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Nadolol

Name: Nadolol
Brand: Selleck Chemicals
SKU: S5023
Rating: 5 (1 reviews)

Synonyms: Corgard, Solgol, Anabet, SQ11725

Catalog No.S5023 Purity: 99.98%

Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.

Nadolol Chemical Structure

CAS: 42200-33-9

Selleck's Nadolol has been cited by 1 publication

Purity & Quality Control

Batch: S502301 DMSO] 61 mg/mL] false] ] ] false] ] ] false Purity: 99.98%

99.98

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Signaling Pathway

Adrenergic Receptor Signaling Pathway

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description

Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.

Targets

β-adrenergic receptor ^[3]

In vitro
In vitro	Nadolol is a new beta-adrenoceptor blocking agent without intrinsic sympathomimetic action and with an extremely long plasma half life^[2]. Nadolol antagonizes isoproterenol-induced tachycardia and ouabain-induced arrhythmias in cats, antagonizes coronary artery ligation-induced ventricular fibrillation and suppresses ventricular ectopic activity during vagal stimulation in dogs^[1].

In Vivo
In vivo	In several experimental models (mongrel cats and mongrel dogs), nadolol is effective against cardiac arrhythmias. This anti-arrhythmic activity appears to be related to fi-adrenergic receptor blockade, an action that would antagonize the ability of catecholamines to induce arrhythmias by alteration of cardiac automaticity and conductivity. It is also effective in preventing ventricular fibrillation induced by ligation of the left anterior descending coronary artery. Nadolol has been demonstrated to have a half-life of 4 to 5 hr in animals. It does not block neuromuscular transmission at the junction of the vagus and heart. Furthermore, nadolol does not depress excitability of the heart, as demonstrated by the lack of effect on diastolic threshold in the intact heart of the dog^[1]. It is rapidly absorbed from the gastrointestinal tract and remarkalely well-tolerated when given in extremely large doses^[3].
Animal Research	Animal Models	Male mongrel cats, 3.0 to 5.0 kg
	Dosages	0.001-0.1 mg/kg
	Administration	i.v.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01010308	Completed	Infantile Hemangioma	The Hospital for Sick Children	November 2009	Phase 2

References

Chemical Information & Solubility

Molecular Weight	309.40	Formula	C₁₇H₂₇NO₄
CAS No.	42200-33-9	SDF	--
Smiles	CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 61 mg/mL ( (197.15 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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