Catalog No.S2040

Nimesulide Chemical Structure

Molecular Weight(MW): 308.31

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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1 Customer Review

  • Nimesulide has no effect on KSHV lytic replication in BCBL-1 cells. The cells induced with TPA for 3 h were treated with the test compounds for 72 h. Then, the effect of nimesulide on cell viability (C) and the number of DNA copies (D) were measured as described in the Methods. CDV (20 µM) is a positive control for inhibiting viral DNA replication. Data were normalized as the fold change compared with the no-TPA induced control. The results are presented as the mean  values with standard deviations (n = 3).

    Viruses, 2015, 7(5):2268-87.. Nimesulide purchased from Selleck.

Purity & Quality Control

Choose Selective COX Inhibitors

Biological Activity

Description Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
COX-2 [1]
26 μM



Solubility (25°C)

In vitro DMSO 62 mg/mL (201.09 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 308.31


CAS No. 51803-78-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01670552 Unknown status Acute and Chronic Inflammation|Dyspepsia EMS February 2016 Phase 3
NCT03119324 Completed Temporomandibular Joint Disorders University of Roma La Sapienza September 2015 Not Applicable
NCT01257126 Withdrawn Upper Respiratory Tract Infections Novartis Pharmaceuticals|Novartis April 2011 Phase 4
NCT01745614 Completed Pain GlaxoSmithKline July 18 2010 Phase 1
NCT01500577 Completed Breast Cancer European Institute of Oncology April 2005 Phase 2
NCT02229747 Completed Pharyngitis Boehringer Ingelheim August 2001 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID