NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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Cited by 86 Publications

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTEfoQ4UUN3ME2wMlAzOTR|IN88US=> MmqyV2FPT0WU
A172 NGXWU4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\nXYNvUUN3ME2wMlE2OzF4IN88US=> M4nqPXNCVkeHUh?=
NCI-H526 MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEToUpVKSzVyPUCuNlg1ODdizszN M1PqOnNCVkeHUh?=
HDLM-2 M4DvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;sUmdKSzVyPUCuN|I{PDVizszN MVTTRW5ITVJ?
HuO-3N1 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNE[2N|Yh|ryP NIXIR2pUSU6JRWK=
NCI-SNU-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu3SGg6UUN3ME2wMlYxQTl2IN88US=> M121dXNCVkeHUh?=
SK-N-AS M3zYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljuTWM2OD1yLk[yNlE3KM7:TR?= MlfiV2FPT0WU
LoVo NWPPW|R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu2TWM2OD1yLki2O|Q6KM7:TR?= M2DQ[nNCVkeHUh?=
LAMA-84 NX7GU2RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\yWpVWUUN3ME2wMlk5QDN|IN88US=> M3rQbHNCVkeHUh?=
CTB-1 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHrTWM2OD1zLkGxOVQ3KM7:TR?= NV\H[mlKW0GQR1XS
KP-N-YS MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHNNGZtUUN3ME2xMlE1OjNzIN88US=> NWHzfHM1W0GQR1XS
HH NUC0VJQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV76WINRUUN3ME2xMlE5ODl|IN88US=> MoqyV2FPT0WU
CHL-1 MnGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLzTlN4UUN3ME2xMlIyOzZ6IN88US=> MofKV2FPT0WU
NB7 NWXNXoRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvJNpUzUUN3ME2xMlI1PzR3IN88US=> NIXH[3RUSU6JRWK=
HL-60 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF70ZpNKSzVyPUGuN|gyQSEQvF2= MVrTRW5ITVJ?
639-V NXu2R4NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTFwNESxNlgh|ryP NXOwd3E1W0GQR1XS
NCI-H1793 MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFwNEW4OEDPxE1? NGDI[2tUSU6JRWK=
NEC8 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fTfmlEPTB;MT61OVM2KM7:TR?= NGXFcVZUSU6JRWK=
PA-1 M4nYdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfrTWM2OD1zLkW4Nlk1KM7:TR?= MkjiV2FPT0WU
D-423MG NHzKS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBNmlEPTB;MT62PVM3OSEQvF2= MkTPV2FPT0WU
NCI-H292 M2PhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i0TWlEPTB;MT63OFAyOyEQvF2= NXvkWG57W0GQR1XS
SK-MEL-1 NYnlXWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37KemlEPTB;MT63PVQ4QSEQvF2= MV\TRW5ITVJ?
LB2241-RCC NE\XUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r3VWlEPTB;Mj6xOFE1PiEQvF2= M13iXXNCVkeHUh?=
SK-MEL-3 NITKOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJwMU[0PUDPxE1? MoLmV2FPT0WU
MHH-PREB-1 NVezcJRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlezTWM2OD1{LkG2OlA6KM7:TR?= MX\TRW5ITVJ?
BFTC-905 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJwMU[2PFch|ryP NHLnXHBUSU6JRWK=
Ramos-2G6-4C10 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPXZ3RKSzVyPUKuNVk6ODlizszN NHPKOpJUSU6JRWK=
G-361 MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPUWldKSzVyPUKuNlE3QCEQvF2= NHrkRoJUSU6JRWK=
MOLT-4 NESyTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwMkG4PFgh|ryP M4TUPHNCVkeHUh?=
DEL NHSwVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjiOYc4UUN3ME2yMlM2PTZ2IN88US=> M1jnT3NCVkeHUh?=
MV-4-11 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nmfWlEPTB;Mj6zO|M6KM7:TR?= NFezVpVUSU6JRWK=
SK-NEP-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJwM{i3PFMh|ryP MWnTRW5ITVJ?
RS4-11 M1;icGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwNU[wNlMh|ryP NFr2[IxUSU6JRWK=
HuH-7 Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi2SYFwUUN3ME2yMlU3PzB{IN88US=> NVzuS4ZWW0GQR1XS
A101D MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPBbVhNUUN3ME2yMlYyOzN6IN88US=> MX3TRW5ITVJ?
KG-1 NU\zT3g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwNke5NlQh|ryP MVXTRW5ITVJ?
KALS-1 M2LWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zDfWlEPTB;Mj62PVY{OyEQvF2= Mo[wV2FPT0WU
VMRC-RCZ NU\IVIlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwN{ezNlgh|ryP NEPmeJhUSU6JRWK=
SK-UT-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jFOmlEPTB;Mz6xOVMyKM7:TR?= Mm\kV2FPT0WU
SW962 NHHEbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\QWGlEPTB;Mz6yNFM2OiEQvF2= NI\GT4RUSU6JRWK=
DBTRG-05MG MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTNwMkiwPFUh|ryP NWD0[odvW0GQR1XS
PANC-08-13 NYK1SndTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS4TWM2OD1|LkSxNlc5KM7:TR?= MU\TRW5ITVJ?
QIMR-WIL MmP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O5VWlEPTB;Mz60NVM1OSEQvF2= NIrtS2ZUSU6JRWK=
SK-MEL-30 NHW3TIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTNwNEK1PVgh|ryP NIXvOYtUSU6JRWK=
697 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn0RllKSzVyPUOuOFQ6QTNizszN MkDuV2FPT0WU
NY MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\tTWM2OD1|LkS1NFIzKM7:TR?= NHrRVFRUSU6JRWK=
ES7 M3n4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwNE[3Nlkh|ryP NYHPO5JLW0GQR1XS
JVM-3 M13Qd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTNwNEiwO|ch|ryP M1;WcnNCVkeHUh?=
U031 NVz2fWd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH76V4VKSzVyPUOuOVk{PjhizszN NWPjN2N6W0GQR1XS
BHT-101 NULSemU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjBe3dKSzVyPUOuOVk6QDVizszN M3TRSnNCVkeHUh?=
8305C NVzNUo9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNwNkG3N|Yh|ryP MlHHV2FPT0WU
MG-63 NXu0SVNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3rTYd2UUN3ME2zMlYzPjd4IN88US=> MlriV2FPT0WU
NOS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn1eZRKSzVyPUOuOlU{OTJizszN Mmj1V2FPT0WU
YH-13 MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNwOEexPFkh|ryP M1;RU3NCVkeHUh?=
LXF-289 NYnIXJY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m3[WlEPTB;Mz65NVA1OSEQvF2= MlPuV2FPT0WU
GOTO M3yw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjVTWM2OD1|LkmxOFkh|ryP MYjTRW5ITVJ?
EKVX MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\p[XlKSzVyPUSuNlI2OjRizszN NG\ZV|hUSU6JRWK=
CAL-51 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf6ZYRKSzVyPUSuNlQ5PTRizszN MlfFV2FPT0WU
AN3-CA NGDIXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwMkW4NVMh|ryP MmXhV2FPT0WU
IA-LM NWrQVHRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHl[VBnUUN3ME20MlI4QTN3IN88US=> NYK2XlZVW0GQR1XS
KU-19-19 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLjdJFUUUN3ME20MlMzQTJzIN88US=> M2HZN3NCVkeHUh?=
A704 NHq5cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTRwNEC4PFgh|ryP M2XEOXNCVkeHUh?=
RH-18 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnuxTWM2OD12LkS0PVU{KM7:TR?= MXfTRW5ITVJ?
IST-MEL1 NEHCRnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTRwNUiyOlMh|ryP MnLlV2FPT0WU
LU-134-A NU\PXnNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvVS2hKSzVyPUSuOVk3QDVizszN NVOxRXc3W0GQR1XS
SF126 NInpfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fpWmlEPTB;ND62NFcyPSEQvF2= MV3TRW5ITVJ?
EFO-27 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTRwNk[1NlUh|ryP MnWyV2FPT0WU
SN12C NYTGTXc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2xXmFHUUN3ME20MlcyQDl6IN88US=> NVzublNXW0GQR1XS
L-363 NECyO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D1eWlEPTB;ND63O|EyPiEQvF2= NH6xR3RUSU6JRWK=
MEL-HO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzjTWM2OD12Lke3PVg6KM7:TR?= NVO2fY5zW0GQR1XS
TYK-nu MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu2O3ZKSzVyPUSuPFAyOjhizszN NUfYWohrW0GQR1XS
MDA-MB-415 NF;o[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTVwMECzNVQh|ryP MVLTRW5ITVJ?
HCC70 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTVwMEO5N|kh|ryP MkjBV2FPT0WU
IGROV-1 M4DoWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTVwMkWyPVIh|ryP MXLTRW5ITVJ?
NCI-H1355 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTVwMkm2JO69VQ>? MVnTRW5ITVJ?
23132-87 NIDEcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPrTWM2OD13LkOyNFI1KM7:TR?= MnjEV2FPT0WU
NB69 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfkTWM2OD13LkOyOFIh|ryP NXmxcGcxW0GQR1XS
HSC-2 NVPSRXBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTVwNEG3O|Mh|ryP NHf1cHNUSU6JRWK=
KYSE-410 NITGbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P2d2lEPTB;NT60O|Y{PiEQvF2= MXnTRW5ITVJ?
GCIY NX\Fd5ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3jeHhDUUN3ME21MlUyOzd6IN88US=> NUe3fYs3W0GQR1XS
A427 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\OZ3JZUUN3ME21MlU{PjZzIN88US=> M4HRe3NCVkeHUh?=
ChaGo-K-1 NX\sdXNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTvTWM2OD13LkW2OVk6KM7:TR?= Mm\SV2FPT0WU
PFSK-1 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHzUGZVUUN3ME21MlYzOTl2IN88US=> MmfzV2FPT0WU
MLMA MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3nTWM2OD13LkizOlA3KM7:TR?= MXrTRW5ITVJ?
RVH-421 NEDLRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTZwMEezN|gh|ryP MU\TRW5ITVJ?
LB1047-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T2U2lEPTB;Nj6xO|UzOiEQvF2= NUTDO5J2W0GQR1XS
MHH-NB-11 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrETWM2OD14LkOyO|IyKM7:TR?= MoPZV2FPT0WU
J-RT3-T3-5 M1XLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fPUWlEPTB;Nj62N|I6OSEQvF2= MnvpV2FPT0WU
UM-UC-3 NUHJXI9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHMTWM2OD14Lk[0N|M1KM7:TR?= NY\XNmI2W0GQR1XS
IST-SL1 Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjZfmxKSzVyPU[uOlk{PjlizszN Mn;wV2FPT0WU
NB14 MmPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPuTWM2OD14Lke5O|YyKM7:TR?= NWDOVXhvW0GQR1XS
NBsusSR MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTSVlZsUUN3ME22MlgzPTB{IN88US=> M2Cxb3NCVkeHUh?=
D-263MG NHHpU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfvUG9jUUN3ME22MlkyODZ6IN88US=> M1:4TXNCVkeHUh?=
NCI-H2347 MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFyyWZVKSzVyPU[uPVMzOTNizszN M2nwWXNCVkeHUh?=
ES8 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTZwOUe1PFgh|ryP NWrEXYRTW0GQR1XS
786-0 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\qUZlWUUN3ME23MlA6Pzh4IN88US=> Ml;5V2FPT0WU
EPLC-272H MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj5NWRKSzVyPUeuNVYzPDZizszN MmH0V2FPT0WU
CAPAN-1 NVnx[Wx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LVemlEPTB;Nz6yOFM2QSEQvF2= MnXnV2FPT0WU
NCI-H82 NE\KNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPxcXNIUUN3ME23MlI3PjV7IN88US=> MojmV2FPT0WU
G-402 M3joWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHofIlKSzVyPUeuN|AxPTFizszN NGG1fo5USU6JRWK=
SW982 M1TzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nlemlEPTB;Nz6zNFIxOyEQvF2= MVHTRW5ITVJ?
OVCAR-4 NFftXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrnTWM2OD15LkOxN|I5KM7:TR?= NUPZVYNGW0GQR1XS
KARPAS-299 NXe2PXNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXVTWM2OD15LkOyOlIzKM7:TR?= NVj3NWNpW0GQR1XS
MIA-PaCa-2 NULofGZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnj[HVKSzVyPUeuN|Y5OjNizszN NF\PbXVUSU6JRWK=
AU565 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTdwNUm4N|Mh|ryP MV7TRW5ITVJ?
GAMG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv6So1KSzVyPUeuOlQyOzFizszN Ml\iV2FPT0WU
HuO9 NXrrOWNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTdwN{G3OFMh|ryP MoDWV2FPT0WU
ACN MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTdwN{SzN{DPxE1? MnG5V2FPT0WU
RO82-W-1 NVu4VItST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xh[mlEPTB;Nz63OFU{OyEQvF2= NF:5PZFUSU6JRWK=
NKM-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELsOGFKSzVyPUeuO|Q6PTVizszN NX7qNnBIW0GQR1XS
CAL-12T M37ZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoToTWM2OD15Lkm0N|UzKM7:TR?= MXHTRW5ITVJ?
FADU NFS1XZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTsTWM2OD16LkCzOlU1KM7:TR?= M3P0TXNCVkeHUh?=
NCI-H28 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomzTWM2OD16LkG2PVYzKM7:TR?= MVLTRW5ITVJ?
LCLC-97TM1 NIr4PGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXNToIyUUN3ME24MlIyOTJ{IN88US=> NEXySHRUSU6JRWK=
CHP-134 NHLvbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjhbllLUUN3ME24MlI1OTh3IN88US=> MWXTRW5ITVJ?
HT-1080 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fXT2lEPTB;OD6yOVA6OyEQvF2= M3i1dHNCVkeHUh?=
PC-3 NHHGXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW4XXhuUUN3ME24MlI4Ozl{IN88US=> MW\TRW5ITVJ?
SNU-449 NF\aS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf3VmRKSzVyPUiuNlc6OyEQvF2= MnPPV2FPT0WU
VA-ES-BJ M3\JT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqxWnprUUN3ME24MlM1Pjh4IN88US=> MULTRW5ITVJ?
HT MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRThwM{[0PUDPxE1? NYjBVZR6W0GQR1XS
HOS NFvINYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi3dpZbUUN3ME24MlM4PTh7IN88US=> M1PEb3NCVkeHUh?=
KNS-62 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRThwM{e3OlIh|ryP M1PKZ3NCVkeHUh?=
OAW-42 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jvPGlEPTB;OD65OVk3PCEQvF2= MoL6V2FPT0WU
A549 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjxdmpDUUN3ME25MlA6PjF{IN88US=> NH\sPFVUSU6JRWK=
CAKI-1 M{G3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTlwMU[2NUDPxE1? NVjFVW9XW0GQR1XS
HCC1937 M{DlU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ntVmlEPTB;OT62PVg3PSEQvF2= M{XadHNCVkeHUh?=
GI-ME-N NYW3Uop4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXZd3pkUUN3ME25MlcxOTN5IN88US=> NHzuS|VUSU6JRWK=
DU-4475 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTlwOU[5N|kh|ryP MlPsV2FPT0WU
EM-2 NVe5Vm1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC3TWM2OD1zMD6yOFI3KM7:TR?= NGrwZ4pUSU6JRWK=
NCI-H1755 NWLUe25sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHZTWM2OD1zMD6yOFI5KM7:TR?= MmXLV2FPT0WU
NCI-H1437 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;BdnJKSzVyPUGwMlU4OjVizszN MlS5V2FPT0WU
VM-CUB-1 NXfNfmVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5dJM{UUN3ME2xNE43OTZ2IN88US=> NYHYOml5W0GQR1XS
A2058 M3;FW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPsT2hKSzVyPUGwMlY1ODRizszN NXvSS4tbW0GQR1XS
BPH-1 MknZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFyLkexOFUh|ryP NHrF[VNUSU6JRWK=
NB5 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFyLke1OVkh|ryP NID6WmJUSU6JRWK=
G-401 M3Pkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFyLke2NlYh|ryP M33BPXNCVkeHUh?=
CAL-72 MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTFyLkiwPVQh|ryP MVXTRW5ITVJ?
SK-MEL-28 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX2UGlKSzVyPUGwMlgzODJizszN MlexV2FPT0WU
C32 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC4WHpKSzVyPUGwMlg{PDdizszN M{fwcHNCVkeHUh?=
NCI-H1155 NWrTO5ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\EOmlEPTB;MUCuPFM4PiEQvF2= M4roXHNCVkeHUh?=
BB49-HNC M1i0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHaSmRFUUN3ME2xNE45PTh4IN88US=> NGjzTXdUSU6JRWK=
GMS-10 NUTYc2ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnXXGZCUUN3ME2xNE45QTdzIN88US=> M4j6R3NCVkeHUh?=
K5 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXWTWM2OD1zMD65NFcyKM7:TR?= MXPTRW5ITVJ?
OS-RC-2 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHZWFY1UUN3ME2xNU4xPTV7IN88US=> M1LrW3NCVkeHUh?=
HTC-C3 Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnOdXdmUUN3ME2xNU4xPzF2IN88US=> NG\mVlZUSU6JRWK=
LB996-RCC M{jERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFzLkC3NlMh|ryP M3X1UHNCVkeHUh?=
NCI-H1563 MlfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLtTWM2OD1zMT6xNFEyKM7:TR?= MYXTRW5ITVJ?
CAL-54 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInNUZRKSzVyPUGxMlQ5OTFizszN MXzTRW5ITVJ?
WM-115 NGPjZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXQTFlJUUN3ME2xNU43QDJ2IN88US=> Mo\nV2FPT0WU
COLO-684 NGr3Z5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPKTWM2OD1zMT63NlY4KM7:TR?= MW\TRW5ITVJ?
HOP-62 NXHDXppLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2wTWM2OD1zMT63OVA5KM7:TR?= MXnTRW5ITVJ?
NCI-H650 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnSyTWM2OD1zMT64PVYyKM7:TR?= M3PtPHNCVkeHUh?=
TE-11 M2TIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXkTWM2OD1zMT65N|E2KM7:TR?= MXvTRW5ITVJ?
COLO-679 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjNTWM2OD1zMT65OFYh|ryP MUXTRW5ITVJ?
FTC-133 M2q2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF{LkCwO|Yh|ryP NGLneYlUSU6JRWK=
D-283MED NIqwWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPIenpKSzVyPUGyMlA2PjlizszN NXi3XmtlW0GQR1XS
SK-PN-DW M3TPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH1VGpZUUN3ME2xNk4yQTB{IN88US=> MVjTRW5ITVJ?
BALL-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF{LkK2OlIh|ryP MVrTRW5ITVJ?
GT3TKB M2j6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7tRodKSzVyPUGyMlMxPzRizszN NVP5bIx2W0GQR1XS
HOP-92 NHjCc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HTUGlEPTB;MUKuOVI{OyEQvF2= NXrlUolpW0GQR1XS
M14 NVe3bG5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfvTWM2OD1zMz6wN|M2KM7:TR?= MYHTRW5ITVJ?
SKG-IIIa M3jabWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF|LkC1OVQh|ryP MUfTRW5ITVJ?
Becker M4TCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLxNVNGUUN3ME2xN{4xPThizszN NGCze2RUSU6JRWK=
ES5 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrB[2Z4UUN3ME2xN{4yOzV4IN88US=> MkXqV2FPT0WU
NCI-H2030 NEK1NmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF|LkKwOlIh|ryP MmjaV2FPT0WU
SNU-423 NVnZUmhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF|LkO4NUDPxE1? NFflSYVUSU6JRWK=
CP50-MEL-B Ml\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTTTWM2OD1zMz62NlMzKM7:TR?= NV\wfVFIW0GQR1XS
NCI-H1092 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF|Lke0O|Uh|ryP MorqV2FPT0WU
8-MG-BA MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPJTWM2OD1zMz63OVE{KM7:TR?= MYTTRW5ITVJ?
CAL-27 NVOzUmNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTQTWM2OD1zND6wO|I4KM7:TR?= NILLVGRUSU6JRWK=
AGS M2XYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL2R21KSzVyPUG0MlE{OTlizszN NYHCZ3BwW0GQR1XS
MZ2-MEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;tfnpmUUN3ME2xOE4yPDh6IN88US=> MYrTRW5ITVJ?
BFTC-909 NF7qeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTVTWM2OD1zND61NFU2KM7:TR?= NVzoTFM{W0GQR1XS
D-566MG NHv2dm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTF2Lke3NFYh|ryP NYnhV5BLW0GQR1XS
MZ7-mel M3jLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HXUGlEPTB;MUWuNVA3PyEQvF2= NVPne5F4W0GQR1XS
TE-5 NWHK[5RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7CTY4zUUN3ME2xOU4zOzN|IN88US=> NFnicXFUSU6JRWK=
647-V NHTIV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i5TWlEPTB;MUWuNlcxPSEQvF2= NWLEdFBkW0GQR1XS
DMS-114 M4nZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfpdVFKSzVyPUG1MlMzQTFizszN M1\1VXNCVkeHUh?=
ME-180 NFX5bIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7nRplUUUN3ME2xOU41Pzh|IN88US=> NHfuS3VUSU6JRWK=
MS-1 NYLseYxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml24TWM2OD1zNT61OlI{KM7:TR?= NEiyWIhUSU6JRWK=
NUGC-3 M3y4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjzSnhKSzVyPUG1MlYzPDVizszN MnPEV2FPT0WU
GB-1 M1TD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjHdYViUUN3ME2xOU43PDN5IN88US=> MXTTRW5ITVJ?
LOXIMVI NX[wUYl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF3Lki5NVkh|ryP MX3TRW5ITVJ?
NCI-H1304 NGDuOnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTmTWM2OD1zNT64PVI5KM7:TR?= M1HifnNCVkeHUh?=
KURAMOCHI Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfhSHdWUUN3ME2xOU46PzFizszN NXfRR2I6W0GQR1XS
SW1783 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XHc2lEPTB;MU[uNFk6OyEQvF2= NGDh[lJUSU6JRWK=
EGI-1 NFPIXJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL6TWM2OD1zNj61N|Y2KM7:TR?= Mk\tV2FPT0WU
KGN MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\sR4JKSzVyPUG2MlU2QDZizszN NHPTNoxUSU6JRWK=
PANC-03-27 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF4Lke2OlIh|ryP NWe0WXU3W0GQR1XS
RH-1 NE\Lb2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LXUGlEPTB;MU[uPFI2KM7:TR?= NWSydpl3W0GQR1XS
HT-1376 NHTYT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7RTWM2OD1zNj64OFQ3KM7:TR?= MVTTRW5ITVJ?
ZR-75-30 NUnUU3BmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\WTWM2OD1zNj65N|YyKM7:TR?= NFX2OGtUSU6JRWK=
TI-73 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXmXJVjUUN3ME2xOk46PDB6IN88US=> MWPTRW5ITVJ?
TK10 NUXQRWhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DXTWlEPTB;MUeuNFA4QSEQvF2= M3nLenNCVkeHUh?=
SW684 NVTu[3JZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTmTWM2OD1zNz6wNVU1KM7:TR?= M4XwZ3NCVkeHUh?=
RPMI-8866 NWPkRYE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvuWY9KSzVyPUG3MlA3QTlizszN MmD1V2FPT0WU
LNCaP-Clone-FGC NYLDT|d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPNTWM2OD1zNz61NlAyKM7:TR?= M2H3VnNCVkeHUh?=
NCI-H2291 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnvTWM2OD1zOD60N|Q2KM7:TR?= MnzGV2FPT0WU
T47D NYjIOI1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELZNINKSzVyPUG4MlQ5QCEQvF2= NFXUfplUSU6JRWK=
A204 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF64NldKSzVyPUG4MlU1PTJizszN M33CfHNCVkeHUh?=
HT-144 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDJT4tKSzVyPUG4Mlc1OjdizszN MUTTRW5ITVJ?
MDA-MB-361 M2fqNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P1fmlEPTB;MUmuNFcyPCEQvF2= M4jEWXNCVkeHUh?=
HCC1806 NEfEbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD1zOT6xOVkyKM7:TR?= MUDTRW5ITVJ?
NCI-H596 NVS4Z2FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17WO2lEPTB;MUmuOlM6OSEQvF2= NGTwVWVUSU6JRWK=
K-562 NXTaZoR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXwTWM2OD1zOT64PVI3KM7:TR?= MWDTRW5ITVJ?
D-336MG Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS1eGNRUUN3ME2xPU46OzJ{IN88US=> MYDTRW5ITVJ?
SK-MEL-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTtTWM2OD1{MD6xOVU6KM7:TR?= NXLGcZZbW0GQR1XS
HEC-1 MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DqSGlEPTB;MkCuOFk4QCEQvF2= M13CXHNCVkeHUh?=
EW-13 NYK3dXp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv3eYJpUUN3ME2yNE42PDR|IN88US=> M2DnXHNCVkeHUh?=
Hs-578-T NGLZ[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL0SpZKSzVyPUKwMlU2QDNizszN M1\aV3NCVkeHUh?=
SJSA-1 NVfYVG1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJyLkW2PFgh|ryP MoXWV2FPT0WU
RCC10RGB M3qwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj1TWM2OD1{MD62O|E6KM7:TR?= NYmybGlTW0GQR1XS
LAN-6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7QNlJKSzVyPUKxMlA{QTZizszN NEPsO4lUSU6JRWK=
NCI-H1048 M1vJXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK2Vo1lUUN3ME2yNU4zOjV6IN88US=> MWjTRW5ITVJ?
CW-2 M1vnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLLVXNKSzVyPUKxMlI4ODVizszN Ml70V2FPT0WU
HCC2157 NWXmdm9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3HTWM2OD1{MT6zOkDPxE1? M{HMTXNCVkeHUh?=
EW-22 NY[zdnBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPr[Wc4UUN3ME2yNU4{PzZizszN NXzXRno5W0GQR1XS
A253 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJzLkS0PFEh|ryP NV32d|NnW0GQR1XS
BE-13 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvUfZFKSzVyPUKxMlYyOTNizszN NHj0RVlUSU6JRWK=
KINGS-1 NVTHOItwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\RNWpKSzVyPUKxMlY{OTZizszN MY\TRW5ITVJ?
ETK-1 NFvuOpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG3dVlPUUN3ME2yNU45OTV{IN88US=> MXzTRW5ITVJ?
NCI-H2452 NEHYR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJzLki2OFch|ryP NEXRN29USU6JRWK=
HPAF-II M1;yNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nM[mlEPTB;MkGuPFkzOyEQvF2= NXviZ3l3W0GQR1XS
D-542MG NUXNcFg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJzLkmwOlkh|ryP MWDTRW5ITVJ?
NCI-H630 NIXNb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjIWXhwUUN3ME2yNk4xOjl4IN88US=> M330SnNCVkeHUh?=
TGBC11TKB NILKfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHUUIpKSzVyPUKyMlA1QSEQvF2= M{Tvd3NCVkeHUh?=
BCPAP MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v3[WlEPTB;MkKuOlEyKM7:TR?= NFi1bGtUSU6JRWK=
HLE NV;uc5hjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zMd2lEPTB;MkKuOlk4KM7:TR?= NFjmemhUSU6JRWK=
NCI-H727 M3XQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJ{LkezOUDPxE1? M4P1VXNCVkeHUh?=
RD NInSVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XwZWlEPTB;MkKuO|UyQCEQvF2= NX;DemgzW0GQR1XS
NCI-H522 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vJXmlEPTB;MkKuPFQ{OSEQvF2= Mn;xV2FPT0WU
CGTH-W-1 NU\RZYlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHObpliUUN3ME2yN{4xPjRzIN88US=> MVvTRW5ITVJ?
SK-LU-1 MkLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PlSmlEPTB;MkOuOFY5OyEQvF2= MmWzV2FPT0WU
BB65-RCC M1rMVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7OTHBvUUN3ME2yN{44QDZ|IN88US=> NEjrdppUSU6JRWK=
HSC-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;UbI9KSzVyPUKzMlg2OjdizszN MoWxV2FPT0WU
SK-MES-1 NX3wdlZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\UTWM2OD1{ND6wNVYyKM7:TR?= MoO1V2FPT0WU
DB NFPTS|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnZU2VKSzVyPUK0MlExOjhizszN NIC4VJJUSU6JRWK=
HO-1-N-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O3WWlEPTB;MkSuN|A6OyEQvF2= M{\ZUHNCVkeHUh?=
MKN1 M1LTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ2Lk[4JO69VQ>? M{HM[XNCVkeHUh?=
MN-60 M3TIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXYUIhKSzVyPUK0Mlg2OTlizszN MknWV2FPT0WU
8505C MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ3LkG4OFUh|ryP NEDRZoRUSU6JRWK=
COLO-320-HSR M4n4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HHOmlEPTB;MkWuNlIxQCEQvF2= M1;5[XNCVkeHUh?=
BB30-HNC NWfTdY9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ3LkK0PFMh|ryP MXvTRW5ITVJ?
KM12 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJ3LkW4NFch|ryP MnHaV2FPT0WU
NB13 Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ3LkW4PVgh|ryP MXPTRW5ITVJ?
HCC2998 NWi3Z5BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm1TWM2OD1{Nj6wNlg{KM7:TR?= MYTTRW5ITVJ?
U-118-MG NG[5NFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:2S2NsUUN3ME2yOk4xQDB6IN88US=> NX\rWXFrW0GQR1XS
NB10 M2nDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDm[45KSzVyPUK2MlI{PCEQvF2= NW\idnlHW0GQR1XS
SK-LMS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ5LkC3NFQh|ryP NF\rNZpUSU6JRWK=
SW1573 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LIPWlEPTB;MkeuNVEh|ryP M4TxdXNCVkeHUh?=
LB373-MEL-D NEKyUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJ5LkGyPVQh|ryP M{LKcHNCVkeHUh?=
DK-MG M2DzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP2TWM2OD1{Nz6xPFE4KM7:TR?= MWTTRW5ITVJ?
RMG-I NVO2XmJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXCb2dVUUN3ME2yO{4zODJ7IN88US=> MofxV2FPT0WU
SW1088 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ5LkWwOFIh|ryP MXLTRW5ITVJ?
SK-OV-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHwTWM2OD1{Nz63OVk{KM7:TR?= MnyyV2FPT0WU
KP-N-YN MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXxR25KSzVyPUK3MlgxPDNizszN MUfTRW5ITVJ?
RPMI-7951 NGm5PJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\hU29KSzVyPUK4MlI1PTZizszN NF7UdoVUSU6JRWK=
CaR-1 M1vyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn4SHVKSzVyPUK4MlU2QDJizszN NED6RVNUSU6JRWK=
MKN7 NXLXTZh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvKTWM2OD1{OD61PVY1KM7:TR?= MoL1V2FPT0WU
CHP-212 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\jcI5KSzVyPUK4Mlc1ODFizszN NY\veVN1W0GQR1XS
KYSE-450 M4L3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTsTWM2OD1{OD64NFkyKM7:TR?= NGfZXnFUSU6JRWK=
RXF393 M1TWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq4TWM2OD1{OT6yPVA3KM7:TR?= NH76XI1USU6JRWK=
P30-OHK MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjCRY9DUUN3ME2yPU4{ODR6IN88US=> NGTNUVVUSU6JRWK=
Ca9-22 NV3VTW8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHoU3ZsUUN3ME2yPU41Ojl7IN88US=> MYHTRW5ITVJ?
RT-112 NVX1c4tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJ7LkS2NVEh|ryP M4i2NXNCVkeHUh?=
ES1 NUnrS|NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID0UHJKSzVyPUK5Mlg2PDRizszN Ml\KV2FPT0WU
HCE-4 NHKyNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGyNHAxUUN3ME2yPU45Pzh4IN88US=> NV:1WHB5W0GQR1XS
AM-38 M2D2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfPcVdLUUN3ME2zNE4xPjB4IN88US=> NELqZ4RUSU6JRWK=
AsPC-1 M1rz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTNyLkiwOVMh|ryP NHLzeZZUSU6JRWK=
TE-9 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;HTWM2OD1|MD64O|M4KM7:TR?= NEm0V|ZUSU6JRWK=
HuP-T4 NIK0OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDiTWM2OD1|MD65OlM5KM7:TR?= MmL3V2FPT0WU
LB2518-MEL Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDBd3RTUUN3ME2zNU4xPzR2IN88US=> NX\iWWtIW0GQR1XS
NCI-H1703 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPqWHgxUUN3ME2zNU4xQTB3IN88US=> NXL3d5hjW0GQR1XS
NCI-H2228 M{myUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTNzLkS2OVEh|ryP MYjTRW5ITVJ?
SCC-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTNzLkmxPFEh|ryP MYfTRW5ITVJ?
KNS-81-FD MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XN[mlEPTB;M{KuNFEzQCEQvF2= M2HRcHNCVkeHUh?=
NTERA-S-cl-D1 M3zBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjoeGUxUUN3ME2zNk4xPzN7IN88US=> NXHvfXdMW0GQR1XS
Daoy MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK0c5BJUUN3ME2zNk4xQDN6IN88US=> MXjTRW5ITVJ?
ES4 NXvIVmxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X5VmlEPTB;M{KuN|kzOiEQvF2= MlHSV2FPT0WU
MHH-ES-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT4emx2UUN3ME2zNk41QDd{IN88US=> NIWz[mxUSU6JRWK=
C-33-A MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq2SXZKSzVyPUOyMlc4OjhizszN M4nyT3NCVkeHUh?=
BHY NE\1fYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTN{Lkm0PVUh|ryP NHzNfoRUSU6JRWK=
Detroit562 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDYTWM2OD1|Mz62OlU4KM7:TR?= MVLTRW5ITVJ?
EW-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DsVmlEPTB;M{OuPVMzOiEQvF2= M4H2UnNCVkeHUh?=
NCI-H1395 M3\FS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrYTWM2OD1|ND6wO|k6KM7:TR?= M4fMc3NCVkeHUh?=
KM-H2 M2PlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[4VllzUUN3ME2zOk41PzR|IN88US=> NGPNRWxUSU6JRWK=
NCI-H520 NW\yPHJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjpTYxKSzVyPUO2Mlc2PDFizszN NEjkVXRUSU6JRWK=
D-392MG NX;oeI8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DVZ2lEPTB;M{euN|M1PCEQvF2= MXzTRW5ITVJ?
NOMO-1 NU\mSWNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHkZYVKSzVyPUO3MlgxQDlizszN NVO3[3pFW0GQR1XS
TE-6 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz1V25kUUN3ME2zPE4yOjRizszN MW\TRW5ITVJ?
HT-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXZXmRKSzVyPUO4MlQ1OzZizszN MmSwV2FPT0WU
RPMI-8226 M3fV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED6VVNKSzVyPUO4Mlk2OTlizszN MlzjV2FPT0WU
U251 NHyyTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXaTWM2OD1|OT6wNVI1KM7:TR?= M4HSTXNCVkeHUh?=
GCT M2TSTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTN7LkG4OVIh|ryP MVHTRW5ITVJ?
A431 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7pTWM2OD1|OT6xPFk1KM7:TR?= M1X2d3NCVkeHUh?=
TE-12 NEGy[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PMeWlEPTB;M{muNlQ1QCEQvF2= M3HLZ3NCVkeHUh?=
HMV-II NHHqPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\4eGlEPTB;M{muOVA1PyEQvF2= M4XnbnNCVkeHUh?=
IST-MES1 M1vKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHWfHM3UUN3ME20NE4yPTB{IN88US=> NX7HR3U4W0GQR1XS
SW13 NXHSVm9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTRyLkWxPUDPxE1? NGTqb5BUSU6JRWK=
SF295 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH3TWM2OD12MD64NFY3KM7:TR?= M4fVPXNCVkeHUh?=
MDA-MB-157 M{nXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTRyLkm0OlIh|ryP NHSxfYpUSU6JRWK=
TE-1 NV\MRXlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTRzLki3NVQh|ryP NEf6OIJUSU6JRWK=
HuCCT1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTR{LkWyPFkh|ryP Mn\uV2FPT0WU
KYSE-510 M{\PWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR|LkG3OVQh|ryP M3nn[XNCVkeHUh?=
NCI-H358 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLDRYFCUUN3ME20OE4xOzB2IN88US=> M4rlSnNCVkeHUh?=
SW900 NUHHWmdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrFTohKSzVyPUS0MlA4PThizszN MoDtV2FPT0WU
CAS-1 NYnxd5VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHETWM2OD12ND6wPVkyKM7:TR?= M3H4b3NCVkeHUh?=
TE-8 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvaPHhKSzVyPUS0MlU3PThizszN NXfKe4dXW0GQR1XS
P12-ICHIKAWA MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF25VmlKSzVyPUS0MlYyOTJizszN NV;GWWdyW0GQR1XS
YKG-1 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVOx[pc{UUN3ME20OE44QDFizszN NF\0ZpdUSU6JRWK=
SNU-C2B MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvzcJFKSzVyPUS0Mlc6ODNizszN NGfTWXpUSU6JRWK=
LCLC-103H M1v0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTR2Lki3NFMh|ryP NHPMeGZUSU6JRWK=
U-87-MG M{W1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF63SHhKSzVyPUS1MlExOjJizszN Mn;BV2FPT0WU
HAL-01 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTaNZVUUUN3ME20OU4yOzd7IN88US=> NET5SFFUSU6JRWK=
OVCAR-8 NWDhTmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\ETWM2OD12NT6zOVY1KM7:TR?= MnrpV2FPT0WU
KYSE-150 NHm5cYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTR5LkGwOVIh|ryP NXTmN21jW0GQR1XS
OE33 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;DOWlEPTB;NEeuNVQzQSEQvF2= M2X5OnNCVkeHUh?=
CAL-62 NGL0VINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTR5LkSwOlgh|ryP MortV2FPT0WU
TCCSUP NHfhUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR5Lk[yOlQh|ryP MoT6V2FPT0WU
H4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj2cFNKSzVyPUS3MlY3OjFizszN NHnOZVFUSU6JRWK=
CP66-MEL MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHITI9KSzVyPUS4MlA4ODRizszN NF;uNpNUSU6JRWK=
SNB75 NHTRb2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmwTWM2OD12OD6xPFc1KM7:TR?= MlfMV2FPT0WU
Mo-T MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljaTWM2OD12OD6yO|kh|ryP MXrTRW5ITVJ?
BT-549 NV;QS2FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Wcm11UUN3ME20PE4{PzJ7IN88US=> NX;mXVVVW0GQR1XS
IGR-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvJTWM2OD12OD62OlQ2KM7:TR?= NGLUPY1USU6JRWK=
NCI-H1299 NGHZOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnOTWM2OD12OD63NlQ5KM7:TR?= MoPvV2FPT0WU
ALL-PO MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnMO5BKSzVyPUS5MlkzPjhizszN NX\4[JZpW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; 

PubMed: 29344644     


SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR.

p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); 

PubMed: 25714019     


Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.

29344644 25714019
In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Could you please suggest formulations of the drug for in vivo injection?

  • Answer:

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • Question 2:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID