Nutlin-3

For research use only.

Catalog No.S1061

68 publications

Nutlin-3 Chemical Structure

CAS No. 890090-75-2

Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.

Selleck's Nutlin-3 has been cited by 68 publications

Purity & Quality Control

Choose Selective Mdm2 Inhibitors

Biological Activity

Description Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.
Targets
Mdm2 [5]
(Cell-free assay)
180 nM
In vitro

Nutlin-3 potently inhibits the MDM2-p53 interaction, leading to the activation of the p53 pathway. Nutlin-3 treatment induces the expression of MDM2 and p21, and displays potent antiproliferative activity with IC50 of ~1.5 μM, only in cells with wild-type p53 such as HCT116, RKO and SJSA-1, but not in the mutant p53 cell lines SW480 and MDA-MB-435. In SJSA-1 cells, Nutlin-3 treatment at 10 μM for 48 hours significantly induces caspase-dependent cell apoptosis by ~45%. Although Nutlin-3 also inhibits the growth and viability of human skin (1043SK) and mouse embryo (NIH/3T3) with IC50 of 2.2 μM and 1.3 μM, respectively, cells remain viable 1 week post-treatment even at 10 μM of Nutlin-3, in contrast with the SJSA-1 cells with viability lost at 3 μM of Nutlin-3 treatment. [1] Nutlin-3 does not induce the phosphorylation of p53 on key serine residues and reveals no difference in their sequence-specific DNA binding and ability to transactivate p53 target genes compared with phosphorylated p53 induced by the genotoxic drugs doxorubicin and etoposide, demonstrating that phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. [2] Although binding less efficiently to MDMX than to MDM2, Nutlin-3 can block the MDMX–p53 interaction and induce the p53 pathway in retinoblastoma cells (Weri1) with IC50 of 0.7 μM. [3] Nutlin-3 at 30 μM also disrupts endogenous p73-HDM2 interaction and enhances the stability and proapoptotic activities of p73, leading to the dose-dependent cell growth inhibition and apoptosis induction in cells without wild-type p53. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SMMC-7721  MkHBSpVv[3Srb36gRZN{[Xl? M2jiNlExKM7:TR?= M{nDbFM3KGh? NV\wO21ETE2VTx?= M2O0W4Rwf25vcnXneYxifGW|IITo[UBxem:2ZXnuJIV5eHKnc4Ppc44hdGW4ZXygc4YheGixc4Doc{1U\XJ|OUKtdFU{ M4PTO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mki2N|EzLz5{NEK4OlMyOjxxYU6=
HuH-7 Ml\MRZBweHSxc3nzJGF{e2G7 M17nSFIxKM7:TR?= NFjHXpk1QCCq MVnEUXNQ Mmi4bY5lfWOnczDhdI9xfG:|aYO= NFHsfZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK4OlMyOid-MkSyPFY{OTJ:L3G+
SMMC-7721  MX3BdI9xfG:|aYOgRZN{[Xl? MYeyNEDPxE1? M1Kz[FQ5KGh? M2HUZmROW09? M3PNO4lv\HWlZYOgZZBweHSxc3nz NVX3VVY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFY{OTJpPkK0Nlg3OzF{PD;hQi=>
HuH-7 MX;D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmfaNU4zPS1{MDFOwG0> MW[yOE81QC95MjDo NXnDOJhiTE2VTx?= NGHDdFlqdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44h\G:|ZTDhcoQhfGmvZTDk[ZBmdmSnboTsfS=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6NkOxNkc,OjR{OE[zNVI9N2F-
SMMC-7721  MmDRR4VtdCCYaXHibYxqfHliQYPzZZk> NHe2cWYyNjJ3LUKwJO69VQ>? MYqyOE81QC95MjDo MoS5SG1UVw>? MlLObY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= Mnu4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OE[zNVIoRjJ2Mki2N|EzRC:jPh?=
RKO NHXRcZNHfW6ldHnvckBCe3OjeR?= Mne2NlAh|ryP NWXl[W5uOjRiaB?= M1vsT4lv\HWlZYOgTG8uOSCneIDy[ZN{cW:wIHH0JJRp\SCuZY\lcEBw\iC2cnHud4NzcXC2aX;u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4NkCwO{c,OjR|Nk[wNFc9N2F-
U2OS  M1fkdmZ2dmO2aX;uJGF{e2G7 MViyNEDPxE1? MlPXNlQhcA>? M3rMS4lv\HWlZYOgTG8uOSCneIDy[ZN{cW:wIHH0JJRp\SCuZY\lcEBw\iC2cnHud4NzcXC2aX;u NYnDPVlwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlYxODdpPkK0N|Y3ODB5PD;hQi=>
RKO M{Pq[2Z2dmO2aX;uJGF{e2G7 NGPyTmszOCEQvF2= MojmNlQhcA>? M1Hvb4lv[3KnYYPld{B1cGVibHX2[Yx{KG:oIITo[UBJVy1zIIDyc5RmcW5iYYOge4VtdCCjczD0bIUheDV|IIDyc5RmcW5? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4NkCwO{c,OjR|Nk[wNFc9N2F-
U2OS  M{TFO2Z2dmO2aX;uJGF{e2G7 M2r2RlIxKM7:TR?= M3PF[FI1KGh? MmDEbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZidHjlJGhQNTFicILveIVqdiCjczD3[YxtKGG|IITo[UBxPTNicILveIVqdg>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4NkCwO{c,OjR|Nk[wNFc9N2F-
MOLM NVfjNGdCTnWwY4Tpc44hSXO|YYm= MVuxNEDPxE1? MXqyOEBp M{KwRpVxemWpdXzheIV{KHSqZTDTU2NUNTFiZYjwdoV{e2mxbh?= M2fNVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEezOVYzLz5{NES3N|U3OjxxYU6=
OCI MmjtSpVv[3Srb36gRZN{[Xl? NVnNclZiOTBizszN NWT3XVJSOjRiaB?= M3f2OZVxemWpdXzheIV{KHSqZTDTU2NUNTFiZYjwdoV{e2mxbh?= NWjDXIw4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O|M2PjJpPkK0OFc{PTZ{PD;hQi=>
BeWo MUTBdI9xfG:|aYOgRZN{[Xl? NGfKXXY{OCEEtV2= NVTSXHdbOjRiaB?= NWDPXVJOcW6lcnXhd4V{KGGyb4D0c5Nqew>? MmjhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OUixOVQoRjJ2NEm4NVU1RC:jPh?=
BeWo MmLISpVv[3Srb36gRZN{[Xl? NXT1WFJJOzBiwsXN M2S5NVI1KGh? NVPGNII6cW6lcnXhd4V{KHB3MzygUYRuOixicEKxJIFv\CCSdX3hJIF1KHSqZTDwdo91\WmwIHzleoVt MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR7OEG1OEc,OjR2OUixOVQ9N2F-
MOML13 NFL2TYxHfW6ldHnvckBCe3OjeR?= MX6xNO69VQ>? MorGNk81KGh? M1z4TIlv[3KnYYPld{B1cGVibHX2[Ywhd2ZicEWz MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3OUe0PUc,OjR4NUm3OFk9N2F-
AML3 MV3GeY5kfGmxbjDBd5NigQ>? NWDIN3hOOTEQvF2= M2KydVIwPCCq NF\XXoZqdmO{ZXHz[ZMhfGinIHzleoVtKG:oIIC1Ny=> NWTibmh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVk4PDlpPkK0OlU6PzR7PD;hQi=>
AML2 MVvGeY5kfGmxbjDBd5NigQ>? NYTQN5lwOTEQvF2= NEjP[VEzNzRiaB?= MXfpcoNz\WG|ZYOgeIhmKGyndnXsJI9nKHB3Mx?= Mkj6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NUm3OFkoRjJ2NkW5O|Q6RC:jPh?=
MOML13 MXLBdI9xfG:|aYOgRZN{[Xl? M4PCdFIwOTBizszN Mnu2NlQwPDhiaB?= MXLpcoR2[2W|IHHwc5B1d3Orcx?= MmLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NUm3OFkoRjJ2NkW5O|Q6RC:jPh?=
AML2 NUi5e2RuSXCxcITvd4l{KEG|c3H5 Moi4Nk8yOCEQvF2= MV2yOE81QCCq NEnNVmdqdmS3Y3XzJIFxd3C2b4Ppdy=> M2XWXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW5O|Q6Lz5{NE[1PVc1QTxxYU6=
U2OS  MmDUSpVv[3Srb36gRZN{[Xl? NI\jSXgzOCEQvF2= NH3FSJkzPCCq M2nLNolv[3KnYYPld{B1cGVibWLORUBt\X[nbIOgc4bDqEKFTELBNUwhSkOOWF|CpIFv\EKFTGe= NV7rV2cyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OlczPTlpPkK0PFY4OjV7PD;hQi=>
Hep3B NVXRNoN5SXCxcITvd4l{KEG|c3H5 NULCSmVucW6mdXPld{BieG:ydH;zbZM> M{\oT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEi0PFA6Lz5{NEi4OFgxQTxxYU6=
Huh-7 NF;We2hCeG:ydH;zbZMhSXO|YYm= NWjnbo96cW6mdXPld{BieG:ydH;zbZM> NIq5[pY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4OFgxQSd-MkS4PFQ5ODl:L3G+
SMMC7721 NIH6TYZCeG:ydH;zbZMhSXO|YYm= MkW4bY5lfWOnczDhdI9xfG:|aYO= NVHuXGd2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PFQ5ODlpPkK0PFg1QDB7PD;hQi=>
HepG2 M2jtbWFxd3C2b4Ppd{BCe3OjeR?= MofLbY5lfWOnczDhdI9xfG:|aYO= NUnGbpBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PFQ5ODlpPkK0PFg1QDB7PD;hQi=>
Hep3B M{\ibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTa[oRZPzJiaB?= M3rKU2ROW09? NVLre5hlUUN3ME2yNE4yQCEEsTCxMlg1KM7:TR?= M4DrOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEi0PFA6Lz5{NEi4OFgxQTxxYU6=
Huh-7 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn2zO|IhcA>? M2fUWGROW09? NGjQe|VKSzVyPUOzMlk3KMLzIEOuPUDPxE1? NFrTTlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4OFgxQSd-MkS4PFQ5ODl:L3G+
SMMC7721/Ac MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO4Xnk4OiCq NIDqTHVFVVOR NX7RXY8xUUN3ME21OU4zOSEEsTC1MlA{KM7:TR?= NEP0fHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4OFgxQSd-MkS4PFQ5ODl:L3G+
SMMC7721 NF\4flhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjQO|IhcA>? M1nxNGROW09? M2rtVGlEPTB;M{GuNlghyrFiND6yJO69VQ>? NHrYe2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4OFgxQSd-MkS4PFQ5ODl:L3G+
HepG2/As M3vrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W4c|czKGh? MkjMSG1UVw>? M3v5O2lEPTB;NkiuNVMhyrFiOT62JO69VQ>? Mln5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OES4NFkoRjJ2OEi0PFA6RC:jPh?=
HepG2 NYHYb3l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXoZ2M1PzJiaB?= MmPHSG1UVw>? M1y5S2lEPTB;M{WuPFYhyrFiMj65JO69VQ>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh6NEiwPUc,OjR6OES4NFk9N2F-
MOLM-13 NVPieXIxTnWwY4Tpc44hSXO|YYm= NGPafnM3yqEQvF2= M4TxcVYhcA>? NVPWPYlMTE2VTx?= MWLlcohidmOnczD0bIUh[WOndInsZZRqd25ib3[gbIl{fG:wZTDINmIh[W6mIHjlZZQhe2ixY3ugdJJwfGWrboOgTJNxOjdiYX7kJGh{eDly NUTrXGpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PFUxQDJpPkK0PFg2ODh{PD;hQi=>
MOLM-13 M3fQT2Z2dmO2aX;uJGF{e2G7 MoD4OuKh|ryP Mm\xNE05KGh? M3iyRWROW09? MoDybY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZicEWzMEBOTE1{LDDwNlEh[W6mIHHj[ZR6dGG2ZXSgdFU{ NVT0VWxVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PFUxQDJpPkK0PFg2ODh{PD;hQi=>
115 NGi1e25HfW6ldHnvckBCe3OjeR?= MYO1JO69VQ>? NFjLVWQ1QCCq MnHqSG1UVw>? NGTsVFBqdmS3Y3XzJJA2Oy2mZYDlcoRmdnRic3Xu[ZNk\W6lZdMg MnH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNke3PFcoRjJ3ME[3O|g4RC:jPh?=
A498 MlL3SpVv[3Srb36gRZN{[Xl? NHHxbHQ2KM7:TR?= NFiweVE1QCCq MmTLSG1UVw>? MmjpbY5lfWOnczDwOVMu\GWyZX7k[Y51KHOnbnXzZ4Vv[2YEoB?= MkHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNke3PFcoRjJ3ME[3O|g4RC:jPh?=
Caki-2 NX3ERlRKTnWwY4Tpc44hSXO|YYm= M1XNNlUh|ryP NWnrV2FPPDhiaB?= NE\zUXVFVVOR NX;OXHZHcW6mdXPld{BxPTNvZHXw[Y5l\W62IIPlcoV{[2WwY3ZCpC=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4N{e4O{c,OjVyNke3PFc9N2F-
ACHN MVrGeY5kfGmxbjDBd5NigQ>? NXjmUndPPSEQvF2= M2DBW|Q5KGh? NYjBeFYzTE2VTx?= M2DMNIlv\HWlZYOgdFU{NWSncHXu[IVvfCC|ZX7ld4NmdmOnwrC= NGC3cVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2O|c5Pyd-MkWwOlc4QDd:L3G+
115 NUXDc2U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK1OGs2KM7:TR?= MoLHOFghcA>? MVzEUXNQ M{HLeYlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4VCpC=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4N{e4O{c,OjVyNke3PFc9N2F-
A498 NFHt[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXQO2E2KM7:TR?= M{OzVlQ5KGh? NWn6UWZITE2VTx?= MVzpcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2wrC= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4N{e4O{c,OjVyNke3PFc9N2F-
Caki-2 NUXXW5NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK1JO69VQ>? M2XJ[VQ5KGh? MUHEUXNQ NVTHNIR[cW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeOKh MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4N{e4O{c,OjVyNke3PFc9N2F-
ACHN NIDKcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P6U|Uh|ryP NF7KUoM1QCCq MWnEUXNQ M3Hzbolv\HWlZYOgZ4VtdCCleXPs[UBienKnc4VCpC=> NXPTS3BSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlc4QDdpPkK1NFY4Pzh5PD;hQi=>
115 MWLGeY5kfGmxbjDBd5NigQ>? M{npVlAvPS9zL{Wg{txO Mn7XOFghcA>? MX;EUXNQ M3;STYxm[WS|IITvJIlv[3KnYYPl[EBmgHC{ZYPzbY9vKG:oIIC1N{BidmRic3;t[UBxPTNidHHy[4V1KGenbnXzPkBOTE1{LDDhcoQheDJz M1TNblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[3O|g4Lz5{NUC2O|c5PzxxYU6=
A498 NIrlSZdHfW6ldHnvckBCe3OjeR?= MnHTNE42NzFxNTFOwG0> MoC2OFghcA>? MlPESG1UVw>? M1rkVYxm[WS|IITvJIlv[3KnYYPl[EBmgHC{ZYPzbY9vKG:oIIC1N{BidmRic3;t[UBxPTNidHHy[4V1KGenbnXzPkBOTE1{LDDhcoQheDJz NEjY[WI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2O|c5Pyd-MkWwOlc4QDd:L3G+
Caki-2 NHuwb4VHfW6ldHnvckBCe3OjeR?= NWLo[HNpOC53L{GvOUDPxE1? NXzGUpBCPDhiaB?= NV22emZjTE2VTx?= Mn;qcIVi\HNidH:gbY5kemWjc3XkJIV5eHKnc4Ppc44hd2ZicEWzJIFv\CC|b33lJJA2OyC2YYLn[ZQh\2WwZYO6JG1FVTJuIHHu[EBxOjF? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4N{e4O{c,OjVyNke3PFc9N2F-
ACHN Mn;iSpVv[3Srb36gRZN{[Xl? M3Tx[VAvPS9zL{Wg{txO Mn;2OFghcA>? MX\EUXNQ MW\s[YFleyC2bzDpcoNz\WG|ZXSg[ZhxemW|c3nvckBw\iCyNUOgZY5lKHOxbXWgdFU{KHSjcnfleEBo\W6nc{qgUWROOixiYX7kJJAzOQ>? MmL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNke3PFcoRjJ3ME[3O|g4RC:jPh?=
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115 NIfiSIZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGTp[44xNjVvMUCg{txO NGWwNWExNTZiZB?= MVvEUXNQ M2LzbYlvcGmkaYTzJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MlPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNke3PFcoRjJ3ME[3O|g4RC:jPh?=
A498 NV;3em97S2WubDDWbYFjcWyrdImgRZN{[Xl? Ml3PNE42NTFyIN88US=> NFGw[pUxNTZiZB?= MlfZSG1UVw>? NEjMbYRqdmirYnn0d{Bxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NVP3cIplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlc4QDdpPkK1NFY4Pzh5PD;hQi=>
Caki-2 MVrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NVXRfZlXOC53LUGwJO69VQ>? M2PHZVAuPiCm MXfEUXNQ MmHHbY5pcWKrdIOgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NF3qS2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2O|c5Pyd-MkWwOlc4QDd:L3G+
ACHN MWjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVSwMlUuOTBizszN NX7iTIFROC14IHS= NWHDN2Z5TE2VTx?= MnPNbY5pcWKrdIOgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NHO0WG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2O|c5Pyd-MkWwOlc4QDd:L3G+
MCF7  NEnDb2tHfW6ldHnvckBCe3OjeR?= NH3MSXkzNjViwsXN MmHzOFghcA>? NVTrWlVWTE2VTx?= Mn3H[IVkemWjc3XzJJRp\SCqb33vcI9od3W|IFTTRkBz\XCjaYKg[pJmeXWnbnPp[ZM> MmXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEW5NFIoRjJ3MEi1PVAzRC:jPh?=
MCF7  NVHTZnFqS2WubDDWbYFjcWyrdImgRZN{[Xl? M2XJdlIvPSEEtV2= MkH3OUBl MnzRSG1UVw>? MlrTd4Vve2m2aYrld{BOS0Z5IITvJHBCWlBiaX7obYJqfGmxbh?= NHnXR|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4OVkxOid-MkWwPFU6ODJ:L3G+
RAW 264.7 Mnu1SpVv[3Srb36gRZN{[Xl? MnXHNVDDqM7:TR?= MXizNEBucW5? NGToXJNqdmirYnn0d{BNWFNvaX7keYNm\CCQTzDwdo9lfWO2aX;uxsA> NWTONmNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxO|I2PDdpPkK1NVczPTR5PD;hQi=>
RAW 264.7 MmfQSpVv[3Srb36gRZN{[Xl? NWP3VHQ6OTEEoN88US=> MY[zNEBucW5? M1zTXZJm\HWlZYOgeIhmKEySUz3heYdu\W62ZXSgeIhmKE6ILd86RkBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZYN1cX[rdIm= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF5MkW0O{c,OjVzN{K1OFc9N2F-
RAW 264.7 NF;2OWhHfW6ldHnvckBCe3OjeR?= NGDTPG8yOMLizszN NITCT3k{OCCvaX6= NHHQe|FxemW4ZX70d{B1cGVicEWzJJJm\HWldHnvckBqdiC{ZYPwc45{\SC2bzDMVHM> Ml;2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzN{K1OFcoRjJ3MUeyOVQ4RC:jPh?=
SUM102PT MnXtSpVv[3Srb36gRZN{[Xl? MWmxNOKh|ryP NHL1[pIzPCCq MnSwSG1UVw>? Mk\vbY5pcWKrdIOgJHRITi4QskOtbY5lfWOnZDDFVGhDOsLibWLORUBidmRicILveIVqdiCneIDy[ZN{cW:w NW\BVItHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOVc4OjlpPkK1NlU4PzJ7PD;hQi=>
SK-BR-7 NYryN2JXTnWwY4Tpc44hSXO|YYm= MV:xNOKh|ryP M363bVI1KGh? MYLEUXNQ MmHHbY5pcWKrdIOgJHRITi4QskOtbY5lfWOnZDDFVGhDOsLibWLORUBidmRicILveIVqdiCneIDy[ZN{cW:w MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ3N{eyPUc,OjV{NUe3Nlk9N2F-
MCF-10CA1a M4qxVGZ2dmO2aX;uJGF{e2G7 NUXqSo5VOTEEoN88US=> NXfW[oc3OjRiaB?= M1u1XWROW09? NXK2[5Z1cW6qaXLpeJMhKFSJRj5OtlMucW6mdXPl[EBGWEiEMtMgcXJPSSCjbnSgdJJwfGWrbjDlfJBz\XO|aX;u MnXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NUe3NlkoRjJ3MkW3O|I6RC:jPh?=
MCF-10CA1a NXGzdGU3TnWwY4Tpc44hSXO|YYm= MkGxNVDDqM7:TR?= MoDYNlQhcA>? M3nQTmROW09? MkLY[IVkemWjc3XzJJRp\SCWR1[t{tI{NWmwZIXj[YQhdVKQQTDs[ZZmdHNib3\NUXAzNMLiTV3QPUwh[W6mwrDpcpRm\3KrbtMg{tLDqDN? NIHOWXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK1O|czQSd-MkWyOVc4Ojl:L3G+
MCF-10A1  NVXMcohYTnWwY4Tpc44hSXO|YYm= M3XNXVExyqEQvF2= NGTOUYgzPC92ODDo NV74dlBoTE2VTx?= MYjpcohq[mm2czDtbYdz[XSrb36gc4Yhdm:{bXHsJIJz\WG|dDDldIl1cGWuaXHsxsA> NV70PHFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOVc4OjlpPkK1NlU4PzJ7PD;hQi=>
MCF-10CA1a MYXGeY5kfGmxbjDBd5NigQ>? NEftTIIyOMLizszN M4XP[lQ5KGh? NY\PWZNqTE2VTx?= NYPJcFh4cW6qaXLpeJMh[mG|YXygbY53[XOrb36gZY5lKHKnZIXj[YQhXEeILd8yN{1qdmS3Y3XkJIlvfmG|aX;uJJRwKGKjc3HsJIxmfmWucx?= NXvscnU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOVc4OjlpPkK1NlU4PzJ7PD;hQi=>
HCT116  MWPGeY5kfGmxbjDBd5NigQ>? MV[xNEDDvU1? M{nHUVI1KGh? MX7jZZV{\XNiYTDwOVMu\GWyZX7k[Y51KHSndILhdIxwcWRiR{GtZZJz\XO2IHnuJIRqeGyxaXSgTGNVOTF4IHPsc45meyCGMzDhcoQhTDh? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN6MEC1OUc,OjV|OECwOVU9N2F-
A2780 MkTsSpVv[3Srb36gRZN{[Xl? MV:xNOKh|ryP MX6yNYjDqA>? MnTzSG1UVw>? MYnk[YNz\WG|ZYOgeIhmKE[xeF2xJIxmfmWucx?= NU\XVId6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0NlY2PDhpPkK1OFI3PTR6PD;hQi=>
NCI-H23 M2W0dmZ2dmO2aX;uJGF{e2G7 NIfke44yOMLizszN M4LXflIycMLi MYLEUXNQ MkXD[IVkemWjc3XzJJRp\SCIb4jNNUBt\X[nbIO= NFmxXJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSyOlU1QCd-MkW0NlY2PDh:L3G+
A2780 NIr2UG5HfW6ldHnvckBCe3OjeR?= NIT1Z3oyOMLizszN M1fablIycMLi NX\ldHlKTE2VTx?= NG\od|ZqdmO{ZXHz[ZMheDV|IIDyc5RmcW5ibHX2[Yx{ M2\QflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEK2OVQ5Lz5{NUSyOlU1QDxxYU6=
NCI-H23 NY\VSlY{TnWwY4Tpc44hSXO|YYm= NVW1[Y1IOTEEoN88US=> MlfqNlFpyqB? MVHEUXNQ NWDoRWY5cW6lcnXhd4V{KHB3MzDwdo91\WmwIHzleoVtew>? MkW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2Mk[1OFgoRjJ3NEK2OVQ5RC:jPh?=
OVCAR10 NVHaSWdETnWwY4Tpc44hSXO|YYm= M{PjclExyqEQvF2= NFvw[HgzOWkEoB?= MlfCSG1UVw>? MlfqbY5kemWjc3XzJJA2OyCycn;0[YlvKGyndnXsdy=> M3LqV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEK2OVQ5Lz5{NUSyOlU1QDxxYU6=
MCF-7 MV\GeY5kfGmxbjDBd5NigQ>? NV7VcW1sOTEEoN88US=> MmH6NE0zPCCq NVnCVHJQcW6mdXPld{BxPTNiYX7kJJAzOS:FaYCx MkjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OEKzO|MoRjJ3NEiyN|c{RC:jPh?=
SMMC-7721 M1TlWmZ2dmO2aX;uJGF{e2G7 NEDwWJcyOCEQvF2= NYfMNJA1OzZiaB?= NX3meVhmTE2VTx?= NV7ZNVRU[2G3c3XzJJRp\SCnY4TvdIlkKGW6cILld5Nqd25ib3[gTWZKOTZ? MkfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3NESzOlEoRjJ3NUS0N|YyRC:jPh?=
SMMC-7721 MU\GeY5kfGmxbjDBd5NigQ>? M3TKPFExKM7:TR?= NUPtXpZMPDhiaB?= NHvhUlhFVVOR MX7pcoNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Ywhd2cEoFnGUmIyyqCvUl7B MoDUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3NESzOlEoRjJ3NUS0N|YyRC:jPh?=
SMMC-7721 MVTGeY5kfGmxbjDBd5NigQ>? NWnmdYFDOTBizszN Mle1OFghcA>? M3HqNmROW09? NIW1[nJqdmS3Y3XzJJRp\SClaILvcYF1cW5vYn;1coQheHKxdHXpckBKTklzNjD0c{Bx[XK2aXHscJkhdG:lYXzpfoUhcW5idHjlJIN6fG:ybHHzceKh MnjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3NESzOlEoRjJ3NUS0N|YyRC:jPh?=
SMMC-7721 NF\YWHhHfW6ldHnvckBCe3OjeR?= NYqyV2VCOTBizszN NV;BdGNVPDhiaB?= MWLEUXNQ NWnUTHQ3[2G3c3XzJGRPSSCGU1Kg[IFu[Wen NUTySYhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1OFQ{PjFpPkK1OVQ1OzZzPD;hQi=>
DU4475  NHPIOFhHfW6ldHnvckBCe3OjeR?= NYPtUlJLPS9zMD:yNEDPxE1? NVLIVXRGOjUEoHi= NHK2OXNld3ewcnXneYxifGW|IGTvZ4EuOSCmb4PlJIRmeGWwZHXueIx6 NFjVTlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUW0O|E4PCd-MkW1OFcyPzR:L3G+
MCF-7  NGLjfWRHfW6ldHnvckBCe3OjeR?= MVyxNOKh|ryP M3\Z[GROW09? MY\pcohq[mm2czDjfYNtcW5iREGgZY5lKESrY3XyxsA> NFnsR|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewNlcxOyd-MkW3NFI4ODN:L3G+
C2C12 M4Hvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTIdo51OTEEoN88UeKh MWCyOE81QC95MjDo NGnx[3lFVVOR M2C0cIlvcGmkaYTzJINmdGy|IIDyc4xq\mW{YYTpc44h[W6mIHTp[oZmemWwdHnheIlwdg>? MmDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{G3PVQoRjJ3OEexO|k1RC:jPh?=
L6 M2rnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXoZoUyOMLizszNxsA> NIK2T5QzPC92OD:3NkBp M4Xlb2ROW09? MoG4bY5pcWKrdIOgZ4VtdHNicILvcIln\XKjdHnvckBidmRiZHnm[oVz\W62aXH0bY9v NIXkXW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3NVc6PCd-MkW4O|E4QTR:L3G+
CRL-5908 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DaPVI1KGh? Mon1TWM2OD1|OD63NUDDuSB{LkSzJO69VQ>? MnfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMkWyN|AoRjJ4MUK1NlMxRC:jPh?=
A549-920 NWnkfFh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3kNlQhcA>? MXHJR|UxRTN|Lki1JOKyKDRwOESg{txO MlvVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMkWyN|AoRjJ4MUK1NlMxRC:jPh?=
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A549 NWnZT4p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[yOEBp NHTmemlKSzVyPUG3MlY5KMLzIESuOVIh|ryP NFizbI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGyOVI{OCd-Mk[xNlUzOzB:L3G+
C666-1 MXXBdI9xfG:|aYOgRZN{[Xl? MWCxNEDDvU1? NF3hc3Q1QC95MjDo MXnEUXNQ M1P6UZNmdnOrdHn6[ZMhSzZ4Nj2xJINmdGy|IITvJINqe3CuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3MkW3OUc,OjZ{NUK1O|U9N2F-
C666-1  NVTXZVZNTnWwY4Tpc44hSXO|YYm= NWHvRWV{OTBiwsXN M3fmUVI1KGh? MYDEUXNQ MXXhZ5RqfmG2ZYOgeIhmKHB3MzDwZZRpf2G7LDD1dJJm\3WuYYTpcocheDV|LDDwNlEh[W6mIF3kcVI> NHjxT2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1NlU4PSd-Mk[yOVI2PzV:L3G+
C666-1 Mn\OR4VtdCCYaXHibYxqfHliQYPzZZk> NEH5ZpkyOCEEtV2= M3zCO|Q5KGh? MonhSG1UVw>? NUPzN5ZWe2Wwc3n0bZpmeyCFNk[2MVEh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gZ4l{eGyjdHnu NVTWW5I1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVI2PzVpPkK2NlUzPTd3PD;hQi=>
C666-1 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jTVmlEPTB;MUmuPVXDuThwOUOg{txO NIHUOIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1NlU4PSd-Mk[yOVI2PzV:L3G+
NP460 NUTNN5cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DodGlEPTB;MkKuPFXDuTFwMUig{txO MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3MkW3OUc,OjZ{NUK1O|U9N2F-
NP69 NEPIfWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;qUYZKSzVyPUOxMlY6yrF{LkW0JO69VQ>? M1TtVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkWyOVc2Lz5{NkK1NlU4PTxxYU6=
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HuH-7 NXrwZpZpTnWwY4Tpc44hSXO|YYm= NGjHZpQyOCEQvF2= MXGzOkBp NWnqU2RtTE2VTx?= MYTkc5dvNXKnZ4XsZZRmeyC2aHWgdJJwfGWrbjDlfJBz\XO|aX;uJIxmfmWuIH;mJJBpd3OyaH:tV4VzOzl{LYC1Ny=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6NkOxNkc,OjR{OE[zNVI9N2F-
AT2 NVSxV5UzTnWwY4Tpc44hSXO|YYm= NWrCe|R5PS9zMDFOwG0> NULjZ2ZEdGWjZIOgeI8h[SC|dXLzeIFvfGmjbDDhZ4N2dXWuYYTpc44hd2ZidHjlJJA2OyCycn;0[YlvKGG|IIflcIwh[XNidHjlJIV5eHKnc4Ppc44hd2ZiaYTzJIRqemWldDD0ZZJo\XS|IICyNUwhVUSPMjDhcoQhfGinIIDyc{1ieG:ydH;0bYMhSkG[IHHu[EBRXU2DIIDyc5RmcW6|wrC= Mny2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NECyNFMoRjJ2MkSwNlA{RC:jPh?=
REH M2\hOWZ2dmO2aX;uJGF{e2G7 NYm1e3h3PS9zMDFOwG0> M{\6doxm[WS|IITvJIEhe3Wkc4ThcpRq[WxiYXPjeY12dGG2aX;uJI9nKHSqZTDwOVMheHKxdHXpckBieyC5ZXzsJIF{KHSqZTDlfJBz\XO|aX;uJI9nKGm2czDkbZJm[3RidHHy[4V1eyCyMkGsJG1FVTJiYX7kJJRp\SCycn:tZZBweHSxdHnjJGJCYCCjbnSgVHVOSSCycn;0[Ylve8Li M{HrOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkSwNlA{Lz5{NEK0NFIxOzxxYU6=
UoCB6 MnX2SpVv[3Srb36gRZN{[Xl? M17EVFUwOTBizszN M1iwZoxm[WS|IITvJIEhe3Wkc4ThcpRq[WxiYXPjeY12dGG2aX;uJI9nKHSqZTDwOVMheHKxdHXpckBieyC5ZXzsJIF{KHSqZTDlfJBz\XO|aX;uJI9nKGm2czDkbZJm[3RidHHy[4V1eyCyMkGsJG1FVTJiYX7kJJRp\SCycn:tZZBweHSxdHnjJGJCYCCjbnSgVHVOSSCycn;0[Ylve8Li NYixW|lCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOFAzODNpPkK0NlQxOjB|PD;hQi=>
AT2 NXfXTnc5S2WubDDWbYFjcWyrdImgRZN{[Xl? MoHFNE0zPSEQvF2= NVi1bJJ3cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M{LhPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkSwNlA{Lz5{NEK0NFIxOzxxYU6=
REH M13CNWNmdGxiVnnhZoltcXS7IFHzd4F6 MUiwMVI2KM7:TR?= NUTmUXVicW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= NXnvSYxQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOFAzODNpPkK0NlQxOjB|PD;hQi=>
UoCB6 NYqwWnZ3S2WubDDWbYFjcWyrdImgRZN{[Xl? MmDhNE0zPSEQvF2= M3;iTIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NFjsZ|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK0NFIxOyd-MkSyOFAzODN:L3G+
A2780 M1;SVGZ2dmO2aX;uJGF{e2G7 M1fXOVUwOTBxMkCg{txO M3LJW|I1KGh? NFnYToZ2eHKnZ4XsZZRmeyCyNUOsJG1FVTJuIICyNUBidmRiRGK1JJBzd3SnaX6gcIV3\Wy|IHTvd4Uh\GWyZX7k[Y51dHoEoB?= M4DXPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUO2NVQ4Lz5{NEGzOlE1PzxxYU6=
H460 MmPRSpVv[3Srb36gRZN{[Xl? NVHnVlBQPS9zMD:yNEDPxE1? NFW1V4czPCCq MUH1dJJm\3WuYYTld{BxPTNuIF3EUVItKHB{MTDhcoQhTFJ3IIDyc5RmcW5ibHX2[Yx{KGSxc3Wg[IVx\W6mZX70cJnDqA>? MonvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzM{[xOFcoRjJ2MUO2NVQ4RC:jPh?=
Lovo  MlHISpVv[3Srb36gRZN{[Xl? NVf6XoZXPS9zMD:yNEDPxE1? MVmyOEBp NYHoN|Z2fXC{ZXf1cIF1\XNicEWzMEBOTE1{LDDwNlEh[W6mIFTSOUBxem:2ZXnuJIxmfmWuczDkc5NmKGSncHXu[IVvfGy7wrC= Mnj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzM{[xOFcoRjJ2MUO2NVQ4RC:jPh?=
A2780 NXnUUZQ5SXCxcITvd4l{KEG|c3H5 NGGxV2Q2NzFyL{KwJO69VQ>? M37MclI1KGh? NHq0UmJmdmijbnPld{BieG:ydH;zbZMhcW6mdXP0bY9vKGK7IFSyOllJN0VzOUXSJI93\XJicnjUVmFKVA>? NWq1dIxwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|YyPDdpPkK0NVM3OTR5PD;hQi=>
H460 NVrrS446SXCxcITvd4l{KEG|c3H5 MX[1M|ExNzJyIN88US=> NWXSVZdUOjRiaB?= NHTtc4RmdmijbnPld{BieG:ydH;zbZMhcW6mdXP0bY9vKGK7IFSyOllJN0VzOUXSJI93\XJicnjUVmFKVA>? NXfLZXNoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|YyPDdpPkK0NVM3OTR5PD;hQi=>
Lovo  NULrdVJHSXCxcITvd4l{KEG|c3H5 NFToeoU2NzFyL{KwJO69VQ>? M{TrU|I1KGh? MUPlcohidmOnczDhdI9xfG:|aYOgbY5lfWO2aX;uJIJ6KER{NknIM2UyQTWUIH;2[ZIhemiWUlHJUC=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|NkG0O{c,OjRzM{[xOFc9N2F-
U87MG NETRelNHfW6ldHnvckBie3OjeR?= M3S3WFExKG2rboO= M1G0d2JqdmSrbnegZYZncW6rdImgeI8hVUSPMjDpckBpfW2jbjDVPFdOTyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJG1FVTJxcEWzJJBzd3SnaX6gbY51\XKjY4Tpc44h[W[2ZYKgNVAhdWmwczDifUByfWGwdHn0ZZRqfmVic3Hu[Jdq[2hiaX3teY5wKGG|c3H5MEBKSzVyIE2gNE4yODR3IN88UU4> Mm\SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyNUC3PFIoRjJ5MEWwO|gzRC:jPh?=
U87MG MkXWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlH5OFghcHK| NUn6bGlJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IE[uOUDPxE1w MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB3MEe4Nkc,OjdyNUC3PFI9N2F-
U343MG M1LUOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4XwelQ5KGi{cx?= Mnz5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXM{SzUWch[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSBzMj62JO69VS5? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB3MEe4Nkc,OjdyNUC3PFI9N2F-
SW620 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NUnyO5R1PzJiaILz MoHuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3c3OjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvOzhizszNMi=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7DbGVOSkx:L3G+
A549 MoX4R5l1d3SxeHnjbZR6KGG|c3H5 NYnJOY54PzJiaILz M3rQcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvPDFizszNMi=> MkD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVkyOzN2Lze+R4hGVUKOPD;hQi=>
SJSA1 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M1HCZlczKGi{cx?= MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTTnNCOSClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNU45OSEQvF2u NV\HOZNYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTlzM{O0M{c,S2iHTVLMQE9iRg>?
HCT116 NFPpN5JEgXSxdH;4bYNqfHliYYPzZZk> NHzVU2k4OiCqcoO= NGHXVZBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDRwNkOg{txONg>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPVE{OzRxJ{7DbGVOSkx:L3G+
PC3 MmTwR5l1d3SxeHnjbZR6KGG|c3H5 M4fWV|czKGi{cx?= MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IE[uN|ch|ryPLh?= M1rMdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE6OTN|ND:nQmNpTU2ETEyvZV4>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
MDM2 / p53 / ALKBH2 / p21 / PUMA; 

PubMed: 23258843     


CCF-STTG1 cells were treated with the MDM2 antagonist nutlin-3 (0–8 µM) for 24h before cell lysates were collected for western blotting.

RRM1 / RRM2 / p53R2 / p21 / p53 / pS6 / S6; 

PubMed: 28507282     


(A) Rh18 cells were treated with different concentrations of nutlin-3 as indicated for 24 hr. Total proteins were extracted for immunoblotting of RRM1, RRM2, γH2AX, p21, p53R2, p53, S6, pS6-235/6 and 4E-BP1. (B) Rh30 cells were treated with different concentrations of nutlin-3 as indicated for 24 hr. Total proteins were extracted for immunoblotting of RRM1, RRM2, γH2AX, p21, p53R2, p53, S6, pS6-235/6 and 4E-BP1. GAPDH and Actin served as loading controls.

23258843 28507282
Immunofluorescence
Lamin A / Lamin C / p16 / H3K9me3; 

PubMed: 30728349     


c Immunofluorescence images of nuclear deformation and p16 expression after Nutlin-3 treatment for different time period. HCT p53+/− cells were treated with Nutlin-3 (1 μM) for different time (24, 48 h). After treatment, cells were subjected to immunofluorescence staining for Lamin A/C (Red), p16 (Green), and counterstained with DAPI (Blue). dImmunofluorescence images of nuclear deformation and decreased expression of H3K9me3 in HCT p53+/− cells (left). Counting of histone H3K9me3-positive cells (middle) and signal intensities (right) on the basis of IF staining. HCT p53+/− cells were treated with Nutlin-3 (1 μM) for different time (24, 48 h). After treatment, cells were IF stained with Lamin A/C (Red), H3K9me3 (Green), and counterstained with DAPI (Blue). *P < 0.05. 

Merlin / cyclin D1 / p53 / MDM2; 

PubMed: 30274821     


The changes in the subcellular localization of proteins in response to Nutlin-3. Nuclear merlin was indicated with white arrows. Scale bar = 50 μm.

p53; 

PubMed: 24286312     


The subcellular localization of p53 was detected under immunofluorescence microscope (1,000×). The cells were treated as indicated and stained for p53 (red). Nuclei were counterstained with DAPI (blue).

30728349 30274821 24286312
Growth inhibition assay
Cell viability; 

PubMed: 29286113     


Inhibitory effect of nutlin-3 for the cell proliferation after cultivate cells at different concentration for three times (24, 48 and 72 h), respectively.

29286113
In vivo Oral administration of Nutlin-3 at 200 mg/kg twice daily for 3 weeks significantly inhibits the tumor growth of SJAS-1 xenografts by 90%, comparable with the effect of doxorubicin treatment with 81% inhibition of tumor growth. [1]

Protocol

Kinase Assay:

[1]

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Biacore study:

Competition assay is performed on a Biacore S51. A Series S Sensor chip CM5 is utilized for the immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~200 response units (1 response unit corresponds to 1 pg of protein per mm2). The concentration of MDM2 protein is kept constant at 300 nM. Nutlin-3 is dissolved in DMSO at 10 mM and further diluted to make a concentration series of Nutlin-3 in each MDM2 test sample. The assay is run at 25 °C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of Nutlin-3 is calculated as a percentage of binding in the absence of Nutlin-3 and IC50 is calculate
Cell Research:

[1]

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  • Cell lines: HCT116, RKO, SJSA-1, SW480, and MDA-MB-435
  • Concentrations: Dissolved in DMSO, final concentrations ~ 30 μM
  • Incubation Time: 8, 24, and 48 hours
  • Method:

    Cells are exposed to various concentrations of Nutlin-3 for 8, 24 and 48 hours. The transcriptional levels of p21 and MDM2 genes are analyzed by real-time PCR, and protein levels by western blotting. Cell viability is measured by the MTT assay. Cell apoptosis is determined by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining with flow cytometry and fluorescence microscopy.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Athymic female nude mice (Nu/Nu-nuBR) injected subcutaneously with SJSA-1 cells
  • Dosages: 200 mg/kg
  • Administration: Orally, twice a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (171.96 mM)
Ethanol 30 mg/mL (51.59 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 581.5
Formula

C30H30Cl2N4O4

CAS No. 890090-75-2
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is this a racemic mixture of Nutlin-3a and Nutlin-3b or just the Nutlin-3a enantiomer?

  • Answer:

    It is a racemate.

Mdm2 Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID