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Nitrofurantoin

Synonyms: Macrodantin, Furadantine, Furadonine

Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.

Nitrofurantoin Chemical Structure

Nitrofurantoin Chemical Structure

CAS: 67-20-9

Selleck's Nitrofurantoin has been cited by 1 publication

Purity & Quality Control

Batch: S453601 DMSO] 47 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

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Biological Activity

Description Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
In vitro
In vitro Nitrofurantoin is very effective against both outdoor and indoor urinary isolates and can be used empirically for uncomplicated urinary tract infections[3]. Nitrofurantoin can directly injure lung parenchymal cells, probably through oxidant mechanisms[2].
Cell Research Cell lines HeLa cell
Concentrations 5, 10, 20, 40 μM
Incubation Time 24 h
Method HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37˚C and measuring the absorbance at 490 nm in a microplate reader.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05630833 Recruiting
Urinary Tract Infections
GlaxoSmithKline
 January 11 2023 Phase 3
NCT05817253 Completed
Clinical Audit|Quality Improvement
University of British Columbia|Ministry of Health British Columbia
 September 23 2021 Not Applicable
NCT04900571 Completed
Pain Postoperative|Irreversible Pulpitis
Altamash Institute of Dental Medicine
 January 1 2021 Phase 4
NCT02727322 Completed
Pelvic Organ Prolapse
Halina M Zyczynski MD|University of Pittsburgh
 August 2016 Phase 4
NCT00678041 Terminated
Urinary Tract Infections
University of Pittsburgh
 May 2008 Not Applicable

Chemical Information & Solubility

Molecular Weight 238.16 Formula

C8H6N4O5
CAS No. 67-20-9 SDF Download Nitrofurantoin SDF
Smiles C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 47 mg/mL ( (197.34 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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