KP-N-YS MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTFwMUSyN|Eh|ryP MkK0V2FPT0WU
HH NULwfVFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL0[GhKSzVyPUGuNVgxQTNizszN NI[3VWlUSU6JRWK=
CHL-1 NIrWdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe1NWtIUUN3ME2xMlIyOzZ6IN88US=> NV7SRnYxW0GQR1XS
NB7 M2XrVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnpcINiUUN3ME2xMlI1PzR3IN88US=> NEnIW4JUSU6JRWK=
HL-60 NWPJR|BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwM{ixPUDPxE1? M4DTNXNCVkeHUh?=
639-V NILVbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwNESxNlgh|ryP MWjTRW5ITVJ?
NCI-H1793 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnpTWM2OD1zLkS1PFQh|ryP M4C4SHNCVkeHUh?=
NEC8 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrjdYpKSzVyPUGuOVU{PSEQvF2= NELndHNUSU6JRWK=
PA-1 MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwNUiyPVQh|ryP M1HzZnNCVkeHUh?=
D-423MG M{DhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnNU3VPUUN3ME2xMlY6OzZzIN88US=> NX[4bXNvW0GQR1XS
NCI-H292 NEPPZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWiyd3F6UUN3ME2xMlc1ODF|IN88US=> NGf0OpRUSU6JRWK=
SK-MEL-1 MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PLZWlEPTB;MT63PVQ4QSEQvF2= NIO1UnRUSU6JRWK=
LB2241-RCC Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqzTWM2OD1{LkG0NVQ3KM7:TR?= M{X3THNCVkeHUh?=
SK-MEL-3 NVLhO|F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7TTWM2OD1{LkG2OFkh|ryP MlLjV2FPT0WU
MHH-PREB-1 NVvKNGxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvKTWM2OD1{LkG2OlA6KM7:TR?= NGXLWlJUSU6JRWK=
BFTC-905 M1OyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK5NpJNUUN3ME2yMlE3Pjh5IN88US=> MVnTRW5ITVJ?
Ramos-2G6-4C10 NGHZV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle0TWM2OD1{LkG5PVA6KM7:TR?= M{L6S3NCVkeHUh?=
G-361 MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvBO5FKSzVyPUKuNlE3QCEQvF2= Ml;kV2FPT0WU
MOLT-4 NF;0S2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS3cXF6UUN3ME2yMlIyQDh6IN88US=> NHO0VG1USU6JRWK=
DEL NIPXdGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uwUGlEPTB;Mj6zOVU3PCEQvF2= NFfGTm1USU6JRWK=
MV-4-11 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rlRmlEPTB;Mj6zO|M6KM7:TR?= M4fSS3NCVkeHUh?=
SK-NEP-1 MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwM{i3PFMh|ryP NX\ZNotHW0GQR1XS
RS4-11 M17Mbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTzR3BKSzVyPUKuOVYxOjNizszN NVPQV4lYW0GQR1XS
HuH-7 MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPKSm1qUUN3ME2yMlU3PzB{IN88US=> MnfrV2FPT0WU
A101D NITBV3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwNkGzN|gh|ryP MYrTRW5ITVJ?
KG-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nGWWlEPTB;Mj62O|kzPCEQvF2= NXW5NG84W0GQR1XS
KALS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PJTWlEPTB;Mj62PVY{OyEQvF2= M3jrUnNCVkeHUh?=
VMRC-RCZ MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPWZpRKSzVyPUKuO|c{OjhizszN M4Ptc3NCVkeHUh?=
SK-UT-1 NWjnPJhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXSTWM2OD1|LkG1N|Eh|ryP NVzu[IdwW0GQR1XS
SW962 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTNwMkCzOVIh|ryP M3vLU3NCVkeHUh?=
DBTRG-05MG NWPLWmd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwMkiwPFUh|ryP MWLTRW5ITVJ?
PANC-08-13 M{KyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTNwNEGyO|gh|ryP Ml7QV2FPT0WU
QIMR-WIL NE[zRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNwNEGzOFEh|ryP MnLXV2FPT0WU
SK-MEL-30 M3XSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLQWotZUUN3ME2zMlQzPTl6IN88US=> MYPTRW5ITVJ?
697 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEewfpZKSzVyPUOuOFQ6QTNizszN MVfTRW5ITVJ?
NY NWSwTXhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXLdVl1UUN3ME2zMlQ2ODJ{IN88US=> MUHTRW5ITVJ?
ES7 M4DtUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInzT3pKSzVyPUOuOFY4OjlizszN MlG0V2FPT0WU
JVM-3 NGPxZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTNwNEiwO|ch|ryP MXfTRW5ITVJ?
U031 NHLWVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rSbWlEPTB;Mz61PVM3QCEQvF2= Mn;WV2FPT0WU
BHT-101 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3KTFk5UUN3ME2zMlU6QTh3IN88US=> NHfyTlFUSU6JRWK=
8305C MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zGOGlEPTB;Mz62NVc{PiEQvF2= NYrpWnRqW0GQR1XS
MG-63 NVv3XoxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID1Z3VKSzVyPUOuOlI3PzZizszN NVnxbYZJW0GQR1XS
NOS-1 NG[yfopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;0TWM2OD1|Lk[1N|EzKM7:TR?= MVjTRW5ITVJ?
YH-13 M3nHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwOEexPFkh|ryP MX;TRW5ITVJ?
LXF-289 M4XqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTNwOUGwOFEh|ryP M{LHXnNCVkeHUh?=
GOTO MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3BTWM2OD1|LkmxOFkh|ryP NVfQRmJ{W0GQR1XS
EKVX Ml65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRwMkK1NlQh|ryP M3:2OXNCVkeHUh?=
CAL-51 M1XEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTRwMkS4OVQh|ryP MlKxV2FPT0WU
AN3-CA NXH4b3ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\GU29uUUN3ME20MlI2QDF|IN88US=> NYXue4Q2W0GQR1XS
IA-LM MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfjTmxKSzVyPUSuNlc6OzVizszN MYfTRW5ITVJ?
KU-19-19 NFzS[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTRwM{K5NlEh|ryP M{fPNnNCVkeHUh?=
A704 M1HiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITkOZpKSzVyPUSuOFA5QDhizszN NGnERXBUSU6JRWK=
RH-18 NE\3[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwNES5OVMh|ryP NVq4[3F6W0GQR1XS
IST-MEL1 NGX6cHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjmU4VKSzVyPUSuOVgzPjNizszN NH3ENJVUSU6JRWK=
LU-134-A M3L6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPCZY5KSzVyPUSuOVk3QDVizszN MWTTRW5ITVJ?
SF126 NV\yd5ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfPboZKSzVyPUSuOlA4OTVizszN Mnn6V2FPT0WU
EFO-27 NW\QVJJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\pUYhiUUN3ME20MlY3PTJ3IN88US=> M1rpbHNCVkeHUh?=
SN12C NV\0bIdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTRwN{G4PVgh|ryP NFz3c|lUSU6JRWK=
L-363 Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTRwN{exNVYh|ryP MnzKV2FPT0WU
MEL-HO NXzDOHNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm3TWM2OD12Lke3PVg6KM7:TR?= M{D0VXNCVkeHUh?=
TYK-nu MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLDTWM2OD12LkiwNVI5KM7:TR?= MX\TRW5ITVJ?
MDA-MB-415 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X5TGlEPTB;NT6wNFMyPCEQvF2= NWDFWZlnW0GQR1XS
HCC70 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTVwMEO5N|kh|ryP M3G5PHNCVkeHUh?=
IGROV-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPZU25KSzVyPUWuNlUzQTJizszN NXjtbZV[W0GQR1XS
NCI-H1355 NF7lc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q3VWlEPTB;NT6yPVYh|ryP NY\5N2R3W0GQR1XS
23132-87 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP2dlQ2UUN3ME21MlMzODJ2IN88US=> MY\TRW5ITVJ?
NB69 NHH1bopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvJNYl{UUN3ME21MlMzPDJizszN MVHTRW5ITVJ?
HSC-2 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf2SplKSzVyPUWuOFE4PzNizszN MVXTRW5ITVJ?
KYSE-410 NXrZfFY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjV[pM1UUN3ME21MlQ4PjN4IN88US=> NWrx[Gp2W0GQR1XS
GCIY NWDoeoJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPTbJpRUUN3ME21MlUyOzd6IN88US=> NEW2V3JUSU6JRWK=
A427 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOXmlEPTB;NT61N|Y3OSEQvF2= NWHnZW5xW0GQR1XS
ChaGo-K-1 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T0VmlEPTB;NT61OlU6QSEQvF2= NHzKUJhUSU6JRWK=
PFSK-1 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDUR|NVUUN3ME21MlYzOTl2IN88US=> MonuV2FPT0WU
MLMA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorCTWM2OD13LkizOlA3KM7:TR?= NXvueIxkW0GQR1XS
RVH-421 M3;L[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWxRohPUUN3ME22MlA4OzN6IN88US=> NWTQc3FnW0GQR1XS
LB1047-RCC NWXoWGJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT4foVoUUN3ME22MlE4PTJ{IN88US=> NV\LdpY{W0GQR1XS
MHH-NB-11 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHuV4l1UUN3ME22MlMzPzJzIN88US=> MWrTRW5ITVJ?
J-RT3-T3-5 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrGV|dMUUN3ME22MlY{OjlzIN88US=> NEDiUnRUSU6JRWK=
UM-UC-3 NGHOfldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlThTWM2OD14Lk[0N|M1KM7:TR?= M{LBXnNCVkeHUh?=
IST-SL1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\aOGlEPTB;Nj62PVM3QSEQvF2= MoO2V2FPT0WU
NB14 NITDXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj3fHV2UUN3ME22Mlc6PzZzIN88US=> M4jvbnNCVkeHUh?=
NBsusSR NXvJeYxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle2TWM2OD14LkiyOVAzKM7:TR?= Mk\lV2FPT0WU
D-263MG NU\DTFBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTZwOUGwOlgh|ryP NWfGcmw3W0GQR1XS
NCI-H2347 NUKzbYNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHZbXE1UUN3ME22Mlk{OjF|IN88US=> NGrZWnVUSU6JRWK=
ES8 NYjyPItNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjmTWM2OD14Lkm3OVg5KM7:TR?= NEj4eVRUSU6JRWK=
786-0 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTdwMEm3PFYh|ryP MXnTRW5ITVJ?
EPLC-272H NGjvSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;qUJpKSzVyPUeuNVYzPDZizszN MUTTRW5ITVJ?
CAPAN-1 NUXjVlJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTGTWM2OD15LkK0N|U6KM7:TR?= NY\sNGVsW0GQR1XS
NCI-H82 NHz5PYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTdwMk[2OVkh|ryP M3;RcXNCVkeHUh?=
G-402 M3[5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULqbIYzUUN3ME23MlMxODVzIN88US=> M3nLdHNCVkeHUh?=
SW982 M3jQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK4TWM2OD15LkOwNlA{KM7:TR?= MUXTRW5ITVJ?
OVCAR-4 M3W4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTdwM{GzNlgh|ryP M1u1PXNCVkeHUh?=
KARPAS-299 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnOSopRUUN3ME23MlMzPjJ{IN88US=> NUXndJZXW0GQR1XS
MIA-PaCa-2 NEG3VlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz0XpBKSzVyPUeuN|Y5OjNizszN NIS2UWRUSU6JRWK=
AU565 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\WVGlEPTB;Nz61PVg{OyEQvF2= M3jMWnNCVkeHUh?=
GAMG MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTdwNkSxN|Eh|ryP M{XOUXNCVkeHUh?=
HuO9 M4TRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorJTWM2OD15LkexO|Q{KM7:TR?= MmLOV2FPT0WU
ACN M4fKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fxN2lEPTB;Nz63OFM{KM7:TR?= M1XQbXNCVkeHUh?=
RO82-W-1 NWL2T4s5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTqTWM2OD15Lke0OVM{KM7:TR?= MkTQV2FPT0WU
NKM-1 NXHjSng6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1G4SmlEPTB;Nz63OFk2PSEQvF2= MV3TRW5ITVJ?
CAL-12T MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DkcGlEPTB;Nz65OFM2OiEQvF2= NH:0Vm9USU6JRWK=
FADU NVToSFdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRThwMEO2OVQh|ryP NF7KRnhUSU6JRWK=
NCI-H28 NWfOfnBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3KydGlEPTB;OD6xOlk3OiEQvF2= MmrrV2FPT0WU
LCLC-97TM1 NGD2U4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;PbpdKSzVyPUiuNlEyOjJizszN MUjTRW5ITVJ?
CHP-134 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LkWGlEPTB;OD6yOFE5PSEQvF2= NGm4WHBUSU6JRWK=
HT-1080 M{nQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPrZ5ZKSzVyPUiuNlUxQTNizszN M3Lq[XNCVkeHUh?=
PC-3 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRThwMkezPVIh|ryP NGWwPZFUSU6JRWK=
SNU-449 NH\YRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XLfGlEPTB;OD6yO|k{KM7:TR?= Mo\yV2FPT0WU
VA-ES-BJ NVLNeo9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f1dmlEPTB;OD6zOFY5PiEQvF2= MlHFV2FPT0WU
HT NF\2UIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRThwM{[0PUDPxE1? NVfTdmV2W0GQR1XS
HOS NF2zUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\UTWM2OD16LkO3OVg6KM7:TR?= NHSyU2JUSU6JRWK=
KNS-62 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjCTWM2OD16LkO3O|YzKM7:TR?= MlzjV2FPT0WU
OAW-42 M3LMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRThwOUW5OlQh|ryP NU\LS2tGW0GQR1XS
A549 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzXTWM2OD17LkC5OlEzKM7:TR?= MUXTRW5ITVJ?
CAKI-1 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPWSIY{UUN3ME25MlE3PjFizszN NXzDUpZMW0GQR1XS
HCC1937 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjI[4ZQUUN3ME25MlY6QDZ3IN88US=> NV3pTpFYW0GQR1XS
GI-ME-N NYrubmJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnVOoluUUN3ME25MlcxOTN5IN88US=> NWL3b|JiW0GQR1XS
DU-4475 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXHSWx[UUN3ME25Mlk3QTN7IN88US=> MULTRW5ITVJ?
EM-2 M1\UUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFyLkK0NlYh|ryP M1uyPHNCVkeHUh?=
NCI-H1755 NIG4NXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTFyLkK0Nlgh|ryP NH:2XohUSU6JRWK=
NCI-H1437 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;OOmlEPTB;MUCuOVczPSEQvF2= MnfCV2FPT0WU
VM-CUB-1 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zKfmlEPTB;MUCuOlE3PCEQvF2= M1TwfnNCVkeHUh?=
A2058 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLHZ3BKSzVyPUGwMlY1ODRizszN NEjqNpFUSU6JRWK=
BPH-1 M33Vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ZTWM2OD1zMD63NVQ2KM7:TR?= MXTTRW5ITVJ?
NB5 NH7qPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fo[mlEPTB;MUCuO|U2QSEQvF2= NFv4N|lUSU6JRWK=
G-401 M4P2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jRVmlEPTB;MUCuO|YzPiEQvF2= M{\OVnNCVkeHUh?=
CAL-72 NED5Z2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jrbGlEPTB;MUCuPFA6PCEQvF2= NI[0RZlUSU6JRWK=
SK-MEL-28 NX[2ZXZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPzTWM2OD1zMD64NlAzKM7:TR?= NIfsSYtUSU6JRWK=
C32 NEWz[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTFyLkizOFch|ryP NXzk[21bW0GQR1XS
NCI-H1155 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLnTWM2OD1zMD64N|c3KM7:TR?= M2TsO3NCVkeHUh?=
BB49-HNC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\wTWM2OD1zMD64OVg3KM7:TR?= NULkeIZXW0GQR1XS
GMS-10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;s[mlEPTB;MUCuPFk4OSEQvF2= MV3TRW5ITVJ?
K5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LVS2lEPTB;MUCuPVA4OSEQvF2= NWL6PFdbW0GQR1XS
OS-RC-2 NVfUdG5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\6TWM2OD1zMT6wOVU6KM7:TR?= NWTaUVFpW0GQR1XS
HTC-C3 NES3SVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j5WmlEPTB;MUGuNFcyPCEQvF2= M{TnRXNCVkeHUh?=
LB996-RCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ntcmlEPTB;MUGuNFczOyEQvF2= M3TXO3NCVkeHUh?=
NCI-H1563 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFzLkGwNVEh|ryP M{\pbXNCVkeHUh?=
CAL-54 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe0VlJtUUN3ME2xNU41QDFzIN88US=> M3\ifXNCVkeHUh?=
WM-115 M3nheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHyXVNKSzVyPUGxMlY5OjRizszN M4XRdnNCVkeHUh?=
COLO-684 MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TFOmlEPTB;MUGuO|I3PyEQvF2= MXzTRW5ITVJ?
HOP-62 M2HC[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PpZ2lEPTB;MUGuO|UxQCEQvF2= MYXTRW5ITVJ?
NCI-H650 NVHaU2JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFzLki5OlEh|ryP MYrTRW5ITVJ?
TE-11 NWDjTYNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPyTWM2OD1zMT65N|E2KM7:TR?= M4Tsb3NCVkeHUh?=
COLO-679 M4nDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPMdGdZUUN3ME2xNU46PDZizszN NFS1Z3hUSU6JRWK=
FTC-133 NWq3V28xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjaTWM2OD1zMj6wNFc3KM7:TR?= M1LmW3NCVkeHUh?=
D-283MED NWTicmRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXYdGtqUUN3ME2xNk4xPTZ7IN88US=> M1rCWnNCVkeHUh?=
SK-PN-DW MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\mTWM2OD1zMj6xPVAzKM7:TR?= M2jDb3NCVkeHUh?=
BALL-1 NVOyW3J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nJS2lEPTB;MUKuNlY3OiEQvF2= MorDV2FPT0WU
GT3TKB Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF{LkOwO|Qh|ryP M2LScXNCVkeHUh?=
HOP-92 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7FTWM2OD1zMj61NlM{KM7:TR?= NVHaPG1qW0GQR1XS
M14 M320eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\l[mlEPTB;MUOuNFM{PSEQvF2= MXPTRW5ITVJ?
SKG-IIIa NInVT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTF|LkC1OVQh|ryP M1j4[HNCVkeHUh?=
Becker MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF|LkC1PEDPxE1? NEPINJJUSU6JRWK=
ES5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTDTWM2OD1zMz6xN|U3KM7:TR?= M1f1[nNCVkeHUh?=
NCI-H2030 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfu[W9KSzVyPUGzMlIxPjJizszN NYm3OVNCW0GQR1XS
SNU-423 NEWzOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrSUXdKSzVyPUGzMlM5OSEQvF2= M3jJfHNCVkeHUh?=
CP50-MEL-B NVvVR3I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrydXMxUUN3ME2xN{43OjN{IN88US=> MmS1V2FPT0WU
NCI-H1092 NGfHUYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn4OXRKSzVyPUGzMlc1PzVizszN NUm2O|E3W0GQR1XS
8-MG-BA NFHa[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X3VGlEPTB;MUOuO|UyOyEQvF2= NFe1e2dUSU6JRWK=
CAL-27 NGXZb3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zLUmlEPTB;MUSuNFczPyEQvF2= NIn0RXVUSU6JRWK=
AGS Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF2LkGzNVkh|ryP MkCwV2FPT0WU
MZ2-MEL NGXzfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV30OG1ZUUN3ME2xOE4yPDh6IN88US=> MYfTRW5ITVJ?
BFTC-909 NVzGXYxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF2LkWwOVUh|ryP NEXxfYNUSU6JRWK=
D-566MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD1TWM2OD1zND63O|A3KM7:TR?= NWnXcYhtW0GQR1XS
MZ7-mel MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHryNFNKSzVyPUG1MlExPjdizszN MXHTRW5ITVJ?
TE-5 MomzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjhXnRKSzVyPUG1MlI{OzNizszN NGTl[I5USU6JRWK=
647-V NV;4S|BsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G1OGlEPTB;MUWuNlcxPSEQvF2= NFrE[VVUSU6JRWK=
DMS-114 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK0TWM2OD1zNT6zNlkyKM7:TR?= MoHvV2FPT0WU
ME-180 NH;UNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy1TJBKSzVyPUG1MlQ4QDNizszN Ml3EV2FPT0WU
MS-1 NYjBe2gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr5UJFUUUN3ME2xOU42PjJ|IN88US=> MnnNV2FPT0WU
NUGC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrr[4VKSzVyPUG1MlYzPDVizszN MXfTRW5ITVJ?
GB-1 NVO1[GV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfTfIx2UUN3ME2xOU43PDN5IN88US=> NXj0TppIW0GQR1XS
LOXIMVI MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P2RmlEPTB;MUWuPFkyQSEQvF2= NF\vW45USU6JRWK=
NCI-H1304 NHPJTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF3Lki5Nlgh|ryP NHztVVhUSU6JRWK=
KURAMOCHI NW\WTotFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV76TVRyUUN3ME2xOU46PzFizszN NXPSVGE6W0GQR1XS
SW1783 NVnCb2l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXyb2UzUUN3ME2xOk4xQTl|IN88US=> M4OxW3NCVkeHUh?=
EGI-1 NV3HToRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrqTWM2OD1zNj61N|Y2KM7:TR?= NFj1b3BUSU6JRWK=
KGN MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\JTWM2OD1zNj61OVg3KM7:TR?= NWH6WYJwW0GQR1XS
PANC-03-27 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH25SWpKSzVyPUG2Mlc3PjJizszN MYjTRW5ITVJ?
RH-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrmXZJKSzVyPUG2MlgzPSEQvF2= NVTp[4hmW0GQR1XS
HT-1376 MnvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXUTnJKSzVyPUG2Mlg1PDZizszN M4P2U3NCVkeHUh?=
ZR-75-30 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjpTWM2OD1zNj65N|YyKM7:TR?= MnnpV2FPT0WU
TI-73 M{PFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoGxTWM2OD1zNj65OFA5KM7:TR?= MoKxV2FPT0WU
TK10 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEToOnZKSzVyPUG3MlAxPzlizszN M{jifHNCVkeHUh?=
SW684 NVfISllTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFSyTXdKSzVyPUG3MlAyPTRizszN MkPPV2FPT0WU
RPMI-8866 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vu[mlEPTB;MUeuNFY6QSEQvF2= Mlu3V2FPT0WU
LNCaP-Clone-FGC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\ndm5KUUN3ME2xO{42OjBzIN88US=> MY\TRW5ITVJ?
NCI-H2291 NV31b4I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfMdoFKSzVyPUG4MlQ{PDVizszN M2m0UnNCVkeHUh?=
T47D MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfuTWM2OD1zOD60PFgh|ryP NIXFdXlUSU6JRWK=
A204 NHz6e21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4CyXmlEPTB;MUiuOVQ2OiEQvF2= MlvHV2FPT0WU
HT-144 NYL4Z5BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnWeVVKSzVyPUG4Mlc1OjdizszN MnvRV2FPT0WU
MDA-MB-361 M{H5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnGTWM2OD1zOT6wO|E1KM7:TR?= MVTTRW5ITVJ?
HCC1806 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF7LkG1PVEh|ryP NWm4UHRsW0GQR1XS
NCI-H596 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHmTWM2OD1zOT62N|kyKM7:TR?= NWTkdIlQW0GQR1XS
K-562 MmTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq3OJdbUUN3ME2xPU45QTJ4IN88US=> NUW4UlFIW0GQR1XS
D-336MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mni0TWM2OD1zOT65N|IzKM7:TR?= NV7YW293W0GQR1XS
SK-MEL-2 M4H2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LCXGlEPTB;MkCuNVU2QSEQvF2= NYLZb3BnW0GQR1XS
HEC-1 M3TpO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJyLkS5O|gh|ryP Mni2V2FPT0WU
EW-13 NF\uRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJyLkW0OFMh|ryP Ml7JV2FPT0WU
Hs-578-T MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\FTWM2OD1{MD61OVg{KM7:TR?= MVrTRW5ITVJ?
SJSA-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHlTWM2OD1{MD61Olg5KM7:TR?= NYTyT3NPW0GQR1XS
RCC10RGB Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\PfItKSzVyPUKwMlY4OTlizszN M1XGbnNCVkeHUh?=
LAN-6 M3zZRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHrTWM2OD1{MT6wN|k3KM7:TR?= MoLsV2FPT0WU
NCI-H1048 M3;zWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJzLkKyOVgh|ryP NECzZXBUSU6JRWK=
CW-2 M2jGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXRTWM2OD1{MT6yO|A2KM7:TR?= NV;5VIhDW0GQR1XS
HCC2157 NFrNOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ZVWlEPTB;MkGuN|Yh|ryP MVPTRW5ITVJ?
EW-22 NXG1Z2FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrseHZKSzVyPUKxMlM4PiEQvF2= M3P6R3NCVkeHUh?=
A253 NHS5UHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHjVmw3UUN3ME2yNU41PDhzIN88US=> NInjUYtUSU6JRWK=
BE-13 MkfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDCTWM2OD1{MT62NVE{KM7:TR?= NYi4fnVMW0GQR1XS
KINGS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X0eWlEPTB;MkGuOlMyPiEQvF2= M2DOU3NCVkeHUh?=
ETK-1 NU\zblQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf0ZmltUUN3ME2yNU45OTV{IN88US=> MnrsV2FPT0WU
NCI-H2452 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nMbWlEPTB;MkGuPFY1PyEQvF2= MYTTRW5ITVJ?
HPAF-II NVvRSWllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PBdGlEPTB;MkGuPFkzOyEQvF2= MVTTRW5ITVJ?
D-542MG NH7CZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJzLkmwOlkh|ryP M{PpXHNCVkeHUh?=
NCI-H630 M{X1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTBTWM2OD1{Mj6wNlk3KM7:TR?= MVzTRW5ITVJ?
TGBC11TKB MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\uOmlEPTB;MkKuNFQ6KM7:TR?= NELBbWVUSU6JRWK=
BCPAP NV;mZXk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJ{Lk[xNUDPxE1? NETkV|VUSU6JRWK=
HLE NWH6VYs1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX4Z49KSzVyPUKyMlY6PyEQvF2= NGHUcWJUSU6JRWK=
NCI-H727 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z3SWlEPTB;MkKuO|M2KM7:TR?= Mn3wV2FPT0WU
RD NVK1ZnN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ{Lke1NVgh|ryP Mo\zV2FPT0WU
NCI-H522 NF7OfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\XZWlEPTB;MkKuPFQ{OSEQvF2= NF3ZSVVUSU6JRWK=
CGTH-W-1 M3\0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJ|LkC2OFEh|ryP M1XVTnNCVkeHUh?=
SK-LU-1 NWDVTlNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJ|LkS2PFMh|ryP MmPRV2FPT0WU
BB65-RCC MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf6TWM2OD1{Mz63PFY{KM7:TR?= NYTTTm1IW0GQR1XS
HSC-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXuNnYxUUN3ME2yN{45PTJ5IN88US=> M4rnZ3NCVkeHUh?=
SK-MES-1 NGS1O49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[0NIp[UUN3ME2yOE4xOTZzIN88US=> MlrJV2FPT0WU
DB MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X6d2lEPTB;MkSuNVAzQCEQvF2= NVjjT4V3W0GQR1XS
HO-1-N-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSxRZZKSzVyPUK0MlMxQTNizszN MWnTRW5ITVJ?
MKN1 MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f1O2lEPTB;MkSuOlgh|ryP M4TyeXNCVkeHUh?=
MN-60 M4XsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LLbGlEPTB;MkSuPFUyQSEQvF2= NI\mbFBUSU6JRWK=
8505C Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jnUWlEPTB;MkWuNVg1PSEQvF2= NHzOepdUSU6JRWK=
COLO-320-HSR NWLPXFh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\xc3RGUUN3ME2yOU4zOjB6IN88US=> NF7jVYdUSU6JRWK=
BB30-HNC NInTcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXqTWM2OD1{NT6yOFg{KM7:TR?= MmPPV2FPT0WU
KM12 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ3LkW4NFch|ryP Mne4V2FPT0WU
NB13 NIO0c3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHycGRiUUN3ME2yOU42QDl6IN88US=> M2TUOXNCVkeHUh?=
HCC2998 NI\uVlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nte2lEPTB;Mk[uNFI5OyEQvF2= M{T3e3NCVkeHUh?=
U-118-MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[yOmZKSzVyPUK2MlA5ODhizszN NYHoPG5QW0GQR1XS
NB10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX3VFdKSzVyPUK2MlI{PCEQvF2= MWfTRW5ITVJ?
SK-LMS-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS3[nBnUUN3ME2yO{4xPzB2IN88US=> M{jwR3NCVkeHUh?=
SW1573 M2Dudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzJTWM2OD1{Nz6xNUDPxE1? NETIVppUSU6JRWK=
LB373-MEL-D NW\ud|JIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO2dXlwUUN3ME2yO{4yOjl2IN88US=> NEXlNnNUSU6JRWK=
DK-MG NIP4WItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fRbmlEPTB;MkeuNVgyPyEQvF2= Ml3pV2FPT0WU
RMG-I NX\GfoFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi0dnZTUUN3ME2yO{4zODJ7IN88US=> NVXtdWRwW0GQR1XS
SW1088 NV3HOYg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nFTWlEPTB;MkeuOVA1OiEQvF2= MYXTRW5ITVJ?
SK-OV-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\hTWM2OD1{Nz63OVk{KM7:TR?= NGXydHBUSU6JRWK=
KP-N-YN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K5PGlEPTB;MkeuPFA1OyEQvF2= NFvLPYtUSU6JRWK=
RPMI-7951 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf0TWM2OD1{OD6yOFU3KM7:TR?= M2LBXXNCVkeHUh?=
CaR-1 MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfBVlFzUUN3ME2yPE42PTh{IN88US=> NIn1VGJUSU6JRWK=
MKN7 NH3MUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYOyR21OUUN3ME2yPE42QTZ2IN88US=> M1zPbHNCVkeHUh?=
CHP-212 NX;SfYNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PsbGlEPTB;MkiuO|QxOSEQvF2= Mm[3V2FPT0WU
KYSE-450 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorITWM2OD1{OD64NFkyKM7:TR?= NX7m[pRsW0GQR1XS
RXF393 NFTWTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zDSWlEPTB;MkmuNlkxPiEQvF2= MWrTRW5ITVJ?
P30-OHK M3[wNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmwTWM2OD1{OT6zNFQ5KM7:TR?= M1jTbXNCVkeHUh?=
Ca9-22 M1XBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TxSGlEPTB;MkmuOFI6QSEQvF2= NGfBdGpUSU6JRWK=
RT-112 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jWVmlEPTB;MkmuOFYyOSEQvF2= MnOzV2FPT0WU
ES1 Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rFRmlEPTB;MkmuPFU1PCEQvF2= M2XOeXNCVkeHUh?=
HCE-4 M{HkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDOTWM2OD1{OT64O|g3KM7:TR?= Ml\CV2FPT0WU
AM-38 NXWzeplPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNyLkC2NFYh|ryP MWLTRW5ITVJ?
AsPC-1 M4n4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33HXmlEPTB;M{CuPFA2OyEQvF2= MUfTRW5ITVJ?
TE-9 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PjO2lEPTB;M{CuPFc{PyEQvF2= NXXDdWpHW0GQR1XS
HuP-T4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PYTGlEPTB;M{CuPVY{QCEQvF2= M3fCN3NCVkeHUh?=
LB2518-MEL MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLETWM2OD1|MT6wO|Q1KM7:TR?= NYe3b|JlW0GQR1XS
NCI-H1703 NHS0T2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLjTWM2OD1|MT6wPVA2KM7:TR?= MlzzV2FPT0WU
NCI-H2228 NGDETY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTNzLkS2OVEh|ryP NYPxT3lOW0GQR1XS
SCC-4 NXnZSGhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\UTZdKSzVyPUOxMlkyQDFizszN NVTXdJVuW0GQR1XS
KNS-81-FD MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN{LkCxNlgh|ryP MUfTRW5ITVJ?
NTERA-S-cl-D1 NWm5eY1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTN{LkC3N|kh|ryP NFTJOZVUSU6JRWK=
Daoy MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS4TWM2OD1|Mj6wPFM5KM7:TR?= MUDTRW5ITVJ?
ES4 M1XD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\lZo9yUUN3ME2zNk4{QTJ{IN88US=> NVLUcJU3W0GQR1XS
MHH-ES-1 NEHV[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTPTWM2OD1|Mj60PFczKM7:TR?= M3TRZnNCVkeHUh?=
C-33-A M1rqT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN{Lke3Nlgh|ryP MVHTRW5ITVJ?
BHY MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLNTWM2OD1|Mj65OFk2KM7:TR?= NYHoO|FHW0GQR1XS
Detroit562 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn5XXVMUUN3ME2zN{43PjV5IN88US=> MU\TRW5ITVJ?
EW-1 NGfK[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN|LkmzNlIh|ryP M3niVXNCVkeHUh?=
NCI-H1395 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN2LkC3PVkh|ryP M3LJOnNCVkeHUh?=
KM-H2 NHrFWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT0TWM2OD1|Nj60O|Q{KM7:TR?= NEXiSpRUSU6JRWK=
NCI-H520 NFTxUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PKb2lEPTB;M{[uO|U1OSEQvF2= MW\TRW5ITVJ?
D-392MG M1zs[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHJTWM2OD1|Nz6zN|Q1KM7:TR?= NUm4SohrW0GQR1XS
NOMO-1 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zQcWlEPTB;M{euPFA5QSEQvF2= MXLTRW5ITVJ?
TE-6 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7oTWM2OD1|OD6xNlQh|ryP NYHOSGtMW0GQR1XS
HT-3 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTN6LkS0N|Yh|ryP NV7OSWRqW0GQR1XS
RPMI-8226 NFfxT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHFTWM2OD1|OD65OVE6KM7:TR?= NIDWNnJUSU6JRWK=
U251 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN7LkCxNlQh|ryP Mn3GV2FPT0WU
GCT NUHtOY1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnYOVlCUUN3ME2zPU4yQDV{IN88US=> M120V3NCVkeHUh?=
A431 NYTFfGNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKzTWM2OD1|OT6xPFk1KM7:TR?= NH\ZUYlUSU6JRWK=
TE-12 NVX5V2gzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XzPGlEPTB;M{muNlQ1QCEQvF2= MVXTRW5ITVJ?
HMV-II M{PXN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTN7LkWwOFch|ryP MV3TRW5ITVJ?
IST-MES1 NEXkN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jXW9GUUN3ME20NE4yPTB{IN88US=> NHe4OZpUSU6JRWK=
SW13 MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjoOG9KSzVyPUSwMlUyQSEQvF2= NHm5cXBUSU6JRWK=
SF295 NVTadnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTpVHVKSzVyPUSwMlgxPjZizszN M1vsbHNCVkeHUh?=
MDA-MB-157 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTRyLkm0OlIh|ryP MXHTRW5ITVJ?
TE-1 NHLzc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLaR2x2UUN3ME20NU45PzF2IN88US=> NFG0XJNUSU6JRWK=
HuCCT1 NHf4enpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r2fWlEPTB;NEKuOVI5QSEQvF2= M1\zfnNCVkeHUh?=
KYSE-510 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL6TWM2OD12Mz6xO|U1KM7:TR?= NUHrUmZmW0GQR1XS
NCI-H358 NWTH[5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTR2LkCzNFQh|ryP NUjrfIJbW0GQR1XS
SW900 NWHTbY9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR2LkC3OVgh|ryP MV7TRW5ITVJ?
CAS-1 NXf2OG5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfYUGs1UUN3ME20OE4xQTlzIN88US=> NF\MVZdUSU6JRWK=
TE-8 MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\xNo5OUUN3ME20OE42PjV6IN88US=> NYnScGdwW0GQR1XS
P12-ICHIKAWA MoL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32wS2lEPTB;NESuOlEyOiEQvF2= M{T1O3NCVkeHUh?=
YKG-1 NFn6d|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny5TWM2OD12ND63PFEh|ryP NYfNXGh7W0GQR1XS
SNU-C2B NEnzOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXPc5hKSzVyPUS0Mlc6ODNizszN MlOyV2FPT0WU
LCLC-103H NXfsdopuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrkTWM2OD12ND64O|A{KM7:TR?= M2Hs[nNCVkeHUh?=
U-87-MG NUjPdmtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;zNWlEPTB;NEWuNVAzOiEQvF2= M{[3bHNCVkeHUh?=
HAL-01 M2j6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLPTWM2OD12NT6xN|c6KM7:TR?= M1HvR3NCVkeHUh?=
OVCAR-8 NXf4TWtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR3LkO1OlQh|ryP MX\TRW5ITVJ?
KYSE-150 NVq5cIw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTR5LkGwOVIh|ryP MUfTRW5ITVJ?
OE33 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\CT2hKSzVyPUS3MlE1OjlizszN NYXuXYNXW0GQR1XS
CAL-62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjD[oFKSzVyPUS3MlQxPjhizszN M4PkS3NCVkeHUh?=
TCCSUP MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPCdZFKSzVyPUS3MlYzPjRizszN NVnkT5hlW0GQR1XS
H4 NFS4WZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHUNmsxUUN3ME20O{43PjJzIN88US=> Mn[5V2FPT0WU
CP66-MEL NELsd2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7SU4NKSzVyPUS4MlA4ODRizszN MkW3V2FPT0WU
SNB75 NV7GeG1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmyTWM2OD12OD6xPFc1KM7:TR?= NH3JfJlUSU6JRWK=
Mo-T MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXzTYRKSzVyPUS4MlI4QSEQvF2= MU\TRW5ITVJ?
BT-549 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LVXWlEPTB;NEiuN|czQSEQvF2= NYDPWXl6W0GQR1XS
IGR-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTR6Lk[2OFUh|ryP NFL6b2RUSU6JRWK=
NCI-H1299 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3kPHNKSzVyPUS4MlczPDhizszN NWDQ[FI1W0GQR1XS
ALL-PO NHnROYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTR7LkmyOlgh|ryP NWnFXZVnW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; 

PubMed: 29344644     


SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR.

p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); 

PubMed: 25714019     


Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.

29344644 25714019
In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID