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Naproxen COX inhibitor

Cat.No.S5177

Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.
Naproxen COX inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 230.26

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S517701 DMSO]46 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 230.26 Formula

C14H14O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 22204-53-1 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O

Solubility

In vitro
Batch:

DMSO : 46 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05900336 Recruiting
Dysmenorrhea|Menstrual Pain|Non-steroidal Anti-inflammatory Drug
Mclean Hospital|United States Department of Defense|NorthShore University HealthSystem
 March 25 2024 Phase 4
NCT05844995 Completed
Orthodontic Pain
Johnson & Johnson Consumer Inc. (J&JCI)|Johnson & Johnson Consumer and Personal Products Worldwide
 September 13 2023 Phase 1
NCT05411718 Recruiting
T Cells|Colorectal Cancer|Lynch Syndrome
M.D. Anderson Cancer Center|National Institutes of Health (NIH)|National Cancer Institute (NCI)
 March 21 2023 Phase 2
NCT05026320 Completed
Soft Tissue Injury
Bayer|Deutsche Sporthochschule Köln
 August 8 2021 Phase 2

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