Home Angiogenesis Src inhibitor - CDK inhibitor - Bcr-Abl inhibitor - CaMK inhibitor - PKD inhibitor 1-Naphthyl PP1(1-NA-PP1) For research use only.

1-Naphthyl PP1(1-NA-PP1)

1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.

1-Naphthyl PP1(1-NA-PP1) Chemical Structure

1-Naphthyl PP1(1-NA-PP1) Chemical Structure

CAS: 221243-82-9

Purity & Quality Control

Batch: S264201 DMSO] 9 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

1-Naphthyl PP1(1-NA-PP1) Related Products

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Biological Activity

Description 1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
Targets
PKD3 [1]
(Cell-free assay)		 PKD2 [1]
(Cell-free assay)		 PKD1 [1]
(Cell-free assay)		 v-Fyn [2]
(Cell-free assay)		 c-Abl [2]
(Cell-free assay)		 Click to View More Targets
109.4 nM 133.4 nM 154.6 nM 0.6 μM 0.6 μM

Chemical Information & Solubility

Molecular Weight 317.39 Formula

C19H19N5
CAS No. 221243-82-9 SDF --
Smiles CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 9 mg/mL ( (28.35 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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