NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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Cited by 25 Publications

6 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NUDuNoR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomwTWM2OD1yLkCyNVQ{KM7:TR?= MXXTRW5ITVJ?
A172 NXPNb|ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluxTWM2OD1yLkG1N|E3KM7:TR?= MoP4V2FPT0WU
NCI-H526 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HRWWlEPTB;MD6yPFQxPyEQvF2= M{Dl[3NCVkeHUh?=
HDLM-2 NXTOfGY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\DRoRiUUN3ME2wMlMzOzR3IN88US=> NXXIW3g3W0GQR1XS
HuO-3N1 NYjYXoNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXnTWM2OD1yLkS2OlM3KM7:TR?= M3\oT3NCVkeHUh?=
NCI-SNU-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwNkC5PVQh|ryP M3nxU3NCVkeHUh?=
SK-N-AS M1\3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Xpc2lEPTB;MD62NlIyPiEQvF2= MkDKV2FPT0WU
LoVo MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzSOIJ4UUN3ME2wMlg3PzR7IN88US=> NILwOpZUSU6JRWK=
LAMA-84 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\XUYRzUUN3ME2wMlk5QDN|IN88US=> M4jCZXNCVkeHUh?=
CTB-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKyTWM2OD1zLkGxOVQ3KM7:TR?= MlfhV2FPT0WU
KP-N-YS M2fZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;DTWM2OD1zLkG0NlMyKM7:TR?= MkXjV2FPT0WU
HH MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnWTWM2OD1zLkG4NFk{KM7:TR?= NUPRTIdsW0GQR1XS
CHL-1 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCy[G1kUUN3ME2xMlIyOzZ6IN88US=> M4PQZXNCVkeHUh?=
NB7 M2S5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHy1[FJKSzVyPUGuNlQ4PDVizszN NHrKN|lUSU6JRWK=
HL-60 NITFUpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnsVJpKSzVyPUGuN|gyQSEQvF2= MV\TRW5ITVJ?
639-V NITieZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nibWlEPTB;MT60OFEzQCEQvF2= Mmf3V2FPT0WU
NCI-H1793 M3z6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPVTWM2OD1zLkS1PFQh|ryP M37GVXNCVkeHUh?=
NEC8 MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLVSZIxUUN3ME2xMlU2OzVizszN MkXxV2FPT0WU
PA-1 M2LUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr6T|dKSzVyPUGuOVgzQTRizszN Mmr2V2FPT0WU
D-423MG MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjLTWM2OD1zLk[5N|YyKM7:TR?= NHT0NYZUSU6JRWK=
NCI-H292 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO1e|hKSzVyPUGuO|QxOTNizszN NFHVWYVUSU6JRWK=
SK-MEL-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDo[lhKSzVyPUGuO|k1PzlizszN NUPhUlNWW0GQR1XS
LB2241-RCC M4DDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTLZplKSzVyPUKuNVQyPDZizszN NVvzRpRjW0GQR1XS
SK-MEL-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHwenNNUUN3ME2yMlE3PDlizszN MnjFV2FPT0WU
MHH-PREB-1 M1zOemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPpfFdKSzVyPUKuNVY3ODlizszN M3vyZnNCVkeHUh?=
BFTC-905 M3r1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJwMU[2PFch|ryP MVrTRW5ITVJ?
Ramos-2G6-4C10 M{XNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfKTWM2OD1{LkG5PVA6KM7:TR?= NYD3VI1GW0GQR1XS
G-361 M{fuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;mTWM2OD1{LkKxOlgh|ryP NXPuUnFIW0GQR1XS
MOLT-4 MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr0fmJUUUN3ME2yMlIyQDh6IN88US=> M4Tsb3NCVkeHUh?=
DEL NFntfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJwM{W1OlQh|ryP M2noeHNCVkeHUh?=
MV-4-11 NV\3UZN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PVcGlEPTB;Mj6zO|M6KM7:TR?= M1L6bnNCVkeHUh?=
SK-NEP-1 NGLzOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwM{i3PFMh|ryP M2XBTnNCVkeHUh?=
RS4-11 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLQVGVZUUN3ME2yMlU3ODJ|IN88US=> M2P0dnNCVkeHUh?=
HuH-7 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjPTWM2OD1{LkW2O|AzKM7:TR?= NWX6Z2dwW0GQR1XS
A101D MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Tqd2lEPTB;Mj62NVM{QCEQvF2= MnHUV2FPT0WU
KG-1 NX;DfVBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHPTWM2OD1{Lk[3PVI1KM7:TR?= NIPYZ3FUSU6JRWK=
KALS-1 M2P1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJwNkm2N|Mh|ryP M4jFUnNCVkeHUh?=
VMRC-RCZ M2r0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn6bGQ6UUN3ME2yMlc4OzJ6IN88US=> M4r5cnNCVkeHUh?=
SK-UT-1 NH3XfVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNwMUWzNUDPxE1? MWfTRW5ITVJ?
SW962 M325OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\rTWM2OD1|LkKwN|UzKM7:TR?= M2LiSHNCVkeHUh?=
DBTRG-05MG M4TxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTNwMkiwPFUh|ryP MXHTRW5ITVJ?
PANC-08-13 M4Xv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\zfVRmUUN3ME2zMlQyOjd6IN88US=> MXPTRW5ITVJ?
QIMR-WIL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLQcWpOUUN3ME2zMlQyOzRzIN88US=> NVv4XW04W0GQR1XS
SK-MEL-30 MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjCVlNNUUN3ME2zMlQzPTl6IN88US=> NInlcIZUSU6JRWK=
697 NEPH[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrzOIRKSzVyPUOuOFQ6QTNizszN NXnQ[Y1yW0GQR1XS
NY NWj1[WFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PuemlEPTB;Mz60OVAzOiEQvF2= MYTTRW5ITVJ?
ES7 MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW4T4xzUUN3ME2zMlQ3PzJ7IN88US=> M2\tZXNCVkeHUh?=
JVM-3 M2PCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7mWnZKSzVyPUOuOFgxPzdizszN NYjxfFg2W0GQR1XS
U031 NI\uPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXmTWM2OD1|LkW5N|Y5KM7:TR?= MWLTRW5ITVJ?
BHT-101 M1vySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jGPGlEPTB;Mz61PVk5PSEQvF2= MUPTRW5ITVJ?
8305C Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL6SVdrUUN3ME2zMlYyPzN4IN88US=> M3XqSHNCVkeHUh?=
MG-63 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HkRmlEPTB;Mz62NlY4PiEQvF2= M2\RTnNCVkeHUh?=
NOS-1 MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLMTWM2OD1|Lk[1N|EzKM7:TR?= NXPEepVWW0GQR1XS
YH-13 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrWbWk6UUN3ME2zMlg4OTh7IN88US=> M{XnV3NCVkeHUh?=
LXF-289 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwOUGwOFEh|ryP NXzMTW5SW0GQR1XS
GOTO NV3QPGpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvXTWM2OD1|LkmxOFkh|ryP MVjTRW5ITVJ?
EKVX NGf0Z2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT2SmQ2UUN3ME20MlIzPTJ2IN88US=> NXfoNHRuW0GQR1XS
CAL-51 NXO2[5lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLHNndKSzVyPUSuNlQ5PTRizszN NIjlemNUSU6JRWK=
AN3-CA MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfFb2VKSzVyPUSuNlU5OTNizszN NFzwNJlUSU6JRWK=
IA-LM NHXVfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXGRnN4UUN3ME20MlI4QTN3IN88US=> M{HwdXNCVkeHUh?=
KU-19-19 M3ixTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml31TWM2OD12LkOyPVIyKM7:TR?= MlzWV2FPT0WU
A704 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRwNEC4PFgh|ryP NUf4OpZ[W0GQR1XS
RH-18 NIKzb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvzTWM2OD12LkS0PVU{KM7:TR?= MoTtV2FPT0WU
IST-MEL1 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHmcVJ5UUN3ME20MlU5OjZ|IN88US=> MV;TRW5ITVJ?
LU-134-A NH\ORYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD4TWM2OD12LkW5Olg2KM7:TR?= MVvTRW5ITVJ?
SF126 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfaTWM2OD12Lk[wO|E2KM7:TR?= NUC2OJJYW0GQR1XS
EFO-27 NG[yRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjsXppIUUN3ME20MlY3PTJ3IN88US=> Mn;uV2FPT0WU
SN12C Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTRwN{G4PVgh|ryP MmfLV2FPT0WU
L-363 NU\CXJE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K5XmlEPTB;ND63O|EyPiEQvF2= Mnv3V2FPT0WU
MEL-HO NFO2UVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTRwN{e5PFkh|ryP MVjTRW5ITVJ?
TYK-nu MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTRwOECxNlgh|ryP NHP2O29USU6JRWK=
MDA-MB-415 M1naW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDJb|FKSzVyPUWuNFA{OTRizszN M1SyTXNCVkeHUh?=
HCC70 NF;We2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwMEO5N|kh|ryP M1vOd3NCVkeHUh?=
IGROV-1 NXHWSlhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml73TWM2OD13LkK1NlkzKM7:TR?= M3XOO3NCVkeHUh?=
NCI-H1355 M1zjbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPOV2FKSzVyPUWuNlk3KM7:TR?= M3q5OnNCVkeHUh?=
23132-87 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHLNVRkUUN3ME21MlMzODJ2IN88US=> NVLpSGRJW0GQR1XS
NB69 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nsdmlEPTB;NT6zNlQzKM7:TR?= NIWzUGdUSU6JRWK=
HSC-2 Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTVwNEG3O|Mh|ryP NEToR4ZUSU6JRWK=
KYSE-410 NGSyWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme3TWM2OD13LkS3OlM3KM7:TR?= MXrTRW5ITVJ?
GCIY NXzab3p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvIO4VKSzVyPUWuOVE{PzhizszN MVnTRW5ITVJ?
A427 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjT[m5[UUN3ME21MlU{PjZzIN88US=> NYDSfmZiW0GQR1XS
ChaGo-K-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTVwNU[1PVkh|ryP MkDqV2FPT0WU
PFSK-1 M3vYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnENW5rUUN3ME21MlYzOTl2IN88US=> Mn\JV2FPT0WU
MLMA MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z3bmlEPTB;NT64N|YxPiEQvF2= M2XRWHNCVkeHUh?=
RVH-421 NWraXGxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW1TWM2OD14LkC3N|M5KM7:TR?= NEm1bWRUSU6JRWK=
LB1047-RCC NXe4W|hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7MTWM2OD14LkG3OVIzKM7:TR?= MWDTRW5ITVJ?
MHH-NB-11 MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j5RWlEPTB;Nj6zNlczOSEQvF2= MofsV2FPT0WU
J-RT3-T3-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTZwNkOyPVEh|ryP NEHEcIVUSU6JRWK=
UM-UC-3 M3G0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEn4cGlKSzVyPU[uOlQ{OzRizszN NVvDWo8{W0GQR1XS
IST-SL1 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTZwNkmzOlkh|ryP MnP1V2FPT0WU
NB14 NYnrVmtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTZwN{m3OlEh|ryP M2ftXnNCVkeHUh?=
NBsusSR MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS3TWM2OD14LkiyOVAzKM7:TR?= Mn\DV2FPT0WU
D-263MG M3zycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjPOo9jUUN3ME22MlkyODZ6IN88US=> NUXCc21NW0GQR1XS
NCI-H2347 NWP5cINYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\sbXNKSzVyPU[uPVMzOTNizszN NU\JU2l[W0GQR1XS
ES8 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv5TWM2OD14Lkm3OVg5KM7:TR?= NGT3bndUSU6JRWK=
786-0 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETRT3lKSzVyPUeuNFk4QDZizszN M2jD[HNCVkeHUh?=
EPLC-272H MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPETWM2OD15LkG2NlQ3KM7:TR?= NF;zV5RUSU6JRWK=
CAPAN-1 M1j2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;MUpYyUUN3ME23MlI1OzV7IN88US=> NXn0WGZnW0GQR1XS
NCI-H82 M2PmdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGro[mlKSzVyPUeuNlY3PTlizszN MoewV2FPT0WU
G-402 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nlWmlEPTB;Nz6zNFA2OSEQvF2= NImzRo9USU6JRWK=
SW982 M2fvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTdwM{CyNFMh|ryP NUjidnVVW0GQR1XS
OVCAR-4 NFzYOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTdwM{GzNlgh|ryP NFrqXlhUSU6JRWK=
KARPAS-299 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfZVZoxUUN3ME23MlMzPjJ{IN88US=> MnPaV2FPT0WU
MIA-PaCa-2 NH30OHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TMOmlEPTB;Nz6zOlgzOyEQvF2= MY\TRW5ITVJ?
AU565 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXYTWM2OD15LkW5PFM{KM7:TR?= M1fJfHNCVkeHUh?=
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HLE M4XDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;SeZVKSzVyPUKyMlY6PyEQvF2= MkDXV2FPT0WU
NCI-H727 NXLtOllkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJ{LkezOUDPxE1? M3zhTnNCVkeHUh?=
RD Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4KzTmlEPTB;MkKuO|UyQCEQvF2= NVjRUFJ4W0GQR1XS
NCI-H522 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnDTWM2OD1{Mj64OFMyKM7:TR?= Mn;0V2FPT0WU
CGTH-W-1 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX2TWM2OD1{Mz6wOlQyKM7:TR?= NH\ieHpUSU6JRWK=
SK-LU-1 NHWxPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK2TWM2OD1{Mz60Olg{KM7:TR?= M4TQNnNCVkeHUh?=
BB65-RCC M{TBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYraUotkUUN3ME2yN{44QDZ|IN88US=> NHHR[FlUSU6JRWK=
HSC-3 MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvkTWM2OD1{Mz64OVI4KM7:TR?= M2rHWnNCVkeHUh?=
SK-MES-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPwTWM2OD1{ND6wNVYyKM7:TR?= NXruflRMW0GQR1XS
DB NIiybYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ2LkGwNlgh|ryP M1rWO3NCVkeHUh?=
HO-1-N-1 M1rNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzaT3RxUUN3ME2yOE4{ODl|IN88US=> NVLHWpM6W0GQR1XS
MKN1 NU\CcnBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorpTWM2OD1{ND62PEDPxE1? Mmj1V2FPT0WU
MN-60 NEP4XWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPxdYlKSzVyPUK0Mlg2OTlizszN NFeyUHRUSU6JRWK=
8505C M2[xUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT4emhKSzVyPUK1MlE5PDVizszN M3nTOXNCVkeHUh?=
COLO-320-HSR NEPKRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHyUnlpUUN3ME2yOU4zOjB6IN88US=> MVXTRW5ITVJ?
BB30-HNC NIPyVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm4TWM2OD1{NT6yOFg{KM7:TR?= NYLKOI5WW0GQR1XS
KM12 NF;mbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvESZY3UUN3ME2yOU42QDB5IN88US=> Mke0V2FPT0WU
NB13 NGfpcI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK4TWM2OD1{NT61PFk5KM7:TR?= NHfvOlVUSU6JRWK=
HCC2998 NGXsNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDVTWM2OD1{Nj6wNlg{KM7:TR?= MWHTRW5ITVJ?
U-118-MG M1\zR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33BeWlEPTB;Mk[uNFgxQCEQvF2= M3LQeHNCVkeHUh?=
NB10 M{XxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ4LkKzOEDPxE1? MWjTRW5ITVJ?
SK-LMS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XJWWlEPTB;MkeuNFcxPCEQvF2= NFrCS5BUSU6JRWK=
SW1573 NUTORWRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrYO3ZqUUN3ME2yO{4yOSEQvF2= NEPHPYhUSU6JRWK=
LB373-MEL-D MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorKTWM2OD1{Nz6xNlk1KM7:TR?= MkLFV2FPT0WU
DK-MG NFvYU4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;PfpFKSzVyPUK3MlE5OTdizszN NFTiZ3ZUSU6JRWK=
RMG-I MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;wSINDUUN3ME2yO{4zODJ7IN88US=> MWPTRW5ITVJ?
SW1088 NW\BOXNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XxfmlEPTB;MkeuOVA1OiEQvF2= M{nSNnNCVkeHUh?=
SK-OV-3 M1TNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPwTWM2OD1{Nz63OVk{KM7:TR?= NGPBWZlUSU6JRWK=
KP-N-YN MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PtTWlEPTB;MkeuPFA1OyEQvF2= MYrTRW5ITVJ?
RPMI-7951 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH4cVdKSzVyPUK4MlI1PTZizszN M4PJWHNCVkeHUh?=
CaR-1 NVPlRVVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ6LkW1PFIh|ryP M1Lj[HNCVkeHUh?=
MKN7 NFe0cWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfQcZBKSzVyPUK4MlU6PjRizszN MorDV2FPT0WU
CHP-212 NGDDeYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjQXYFKUUN3ME2yPE44PDBzIN88US=> M2OzTXNCVkeHUh?=
KYSE-450 MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[zS4p[UUN3ME2yPE45ODlzIN88US=> MULTRW5ITVJ?
RXF393 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ7LkK5NFYh|ryP NUHub3pDW0GQR1XS
P30-OHK M2nXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJ7LkOwOFgh|ryP MXHTRW5ITVJ?
Ca9-22 M1f0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljKTWM2OD1{OT60Nlk6KM7:TR?= MoPMV2FPT0WU
RT-112 M3PleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzSWGVCUUN3ME2yPU41PjFzIN88US=> M4O1NHNCVkeHUh?=
ES1 NUjQR2M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;rTWM2OD1{OT64OVQ1KM7:TR?= MVHTRW5ITVJ?
HCE-4 NX64cVJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSxXZM5UUN3ME2yPU45Pzh4IN88US=> NH\ZSJVUSU6JRWK=
AM-38 NV3ae|c1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXI[YJ3UUN3ME2zNE4xPjB4IN88US=> NHztXXFUSU6JRWK=
AsPC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjw[YhKSzVyPUOwMlgxPTNizszN MW\TRW5ITVJ?
TE-9 M1TUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\STWlEPTB;M{CuPFc{PyEQvF2= MVrTRW5ITVJ?
HuP-T4 MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzDO|JKSzVyPUOwMlk3OzhizszN MV;TRW5ITVJ?
LB2518-MEL M{nDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTNzLkC3OFQh|ryP NHzafYZUSU6JRWK=
NCI-H1703 M{n6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPGPVFJUUN3ME2zNU4xQTB3IN88US=> NYfkT3ZPW0GQR1XS
NCI-H2228 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH76WJdKSzVyPUOxMlQ3PTFizszN MUfTRW5ITVJ?
SCC-4 NFTNRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHoTWM2OD1|MT65NVgyKM7:TR?= MkjHV2FPT0WU
KNS-81-FD M2PsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLR[opKSzVyPUOyMlAyOjhizszN MWDTRW5ITVJ?
NTERA-S-cl-D1 M3vZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fTdWlEPTB;M{KuNFc{QSEQvF2= NHzmOFJUSU6JRWK=
Daoy NUD5UVFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPWdnRKSzVyPUOyMlA5OzhizszN NIXlPIpUSU6JRWK=
ES4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrERm0{UUN3ME2zNk4{QTJ{IN88US=> MmPzV2FPT0WU
MHH-ES-1 M{HFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvZflVKSzVyPUOyMlQ5PzJizszN M4W1bXNCVkeHUh?=
C-33-A NV3CeWJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN{Lke3Nlgh|ryP M2T4TXNCVkeHUh?=
BHY M3XQ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGyTWM2OD1|Mj65OFk2KM7:TR?= Mm\tV2FPT0WU
Detroit562 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEK4eJRKSzVyPUOzMlY3PTdizszN NEPweVZUSU6JRWK=
EW-1 M1nROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnWTWM2OD1|Mz65N|IzKM7:TR?= MmnkV2FPT0WU
NCI-H1395 NGCwVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[5bplKSzVyPUO0MlA4QTlizszN NE\wUHdUSU6JRWK=
KM-H2 M4S5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjWPFZKSzVyPUO2MlQ4PDNizszN MmP6V2FPT0WU
NCI-H520 NEfzWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTN4Lke1OFEh|ryP NV:xT2dqW0GQR1XS
D-392MG NGG3fFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfJSHJJUUN3ME2zO{4{OzR2IN88US=> Mli3V2FPT0WU
NOMO-1 M{X2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jK[mlEPTB;M{euPFA5QSEQvF2= MVHTRW5ITVJ?
TE-6 MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN6LkGyOEDPxE1? MkjZV2FPT0WU
HT-3 NXrxS|RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\1W5dKSzVyPUO4MlQ1OzZizszN NWTnTmRXW0GQR1XS
RPMI-8226 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnKNGw6UUN3ME2zPE46PTF7IN88US=> MXHTRW5ITVJ?
U251 Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHUUY15UUN3ME2zPU4xOTJ2IN88US=> M1S5WXNCVkeHUh?=
GCT NXSwR4YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3mTWM2OD1|OT6xPFUzKM7:TR?= MkfWV2FPT0WU
A431 NF:wPJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjwZZprUUN3ME2zPU4yQDl2IN88US=> NHzCW4hUSU6JRWK=
TE-12 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\Fe2lEPTB;M{muNlQ1QCEQvF2= MYDTRW5ITVJ?
HMV-II M2DpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN7LkWwOFch|ryP Mnu0V2FPT0WU
IST-MES1 NHflSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRyLkG1NFIh|ryP NEXWTnJUSU6JRWK=
SW13 NYPVZ2JqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTRyLkWxPUDPxE1? NYrkVmc2W0GQR1XS
SF295 M4r6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKyU4JNUUN3ME20NE45ODZ4IN88US=> MXfTRW5ITVJ?
MDA-MB-157 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTRyLkm0OlIh|ryP MX3TRW5ITVJ?
TE-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGWxVodKSzVyPUSxMlg4OTRizszN M1zRV3NCVkeHUh?=
HuCCT1 NEi1[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3DTWM2OD12Mj61Nlg6KM7:TR?= NV3FdJhbW0GQR1XS
KYSE-510 NWS2Toc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHXVWlzUUN3ME20N{4yPzV2IN88US=> M4C3d3NCVkeHUh?=
NCI-H358 M4XHS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\qR2lEPTB;NESuNFMxPCEQvF2= NUjPPY9iW0GQR1XS
SW900 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\RToh6UUN3ME20OE4xPzV6IN88US=> M1zBVHNCVkeHUh?=
CAS-1 M{\EdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR2LkC5PVEh|ryP M2\YOHNCVkeHUh?=
TE-8 NUPGdpVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTR2LkW2OVgh|ryP MmXyV2FPT0WU
P12-ICHIKAWA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIryVGZKSzVyPUS0MlYyOTJizszN NEXXfG5USU6JRWK=
YKG-1 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3NTWM2OD12ND63PFEh|ryP M4ryNnNCVkeHUh?=
SNU-C2B MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nQV2lEPTB;NESuO|kxOyEQvF2= NHj6XYxUSU6JRWK=
LCLC-103H M1jRdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTqeGFKSzVyPUS0Mlg4ODNizszN NYLkdYN4W0GQR1XS
U-87-MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLvTWM2OD12NT6xNFIzKM7:TR?= MonRV2FPT0WU
HAL-01 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnLbXRKSzVyPUS1MlE{PzlizszN M1HKV3NCVkeHUh?=
OVCAR-8 NHzIfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nKXmlEPTB;NEWuN|U3PCEQvF2= NV;VdG8zW0GQR1XS
KYSE-150 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3sfFU2UUN3ME20O{4yODV{IN88US=> M4rybHNCVkeHUh?=
OE33 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR5LkG0Nlkh|ryP M2G4XnNCVkeHUh?=
CAL-62 MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M16xNmlEPTB;NEeuOFA3QCEQvF2= MojkV2FPT0WU
TCCSUP MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTR5Lk[yOlQh|ryP MXTTRW5ITVJ?
H4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPQ[3RDUUN3ME20O{43PjJzIN88US=> NV\4SGVmW0GQR1XS
CP66-MEL NYK0TVltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTwTWM2OD12OD6wO|A1KM7:TR?= M2q4S3NCVkeHUh?=
SNB75 M3TlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\0OYFKSzVyPUS4MlE5PzRizszN MUPTRW5ITVJ?
Mo-T M3[0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D6cmlEPTB;NEiuNlc6KM7:TR?= NF65WldUSU6JRWK=
BT-549 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHjXJpCUUN3ME20PE4{PzJ7IN88US=> NUfEPVVPW0GQR1XS
IGR-1 NHW3dYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjj[olKSzVyPUS4MlY3PDVizszN NWLIWnBPW0GQR1XS
NCI-H1299 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fEfGlEPTB;NEiuO|I1QCEQvF2= MmLHV2FPT0WU
ALL-PO MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\IN24yUUN3ME20PU46OjZ6IN88US=> Moe4V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID