NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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Cited by 25 Publications

6 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 M2rrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEKxOFMh|ryP NGPObFhUSU6JRWK=
A172 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXXU|VyUUN3ME2wMlE2OzF4IN88US=> MWTTRW5ITVJ?
NCI-H526 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMki0NFch|ryP MWfTRW5ITVJ?
HDLM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwM{KzOFUh|ryP MUDTRW5ITVJ?
HuO-3N1 M336Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHjdIJjUUN3ME2wMlQ3PjN4IN88US=> NU\kTmZ5W0GQR1XS
NCI-SNU-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHQU5ZRUUN3ME2wMlYxQTl2IN88US=> NFTycYNUSU6JRWK=
SK-N-AS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNkKyNVYh|ryP MYDTRW5ITVJ?
LoVo NF;wUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M134XWlEPTB;MD64Olc1QSEQvF2= MUPTRW5ITVJ?
LAMA-84 NHLxbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nl[mlEPTB;MD65PFg{OyEQvF2= NEnvTIpUSU6JRWK=
CTB-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK3R3ZYUUN3ME2xMlEyPTR4IN88US=> M165[HNCVkeHUh?=
KP-N-YS NW\GfIZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPDcmFRUUN3ME2xMlE1OjNzIN88US=> MUPTRW5ITVJ?
HH MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPoTWM2OD1zLkG4NFk{KM7:TR?= NFnyPWNUSU6JRWK=
CHL-1 M1e4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTITWM2OD1zLkKxN|Y5KM7:TR?= MnPTV2FPT0WU
NB7 M1TGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDlVWxKSzVyPUGuNlQ4PDVizszN M1TRc3NCVkeHUh?=
HL-60 NIiwenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W2UmlEPTB;MT6zPFE6KM7:TR?= MmLEV2FPT0WU
639-V M2\4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfPZ4ZYUUN3ME2xMlQ1OTJ6IN88US=> M2m5W3NCVkeHUh?=
NCI-H1793 NFW4dXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFwNEW4OEDPxE1? MkfXV2FPT0WU
NEC8 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwNUWzOUDPxE1? M4[y[HNCVkeHUh?=
PA-1 MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHmSI5RUUN3ME2xMlU5Ojl2IN88US=> NGC1fJNUSU6JRWK=
D-423MG NHPXNINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFwNkmzOlEh|ryP M1fUUnNCVkeHUh?=
NCI-H292 NFroOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrtZWVGUUN3ME2xMlc1ODF|IN88US=> NWD5R5ZOW0GQR1XS
SK-MEL-1 MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;6PGlEPTB;MT63PVQ4QSEQvF2= MWjTRW5ITVJ?
LB2241-RCC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzQV3pEUUN3ME2yMlE1OTR4IN88US=> NYDEbm9MW0GQR1XS
SK-MEL-3 NHHacZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwMU[0PUDPxE1? MX3TRW5ITVJ?
MHH-PREB-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\EPFRtUUN3ME2yMlE3PjB7IN88US=> M{jwWnNCVkeHUh?=
BFTC-905 MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJwMU[2PFch|ryP MoDTV2FPT0WU
Ramos-2G6-4C10 NUTJXopbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zoN2lEPTB;Mj6xPVkxQSEQvF2= NY\LXIkxW0GQR1XS
G-361 M3f6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkOzTWM2OD1{LkKxOlgh|ryP NVHQd4dRW0GQR1XS
MOLT-4 M4L1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rIfWlEPTB;Mj6yNVg5QCEQvF2= NYT5W5dmW0GQR1XS
DEL NIrBRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTIOGpqUUN3ME2yMlM2PTZ2IN88US=> NEjYZ29USU6JRWK=
MV-4-11 M4\XTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqzRppsUUN3ME2yMlM4OzlizszN M3;GfXNCVkeHUh?=
SK-NEP-1 NIS0UW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK0WJZKSzVyPUKuN|g4QDNizszN M13JXHNCVkeHUh?=
RS4-11 MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHx[nBIUUN3ME2yMlU3ODJ|IN88US=> NX2yd2p4W0GQR1XS
HuH-7 M4jqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYKwXo9oUUN3ME2yMlU3PzB{IN88US=> MY\TRW5ITVJ?
A101D NGrPbllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M130RmlEPTB;Mj62NVM{QCEQvF2= MUjTRW5ITVJ?
KG-1 MkfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[zTWM2OD1{Lk[3PVI1KM7:TR?= NHvwe3hUSU6JRWK=
KALS-1 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm2TWM2OD1{Lk[5OlM{KM7:TR?= MlG0V2FPT0WU
VMRC-RCZ MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fo[mlEPTB;Mj63O|MzQCEQvF2= NES4W2VUSU6JRWK=
SK-UT-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPqV2FUUUN3ME2zMlE2OzFizszN NXrG[JBDW0GQR1XS
SW962 MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:wTWM2OD1|LkKwN|UzKM7:TR?= NHy0XGNUSU6JRWK=
DBTRG-05MG NWDpfY5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\yTWM2OD1|LkK4NFg2KM7:TR?= Mn3tV2FPT0WU
PANC-08-13 M4rmT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TCW2lEPTB;Mz60NVI4QCEQvF2= MoPHV2FPT0WU
QIMR-WIL NITsV2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnIXmhKSzVyPUOuOFE{PDFizszN M3zDOHNCVkeHUh?=
SK-MEL-30 M1HEcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Py[WlEPTB;Mz60NlU6QCEQvF2= MVPTRW5ITVJ?
697 M4HMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwNES5PVMh|ryP MVzTRW5ITVJ?
NY NGfGZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnve|VVUUN3ME2zMlQ2ODJ{IN88US=> M4jMOHNCVkeHUh?=
ES7 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfPVYxKSzVyPUOuOFY4OjlizszN Mnj2V2FPT0WU
JVM-3 NWLXZWhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPB[oJKSzVyPUOuOFgxPzdizszN MorFV2FPT0WU
U031 NEPmOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjzTWM2OD1|LkW5N|Y5KM7:TR?= M37sXHNCVkeHUh?=
BHT-101 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPpSVVmUUN3ME2zMlU6QTh3IN88US=> M{K3[XNCVkeHUh?=
8305C MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrrdoxKSzVyPUOuOlE4OzZizszN M1HMVHNCVkeHUh?=
MG-63 NVO1NYNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTNwNkK2O|Yh|ryP NXrRdHh5W0GQR1XS
NOS-1 M1HVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjFTWM2OD1|Lk[1N|EzKM7:TR?= M2GxbnNCVkeHUh?=
YH-13 NUfaVIwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNwOEexPFkh|ryP NIK0N3VUSU6JRWK=
LXF-289 NFznU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTNwOUGwOFEh|ryP NIKyNWNUSU6JRWK=
GOTO MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTNwOUG0PUDPxE1? MWfTRW5ITVJ?
EKVX Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j2TmlEPTB;ND6yNlUzPCEQvF2= MUTTRW5ITVJ?
CAL-51 M4DhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXob3FjUUN3ME20MlI1QDV2IN88US=> NHXTb3ZUSU6JRWK=
AN3-CA NH\pdmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;3NWlEPTB;ND6yOVgyOyEQvF2= NIKxbYtUSU6JRWK=
IA-LM NYTrPJF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv3O3RCUUN3ME20MlI4QTN3IN88US=> NYLnVlNQW0GQR1XS
KU-19-19 M4PKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;RXIZKSzVyPUSuN|I6OjFizszN NGHMW|JUSU6JRWK=
A704 NF65NVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S5PGlEPTB;ND60NFg5QCEQvF2= MmPKV2FPT0WU
RH-18 NWHZZY1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRwNES5OVMh|ryP NXqwV|BTW0GQR1XS
IST-MEL1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TBVWlEPTB;ND61PFI3OyEQvF2= NEC0eYlUSU6JRWK=
LU-134-A MmDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTRwNUm2PFUh|ryP MkjjV2FPT0WU
SF126 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[z[3Q2UUN3ME20MlYxPzF3IN88US=> NIjsUppUSU6JRWK=
EFO-27 M3LHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HkemlEPTB;ND62OlUzPSEQvF2= MYLTRW5ITVJ?
SN12C NX;6XYNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTRwN{G4PVgh|ryP NGn0fmlUSU6JRWK=
L-363 M4P2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTRwN{exNVYh|ryP NF:1OlFUSU6JRWK=
MEL-HO M3;Sb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r6T2lEPTB;ND63O|k5QSEQvF2= NV3FTIdNW0GQR1XS
TYK-nu NGXpfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jINmlEPTB;ND64NFEzQCEQvF2= MX\TRW5ITVJ?
MDA-MB-415 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfpPYVKSzVyPUWuNFA{OTRizszN NGTuZldUSU6JRWK=
HCC70 NH7kVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TRVWlEPTB;NT6wN|k{QSEQvF2= MWDTRW5ITVJ?
IGROV-1 NFLhXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTVwMkWyPVIh|ryP MnPOV2FPT0WU
NCI-H1355 MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPhTWM2OD13LkK5OkDPxE1? MWjTRW5ITVJ?
23132-87 NXHYcox4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fZfmlEPTB;NT6zNlAzPCEQvF2= NYrPS2tQW0GQR1XS
NB69 MonmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT2NlJvUUN3ME21MlMzPDJizszN MkPOV2FPT0WU
HSC-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTVwNEG3O|Mh|ryP NFr5fI1USU6JRWK=
KYSE-410 NX\h[mxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD13LkS3OlM3KM7:TR?= NXXOfldvW0GQR1XS
GCIY MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLXWWhLUUN3ME21MlUyOzd6IN88US=> NF\RVoNUSU6JRWK=
A427 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTVwNUO2OlEh|ryP M4Pt[nNCVkeHUh?=
ChaGo-K-1 M1vUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTVwNU[1PVkh|ryP NYXn[WI3W0GQR1XS
PFSK-1 NES2XphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTVwNkKxPVQh|ryP M3m3cnNCVkeHUh?=
MLMA M4rnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:3ZmlEPTB;NT64N|YxPiEQvF2= MWXTRW5ITVJ?
RVH-421 NXrq[FdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XnfGlEPTB;Nj6wO|M{QCEQvF2= MkfWV2FPT0WU
LB1047-RCC NGXCeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HkcGlEPTB;Nj6xO|UzOiEQvF2= NIfGN2xUSU6JRWK=
MHH-NB-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vxfWlEPTB;Nj6zNlczOSEQvF2= NX\Fb|RIW0GQR1XS
J-RT3-T3-5 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPqOHJKSzVyPU[uOlMzQTFizszN MonqV2FPT0WU
UM-UC-3 NIjCdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\IWZlKSzVyPU[uOlQ{OzRizszN MYXTRW5ITVJ?
IST-SL1 Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjCNVY1UUN3ME22MlY6OzZ7IN88US=> M1O5ZXNCVkeHUh?=
NB14 M3[xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fhT2lEPTB;Nj63PVc3OSEQvF2= NXq4NWJOW0GQR1XS
NBsusSR MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHoSIpKSzVyPU[uPFI2ODJizszN M13ic3NCVkeHUh?=
D-263MG NXPMWY1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTZwOUGwOlgh|ryP MmnyV2FPT0WU
NCI-H2347 Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3DTWM2OD14LkmzNlE{KM7:TR?= MVzTRW5ITVJ?
ES8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTZwOUe1PFgh|ryP MnjvV2FPT0WU
786-0 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPxR|NUUUN3ME23MlA6Pzh4IN88US=> NF;hXYNUSU6JRWK=
EPLC-272H NFrvUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLVTWM2OD15LkG2NlQ3KM7:TR?= NHG2VnZUSU6JRWK=
CAPAN-1 M1PhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTdwMkSzOVkh|ryP M1TRNHNCVkeHUh?=
NCI-H82 M2\nbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTdwMk[2OVkh|ryP M2r6WnNCVkeHUh?=
G-402 M3zTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTdwM{CwOVEh|ryP M1TlWHNCVkeHUh?=
SW982 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3ZTWM2OD15LkOwNlA{KM7:TR?= MXHTRW5ITVJ?
OVCAR-4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT1d2lKSzVyPUeuN|E{OjhizszN MkG5V2FPT0WU
KARPAS-299 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq0e5hKSzVyPUeuN|I3OjJizszN M13mcHNCVkeHUh?=
MIA-PaCa-2 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorwTWM2OD15LkO2PFI{KM7:TR?= NGjqdGpUSU6JRWK=
AU565 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX6Z2tKSzVyPUeuOVk5OzNizszN MYTTRW5ITVJ?
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SJSA-1 NIXle3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnVT3hMUUN3ME2yNE42Pjh6IN88US=> MVjTRW5ITVJ?
RCC10RGB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJyLk[3NVkh|ryP NVfJOIhtW0GQR1XS
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HLE MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ{Lk[5O{DPxE1? MlL6V2FPT0WU
NCI-H727 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrVTJBKSzVyPUKyMlc{PSEQvF2= MoflV2FPT0WU
RD MmLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXmTWM2OD1{Mj63OVE5KM7:TR?= MmjBV2FPT0WU
NCI-H522 NVLCe41zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DxO2lEPTB;MkKuPFQ{OSEQvF2= MknRV2FPT0WU
CGTH-W-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJ|LkC2OFEh|ryP NVX1T4NrW0GQR1XS
SK-LU-1 M4nsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{noXWlEPTB;MkOuOFY5OyEQvF2= NXy5SHNmW0GQR1XS
BB65-RCC MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnYUHg{UUN3ME2yN{44QDZ|IN88US=> M{\GUnNCVkeHUh?=
HSC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\oemlEPTB;MkOuPFUzPyEQvF2= MUPTRW5ITVJ?
SK-MES-1 M{Pud2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTTXo1WUUN3ME2yOE4xOTZzIN88US=> NHOybpBUSU6JRWK=
DB NILDbYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrjdnpKSzVyPUK0MlExOjhizszN MU\TRW5ITVJ?
HO-1-N-1 NV\uVolPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2flSmlEPTB;MkSuN|A6OyEQvF2= NEK0bpNUSU6JRWK=
MKN1 M1Phdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ2Lk[4JO69VQ>? NWLCUoE{W0GQR1XS
MN-60 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTKTWM2OD1{ND64OVE6KM7:TR?= Mlz4V2FPT0WU
8505C Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ3LkG4OFUh|ryP M{Lwc3NCVkeHUh?=
COLO-320-HSR NEjyc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m2eGlEPTB;MkWuNlIxQCEQvF2= MWjTRW5ITVJ?
BB30-HNC M4jnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PGPWlEPTB;MkWuNlQ5OyEQvF2= MnrhV2FPT0WU
KM12 M2GzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ3LkW4NFch|ryP NV71XpVkW0GQR1XS
NB13 M3e5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r1R2lEPTB;MkWuOVg6QCEQvF2= NVTrOG17W0GQR1XS
HCC2998 M{W5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT4WHhvUUN3ME2yOk4xOjh|IN88US=> M4DQfHNCVkeHUh?=
U-118-MG NY\E[pVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojRTWM2OD1{Nj6wPFA5KM7:TR?= NH;tUJRUSU6JRWK=
NB10 NFT3fZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y0emlEPTB;Mk[uNlM1KM7:TR?= NUXLTGQ6W0GQR1XS
SK-LMS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX6fphKSzVyPUK3MlA4ODRizszN M1vwXnNCVkeHUh?=
SW1573 M1f6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDKTWM2OD1{Nz6xNUDPxE1? MnzCV2FPT0WU
LB373-MEL-D NGnuWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPoeotNUUN3ME2yO{4yOjl2IN88US=> M2HTOHNCVkeHUh?=
DK-MG MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ5LkG4NVch|ryP NF36SWNUSU6JRWK=
RMG-I MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi4NFlnUUN3ME2yO{4zODJ7IN88US=> MoOxV2FPT0WU
SW1088 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\WTWM2OD1{Nz61NFQzKM7:TR?= NV3QWWxZW0GQR1XS
SK-OV-3 MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nXV2lEPTB;MkeuO|U6OyEQvF2= M4nRRXNCVkeHUh?=
KP-N-YN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HXbGlEPTB;MkeuPFA1OyEQvF2= MWnTRW5ITVJ?
RPMI-7951 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jkZmlEPTB;MkiuNlQ2PiEQvF2= Mo[2V2FPT0WU
CaR-1 NYLTZVZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPjfIpZUUN3ME2yPE42PTh{IN88US=> M33wb3NCVkeHUh?=
MKN7 NVLuZmxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrsU3hKSzVyPUK4MlU6PjRizszN NXjxXpNiW0GQR1XS
CHP-212 M{HuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ6Lke0NFEh|ryP NYrPUpBZW0GQR1XS
KYSE-450 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXLTWM2OD1{OD64NFkyKM7:TR?= M3rNN3NCVkeHUh?=
RXF393 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJ7LkK5NFYh|ryP M1u2RnNCVkeHUh?=
P30-OHK Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfzXFlKSzVyPUK5MlMxPDhizszN MoDoV2FPT0WU
Ca9-22 NFj3OJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli0TWM2OD1{OT60Nlk6KM7:TR?= MkXDV2FPT0WU
RT-112 NVnvNnN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDS[2JzUUN3ME2yPU41PjFzIN88US=> MoO1V2FPT0WU
ES1 NHOxOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3vTodjUUN3ME2yPU45PTR2IN88US=> MVrTRW5ITVJ?
HCE-4 NV7BN4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfu[JZ{UUN3ME2yPU45Pzh4IN88US=> MXjTRW5ITVJ?
AM-38 NGfQfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TJemlEPTB;M{CuNFYxPiEQvF2= NH;wN4tUSU6JRWK=
AsPC-1 MmLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjzN4d{UUN3ME2zNE45ODV|IN88US=> NYTpdGhnW0GQR1XS
TE-9 NETQN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[zTWM2OD1|MD64O|M4KM7:TR?= M1XGRXNCVkeHUh?=
HuP-T4 NHraVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[3RnBRUUN3ME2zNE46PjN6IN88US=> Mlj6V2FPT0WU
LB2518-MEL NGDpO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTNzLkC3OFQh|ryP MVvTRW5ITVJ?
NCI-H1703 NIWzVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\q[oFKSzVyPUOxMlA6ODVizszN MkXRV2FPT0WU
NCI-H2228 NVnSZ|BsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHMcINKSzVyPUOxMlQ3PTFizszN MU\TRW5ITVJ?
SCC-4 NX3K[3Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNzLkmxPFEh|ryP NFnlWZRUSU6JRWK=
KNS-81-FD M1fRRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXZTWM2OD1|Mj6wNVI5KM7:TR?= MlXuV2FPT0WU
NTERA-S-cl-D1 NGDqcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37jd2lEPTB;M{KuNFc{QSEQvF2= MYHTRW5ITVJ?
Daoy MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTVTHVKSzVyPUOyMlA5OzhizszN NUjZeJZNW0GQR1XS
ES4 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnOfJY1UUN3ME2zNk4{QTJ{IN88US=> NH;wXGNUSU6JRWK=
MHH-ES-1 NIT3OZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN{LkS4O|Ih|ryP Mom2V2FPT0WU
C-33-A MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17hXGlEPTB;M{KuO|czQCEQvF2= NVzKWY5lW0GQR1XS
BHY MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlztTWM2OD1|Mj65OFk2KM7:TR?= MmfxV2FPT0WU
Detroit562 NXnmTZBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Ljd2lEPTB;M{OuOlY2PyEQvF2= NHfocWtUSU6JRWK=
EW-1 M1raV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrlTWM2OD1|Mz65N|IzKM7:TR?= M3PoSXNCVkeHUh?=
NCI-H1395 NYXucIVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm0TGpvUUN3ME2zOE4xPzl7IN88US=> M{XIWnNCVkeHUh?=
KM-H2 NYXIfGRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorUTWM2OD1|Nj60O|Q{KM7:TR?= NWXwbVJ2W0GQR1XS
NCI-H520 NYTSeZRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3wUlNFUUN3ME2zOk44PTRzIN88US=> NELHWHZUSU6JRWK=
D-392MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\6SWlEPTB;M{euN|M1PCEQvF2= NHGzfItUSU6JRWK=
NOMO-1 MnrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvHPI1XUUN3ME2zO{45ODh7IN88US=> MlHaV2FPT0WU
TE-6 NGLZ[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jxcmlEPTB;M{iuNVI1KM7:TR?= NED4OYNUSU6JRWK=
HT-3 M4HsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTN6LkS0N|Yh|ryP MVrTRW5ITVJ?
RPMI-8226 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\Ue2lEPTB;M{iuPVUyQSEQvF2= MlyyV2FPT0WU
U251 NF3YdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjiNoFKSzVyPUO5MlAyOjRizszN NXrOeFhQW0GQR1XS
GCT NHH6eIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;od2lEPTB;M{muNVg2OiEQvF2= MWjTRW5ITVJ?
A431 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTN7LkG4PVQh|ryP M1H1dXNCVkeHUh?=
TE-12 M4myV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;2TWM2OD1|OT6yOFQ5KM7:TR?= Mnr6V2FPT0WU
HMV-II MmqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTN7LkWwOFch|ryP NHHkboJUSU6JRWK=
IST-MES1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTRyLkG1NFIh|ryP MlTwV2FPT0WU
SW13 NGXW[GxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrwRlZ5UUN3ME20NE42OTlizszN M{L2[3NCVkeHUh?=
SF295 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;aR4JKSzVyPUSwMlgxPjZizszN NYXJcZRVW0GQR1XS
MDA-MB-157 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDNPG9vUUN3ME20NE46PDZ{IN88US=> NYjkSHoyW0GQR1XS
TE-1 NEfxfYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmwTIp2UUN3ME20NU45PzF2IN88US=> MV3TRW5ITVJ?
HuCCT1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\YTWM2OD12Mj61Nlg6KM7:TR?= M4XBZXNCVkeHUh?=
KYSE-510 NUjRSI56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\VeXJKSzVyPUSzMlE4PTRizszN MVTTRW5ITVJ?
NCI-H358 NIrDTYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXwc5dKSzVyPUS0MlA{ODRizszN MnHjV2FPT0WU
SW900 MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGSxRYpKSzVyPUS0MlA4PThizszN MX\TRW5ITVJ?
CAS-1 NInrN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvGTWM2OD12ND6wPVkyKM7:TR?= MnXWV2FPT0WU
TE-8 NEfpRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLMTWM2OD12ND61OlU5KM7:TR?= MUfTRW5ITVJ?
P12-ICHIKAWA MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjpdo1KSzVyPUS0MlYyOTJizszN NVfGdppuW0GQR1XS
YKG-1 MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofLTWM2OD12ND63PFEh|ryP MmH6V2FPT0WU
SNU-C2B NFjmOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrrWVVKSzVyPUS0Mlc6ODNizszN Mny1V2FPT0WU
LCLC-103H M3nBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq1TWM2OD12ND64O|A{KM7:TR?= MVXTRW5ITVJ?
U-87-MG NGq3VYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTxTWM2OD12NT6xNFIzKM7:TR?= MlPoV2FPT0WU
HAL-01 NHP0eXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLqTWM2OD12NT6xN|c6KM7:TR?= Mm\RV2FPT0WU
OVCAR-8 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC0[Wh1UUN3ME20OU4{PTZ2IN88US=> MoH6V2FPT0WU
KYSE-150 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ex[GlEPTB;NEeuNVA2OiEQvF2= Ml23V2FPT0WU
OE33 NHPOdZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[0dJRKSzVyPUS3MlE1OjlizszN NHn5PYFUSU6JRWK=
CAL-62 NXfaXVRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[1PI4yUUN3ME20O{41ODZ6IN88US=> MYDTRW5ITVJ?
TCCSUP MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX6TWM2OD12Nz62NlY1KM7:TR?= NHm4O4dUSU6JRWK=
H4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDZWVlKSzVyPUS3MlY3OjFizszN NYKyWpVJW0GQR1XS
CP66-MEL MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LzemlEPTB;NEiuNFcxPCEQvF2= NUDGW5lmW0GQR1XS
SNB75 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTR6LkG4O|Qh|ryP MVXTRW5ITVJ?
Mo-T MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLBb3dEUUN3ME20PE4zPzlizszN NIjzT5VUSU6JRWK=
BT-549 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHziTmZKSzVyPUS4MlM4OjlizszN MVHTRW5ITVJ?
IGR-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv5ZphKSzVyPUS4MlY3PDVizszN NELUfHFUSU6JRWK=
NCI-H1299 NUn6O|RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPxeXd4UUN3ME20PE44OjR6IN88US=> NF\tNVBUSU6JRWK=
ALL-PO M2[zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\rTWM2OD12OT65NlY5KM7:TR?= NGO2SVBUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID