Ningetinib

Catalog No.S6870 Synonyms: CT-053, DE-120, CT053PTSA

For research use only.

Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.

Ningetinib Chemical Structure

CAS No. 1394820-69-9

Purity & Quality Control

Choose Selective c-Met Inhibitors

Other c-Met Products

Biological Activity

Description Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.
Targets
Axl [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
c-Met [1]
(Cell-free assay)
1.0 nM 1.9 nM 6.7 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 556.58
Formula

C31H29FN4O5

CAS No. 1394820-69-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04992858 Not yet recruiting Drug: CT053PTSA Advanced NSCLC Sunshine Lake Pharma Co. Ltd. November 27 2022 Phase 2
NCT03975907 Active not recruiting Biological: CAR-BCMA T Cells Multiple Myeloma CARsgen Therapeutics Co. Ltd.|Beijing Chao Yang Hospital|The First Affiliated Hospital of Soochow University|Xinhua Hospital Shanghai Jiao Tong University School of Medicine|Tianjin Medical University General Hospital|First Affiliated Hospital of Zhejiang University|Beijing Hospital|Shanghai Tongji Hospital Tongji University School of Medicine|First Affiliated Hospital of Wenzhou Medical University|Xiangya Hospital of Central South University|Peking University People''s Hospital|Qilu Hospital of Shandong University|Sun Yat-sen University|First Affiliated Hospital Sun Yat-Sen University June 10 2019 Phase 1|Phase 2
NCT04577703 Completed Drug: CT053PTSA Advanced Solid Tumors Sunshine Lake Pharma Co. Ltd. February 8 2014 Phase 1
NCT02022501 Completed Drug: DE-120 Age-Related Macular Degeneration Santen Inc. January 2014 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Ningetinib | Ningetinib supplier | purchase Ningetinib | Ningetinib cost | Ningetinib manufacturer | order Ningetinib | Ningetinib distributor