NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

Size Price Stock Quantity  
USD 70 In stock
USD 120 In stock
USD 370 In stock
USD 970 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

6 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 M{[yeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzlTWM2OD1yLkCyNVQ{KM7:TR?= NGG5[IpUSU6JRWK=
A172 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMUWzNVYh|ryP NIfXVFlUSU6JRWK=
NCI-H526 NFPhZ5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTVTWM2OD1yLkK4OFA4KM7:TR?= NFqwOIxUSU6JRWK=
HDLM-2 M{f1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\GcoxTUUN3ME2wMlMzOzR3IN88US=> M3TCO3NCVkeHUh?=
HuO-3N1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknoTWM2OD1yLkS2OlM3KM7:TR?= M4T1UHNCVkeHUh?=
NCI-SNU-1 M2\hNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHpeohKSzVyPUCuOlA6QTRizszN MlfCV2FPT0WU
SK-N-AS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDZVpJKSzVyPUCuOlIzOTZizszN NUS5[W9kW0GQR1XS
LoVo NVTDRXE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHW[nJXUUN3ME2wMlg3PzR7IN88US=> MlTkV2FPT0WU
LAMA-84 M1q2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwOUi4N|Mh|ryP NH\rWlhUSU6JRWK=
CTB-1 M4q0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SxfmlEPTB;MT6xNVU1PiEQvF2= MlvTV2FPT0WU
KP-N-YS M2L6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorITWM2OD1zLkG0NlMyKM7:TR?= NGPGbmtUSU6JRWK=
HH MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTFwMUiwPVMh|ryP NEjRRZVUSU6JRWK=
CHL-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PqZ2lEPTB;MT6yNVM3QCEQvF2= MnfLV2FPT0WU
NB7 NXzSeIhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDGfYl4UUN3ME2xMlI1PzR3IN88US=> NEfC[IhUSU6JRWK=
HL-60 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPBTWM2OD1zLkO4NVkh|ryP Mlm2V2FPT0WU
639-V NVfvNJdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEny[ZZKSzVyPUGuOFQyOjhizszN MmrZV2FPT0WU
NCI-H1793 NIrBe4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwNEW4OEDPxE1? NEf2V2xUSU6JRWK=
NEC8 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;acnVYUUN3ME2xMlU2OzVizszN MojlV2FPT0WU
PA-1 NXL0WlhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTOTWM2OD1zLkW4Nlk1KM7:TR?= NUTseXd1W0GQR1XS
D-423MG NUi2XJFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTPTWM2OD1zLk[5N|YyKM7:TR?= MW\TRW5ITVJ?
NCI-H292 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHOR4tKSzVyPUGuO|QxOTNizszN NXfaOJBCW0GQR1XS
SK-MEL-1 NIn3T|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPVUm85UUN3ME2xMlc6PDd7IN88US=> NIPFSGtUSU6JRWK=
LB2241-RCC NYPyd29CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[2UFRKSzVyPUKuNVQyPDZizszN M4HmR3NCVkeHUh?=
SK-MEL-3 NUH3coZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rEb2lEPTB;Mj6xOlQ6KM7:TR?= NGO3eGRUSU6JRWK=
MHH-PREB-1 NV\tdIE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXToSmZ6UUN3ME2yMlE3PjB7IN88US=> MVzTRW5ITVJ?
BFTC-905 NGTRWpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXWTWM2OD1{LkG2Olg4KM7:TR?= M1T1c3NCVkeHUh?=
Ramos-2G6-4C10 M{fGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXwNIVWUUN3ME2yMlE6QTB7IN88US=> MXPTRW5ITVJ?
G-361 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvmRXpKSzVyPUKuNlE3QCEQvF2= NWf1bHYyW0GQR1XS
MOLT-4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjkWZpKSzVyPUKuNlE5QDhizszN NX61U28zW0GQR1XS
DEL M1LkXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojsTWM2OD1{LkO1OVY1KM7:TR?= Moe0V2FPT0WU
MV-4-11 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLyTWM2OD1{LkO3N|kh|ryP NGPSZ2xUSU6JRWK=
SK-NEP-1 NYrsWXlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJwM{i3PFMh|ryP Mkf5V2FPT0WU
RS4-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrnfGFKSzVyPUKuOVYxOjNizszN Mn;VV2FPT0WU
HuH-7 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;QNGFKSzVyPUKuOVY4ODJizszN MUPTRW5ITVJ?
A101D NIXKdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjsTWM2OD1{Lk[xN|M5KM7:TR?= NGPCW2JUSU6JRWK=
KG-1 NYjmXmY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LsbWlEPTB;Mj62O|kzPCEQvF2= NETB[4xUSU6JRWK=
KALS-1 NHPwcppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorKTWM2OD1{Lk[5OlM{KM7:TR?= MoDqV2FPT0WU
VMRC-RCZ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjlXo5NUUN3ME2yMlc4OzJ6IN88US=> NFfVdZpUSU6JRWK=
SK-UT-1 Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi4cJFKSzVyPUOuNVU{OSEQvF2= NVXKPW9YW0GQR1XS
SW962 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3j[m5KSzVyPUOuNlA{PTJizszN Mn\WV2FPT0WU
DBTRG-05MG NFHWUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17rPWlEPTB;Mz6yPFA5PSEQvF2= MoDFV2FPT0WU
PANC-08-13 NEG5dG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPHTWM2OD1|LkSxNlc5KM7:TR?= NH23OVRUSU6JRWK=
QIMR-WIL M1PoW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlOzTWM2OD1|LkSxN|QyKM7:TR?= MnvBV2FPT0WU
SK-MEL-30 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\kS2lEPTB;Mz60NlU6QCEQvF2= NULHW482W0GQR1XS
697 M4XDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES1clZKSzVyPUOuOFQ6QTNizszN NG\mUWpUSU6JRWK=
NY Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTNwNEWwNlIh|ryP MWrTRW5ITVJ?
ES7 M2fZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Dx[mlEPTB;Mz60OlczQSEQvF2= MX7TRW5ITVJ?
JVM-3 NIjObmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v0b2lEPTB;Mz60PFA4PyEQvF2= NUm5eINMW0GQR1XS
U031 NYDjV49HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNwNUmzOlgh|ryP NGDmb25USU6JRWK=
BHT-101 NX65UYk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNwNUm5PFUh|ryP M{CxSHNCVkeHUh?=
8305C MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwNkG3N|Yh|ryP MkPaV2FPT0WU
MG-63 NX7kXlRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLsN|doUUN3ME2zMlYzPjd4IN88US=> M1nhWnNCVkeHUh?=
NOS-1 Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HhVmlEPTB;Mz62OVMyOiEQvF2= M{jVU3NCVkeHUh?=
YH-13 NInmeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr2dmtKSzVyPUOuPFcyQDlizszN MWHTRW5ITVJ?
LXF-289 NFnDdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXOTWM2OD1|LkmxNFQyKM7:TR?= M{\icnNCVkeHUh?=
GOTO NFvOWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHic5JHUUN3ME2zMlkyPDlizszN MXfTRW5ITVJ?
EKVX NVuyNVBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jvTGlEPTB;ND6yNlUzPCEQvF2= Mn;1V2FPT0WU
CAL-51 NVTve5BTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr3T3BKSzVyPUSuNlQ5PTRizszN Mlf3V2FPT0WU
AN3-CA MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTRwMkW4NVMh|ryP MUXTRW5ITVJ?
IA-LM Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRwMke5N|Uh|ryP Mn\SV2FPT0WU
KU-19-19 NYDxZpd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTRwM{K5NlEh|ryP NXzMeGRqW0GQR1XS
A704 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHsXnRKSzVyPUSuOFA5QDhizszN NH7HdVJUSU6JRWK=
RH-18 NHLGelhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vOTWlEPTB;ND60OFk2OyEQvF2= NEjGTllUSU6JRWK=
IST-MEL1 NIWwWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnryTWM2OD12LkW4NlY{KM7:TR?= M{HqW3NCVkeHUh?=
LU-134-A MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjyUZhKSzVyPUSuOVk3QDVizszN MmWyV2FPT0WU
SF126 NGXqT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLyTmRDUUN3ME20MlYxPzF3IN88US=> Mk[xV2FPT0WU
EFO-27 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvMVosyUUN3ME20MlY3PTJ3IN88US=> M{Ds[XNCVkeHUh?=
SN12C NImxZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWzRXJiUUN3ME20MlcyQDl6IN88US=> MWfTRW5ITVJ?
L-363 NUPtUHhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDhTWM2OD12Lke3NVE3KM7:TR?= MXHTRW5ITVJ?
MEL-HO Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTRwN{e5PFkh|ryP NFzHPWRUSU6JRWK=
TYK-nu NUHVTI86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n4OGlEPTB;ND64NFEzQCEQvF2= MnHFV2FPT0WU
MDA-MB-415 MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4mxdmlEPTB;NT6wNFMyPCEQvF2= MV\TRW5ITVJ?
HCC70 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XObWlEPTB;NT6wN|k{QSEQvF2= NI[wToNUSU6JRWK=
IGROV-1 NFjnPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXQXXFKSzVyPUWuNlUzQTJizszN NIOzZ|BUSU6JRWK=
NCI-H1355 NXflTY5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\veI5KSzVyPUWuNlk3KM7:TR?= MWXTRW5ITVJ?
23132-87 Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj4WnZKSzVyPUWuN|IxOjRizszN NUP3XJlRW0GQR1XS
NB69 M2K2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTVwM{K0NkDPxE1? MnT3V2FPT0WU
HSC-2 NWnoUFBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTVwNEG3O|Mh|ryP Ml72V2FPT0WU
KYSE-410 NXn1col6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XCRmlEPTB;NT60O|Y{PiEQvF2= MWnTRW5ITVJ?
GCIY M1HTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4SxWGlEPTB;NT61NVM4QCEQvF2= M17HUHNCVkeHUh?=
A427 M{HYPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzJVGxKSzVyPUWuOVM3PjFizszN MY\TRW5ITVJ?
ChaGo-K-1 M4faZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3BZWRKSzVyPUWuOVY2QTlizszN MnL1V2FPT0WU
PFSK-1 NV20NXBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\6TWM2OD13Lk[yNVk1KM7:TR?= MnW2V2FPT0WU
MLMA NFzSOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrtWXBKSzVyPUWuPFM3ODZizszN MWPTRW5ITVJ?
RVH-421 M2PLe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTZwMEezN|gh|ryP MnXKV2FPT0WU
LB1047-RCC M2Hnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrhN5NKSzVyPU[uNVc2OjJizszN MWTTRW5ITVJ?
MHH-NB-11 NVvEOnJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjYS4Y1UUN3ME22MlMzPzJzIN88US=> M3\P[HNCVkeHUh?=
J-RT3-T3-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL1VolZUUN3ME22MlY{OjlzIN88US=> MkDkV2FPT0WU
UM-UC-3 NV;3PHFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e5VWlEPTB;Nj62OFM{PCEQvF2= NYTuVW9DW0GQR1XS
IST-SL1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmq5TWM2OD14Lk[5N|Y6KM7:TR?= MlHMV2FPT0WU
NB14 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfyTWM2OD14Lke5O|YyKM7:TR?= MlHCV2FPT0WU
NBsusSR M4fVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTZwOEK1NFIh|ryP M4TnRXNCVkeHUh?=
D-263MG MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrHeFVwUUN3ME22MlkyODZ6IN88US=> NUfDTXJCW0GQR1XS
NCI-H2347 MlfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfrb4J3UUN3ME22Mlk{OjF|IN88US=> MnzhV2FPT0WU
ES8 M1ixcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3XlBsUUN3ME22Mlk4PTh6IN88US=> NGHERlRUSU6JRWK=
786-0 M1LSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W0cWlEPTB;Nz6wPVc5PiEQvF2= NYXCbIJiW0GQR1XS
EPLC-272H NFXuWJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTdwMU[yOFYh|ryP MWrTRW5ITVJ?
CAPAN-1 NX\aVY1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDKUodFUUN3ME23MlI1OzV7IN88US=> M2fsSHNCVkeHUh?=
NCI-H82 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTdwMk[2OVkh|ryP NYH0PXBzW0GQR1XS
G-402 NYjVSWdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHhTWM2OD15LkOwNFUyKM7:TR?= MkXIV2FPT0WU
SW982 M3TpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[y[mViUUN3ME23MlMxOjB|IN88US=> MmD0V2FPT0WU
OVCAR-4 MmrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjwSJRKSzVyPUeuN|E{OjhizszN M{HTb3NCVkeHUh?=
KARPAS-299 NX[xPWttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPibZJKSzVyPUeuN|I3OjJizszN NX\CNpBUW0GQR1XS
MIA-PaCa-2 NEfrUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3CTWM2OD15LkO2PFI{KM7:TR?= NFewNZdUSU6JRWK=
AU565 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\LZWlEPTB;Nz61PVg{OyEQvF2= M33FZXNCVkeHUh?=
GAMG MnW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPYTWM2OD15Lk[0NVMyKM7:TR?= NV\WRmh[W0GQR1XS
HuO9 NFnjfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTpWVZHUUN3ME23MlcyPzR|IN88US=> NYGxSWZ6W0GQR1XS
ACN MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPNVo8zUUN3ME23Mlc1OzNizszN NGKyUY9USU6JRWK=
RO82-W-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXr[lk2UUN3ME23Mlc1PTN|IN88US=> NEDjXWNUSU6JRWK=
NKM-1 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nXO2lEPTB;Nz63OFk2PSEQvF2= MU\TRW5ITVJ?
CAL-12T NIDRUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTdwOUSzOVIh|ryP M2DCXXNCVkeHUh?=
FADU NU\RVFh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe1[lhKSzVyPUiuNFM3PTRizszN MoWxV2FPT0WU
NCI-H28 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fVWmlEPTB;OD6xOlk3OiEQvF2= MmLSV2FPT0WU
LCLC-97TM1 NYX3bZc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRThwMkGxNlIh|ryP NUDONFZ1W0GQR1XS
CHP-134 M{D5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLWSnByUUN3ME24MlI1OTh3IN88US=> MV;TRW5ITVJ?
HT-1080 NF32bVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXvTWM2OD16LkK1NFk{KM7:TR?= NXG2O2lKW0GQR1XS
PC-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRThwMkezPVIh|ryP NVPtNlA4W0GQR1XS
SNU-449 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfWUoFFUUN3ME24MlI4QTNizszN NHGzfnRUSU6JRWK=
VA-ES-BJ MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT1TWM2OD16LkO0Olg3KM7:TR?= MYnTRW5ITVJ?
HT Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRThwM{[0PUDPxE1? NXXVdnhGW0GQR1XS
HOS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfZb|VHUUN3ME24MlM4PTh7IN88US=> NYHWcph{W0GQR1XS
KNS-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHYOI5qUUN3ME24MlM4PzZ{IN88US=> NXHySHhVW0GQR1XS
OAW-42 M4\2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRThwOUW5OlQh|ryP M2fsUnNCVkeHUh?=
A549 NIXXTXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTlwMEm2NVIh|ryP NF74T5hUSU6JRWK=
CAKI-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\NTWlEPTB;OT6xOlYyKM7:TR?= M2rhZ3NCVkeHUh?=
HCC1937 MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr0TWM2OD17Lk[5PFY2KM7:TR?= NWfN[FMxW0GQR1XS
GI-ME-N NYD3[nhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W3WWlEPTB;OT63NFE{PyEQvF2= NEX1OlFUSU6JRWK=
DU-4475 M1S2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjTVVFKSzVyPUmuPVY6OzlizszN MkPQV2FPT0WU
EM-2 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP6R4Y1UUN3ME2xNE4zPDJ4IN88US=> NF:wcVlUSU6JRWK=
NCI-H1755 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFyLkK0Nlgh|ryP M1zSTHNCVkeHUh?=
NCI-H1437 NW\0Wm1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj5O2pKSzVyPUGwMlU4OjVizszN MVjTRW5ITVJ?
VM-CUB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDMTWM2OD1zMD62NVY1KM7:TR?= NETrU3BUSU6JRWK=
A2058 M3:4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIC5bGZKSzVyPUGwMlY1ODRizszN MVPTRW5ITVJ?
BPH-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLWR452UUN3ME2xNE44OTR3IN88US=> M{nSTnNCVkeHUh?=
NB5 M1;xWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljaTWM2OD1zMD63OVU6KM7:TR?= MljEV2FPT0WU
G-401 M1vTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG1TWM2OD1zMD63OlI3KM7:TR?= NHfkR4FUSU6JRWK=
CAL-72 NXTPcXZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHRTWM2OD1zMD64NFk1KM7:TR?= NV2yZoE{W0GQR1XS
SK-MEL-28 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4noTWlEPTB;MUCuPFIxOiEQvF2= MkXOV2FPT0WU
C32 NGnZZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ZUo5KSzVyPUGwMlg{PDdizszN NEHBZW9USU6JRWK=
NCI-H1155 M17VbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\nOWlEPTB;MUCuPFM4PiEQvF2= NVrZeHNzW0GQR1XS
BB49-HNC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HyUGlEPTB;MUCuPFU5PiEQvF2= MWDTRW5ITVJ?
GMS-10 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\ifmZiUUN3ME2xNE45QTdzIN88US=> MU\TRW5ITVJ?
K5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX0UlBKSzVyPUGwMlkxPzFizszN MX;TRW5ITVJ?
OS-RC-2 M4H1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3rTG5KSzVyPUGxMlA2PTlizszN NXfxUIp[W0GQR1XS
HTC-C3 M2LZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\vTWM2OD1zMT6wO|E1KM7:TR?= M4\6XHNCVkeHUh?=
LB996-RCC NFy3UY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PjOGlEPTB;MUGuNFczOyEQvF2= Mnm0V2FPT0WU
NCI-H1563 Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;ETWM2OD1zMT6xNFEyKM7:TR?= NYTTZVhEW0GQR1XS
CAL-54 M2L4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny4TWM2OD1zMT60PFEyKM7:TR?= MWPTRW5ITVJ?
WM-115 NH:2Tm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFzLk[4NlQh|ryP NUS0[ZhiW0GQR1XS
COLO-684 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e0N2lEPTB;MUGuO|I3PyEQvF2= MlXlV2FPT0WU
HOP-62 M1jlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTFzLke1NFgh|ryP NFfV[2ZUSU6JRWK=
NCI-H650 M3fu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PJeGlEPTB;MUGuPFk3OSEQvF2= NX\mTphHW0GQR1XS
TE-11 Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFzLkmzNVUh|ryP M2S0Z3NCVkeHUh?=
COLO-679 NFjWSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjQTWM2OD1zMT65OFYh|ryP Mn;sV2FPT0WU
FTC-133 NFWxbnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKzZpBKSzVyPUGyMlAxPzZizszN NYTWcIg2W0GQR1XS
D-283MED NYO3UlhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HEOmlEPTB;MUKuNFU3QSEQvF2= NXvxfGZUW0GQR1XS
SK-PN-DW MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPkZZJKSzVyPUGyMlE6ODJizszN NFvFUW5USU6JRWK=
BALL-1 NFPZWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrpTWM2OD1zMj6yOlYzKM7:TR?= MkHQV2FPT0WU
GT3TKB NXv1OIJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\aPHVKSzVyPUGyMlMxPzRizszN MlPYV2FPT0WU
HOP-92 M3Phemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y0OGlEPTB;MUKuOVI{OyEQvF2= NHHJdJBUSU6JRWK=
M14 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7PRW45UUN3ME2xN{4xOzN3IN88US=> NIjGWYZUSU6JRWK=
SKG-IIIa MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHkO5pwUUN3ME2xN{4xPTV2IN88US=> MYTTRW5ITVJ?
Becker MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuxVJNKSzVyPUGzMlA2QCEQvF2= NYmwXWdvW0GQR1XS
ES5 NYroZ|hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;uTHBiUUN3ME2xN{4yOzV4IN88US=> M3TDUHNCVkeHUh?=
NCI-H2030 NXPoZ4F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfLb25HUUN3ME2xN{4zODZ{IN88US=> MUfTRW5ITVJ?
SNU-423 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF|LkO4NUDPxE1? NEflfYdUSU6JRWK=
CP50-MEL-B NEm4bo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;EeppKSzVyPUGzMlYzOzJizszN Mk\ZV2FPT0WU
NCI-H1092 NHOxTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrjTlBKSzVyPUGzMlc1PzVizszN MnrTV2FPT0WU
8-MG-BA MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn2NpN5UUN3ME2xN{44PTF|IN88US=> NVPmT2llW0GQR1XS
CAL-27 M2C0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF2LkC3Nlch|ryP NWrq[2tMW0GQR1XS
AGS NV36TII{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnywTWM2OD1zND6xN|E6KM7:TR?= M2foR3NCVkeHUh?=
MZ2-MEL MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF2LkG0PFgh|ryP M13kcnNCVkeHUh?=
BFTC-909 M1y2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPpS2RKSzVyPUG0MlUxPTVizszN M13ke3NCVkeHUh?=
D-566MG NXLFZWttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DK[WlEPTB;MUSuO|cxPiEQvF2= MkHIV2FPT0WU
MZ7-mel NIHnVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj3T49KSzVyPUG1MlExPjdizszN Mn;WV2FPT0WU
TE-5 NHXIZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETnXWpKSzVyPUG1MlI{OzNizszN M3ToOnNCVkeHUh?=
647-V M2\3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjiTWM2OD1zNT6yO|A2KM7:TR?= NVHRUpdVW0GQR1XS
DMS-114 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jWXmlEPTB;MUWuN|I6OSEQvF2= MUfTRW5ITVJ?
ME-180 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF3LkS3PFMh|ryP MVvTRW5ITVJ?
MS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS0TWM2OD1zNT61OlI{KM7:TR?= NUTIemR7W0GQR1XS
NUGC-3 NYfDbXh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe4OnJNUUN3ME2xOU43OjR3IN88US=> MnXoV2FPT0WU
GB-1 MkTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF3Lk[0N|ch|ryP NYf1OpBIW0GQR1XS
LOXIMVI NWTlcZp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:1RmdKSzVyPUG1Mlg6OTlizszN MoDHV2FPT0WU
NCI-H1304 NFvEenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fIVWlEPTB;MUWuPFkzQCEQvF2= NF3CbnVUSU6JRWK=
KURAMOCHI MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHjTWM2OD1zNT65O|Eh|ryP M1[1TXNCVkeHUh?=
SW1783 NVLROWxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTF4LkC5PVMh|ryP NIq0RlhUSU6JRWK=
EGI-1 Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX1TWM2OD1zNj61N|Y2KM7:TR?= MmrKV2FPT0WU
KGN NYryPYhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\UZ|hsUUN3ME2xOk42PTh4IN88US=> MWXTRW5ITVJ?
PANC-03-27 M3jxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG4WppKSzVyPUG2Mlc3PjJizszN MYHTRW5ITVJ?
RH-1 NEK2SlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjoVnJUUUN3ME2xOk45OjVizszN MlLKV2FPT0WU
HT-1376 M4HUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXnXHcxUUN3ME2xOk45PDR4IN88US=> MX3TRW5ITVJ?
ZR-75-30 M4C5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTF4LkmzOlEh|ryP NGKz[VhUSU6JRWK=
TI-73 NEiwZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTF4Lkm0NFgh|ryP NV;FXGdnW0GQR1XS
TK10 M2WycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj6NWUyUUN3ME2xO{4xODd7IN88US=> MWXTRW5ITVJ?
SW684 NXT0OJQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof6TWM2OD1zNz6wNVU1KM7:TR?= NELYSmFUSU6JRWK=
RPMI-8866 NWnBZoNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF5LkC2PVkh|ryP M4r4eHNCVkeHUh?=
LNCaP-Clone-FGC NGTXZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF5LkWyNFEh|ryP MYTTRW5ITVJ?
NCI-H2291 NVTwdVlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDQTWM2OD1zOD60N|Q2KM7:TR?= M3[wS3NCVkeHUh?=
T47D NUPFNohST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\Yb2xKSzVyPUG4MlQ5QCEQvF2= M2jiOHNCVkeHUh?=
A204 NGflUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfYdWtnUUN3ME2xPE42PDV{IN88US=> NIjINJJUSU6JRWK=
HT-144 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfhZ4FKSzVyPUG4Mlc1OjdizszN M3vwTXNCVkeHUh?=
MDA-MB-361 M3jxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLDTWM2OD1zOT6wO|E1KM7:TR?= M3mwUnNCVkeHUh?=
HCC1806 M363c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF7LkG1PVEh|ryP M1\5RnNCVkeHUh?=
NCI-H596 NGmxOXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmniTWM2OD1zOT62N|kyKM7:TR?= NVTzeFV5W0GQR1XS
K-562 NGrJT4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PhN2lEPTB;MUmuPFkzPiEQvF2= MkfaV2FPT0WU
D-336MG Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf0TWM2OD1zOT65N|IzKM7:TR?= MYPTRW5ITVJ?
SK-MEL-2 NUTSSWdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJyLkG1OVkh|ryP MWDTRW5ITVJ?
HEC-1 M{XLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrpTWM2OD1{MD60PVc5KM7:TR?= NIPzOWhUSU6JRWK=
EW-13 NELWOXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jROWlEPTB;MkCuOVQ1OyEQvF2= M4[wbHNCVkeHUh?=
Hs-578-T Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fFeGlEPTB;MkCuOVU5OyEQvF2= MVPTRW5ITVJ?
SJSA-1 NHrtb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJyLkW2PFgh|ryP MUfTRW5ITVJ?
RCC10RGB MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJyLk[3NVkh|ryP NWfRS|F7W0GQR1XS
LAN-6 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT6bIx{UUN3ME2yNU4xOzl4IN88US=> NFjwZolUSU6JRWK=
NCI-H1048 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fwW2lEPTB;MkGuNlI2QCEQvF2= Mly1V2FPT0WU
CW-2 M2jsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn5SZg{UUN3ME2yNU4zPzB3IN88US=> MmLRV2FPT0WU
HCC2157 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jQfGlEPTB;MkGuN|Yh|ryP NV;3fYsyW0GQR1XS
EW-22 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzBeYtiUUN3ME2yNU4{PzZizszN NInr[4RUSU6JRWK=
A253 M1v2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7VboZ{UUN3ME2yNU41PDhzIN88US=> M{TNS3NCVkeHUh?=
BE-13 NYP6[|ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJzLk[xNVMh|ryP NY\veYp3W0GQR1XS
KINGS-1 NInKfW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjXRoJmUUN3ME2yNU43OzF4IN88US=> NH7Mc3VUSU6JRWK=
ETK-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;0cmlEPTB;MkGuPFE2OiEQvF2= MVPTRW5ITVJ?
NCI-H2452 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvkTWM2OD1{MT64OlQ4KM7:TR?= MmfTV2FPT0WU
HPAF-II NX;uSotnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;W[mhKSzVyPUKxMlg6OjNizszN NG\MVY1USU6JRWK=
D-542MG NX;HNFR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJzLkmwOlkh|ryP M2HwR3NCVkeHUh?=
NCI-H630 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPKN3lGUUN3ME2yNk4xOjl4IN88US=> NUPZVWZ1W0GQR1XS
TGBC11TKB MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjNNmdKSzVyPUKyMlA1QSEQvF2= NHT5Tm5USU6JRWK=
BCPAP NVLJdHVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG4cJZ4UUN3ME2yNk43OTFizszN MVvTRW5ITVJ?
HLE MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\3NYRpUUN3ME2yNk43QTdizszN MYLTRW5ITVJ?
NCI-H727 MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ{LkezOUDPxE1? MYfTRW5ITVJ?
RD M13GZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXWwUVZmUUN3ME2yNk44PTF6IN88US=> MVPTRW5ITVJ?
NCI-H522 M3f5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHrN445UUN3ME2yNk45PDNzIN88US=> MX7TRW5ITVJ?
CGTH-W-1 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi1TYdJUUN3ME2yN{4xPjRzIN88US=> NFPlUldUSU6JRWK=
SK-LU-1 M3fXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDzZnFLUUN3ME2yN{41Pjh|IN88US=> Mmr5V2FPT0WU
BB65-RCC MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP6PYVOUUN3ME2yN{44QDZ|IN88US=> NYCzWI9kW0GQR1XS
HSC-3 NXrsUpNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ|Lki1Nlch|ryP MonTV2FPT0WU
SK-MES-1 NWjzUWhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomwTWM2OD1{ND6wNVYyKM7:TR?= M{[yOnNCVkeHUh?=
DB MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1POZWlEPTB;MkSuNVAzQCEQvF2= MVrTRW5ITVJ?
HO-1-N-1 M2XZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP6T5hKSzVyPUK0MlMxQTNizszN NFvEb4tUSU6JRWK=
MKN1 NH3NcnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ2Lk[4JO69VQ>? NFS3cGRUSU6JRWK=
MN-60 M3SwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH1TWM2OD1{ND64OVE6KM7:TR?= NFHGSIRUSU6JRWK=
8505C MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlziTWM2OD1{NT6xPFQ2KM7:TR?= NEnUTHdUSU6JRWK=
COLO-320-HSR M1Xrc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDVTWM2OD1{NT6yNlA5KM7:TR?= MVPTRW5ITVJ?
BB30-HNC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[yU41KSzVyPUK1MlI1QDNizszN NHvibplUSU6JRWK=
KM12 NFXZe2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJ3LkW4NFch|ryP MWnTRW5ITVJ?
NB13 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LlVmlEPTB;MkWuOVg6QCEQvF2= MYrTRW5ITVJ?
HCC2998 NGPpenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zj[GlEPTB;Mk[uNFI5OyEQvF2= MX;TRW5ITVJ?
U-118-MG Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2juVmlEPTB;Mk[uNFgxQCEQvF2= NF3KNItUSU6JRWK=
NB10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfTb4h2UUN3ME2yOk4zOzRizszN MkjXV2FPT0WU
SK-LMS-1 NHHJeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDCSog6UUN3ME2yO{4xPzB2IN88US=> NGGxbI5USU6JRWK=
SW1573 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJ5LkGxJO69VQ>? M{HYbXNCVkeHUh?=
LB373-MEL-D MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfqTWM2OD1{Nz6xNlk1KM7:TR?= M2nN[XNCVkeHUh?=
DK-MG MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli0TWM2OD1{Nz6xPFE4KM7:TR?= M3;xWXNCVkeHUh?=
RMG-I NGL5WZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;uW3FKSzVyPUK3MlIxOjlizszN MVXTRW5ITVJ?
SW1088 M1zENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfQXY5CUUN3ME2yO{42ODR{IN88US=> NXT0dlJjW0GQR1XS
SK-OV-3 MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\rdVhKSzVyPUK3Mlc2QTNizszN MVHTRW5ITVJ?
KP-N-YN MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv3VZIyUUN3ME2yO{45ODR|IN88US=> MYXTRW5ITVJ?
RPMI-7951 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm1bVlPUUN3ME2yPE4zPDV4IN88US=> NXTlcHAzW0GQR1XS
CaR-1 M4\Rdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ6LkW1PFIh|ryP NIGxVpRUSU6JRWK=
MKN7 NUjmc5g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnIVVFKSzVyPUK4MlU6PjRizszN NULYS3hGW0GQR1XS
CHP-212 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\ROVlKSzVyPUK4Mlc1ODFizszN NUXEbWpTW0GQR1XS
KYSE-450 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\6dYlNUUN3ME2yPE45ODlzIN88US=> NUf2SYlyW0GQR1XS
RXF393 NH32O|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rOS2lEPTB;MkmuNlkxPiEQvF2= MlqxV2FPT0WU
P30-OHK MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ7LkOwOFgh|ryP MV;TRW5ITVJ?
Ca9-22 NUm3Rpk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;1ZphzUUN3ME2yPU41Ojl7IN88US=> NYPCTWtNW0GQR1XS
RT-112 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXnTWM2OD1{OT60OlEyKM7:TR?= M{LN[nNCVkeHUh?=
ES1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXiTWM2OD1{OT64OVQ1KM7:TR?= NUXNU4ZwW0GQR1XS
HCE-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;MPIFKSzVyPUK5Mlg4QDZizszN MYDTRW5ITVJ?
AM-38 NHjZSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3zTWM2OD1|MD6wOlA3KM7:TR?= MkLkV2FPT0WU
AsPC-1 M4ntfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLLRnRKSzVyPUOwMlgxPTNizszN MYjTRW5ITVJ?
TE-9 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[4fHlKSzVyPUOwMlg4OzdizszN M4Hh[3NCVkeHUh?=
HuP-T4 NVK1elBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[4WnlEUUN3ME2zNE46PjN6IN88US=> NYPzSlg2W0GQR1XS
LB2518-MEL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYThbmN6UUN3ME2zNU4xPzR2IN88US=> M37OcnNCVkeHUh?=
NCI-H1703 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml6yTWM2OD1|MT6wPVA2KM7:TR?= M3nsNHNCVkeHUh?=
NCI-H2228 MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTpUpNyUUN3ME2zNU41PjVzIN88US=> NULRTHdSW0GQR1XS
SCC-4 NULvZmZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLDTWM2OD1|MT65NVgyKM7:TR?= M2ThVnNCVkeHUh?=
KNS-81-FD MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO0TWM2OD1|Mj6wNVI5KM7:TR?= NI[ySIxUSU6JRWK=
NTERA-S-cl-D1 NV\UVZZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LTc2lEPTB;M{KuNFc{QSEQvF2= MV3TRW5ITVJ?
Daoy NFPUOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHoRplKSzVyPUOyMlA5OzhizszN MmfMV2FPT0WU
ES4 NELWOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHpTWM2OD1|Mj6zPVIzKM7:TR?= NIrKZ3lUSU6JRWK=
MHH-ES-1 NGjMZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN{LkS4O|Ih|ryP MWnTRW5ITVJ?
C-33-A NVXyT2lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN{Lke3Nlgh|ryP NInJU|lUSU6JRWK=
BHY NGLvWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN{Lkm0PVUh|ryP M2LMUHNCVkeHUh?=
Detroit562 NYTJSGZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uz[GlEPTB;M{OuOlY2PyEQvF2= M2njcHNCVkeHUh?=
EW-1 NXPUbnhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELMdmVKSzVyPUOzMlk{OjJizszN Ml\MV2FPT0WU
NCI-H1395 M2TBRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN2LkC3PVkh|ryP MVnTRW5ITVJ?
KM-H2 NFi5botIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmroTWM2OD1|Nj60O|Q{KM7:TR?= MUTTRW5ITVJ?
NCI-H520 M2X6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIriW4hKSzVyPUO2Mlc2PDFizszN M17PeHNCVkeHUh?=
D-392MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G2cmlEPTB;M{euN|M1PCEQvF2= M12wV3NCVkeHUh?=
NOMO-1 NGP5cYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknPTWM2OD1|Nz64NFg6KM7:TR?= M3TFRXNCVkeHUh?=
TE-6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfVTWM2OD1|OD6xNlQh|ryP NEm0[oRUSU6JRWK=
HT-3 NUSw[GhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vNVGlEPTB;M{iuOFQ{PiEQvF2= MWTTRW5ITVJ?
RPMI-8226 M3vIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH0TWM2OD1|OD65OVE6KM7:TR?= MYHTRW5ITVJ?
U251 NGjzVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXWTWM2OD1|OT6wNVI1KM7:TR?= M4nFc3NCVkeHUh?=
GCT MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rNU2lEPTB;M{muNVg2OiEQvF2= MoTjV2FPT0WU
A431 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTN7LkG4PVQh|ryP NFXCZYZUSU6JRWK=
TE-12 NXPae5BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D0[WlEPTB;M{muNlQ1QCEQvF2= M3jJXHNCVkeHUh?=
HMV-II NVjJU5lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\kSIJKSzVyPUO5MlUxPDdizszN MnHzV2FPT0WU
IST-MES1 M3rCPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfZTWM2OD12MD6xOVAzKM7:TR?= MVjTRW5ITVJ?
SW13 NG\3NWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVyxdoJTUUN3ME20NE42OTlizszN M{PWOnNCVkeHUh?=
SF295 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWflPFhlUUN3ME20NE45ODZ4IN88US=> MWfTRW5ITVJ?
MDA-MB-157 NUSyOVBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3hfJU{UUN3ME20NE46PDZ{IN88US=> M1nHR3NCVkeHUh?=
TE-1 NIP0[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf4U2FHUUN3ME20NU45PzF2IN88US=> MXvTRW5ITVJ?
HuCCT1 NHzSZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnk[5FKSzVyPUSyMlUzQDlizszN NIGzZWpUSU6JRWK=
KYSE-510 NULISm94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37zWWlEPTB;NEOuNVc2PCEQvF2= MWLTRW5ITVJ?
NCI-H358 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR2LkCzNFQh|ryP MXzTRW5ITVJ?
SW900 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\LOI9KSzVyPUS0MlA4PThizszN NF35dWZUSU6JRWK=
CAS-1 NVzpZ5N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XVemlEPTB;NESuNFk6OSEQvF2= NWPlTnMzW0GQR1XS
TE-8 M3T6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK2b2hKSzVyPUS0MlU3PThizszN NGe3ZWRUSU6JRWK=
P12-ICHIKAWA NXrlSWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR2Lk[xNVIh|ryP M33UTHNCVkeHUh?=
YKG-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TiSGlEPTB;NESuO|gyKM7:TR?= MUjTRW5ITVJ?
SNU-C2B NX:1bZpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TpZ2lEPTB;NESuO|kxOyEQvF2= MnHQV2FPT0WU
LCLC-103H MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTR2Lki3NFMh|ryP MYDTRW5ITVJ?
U-87-MG NGKxN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2GwdGlEPTB;NEWuNVAzOiEQvF2= NXf5W4hrW0GQR1XS
HAL-01 M2nCe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTR3LkGzO|kh|ryP M3XaNnNCVkeHUh?=
OVCAR-8 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKwTWM2OD12NT6zOVY1KM7:TR?= NVL3WWJvW0GQR1XS
KYSE-150 NUm5d2h7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDpTWM2OD12Nz6xNFUzKM7:TR?= NYLiOJI6W0GQR1XS
OE33 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX1TWM2OD12Nz6xOFI6KM7:TR?= MWPTRW5ITVJ?
CAL-62 M1v2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrmUXNyUUN3ME20O{41ODZ6IN88US=> M1[3WHNCVkeHUh?=
TCCSUP NH:5O25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR5Lk[yOlQh|ryP MmS2V2FPT0WU
H4 M3KwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HWTmlEPTB;NEeuOlYzOSEQvF2= NF7hPVdUSU6JRWK=
CP66-MEL MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rBdmlEPTB;NEiuNFcxPCEQvF2= MkDTV2FPT0WU
SNB75 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:1S2lEPTB;NEiuNVg4PCEQvF2= MW\TRW5ITVJ?
Mo-T MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPGPIVKSzVyPUS4MlI4QSEQvF2= MYDTRW5ITVJ?
BT-549 NIK2WoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnXTWM2OD12OD6zO|I6KM7:TR?= MmXhV2FPT0WU
IGR-1 NIjyXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SwVmlEPTB;NEiuOlY1PSEQvF2= M2jzWHNCVkeHUh?=
NCI-H1299 NVTINotyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTR6LkeyOFgh|ryP NVHmSYI2W0GQR1XS
ALL-PO NVz6SYI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ORWlEPTB;NEmuPVI3QCEQvF2= MWTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

Related DNA-PK Products

Tags: buy NU7441 (KU-57788) | NU7441 (KU-57788) supplier | purchase NU7441 (KU-57788) | NU7441 (KU-57788) cost | NU7441 (KU-57788) manufacturer | order NU7441 (KU-57788) | NU7441 (KU-57788) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID