Home Metabolism ATP-citrate lyase inhibitor NDI-091143 For research use only.

NDI-091143

NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an IC50 of 2.1 nM in the ADP-Glo assay.

NDI-091143 Chemical Structure

NDI-091143 Chemical Structure

CAS: 2375840-87-0

Selleck's NDI-091143 has been cited by 3 publications

Purity & Quality Control

Batch: S887801 DMSO] 91 mg/mL] false] Ethanol] 3 mg/mL] false] Water] Insoluble] false Purity: 99.94%
99.94

NDI-091143 Related Products

Choose Selective ATP-citrate lyase Inhibitors

Biological Activity

Description NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an IC50 of 2.1 nM in the ADP-Glo assay.
Targets
ATP-citrate lyase [1]
(Cell-free assay)
7.0 nM(Ki)
In vitro
In vitro

ACLY inhibitor NDI091143 exerts dose-dependent inhibition of T24 and T24T clonogenic survival. [1]
Cell Research Cell lines BCa cell lines (UMUC3, T24, T24T)
Concentrations 5-100 μM
Incubation Time 10–14 days
Method

BCa cells are plated in wells of 6-well plates at a density of 500 cells/ well, and allowed to attach for 16 h, before being treated with NDI091143 for further 10–14 days. Formation of cell colonies > 50 cells/colony is confirmed by examination under inverted microscope. Plates are then fixed with 4% paraformaldehyde and are stained with crystal violet.

Chemical Information & Solubility

Molecular Weight 453.84 Formula

C20H14ClF2NO5S
CAS No. 2375840-87-0 SDF --
Smiles COC(=O)C1=CC(=C(C(=C1)Cl)O)S(=O)(=O)NC2=C(C=C(C(=C2)C3=CC=CC=C3)F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 91 mg/mL ( (200.51 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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