Ningetinib

For research use only.

Catalog No.S6870 Synonyms: CT-053, DE-120, CT053PTSA

Ningetinib Chemical Structure

CAS No. 1394820-69-9

Ningetinib is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.

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Biological Activity

Description Ningetinib is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.
Targets
Axl [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
c-Met [1]
(Cell-free assay)
1.0 nM 1.9 nM 6.7 nM

Protocol

Solubility (25°C)

In vitro DMSO 20 mg/mL (35.93 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 556.58
Formula

C31H29FN4O5

CAS No. 1394820-69-9
Storage powder
in solvent
Synonyms CT-053, DE-120, CT053PTSA
Smiles CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03915184 Recruiting Biological: CT053 Multiple Myeloma Carsgen Therapeutics Ltd. September 25 2019 Phase 1
NCT03975907 Recruiting Biological: CAR-BCMA T Cells Multiple Myeloma Carsgen Therapeutics Ltd.|Beijing Chao Yang Hospital|The First Affiliated Hospital of Soochow University|Xinhua Hospital Shanghai Jiao Tong University School of Medicine|Tianjin Medical University General Hospital|First Affiliated Hospital of Zhejiang University|Beijing Hospital|Shanghai Tongji Hospital Tongji University School of Medicine|First Affiliated Hospital of Wenzhou Medical University|Xiangya Hospital of Central South University|Peking University People''s Hospital|Qilu Hospital of Shandong University|Sun Yat-sen University|First Affiliated Hospital Sun Yat-Sen University June 10 2019 Phase 1|Phase 2
NCT02022501 Completed Drug: DE-120 Age-Related Macular Degeneration Santen Inc. January 2014 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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c-Met Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID