NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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6 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 M3vpc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTPTWM2OD1yLkCyNVQ{KM7:TR?= MkTUV2FPT0WU
A172 NYXTeId3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUWzNVYh|ryP Ml3rV2FPT0WU
NCI-H526 NXTUTIVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIewZWJKSzVyPUCuNlg1ODdizszN M1\hb3NCVkeHUh?=
HDLM-2 M3S4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TobWlEPTB;MD6zNlM1PSEQvF2= NVOzWYc6W0GQR1XS
HuO-3N1 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PpfWlEPTB;MD60OlY{PiEQvF2= NVXVU2pMW0GQR1XS
NCI-SNU-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXN[nZKSzVyPUCuOlA6QTRizszN MUfTRW5ITVJ?
SK-N-AS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknYTWM2OD1yLk[yNlE3KM7:TR?= NVzQdZRWW0GQR1XS
LoVo NHTWUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDLTWM2OD1yLki2O|Q6KM7:TR?= MYjTRW5ITVJ?
LAMA-84 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P5TmlEPTB;MD65PFg{OyEQvF2= NGfEPXBUSU6JRWK=
CTB-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPiSlZDUUN3ME2xMlEyPTR4IN88US=> MnLoV2FPT0WU
KP-N-YS NUi0enRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fDRWlEPTB;MT6xOFI{OSEQvF2= Mon0V2FPT0WU
HH Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFwMUiwPVMh|ryP NGC5VGtUSU6JRWK=
CHL-1 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;FOmlEPTB;MT6yNVM3QCEQvF2= MYfTRW5ITVJ?
NB7 NYP2cHV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwMkS3OFUh|ryP M{HETXNCVkeHUh?=
HL-60 M{T0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHoVZFKSzVyPUGuN|gyQSEQvF2= MYPTRW5ITVJ?
639-V M2LRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfERo9KSzVyPUGuOFQyOjhizszN MUHTRW5ITVJ?
NCI-H1793 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwNEW4OEDPxE1? NVXBO|I{W0GQR1XS
NEC8 NUH4Xlc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLO[HRKSzVyPUGuOVU{PSEQvF2= Mk\DV2FPT0WU
PA-1 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwNUiyPVQh|ryP MnzLV2FPT0WU
D-423MG MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorrTWM2OD1zLk[5N|YyKM7:TR?= MmL6V2FPT0WU
NCI-H292 M4TkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDXTWM2OD1zLke0NFE{KM7:TR?= MnTsV2FPT0WU
SK-MEL-1 NVezNmNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEThPIhKSzVyPUGuO|k1PzlizszN M{X3PHNCVkeHUh?=
LB2241-RCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\RcmlEPTB;Mj6xOFE1PiEQvF2= MUHTRW5ITVJ?
SK-MEL-3 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rxT2lEPTB;Mj6xOlQ6KM7:TR?= MlLXV2FPT0WU
MHH-PREB-1 M1nIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\xPJFlUUN3ME2yMlE3PjB7IN88US=> M33tRnNCVkeHUh?=
BFTC-905 NV7MeGk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zrT2lEPTB;Mj6xOlY5PyEQvF2= NHnWdFdUSU6JRWK=
Ramos-2G6-4C10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PhO2lEPTB;Mj6xPVkxQSEQvF2= M{PBeXNCVkeHUh?=
G-361 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXPfZRRUUN3ME2yMlIyPjhizszN NGnkTXRUSU6JRWK=
MOLT-4 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\LSItKSzVyPUKuNlE5QDhizszN M{O2O3NCVkeHUh?=
DEL NXHaTXhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\DfmlEPTB;Mj6zOVU3PCEQvF2= MY\TRW5ITVJ?
MV-4-11 M4P0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwM{ezPUDPxE1? NH3jdZhUSU6JRWK=
SK-NEP-1 NWXG[Wc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHoVJBKSzVyPUKuN|g4QDNizszN MkHNV2FPT0WU
RS4-11 M2jDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHNTWM2OD1{LkW2NFI{KM7:TR?= MUnTRW5ITVJ?
HuH-7 M2THbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TreGlEPTB;Mj61OlcxOiEQvF2= NF;rV21USU6JRWK=
A101D NVHwWmZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j4UWlEPTB;Mj62NVM{QCEQvF2= Mm[wV2FPT0WU
KG-1 M3TPNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f1ZWlEPTB;Mj62O|kzPCEQvF2= NH7XOIpUSU6JRWK=
KALS-1 M4X6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljqTWM2OD1{Lk[5OlM{KM7:TR?= M{fRTHNCVkeHUh?=
VMRC-RCZ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXFT5YzUUN3ME2yMlc4OzJ6IN88US=> NGi4ZXJUSU6JRWK=
SK-UT-1 NIfyXppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[4SI1{UUN3ME2zMlE2OzFizszN M4j6W3NCVkeHUh?=
SW962 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVroeYFUUUN3ME2zMlIxOzV{IN88US=> NGq2N3lUSU6JRWK=
DBTRG-05MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfJSWdKSzVyPUOuNlgxQDVizszN M4S5PHNCVkeHUh?=
PANC-08-13 M17jNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfYTWM2OD1|LkSxNlc5KM7:TR?= MoLqV2FPT0WU
QIMR-WIL NGXreIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTNwNEGzOFEh|ryP MYDTRW5ITVJ?
SK-MEL-30 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrRfYFKSzVyPUOuOFI2QThizszN NYPwc2c5W0GQR1XS
697 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwNES5PVMh|ryP M3XwNHNCVkeHUh?=
NY NHP6WYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLDTJNKSzVyPUOuOFUxOjJizszN NWXHc3h6W0GQR1XS
ES7 NEPwN2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\IXpFKSzVyPUOuOFY4OjlizszN MofWV2FPT0WU
JVM-3 NUXXTndxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIiwPY5KSzVyPUOuOFgxPzdizszN M2W5OXNCVkeHUh?=
U031 M4\OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTNwNUmzOlgh|ryP NEXFOllUSU6JRWK=
BHT-101 MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D6WGlEPTB;Mz61PVk5PSEQvF2= MWrTRW5ITVJ?
8305C NHPEOmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwNkG3N|Yh|ryP NVnN[G5HW0GQR1XS
MG-63 NYWyVYk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;3c2lEPTB;Mz62NlY4PiEQvF2= NE\NO2tUSU6JRWK=
NOS-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLXZoVKSzVyPUOuOlU{OTJizszN M1X2VHNCVkeHUh?=
YH-13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO3[5FKSzVyPUOuPFcyQDlizszN NXzWeoRjW0GQR1XS
LXF-289 NGXRW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTNwOUGwOFEh|ryP M{fieXNCVkeHUh?=
GOTO NGrhdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTNwOUG0PUDPxE1? MX;TRW5ITVJ?
EKVX NGHtbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXpTWM2OD12LkKyOVI1KM7:TR?= M2HxVHNCVkeHUh?=
CAL-51 M3;L[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrTTWM2OD12LkK0PFU1KM7:TR?= MWPTRW5ITVJ?
AN3-CA MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTRwMkW4NVMh|ryP MnTjV2FPT0WU
IA-LM MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrRflZoUUN3ME20MlI4QTN3IN88US=> NEXrVGVUSU6JRWK=
KU-19-19 M4ThXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXtTWM2OD12LkOyPVIyKM7:TR?= Ml\jV2FPT0WU
A704 M3HoWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXXN|BnUUN3ME20MlQxQDh6IN88US=> NWXvR2U1W0GQR1XS
RH-18 NWe2cZc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HQUmlEPTB;ND60OFk2OyEQvF2= MYfTRW5ITVJ?
IST-MEL1 MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LPW2lEPTB;ND61PFI3OyEQvF2= MUHTRW5ITVJ?
LU-134-A NYr0UHBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jxN2lEPTB;ND61PVY5PSEQvF2= MnnJV2FPT0WU
SF126 NHL5fo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LZOWlEPTB;ND62NFcyPSEQvF2= M3\NSHNCVkeHUh?=
EFO-27 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTRwNk[1NlUh|ryP M{fHfnNCVkeHUh?=
SN12C NXewc2wyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTafoJbUUN3ME20MlcyQDl6IN88US=> NVjNRmptW0GQR1XS
L-363 NWfyWplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K0R2lEPTB;ND63O|EyPiEQvF2= NV;hOI9jW0GQR1XS
MEL-HO NGO1VZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzuTWM2OD12Lke3PVg6KM7:TR?= MWTTRW5ITVJ?
TYK-nu MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfxdmdKSzVyPUSuPFAyOjhizszN MWLTRW5ITVJ?
MDA-MB-415 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vGb2lEPTB;NT6wNFMyPCEQvF2= MV\TRW5ITVJ?
HCC70 NGHnZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTVwMEO5N|kh|ryP Mnu5V2FPT0WU
IGROV-1 NEPVbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnVTWM2OD13LkK1NlkzKM7:TR?= M{n6S3NCVkeHUh?=
NCI-H1355 NF;qe4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4noSmlEPTB;NT6yPVYh|ryP M{DTZXNCVkeHUh?=
23132-87 Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK5dXJYUUN3ME21MlMzODJ2IN88US=> MVfTRW5ITVJ?
NB69 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV25XIFyUUN3ME21MlMzPDJizszN M2TRNHNCVkeHUh?=
HSC-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXCTWM2OD13LkSxO|c{KM7:TR?= MY\TRW5ITVJ?
KYSE-410 M3vRcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\VTWM2OD13LkS3OlM3KM7:TR?= M3nkXHNCVkeHUh?=
GCIY NETnOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG0RppKSzVyPUWuOVE{PzhizszN NIPSSHJUSU6JRWK=
A427 M4HPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTVwNUO2OlEh|ryP Ml;3V2FPT0WU
ChaGo-K-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rPb2lEPTB;NT61OlU6QSEQvF2= NXHwWJZqW0GQR1XS
PFSK-1 M{OzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLxVG1KSzVyPUWuOlIyQTRizszN NXTQeWVzW0GQR1XS
MLMA NITTNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv4PZBKSzVyPUWuPFM3ODZizszN NH7PZ2hUSU6JRWK=
RVH-421 NIf1VYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjWdYtKSzVyPU[uNFc{OzhizszN NH;GdVdUSU6JRWK=
LB1047-RCC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrnT5FKSzVyPU[uNVc2OjJizszN MWDTRW5ITVJ?
MHH-NB-11 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH6TWM2OD14LkOyO|IyKM7:TR?= NUnHU4piW0GQR1XS
J-RT3-T3-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnFTWM2OD14Lk[zNlkyKM7:TR?= MnXVV2FPT0WU
UM-UC-3 NGLE[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DKdGlEPTB;Nj62OFM{PCEQvF2= NFXu[nVUSU6JRWK=
IST-SL1 M3LvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYiwUGpUUUN3ME22MlY6OzZ7IN88US=> NYD3d5R5W0GQR1XS
NB14 NGHvdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTZwN{m3OlEh|ryP NFXMXlRUSU6JRWK=
NBsusSR M3zQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\4OFB[UUN3ME22MlgzPTB{IN88US=> NFzD[pdUSU6JRWK=
D-263MG MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHYc2dKSzVyPU[uPVExPjhizszN NVizR5RwW0GQR1XS
NCI-H2347 M1rubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS3TWM2OD14LkmzNlE{KM7:TR?= MXHTRW5ITVJ?
ES8 M{fIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvCUJlKSzVyPU[uPVc2QDhizszN NHPscW1USU6JRWK=
786-0 M4DuUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7PNodlUUN3ME23MlA6Pzh4IN88US=> MW\TRW5ITVJ?
EPLC-272H NH31NmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrPbINuUUN3ME23MlE3OjR4IN88US=> MoPyV2FPT0WU
CAPAN-1 M4j1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTdwMkSzOVkh|ryP MnzQV2FPT0WU
NCI-H82 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\jTWM2OD15LkK2OlU6KM7:TR?= MlTGV2FPT0WU
G-402 NX3vfIZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DhbGlEPTB;Nz6zNFA2OSEQvF2= NUfa[4ppW0GQR1XS
SW982 NYDYUpA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTdwM{CyNFMh|ryP NHHzXnFUSU6JRWK=
OVCAR-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTdwM{GzNlgh|ryP NYPJO4dxW0GQR1XS
KARPAS-299 NYCxN3pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7EZlBFUUN3ME23MlMzPjJ{IN88US=> NVTQfI84W0GQR1XS
MIA-PaCa-2 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO1W2xKSzVyPUeuN|Y5OjNizszN NFvlSppUSU6JRWK=
AU565 M1XZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLIPGlKSzVyPUeuOVk5OzNizszN M{e5W3NCVkeHUh?=
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NCI-H727 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJ{LkezOUDPxE1? M37QenNCVkeHUh?=
RD NFL5[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJ{Lke1NVgh|ryP NH:zcGhUSU6JRWK=
NCI-H522 NIq2NZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfWcHE5UUN3ME2yNk45PDNzIN88US=> MUDTRW5ITVJ?
CGTH-W-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ|LkC2OFEh|ryP M{GxS3NCVkeHUh?=
SK-LU-1 MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX2c|FKSzVyPUKzMlQ3QDNizszN MmjTV2FPT0WU
BB65-RCC M3r0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7KTWM2OD1{Mz63PFY{KM7:TR?= NXW0SJZCW0GQR1XS
HSC-3 M3zJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTqTWM2OD1{Mz64OVI4KM7:TR?= M2faZnNCVkeHUh?=
SK-MES-1 NXK2PYEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ2LkCxOlEh|ryP NIHEUWVUSU6JRWK=
DB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnSTWM2OD1{ND6xNFI5KM7:TR?= MoHlV2FPT0WU
HO-1-N-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ2LkOwPVMh|ryP NIe5fWFUSU6JRWK=
MKN1 NHWx[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPJTWM2OD1{ND62PEDPxE1? NIDGXmFUSU6JRWK=
MN-60 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLSWmRpUUN3ME2yOE45PTF7IN88US=> MmHVV2FPT0WU
8505C M37rbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[0cIxKSzVyPUK1MlE5PDVizszN MmXUV2FPT0WU
COLO-320-HSR MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jJV2lEPTB;MkWuNlIxQCEQvF2= MnzpV2FPT0WU
BB30-HNC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDKXYt7UUN3ME2yOU4zPDh|IN88US=> MVHTRW5ITVJ?
KM12 M1fIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTEOm1ZUUN3ME2yOU42QDB5IN88US=> MnLMV2FPT0WU
NB13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjaZpVkUUN3ME2yOU42QDl6IN88US=> MX\TRW5ITVJ?
HCC2998 NEHmNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ4LkCyPFMh|ryP M{Ta[HNCVkeHUh?=
U-118-MG NVvzTZJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJ4LkC4NFgh|ryP MVnTRW5ITVJ?
NB10 M17WUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly4TWM2OD1{Nj6yN|Qh|ryP M{\JenNCVkeHUh?=
SK-LMS-1 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH22[WhKSzVyPUK3MlA4ODRizszN MkLtV2FPT0WU
SW1573 Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nX[GlEPTB;MkeuNVEh|ryP MXTTRW5ITVJ?
LB373-MEL-D MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ5LkGyPVQh|ryP MV7TRW5ITVJ?
DK-MG NWOzPYtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfETWM2OD1{Nz6xPFE4KM7:TR?= M3f3TXNCVkeHUh?=
RMG-I MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ5LkKwNlkh|ryP NUf0UpluW0GQR1XS
SW1088 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPCZVNDUUN3ME2yO{42ODR{IN88US=> M4i3[HNCVkeHUh?=
SK-OV-3 NFW0Z4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlOxTWM2OD1{Nz63OVk{KM7:TR?= NGjiXFhUSU6JRWK=
KP-N-YN Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XWcWlEPTB;MkeuPFA1OyEQvF2= MUfTRW5ITVJ?
RPMI-7951 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P0dmlEPTB;MkiuNlQ2PiEQvF2= NV7GfWFSW0GQR1XS
CaR-1 NWLJenZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\Gc2lEPTB;MkiuOVU5OiEQvF2= MkXkV2FPT0WU
MKN7 NFPGelFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1f2ZWlEPTB;MkiuOVk3PCEQvF2= NF:wSY1USU6JRWK=
CHP-212 M{\XU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJ6Lke0NFEh|ryP M2PTbXNCVkeHUh?=
KYSE-450 M1zTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjWUXpKSzVyPUK4MlgxQTFizszN NGXpWYFUSU6JRWK=
RXF393 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XBTWlEPTB;MkmuNlkxPiEQvF2= MVTTRW5ITVJ?
P30-OHK NYfFfoNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nRRWlEPTB;MkmuN|A1QCEQvF2= MYPTRW5ITVJ?
Ca9-22 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrXTWM2OD1{OT60Nlk6KM7:TR?= NXfRNZpWW0GQR1XS
RT-112 M375Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ7LkS2NVEh|ryP MVHTRW5ITVJ?
ES1 MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nwfmlEPTB;MkmuPFU1PCEQvF2= NGXrNo9USU6JRWK=
HCE-4 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJ7Lki3PFYh|ryP MVfTRW5ITVJ?
AM-38 NIfufohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zLUmlEPTB;M{CuNFYxPiEQvF2= M3ywNnNCVkeHUh?=
AsPC-1 NH7pbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNyLkiwOVMh|ryP M4j2dnNCVkeHUh?=
TE-9 M4jRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTNyLki3N|ch|ryP MXLTRW5ITVJ?
HuP-T4 NHvSOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPqRZhKSzVyPUOwMlk3OzhizszN Mkm3V2FPT0WU
LB2518-MEL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\hWY11UUN3ME2zNU4xPzR2IN88US=> NUH3XI1nW0GQR1XS
NCI-H1703 NF7jV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PkUmlEPTB;M{GuNFkxPSEQvF2= NYXGPY45W0GQR1XS
NCI-H2228 NF;rT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrlV3JKSzVyPUOxMlQ3PTFizszN M2fleHNCVkeHUh?=
SCC-4 NEfnSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG4PZdKSzVyPUOxMlkyQDFizszN NFv5N|lUSU6JRWK=
KNS-81-FD NX\lNHM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXHOWdpUUN3ME2zNk4xOTJ6IN88US=> NUP5[4QzW0GQR1XS
NTERA-S-cl-D1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HpOGlEPTB;M{KuNFc{QSEQvF2= MXPTRW5ITVJ?
Daoy NVLaUJJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTPXWxMUUN3ME2zNk4xQDN6IN88US=> NVfmNmZqW0GQR1XS
ES4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fWR2lEPTB;M{KuN|kzOiEQvF2= NGPESJdUSU6JRWK=
MHH-ES-1 Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTN{LkS4O|Ih|ryP M2X5OHNCVkeHUh?=
C-33-A Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MneyTWM2OD1|Mj63O|I5KM7:TR?= MkfPV2FPT0WU
BHY NH3weI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jzSWlEPTB;M{KuPVQ6PSEQvF2= MnfuV2FPT0WU
Detroit562 M1HOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7pTWM2OD1|Mz62OlU4KM7:TR?= MoO0V2FPT0WU
EW-1 M{LnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1noPWlEPTB;M{OuPVMzOiEQvF2= MnPNV2FPT0WU
NCI-H1395 M2faPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK2TWM2OD1|ND6wO|k6KM7:TR?= Mke0V2FPT0WU
KM-H2 NIO0cW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ETWM2OD1|Nj60O|Q{KM7:TR?= NFXrTXJUSU6JRWK=
NCI-H520 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL0TWM2OD1|Nj63OVQyKM7:TR?= NH7hXWdUSU6JRWK=
D-392MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLRTWM2OD1|Nz6zN|Q1KM7:TR?= M37QW3NCVkeHUh?=
NOMO-1 NHu5NYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPjbIVVUUN3ME2zO{45ODh7IN88US=> NYHEN|FvW0GQR1XS
TE-6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorwTWM2OD1|OD6xNlQh|ryP NIrsWoNUSU6JRWK=
HT-3 M1fucmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTN6LkS0N|Yh|ryP MlixV2FPT0WU
RPMI-8226 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\wWWlEPTB;M{iuPVUyQSEQvF2= NV3leGs1W0GQR1XS
U251 NES5cHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD1TWM2OD1|OT6wNVI1KM7:TR?= MW\TRW5ITVJ?
GCT NIfodZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTN7LkG4OVIh|ryP NHzoO21USU6JRWK=
A431 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T4fmlEPTB;M{muNVg6PCEQvF2= MmHiV2FPT0WU
TE-12 NEXpOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TvO2lEPTB;M{muNlQ1QCEQvF2= NXPnVVVrW0GQR1XS
HMV-II MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN7LkWwOFch|ryP MYTTRW5ITVJ?
IST-MES1 NU\zboVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTRyLkG1NFIh|ryP Moe5V2FPT0WU
SW13 MmS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LJZWlEPTB;NECuOVE6KM7:TR?= Ml\OV2FPT0WU
SF295 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XySmlEPTB;NECuPFA3PiEQvF2= Mo\0V2FPT0WU
MDA-MB-157 M33OVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fWXmlEPTB;NECuPVQ3OiEQvF2= MoiwV2FPT0WU
TE-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\EcGlEPTB;NEGuPFcyPCEQvF2= MXzTRW5ITVJ?
HuCCT1 M2HBSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTR{LkWyPFkh|ryP NX74UmtqW0GQR1XS
KYSE-510 Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTR|LkG3OVQh|ryP NFXrRZBUSU6JRWK=
NCI-H358 NGryZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITlNHNKSzVyPUS0MlA{ODRizszN MmiwV2FPT0WU
SW900 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDPN2pKSzVyPUS0MlA4PThizszN NXrBUXFWW0GQR1XS
CAS-1 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXSeXR{UUN3ME20OE4xQTlzIN88US=> MVHTRW5ITVJ?
TE-8 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfYTJZsUUN3ME20OE42PjV6IN88US=> NHnMTFhUSU6JRWK=
P12-ICHIKAWA MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi2cXRKSzVyPUS0MlYyOTJizszN MmnHV2FPT0WU
YKG-1 M{jsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\xNVdzUUN3ME20OE44QDFizszN M{D6TXNCVkeHUh?=
SNU-C2B NVH1boVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fWWmlEPTB;NESuO|kxOyEQvF2= MlL2V2FPT0WU
LCLC-103H M{e4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7STWM2OD12ND64O|A{KM7:TR?= NWP5dWZSW0GQR1XS
U-87-MG NUjIfWpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\QTWM2OD12NT6xNFIzKM7:TR?= MXrTRW5ITVJ?
HAL-01 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\XXmlEPTB;NEWuNVM4QSEQvF2= NV7pWHRQW0GQR1XS
OVCAR-8 NGfGSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTxboVMUUN3ME20OU4{PTZ2IN88US=> M3rBPHNCVkeHUh?=
KYSE-150 Ml;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrGTHlRUUN3ME20O{4yODV{IN88US=> Ml7sV2FPT0WU
OE33 Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTR5LkG0Nlkh|ryP NIi3O29USU6JRWK=
CAL-62 NF\1SJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7LfW5FUUN3ME20O{41ODZ6IN88US=> Mn[5V2FPT0WU
TCCSUP M2\2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTR5Lk[yOlQh|ryP M1\tN3NCVkeHUh?=
H4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonWTWM2OD12Nz62OlIyKM7:TR?= M3nwNnNCVkeHUh?=
CP66-MEL M1zleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzSXYtiUUN3ME20PE4xPzB2IN88US=> NX;WfHdnW0GQR1XS
SNB75 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TFOGlEPTB;NEiuNVg4PCEQvF2= M4i0SXNCVkeHUh?=
Mo-T MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkfoF[UUN3ME20PE4zPzlizszN NHT0VY1USU6JRWK=
BT-549 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TNcWlEPTB;NEiuN|czQSEQvF2= MVjTRW5ITVJ?
IGR-1 NELwWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[4d5JKSzVyPUS4MlY3PDVizszN M2DUWXNCVkeHUh?=
NCI-H1299 M33nWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L6UGlEPTB;NEiuO|I1QCEQvF2= M2HufnNCVkeHUh?=
ALL-PO NVH0UG1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTR7LkmyOlgh|ryP NIXle5FUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID